4.6 Article

Ssa1-targeted antibody prevents host invasion by Candida albicans

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, Research & Experimental

Antibodies to watch in 2022

Helene Kaplon et al.

Summary: This article provides a summary of key events in the development of commercial antibody therapeutics in 2021 and a glimpse into potential events in 2022. The regulatory review process for antibody therapeutics targeting the SARS-CoV-2 coronavirus has been expedited, leading to emergency use authorizations and full approvals in multiple countries. Additionally, the late-stage commercial clinical pipeline for antibody therapeutics, excluding those for COVID-19, has seen significant growth over the past year.
Article Microbiology

Antibody evasion of SARS-CoV-2 Omicron BA.1, BA.1.1, BA.2, and BA.3 sub-lineages

Jingwen Ai et al.

Summary: This study compared the neutralization efficacy of vaccine-induced or monoclonal antibodies against different sub-lineages of the Omicron variant. The results showed that current vaccines have low neutralization activity, but both homologous and heterologous boosters significantly improved neutralization titers. The study also found that most monoclonal antibodies lost their neutralizing activity, while some demonstrated distinct neutralization patterns among Omicron sub-lineages, indicating antigenic differences.

CELL HOST & MICROBE (2022)

Review Biochemistry & Molecular Biology

Designing antibodies as therapeutics

Paul J. Carter et al.

Summary: Antibody therapeutics have significant health benefits and are rapidly expanding. This article provides an overview of current antibody therapeutics, including formats, targets, therapeutic areas, and administration routes. It also highlights emerging directions in antibody design, such as enhancing antibodies for cancer treatment and delivering antibodies to specific organs. In addition, the challenges of antibody developability and the potential of machine learning in antibody discovery are discussed.
Article Microbiology

The prophylactic effects of monoclonal antibodies targeting the cell wall Pmt4 protein epitopes of Candida albicans in a murine model of invasive candidiasis

Xiaojuan Wang et al.

Summary: Monoclonal antibodies targeting protein mannosyltransferase 4 of C. albicans have been found to be effective in alleviating symptoms and improving survival rate of candidiasis. These antibodies exert their immunotherapeutic effects through opsonophagocytosis and opsonic killing activity.

FRONTIERS IN MICROBIOLOGY (2022)

Review Microbiology

Antifungal Combinations against Candida Species: From Bench to Bedside

Simona Fioriti et al.

Summary: Candida spp. is a major pathogen causing fungal infections in hospitalized patients and nosocomial bloodstream infections. Combination therapy has gained significant interest in the treatment of Candida infections. Various combinations of antifungal agents have shown synergistic effects against difficult-to-treat Candida species and improved outcomes compared to monotherapy. However, further in vitro and clinical studies are needed to establish the effectiveness of combination therapy as a reliable treatment option.

JOURNAL OF FUNGI (2022)

Review Chemistry, Multidisciplinary

Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

Yunjin Lee et al.

Summary: This article discusses the major role of fungal infections in infectious disease-related deaths worldwide, the prevalence of Candida species in invasive mycotic diseases, and the limitations of current antifungal drugs. It also focuses on the resistance mechanisms of Candida species and potential therapeutic strategies to combat antifungal resistance.

CHEMICAL REVIEWS (2021)

Review Microbiology

Candida albicans-The Virulence Factors and Clinical Manifestations of Infection

Jasminka Talapko et al.

Summary: Candida albicans is a common commensal fungus in the human body, which can cause various infections when the balance with the host immune system is disrupted. Factors such as dysbiosis of microbiota, immune dysfunction, and mucosal barrier damage contribute to the transition of C. albicans from a normal flora to a pathogenic state. The presence of C. albicans in the bloodstream can lead to invasive infections.

JOURNAL OF FUNGI (2021)

Review Biochemistry & Molecular Biology

Tackling COVID-19 with neutralizing monoclonal antibodies

Davide Corti et al.

Summary: Monoclonal antibodies have revolutionized the treatment of several human diseases, including cancer, autoimmunity, and infectious diseases. Lessons learned from the COVID-19 pandemic have paved the way for the development of more monoclonal antibody-based therapeutics.
Article Biochemistry & Molecular Biology

Candida Cell-Surface-Specific Monoclonal Antibodies Protect Mice against Candida auris Invasive Infection

Jonothan Rosario-Colon et al.

Summary: This study introduced a novel approach to treating C. auris disseminated infections through passive transfer of monoclonal antibodies targeting specific antigens, which showed significantly enhanced survival and reduction of fungal burdens. The combination of beta-Man(3)-specific mAb and peptide-specific mAbs demonstrated greater protection compared to individual mAb treatment against medically important Candida species, including multidrug-resistant C. auris.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Conformational equilibria in allosteric control of Hsp70 chaperones

Wei Wang et al.

Summary: Researchers characterized biochemical properties of selected domain-interface mutants in bacterial Hsp70 DnaK and developed a theoretical model to explain allosteric equilibria among Hsp70 conformational states. They proposed a restraining state and a stimulating state to describe the different characteristics of Hsp70 in ATP hydrolysis and peptide binding.

