期刊
FRONTIERS IN MICROBIOLOGY
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2023.1242163
关键词
RsgA; phage inhibition; ribosome inactivation; persistence; ribosomes
类别
By studying E. coli proteins, we found that the GTPase RsgA can inhibit lytic phage T4 by inactivating ribosomes.
Introduction: Bacteria must combat phages, and myriad bacterial anti-phage systems have been discovered that reduce host metabolism, for example, by depleting energetic compounds like ATP and NADC. Hence, these systems indirectly inhibit protein production. Surprisingly, direct reduction of ribosome activity has not been demonstrated to thwart phage. Methods: Here, by producing each of the 4,287 Escherichia coli proteins and selecting for anti-phage activity that leads to enhanced growth, we investigated the role of host proteins in phage inhibition. Results and discussion: We identified that E. coli GTPase RsgA inhibits lytic phage T4 by inactivating ribosomes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据