期刊
NANOSCALE
卷 8, 期 22, 页码 11392-11397出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6nr03385g
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资金
- Council of Scientific and Industrial Research (CSIR)
- SCTIMST
- Science and Engineering Research Board (SERB) [SR/S1/OC-67/2012]
- CSIR, New Delhi [CSC 0134]
- Nanomaterials: Applications and Impact on Safety, Health and Environment (NanoSHE) [BSC 0112]
- Department of Biotechnology (DBT) [BT/PR14698/NNT/28/832/2015]
- ICMR [5/13/128/2011/NCD-III]
Herein, we have examined distinctive structural and functional variations of cellular components during apoptotic cell death induced by a targeted theranostic nanoprobe, MMP-SQ@GNR@LAH-DOX, which acted as a SERS on/off probe in the presence of a MMP protease and executed synergistic photothermal chemotherapy, as reflected by the SERS fingerprinting, corresponding to the phosphodiester backbone of DNA.
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