Recent advances on cyclodepsipeptides: biologically active compounds for drug research

Cyclodepsipeptides are a large family of peptide-related natural products consisting of hydroxy and amino acids linked by amide and ester bonds. A number of cyclodepsipeptides have been isolated and characterized from fungi and bacteria. Most of them showed antitumor, antifungal, antiviral, antimalarial, and antitrypanosomal properties. Herein, this review summarizes the recent literatures (2010-2022) on the progress of cyclodepsipeptides from fungi and bacteria except for those of marine origin, in order to enrich our knowledge about their structural features and biological sources.

Automated summary

Cyclodepsipeptides are a diverse group of peptide-related natural products found in fungi and bacteria. They possess various biological activities, including antitumor, antifungal, antiviral, antimalarial, and antitrypanosomal properties. This review provides a summary of recent research progress on cyclodepsipeptides from fungi and bacteria, excluding those of marine origin, aiming to enhance our understanding of their structural features and biological sources.