Prevalence, drug resistance, molecular typing and comparative genomics analysis of MRSA strains from a tertiary A hospital in Shanxi Province, China

Article Immunology

Prevalence, multiple antibiotic resistance and virulence profile of methicillin-resistant Staphylococcus aureus (MRSA) in retail poultry meat from Edo, Nigeria

Etinosa O. Igbinosa et al.

Summary: The presence of methicillin-resistant Staphylococcus aureus (MRSA) in meat in Nigeria is a concern for public health.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2023)

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Review Microbiology

A genetic regulatory see-saw of biofilm and virulence in MRSA pathogenesis

Hardi Patel et al.

Summary: Staphylococcus aureus is a common pathogen causing infectious diseases, and it has the ability to form robust biofilm and secrete diverse virulence factors. The genetic regulation of biofilm formation and virulence factors secretion plays a crucial role in the pathogenesis of MRSA infections.

FRONTIERS IN MICROBIOLOGY (2023)

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Review Infectious Diseases

Progress in the Prevalence, Classification and Drug Resistance Mechanisms of Methicillin-Resistant Staphylococcus aureus

Zhuru Hou et al.

Summary: This article summarizes the epidemic characteristics and classifications of Staphylococcus aureus, as well as the drug resistance mechanisms of MRSA (SCCmec element, vanA operon, biofilm, and active efflux pump system) and novel therapy strategies, providing a theoretical basis for the treatment of MRSA infection.

INFECTION AND DRUG RESISTANCE (2023)

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Article Immunology

Impact of polymorphisms in blaZ, blaR1 and blaI genes and their relationship with β-lactam resistance in S. aureus strains isolated from bovine mastitis

Gabriela Dias Rocha et al.

Summary: This study investigated the genetic and phenotypic resistance to beta-lactams in Staphylococcus aureus and found that mutations in certain genes can alter the function of proteins, explaining the sensitivity of resistant isolates to beta-lactams.

MICROBIAL PATHOGENESIS (2022)

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Article Immunology

Methicillin-resistant Staphylococcus aureus in China: a multicentre longitudinal study and whole-genome sequencing

Bingjie Wang et al.

Summary: The aim of this study was to investigate the genomic epidemiology of MRSA in China and identify the predominant lineages and their associated genomic and phenotypic characteristics. The study found that CC59, CC5, and CC8 were the major lineages, with CC59 replacing CC8 as the predominant lineage over time. Different lineages of MRSA exhibited varying levels of antimicrobial resistance and carried different resistance determinants. Additionally, different lineages carried multiple virulence genes involved in various functions.

EMERGING MICROBES & INFECTIONS (2022)

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Article Infectious Diseases

Current Status of Staphylococcal Cassette Chromosome mec (SCCmec)

Yuki Uehara

Summary: This review summarizes the current status of SCCmec types and subtypes, as well as the nomenclature rules and identification methods. It provides guidance for screening and studying the drug resistance of methicillin-resistant Staphylococcus aureus.

ANTIBIOTICS-BASEL (2022)

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Article Microbiology

A Practical Approach for Predicting Antimicrobial Phenotype Resistance in Staphylococcus aureus Through Machine Learning Analysis of Genome Data

Shuyi Wang et al.

Summary: With the reduction in sequencing price and acceleration of sequencing speed, it is increasingly important to directly link the genotype and phenotype of bacteria. In this study, machine learning algorithms were used to predict the minimum inhibitory concentrations of antimicrobial agents for Staphylococcus aureus, achieving high agreement rates and providing important information for clinical treatment.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Multidisciplinary Sciences

Whole genome sequencing reveals new links between spa t172/CC59 methicillin-resistant Staphylococcus aureus cases in low-endemicity region of Southwest Finland, 2007-2016

Jaakko Silvola et al.

Summary: The incidence of MRSA infections in Finland has been relatively low, but the t172 strain has been increasing in Southwest Finland. By studying the molecular epidemiology of t172-MRSA, the transmission of this strain was better understood. Whole genome sequencing revealed the presence of multiple t172-MRSA subclones in regional healthcare and the community, highlighting the importance of targeted surveillance.

SCIENTIFIC REPORTS (2022)

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Review Biochemistry & Molecular Biology

Molecular Mechanisms of Drug Resistance in Staphylococcus aureus

Beata Mlynarczyk-Bonikowska et al.

Summary: This paper discusses the mechanisms of drug resistance in S. aureus, including resistance to beta-lactam antibiotics, glycopeptides, oxazolidinones, MLS-B, aminoglycosides and spectinomicin, fluoroquinolones, tetracyclines, mupirocin, fusidic acid, daptomycin, as well as other antibiotics and chemotherapeutics. It also covers the molecular epidemiology of MRSA.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Immunology

Contribution of Staphylococcal Enterotoxin B to Staphylococcus aureus Systemic Infection

Justin S. Bae et al.

Summary: The study found that Staphylococcal enterotoxin B (SEB) contributes significantly to the pathogenicity of Staphylococcus aureus, suggesting the value of including SEB as a target in multipronged antistaphylococcal drug development strategies. Furthermore, it indicates that SEB contributes to fatal exacerbation of community-associated methicillin-resistant S. aureus infection.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Microbiology

Clonality, virulence genes, and antibiotic resistance of Staphylococcus aureus isolated from blood in Shandong, China

Xuezhi Wang et al.

Summary: This study conducted a detailed characterization of S. aureus in BSI patients in Shandong, China, revealing higher antibiotic resistance rates in MRSA isolates alongside specific virulence genes and genotypic distributions, which varied over time.

BMC MICROBIOLOGY (2021)

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Article Microbiology

Molecular Characteristics of Staphylococcus aureus From Food Samples and Food Poisoning Outbreaks in Shijiazhuang, China

Guoping Lv et al.

Summary: This study investigated the characteristics of Staphylococcus aureus from food samples and food poisoning outbreaks in Shijiazhuang City, revealing certain clonal complexes to be more prevalent in foodborne S. aureus and food poisoning outbreaks. Additionally, a variety of staphylococcal enterotoxin types were detected in the food poisoning isolates.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Biochemistry & Molecular Biology