期刊
GENETICS
卷 225, 期 3, 页码 -出版社
GENETICS SOCIETY AMERICA
DOI: 10.1093/genetics/iyad165
关键词
hedgehog; noncanonical signaling; cell migration; germ cells; Drosophila
In addition to specifying cell fate, the Hedgehog pathway also guides cell migration in various tissues. This study focuses on the role of the Hedgehog pathway in guiding the migration of primordial germ cells (PGCs) in Drosophila embryos. The results show that Hh produced by mesodermal cells guides PGC migration, Hmgcr enhances guidance signals from SGPs, and factors required in Hh receiving cells in other contexts function in PGCs to help direct migration towards SGPs.
In addition to inducing nonautonomous specification of cell fate in both Drosophila and vertebrates, the Hedgehog pathway guides cell migration in a variety of different tissues. Although its role in axon guidance in the vertebrate nervous system is widely recognized, its role in guiding the migratory path of primordial germ cells (PGCs) from the outside surface of the Drosophila embryo through the midgut and mesoderm to the SGPs (somatic gonadal precursors) has been controversial. Here we present new experiments demonstrating (1) that Hh produced by mesodermal cells guides PGC migration, (2) that HMG CoenzymeA reductase (Hmgcr) potentiates guidance signals emanating from the SGPs, functioning upstream of hh and of 2 Hh pathway genes important for Hh-containing cytonemes, and (3) that factors required in Hh receiving cells in other contexts function in PGCs to help direct migration toward the SGPs. We also compare the data reported by 4 different laboratories that have studied the role of the Hh pathway in guiding PGC migration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据