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Review
Cardiac & Cardiovascular Systems
Optimizing Foundational Therapies in Patients With HFrEF How Do We Translate These Findings Into Clinical Care?
Abhinav Sharma et al.
Summary: Patients with heart failure and reduced ejection fraction (HFrEF) have a high risk of adverse outcomes. It is crucial to initiate and titrate guideline-directed medical therapy (GDMT) to reduce morbidity and mortality. Clinical practice guidelines emphasize the need for early initiation of therapies that have cardiovascular benefit. However, many barriers exist in the initiation and optimization of GDMT.
JACC-BASIC TO TRANSLATIONAL SCIENCE (2022)
Review
Cardiac & Cardiovascular Systems
Treatment of HF in an Era of Multiple Therapies Statement From the HF Collaboratory
Ankeet S. Bhatt et al.
Summary: The treatment of heart failure with reduced ejection fraction has evolved over time, with multiple therapies being evaluated simultaneously. Implementation science has lagged behind discovery science, and further complexities are expected with over 200 ongoing clinical trials in heart failure. The development of a decision-making framework by the Heart Failure Collaboratory aims to address the expanding therapeutic options in the current era.
JACC-HEART FAILURE (2021)
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