期刊
NANOSCALE
卷 8, 期 25, 页码 12406-12429出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr08534a
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资金
- National Natural Science Foundation of China [21535005, 21505157]
- National Basic Research Program of China (863 Program) [2013AA032204]
- 111 Project [111-2-10]
- Collaborative Innovation Center for Chemistry and Molecular Medicine
- Fund for Young Scientists of Shandong Province [BS2015SF001]
- Fundamental Research Funds for the Central Universities [15CX02070A]
The study of cancer is of great significance to human survival and development, due to the fact that cancer has become one of the greatest threats to human health. In recent years, the rapid progress of nanoscience and nanotechnology has brought new and bright opportunities to this field. In particular, the applications of quantum dots (QDs) and magnetic nanoparticles (MNPs) have greatly promoted early diagnosis and effective therapy of cancer. In this review, we focus on fluorescent/magnetic micro/nanospheres based on QDs and/or MNPs (we may call them nanoparticle-sphere (NP-sphere) composites) from their preparation to their bio-application in cancer research. Firstly, we outline and compare the main four kinds of methods for fabricating NP-sphere composites, including their design principles, operation processes, and characteristics (merits and limitations). The NP-sphere composites successfully inherit the unique fluorescence or magnetic properties of QDs or MNPs. Moreover, compared with the nanoparticles (NPs) alone, the NP-sphere composites show superior properties, which are also discussed in this review. Then, we summarize their recent applications in cancer research from three aspects, that is: separation and enrichment of target tumor cells or biomarkers; cancer diagnosis mainly through medical imaging or tumor biomarker detection; and cancer therapy via targeted drug delivery systems. Finally, we provide some perspectives on the future challenges and development trends of the NP-sphere composites.
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