MOLECULAR CELL (2021)

Article Biochemistry & Molecular Biology

Genetic analysis of Hsp70 phosphorylation sites reveals a role in Candida albicans cell and colony morphogenesis

Ziva Weissman et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2020)

Review Biochemistry & Molecular Biology

Recognition of Fungal Components by the Host Immune System

Laura C. Garcia-Carnero et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2020)

Article Microbiology

Identification of Human Single-Domain Antibodies against SARS-CoV-2

Yanling Wu et al.

CELL HOST & MICROBE (2020)

Review Immunology

New Insights in Candida albicans Innate Immunity at the Mucosa: Toxins, Epithelium, Metabolism, and Beyond

Aize Pellon et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Review Infectious Diseases

Mechanism of Candida pathogenesis: revisiting the vital drivers

Ifeanyi Elibe Mba et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2020)

Review Critical Care Medicine

Invasive candidiasis in critical care: challenges and future directions

C. Logan et al.

INTENSIVE CARE MEDICINE (2020)

Review Medicine, General & Internal

Functional and phenotypic heterogeneity of Th17 cells in health and disease

Jonas Bystrom et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Biochemical Research Methods

The external face of Candida albicans: A proteomic view of the cell surface and the extracellular environment

Ana Gil-Bona et al.

JOURNAL OF PROTEOMICS (2018)

Review Immunology

Beyond binding: antibody effector functions in infectious diseases

Lenette L. Lu et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Editorial Material Microbiology

Stop neglecting fungi

[Anonymous]

NATURE MICROBIOLOGY (2017)

Review Microbiology

Candida albicans-epithelial interactions and induction of mucosal innate immunity

Julian R. Naglik et al.

CURRENT OPINION IN MICROBIOLOGY (2017)

Article Immunology

Invasive Candidiasis

Todd P. McCarty et al.

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2016)

Review Microbiology

Heat shock protein 90 (Hsp90): A novel antifungal target against Aspergillus fumigatus

Frederic Lamoth et al.

CRITICAL REVIEWS IN MICROBIOLOGY (2016)

Review Medicine, General & Internal

Emerging Threats in Antifungal-Resistant Fungal Pathogens

Dominique Sanglard

FRONTIERS IN MEDICINE (2016)

Article Biochemistry & Molecular Biology

Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions

Patrick G. Needham et al.

JOURNAL OF MOLECULAR BIOLOGY (2015)

Review Medicine, General & Internal

Invasive Candidiasis

Bart Jan Kullberg et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Review Medicine, Research & Experimental

The therapeutic monoclonal antibody market

Dawn M. Ecker et al.

Article Medicine, Research & Experimental

Host Cell Invasion by Medically Important Fungi

Donald C. Sheppard et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2015)

Review Immunology

Immune defence against Candida fungal infections

Mihai G. Netea et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Article Medicine, General & Internal

Multistate Point- Prevalence Survey of Health Care- Associated Infections

Shelley S. Magill et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Review Immunology

Human Monoclonal Antibody-Based Therapy in the Treatment of Invasive Candidiasis

Francesca Bugli et al.

CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2013)

Review Pharmacology & Pharmacy

Invasive candidiasis: update on current pharmacotherapy options and future perspectives

Athanasios Tragiannidis et al.

EXPERT OPINION ON PHARMACOTHERAPY (2013)

Article Pharmacology & Pharmacy

Monoclonal antibody therapeutics: history and future

Nicholas A. P. S. Buss et al.

CURRENT OPINION IN PHARMACOLOGY (2012)

Review Microbiology

Candida albicans morphogenesis and host defence: discriminating invasion from colonization

Neil A. R. Gow et al.

NATURE REVIEWS MICROBIOLOGY (2012)

Review Microbiology

Biology of the Heat Shock Response and Protein Chaperones: Budding Yeast (Saccharomyces cerevisiae) as a Model System

Jacob Verghese et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2012)

Review Multidisciplinary Sciences

Interactions Between the Microbiota and the Immune System

Lora V. Hooper et al.

SCIENCE (2012)

Review Immunology

Plasmodial heat shock proteins: targets for chemotherapy

Addmore Shonhai

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY (2010)

Article Immunology

Potential of anti-Candida antibodies in immunoprophylaxis

Jonathan Cabezas et al.

IMMUNOTHERAPY (2010)

Review Microbiology

Breaking the wall: targeting of the endothelium by pathogenic bacteria

Emmanuel Lemichez et al.

NATURE REVIEWS MICROBIOLOGY (2010)

Article Microbiology

Host Cell Invasion and Virulence Mediated by Candida albicans Ssa1

Jianing N. Sun et al.

PLOS PATHOGENS (2010)

Review Pharmacology & Pharmacy

Therapeutic antibodies: successes, limitations and hopes for the future

Patrick Chames et al.

BRITISH JOURNAL OF PHARMACOLOGY (2009)

Review Microbiology

Candida-host cell receptor-ligand interactions

Scott G. Filler

CURRENT OPINION IN MICROBIOLOGY (2006)

Review Cell Biology

Contributions of hyphae and hypha-co-regulated genes to Candida albicans virulence

CA Kumamoto et al.

CELLULAR MICROBIOLOGY (2005)

Article Biotechnology & Applied Microbiology

Heat shock protein-mediated resistance to high hydrostatic pressure in Escherichia coli

A Aertsen et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2004)

Article Biochemistry & Molecular Biology

Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5

XWS Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)