期刊
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2023.1218565
关键词
lung-gut crosstalk; common mucosal immune system; respiratory disease; inflammatory bowel disease; microbiota
Both lung and gut are part of the common mucosal immune system (CMIS), which are defense organs against pathogens and involved in innate and adaptive immunity. There is increasing evidence of lung-gut crosstalk, where stimulation of one organ can affect the other, leading to complications and disturbances in both respiratory and intestinal diseases. The intestinal microbiota plays a significant role in these diseases, and imbalance in intestinal microbial composition can contribute to inflammation and disease persistence. This review summarizes the examples and possible mechanisms of lung-gut crosstalk in respiratory disease and inflammatory bowel disease (IBD), and discusses the potential of shaping the intestinal flora for treating respiratory diseases.
Both lung and gut belong to the common mucosal immune system (CMIS), with huge surface areas exposed to the external environment. They are the main defense organs against the invasion of pathogens and play a key role in innate and adaptive immunity. Recently, more and more evidence showed that stimulation of one organ can affect the other, as exemplified by intestinal complications during respiratory disease and vice versa, which is called lung-gut crosstalk. Intestinal microbiota plays an important role in respiratory and intestinal diseases. It is known that intestinal microbial imbalance is related to inflammatory bowel disease (IBD), this imbalance could impact the integrity of the intestinal epithelial barrier and leads to the persistence of inflammation, however, gut microbial disturbances have also been observed in respiratory diseases such as asthma, allergy, chronic obstructive pulmonary disease (COPD), and respiratory infection. It is not fully clarified how these disorders happened. In this review, we summarized the latest examples and possible mechanisms of lung-gut crosstalk in respiratory disease and IBD and discussed the strategy of shaping intestinal flora to treat respiratory diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据