CACO: A Core-Attachment Method With Cross-Species Functional Ortholog Information to Detect Human Protein Complexes

Protein complexes play an essential role in living cells. Detecting protein complexes is crucial to understand protein functions and treat complex diseases. Due to high time and resource consumption of experiment approaches, many computational approaches have been proposed to detect protein complexes. However, most of them are only based on protein-protein interaction (PPI) networks, which heavily suffer from the noise in PPI networks. Therefore, we propose a novel core-attachment method, named CACO, to detect human protein complexes, by integrating the functional information from other species via protein ortholog relations. First, CACO constructs a cross-species ortholog relation matrix and transfers GO terms from other species as a reference to evaluate the confidence of PPIs. Then, a PPI filter strategy is adopted to clean the PPI network and thus a weighted clean PPI network is constructed. Finally, a new effective core-attachment algorithm is proposed to detect protein complexes from the weighted PPI network. Compared to other thirteen state-of-the-art methods, CACO outperforms all of them in terms of F-measure and Composite Score, showing that integrating ortholog information and the proposed core-attachment algorithm are effective in detecting protein complexes.

Automated summary

Protein complexes are essential in living cells and detecting them is crucial for understanding protein functions and treating complex diseases. This study proposes a novel method, CACO, to detect human protein complexes by integrating functional information from other species via protein ortholog relations. The method outperforms other state-of-the-art methods in terms of F-measure and Composite Score, demonstrating the effectiveness of integrating ortholog information and the proposed core-attachment algorithm in detecting protein complexes.