☆ 4.7 Review

Helicobacter pylori infection: a dynamic process from diagnosis to treatment

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2023)

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Article Gastroenterology & Hepatology

Helicobacter pylori promotes colorectal carcinogenesis by deregulating intestinal immunity and inducing a mucus-degrading microbiota signature

Anna Ralser et al.

Summary: Helicobacter pylori infection is the most common bacterial infection worldwide and is associated with an increased risk of both gastric cancer and colorectal cancer. However, the direct causality and functional connection between H. pylori infection and colon cancer are still unclear.

GUT (2023)

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Article Medicine, General & Internal

Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer

Yoshiaki Usui et al.

Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.

NEW ENGLAND JOURNAL OF MEDICINE (2023)

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Review Microbiology

Role of the skin microbiota and intestinal microbiome in rosacea

Weitao Zhu et al.

Summary: Rosacea is a chronic inflammatory skin disorder affecting the centrofacial region. Its etiology and treatment methods are still unclear. This review examines common bacterial species found in the skin and gut microbiota of rosacea patients and their role in pathogenesis. Additionally, it summarizes the impact of factors such as temperature and age on rosacea and reviews commonly used clinical treatment methods, including antibiotics and probiotics, along with their mechanisms and precautions.

FRONTIERS IN MICROBIOLOGY (2023)

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Article Multidisciplinary Sciences

Development of serological assays to identify Helicobacter suis and H. pylori infections

Hidenori Matsu et al.

Summary: Helicobacter suis, the most common gastric non-Helicobacter pylori Helicobacter species found in humans, has been suggested to cause many cases of gastric disease, but the transmission route from hogs remains unclear. Diagnostic methods for H. suis infection often yield negative results, making it difficult to diagnose without gastric biopsy specimens. This study introduces the use of whole-bacterial cell ELISA to simultaneously assess H. suis and H. pylori infections, with high accuracy and sensitivity.

ISCIENCE (2023)

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Article Gastroenterology & Hepatology

Proton pump inhibitor use and the risk of metachronous gastric cancer after H. pylori eradication in patients who underwent endoscopic resection for gastric neoplasms: A population-based cohort study

Eun Jeong Gong et al.

Summary: This study investigated the impact of long-term proton pump inhibitor (PPI) use on metachronous gastric cancer in high-risk patients who underwent endoscopic resection of gastric neoplasms after Helicobacter pylori eradication. The results showed that long-term PPI use was associated with an increased risk of metachronous gastric cancer. These findings remained robust after sensitivity analysis and propensity score-matched analysis.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2023)

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Article Gastroenterology & Hepatology

Long-term effect of Helicobacter pylori eradication on colorectal cancer incidences

Chuan-Guo Guo et al.

Summary: This population-based retrospective cohort study aimed to determine whether H. pylori eradication therapy reduces the risk of colorectal cancer (CRC). The results showed that the risk of CRC was initially higher in H. pylori-infected subjects but gradually decreased over time and became lower than the general population after 10 years of H. pylori eradication, particularly for rectal cancer.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2023)

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Article Gastroenterology & Hepatology

V Spanish Consensus Conference on Helicobacter pylori infection treatment

Javier P. Gisbert et al.

Summary: Helicobacter pylori infection is common in the Spanish population and is the main cause of chronic gastritis, peptic ulcer, and gastric cancer. Recently, experts in Spain developed recommendations for eradication therapy, with quadruple therapies being recommended as first-line treatments.

GASTROENTEROLOGIA Y HEPATOLOGIA (2022)

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Review Gastroenterology & Hepatology

Prevalence of Helicobacter pylori infection in China: A systematic review and meta-analysis

Shuai Ren et al.

Summary: This study systematically evaluated the longitudinal trends in H. pylori prevalence in China and found that while the infection rate has been decreasing, it is still high with an estimated 589 million individuals infected. The prevalence decreases with time from 1983-1994 to 2015-2019 and increases with age, ranging from children and adolescents to adults. Targeted H. pylori eradication strategies may be considered in areas or populations with a high incidence of gastric cancer.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Article Immunology

Characteristics of Helicobacter pylori Heteroresistance in Gastric Biopsies and Its Clinical Relevance

You-hua Wang et al.

Summary: This study found that heteroresistance genotypes for clarithromycin and levofloxacin were not rare in H. pylori. The majority of these genotypes showed susceptibility to clarithromycin and resistance to levofloxacin. Patients infected with heteroresistance genotype strains had a lower peptic ulcer detection rate.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Review Immunology

Helicobacter Pylori and Autoimmune Diseases: Involving Multiple Systems

Li Wang et al.

Summary: Through nearly 40 years of research, it has been found that Helicobacter pylori is associated with the natural history of many upper gastrointestinal diseases and may be associated with other types of autoimmune diseases.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Gastroenterology & Hepatology

Persistent advanced periductal fibrosis is associated with cagA-positive Helicobacter pylori infection in post-praziquantel treatment of opisthorchiasis

Hang Thi Thu Phung et al.

Summary: This study suggests that H. pylori, especially the cagA-positive strain, contributes to persistent APF in opisthorchiasis patients. It is recommended to consider supplementary antibiotic treatment for H. pylori to reduce the risk of persistent APF and eventually cholangiocarcinoma.

HELICOBACTER (2022)

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Article Biochemistry & Molecular Biology

Helicobacter pylori Urease: Potential Contributions to Alzheimer's Disease

Augusto F. Uberti et al.

Summary: Alzheimer's disease (AD) causes dementia and memory loss in the elderly. Research suggests a possible association between Helicobacter pylori infection and tauopathies such as AD, potentially mediated by the bacterium's urease enzyme.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Microbiology

Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model

Sebastian Suerbaum et al.

Summary: This study developed a novel screening system for inhibitors of H. pylori motility and flagellar assembly, and identified numerous novel antibacterial and anti-motility compounds (antimotilins). One of the antimotilin compounds showed good efficacy in reducing bacterial colonization in a mouse model, indicating its potential as a therapy against H. pylori infection.

MBIO (2022)

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Article Gastroenterology & Hepatology

Association of Helicobacter pylori enrichment in colorectal adenoma tissue on clinical and pathological features of adenoma

Zhaomeng Zhuang et al.

Summary: This study investigated the enrichment of Helicobacter pylori (Hp) in adenoma tissue of patients with colorectal adenoma and analyzed its correlation with the clinical and pathological characteristics of colorectal adenoma. The results showed that gastric Hp infection was significantly correlated with Hp enrichment in colorectal adenomas, and Hp enrichment was also associated with the diameter, pathological type, and malignancy of adenoma.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2022)

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Review Medicine, General & Internal

Susceptibility-Guided Therapy vs. Bismuth-Containing Quadruple Therapy as the First-Line Treatment for Helicobacter pylori Infection: A Systematic Review and Meta-Analysis

Yaobin Ouyang et al.

Summary: Compared with bismuth-containing quadruple therapy (BQT), susceptibility-guided therapy (SGT) has higher efficacy and similar safety as the first-line treatment for Helicobacter pylori infection.

FRONTIERS IN MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

CagA+ Helicobacter pylori, Not CagA- Helicobacter pylori, Infection Impairs Endothelial Function Through Exosomes-Mediated ROS Formation

Xiujuan Xia et al.

Summary: This study found that CagA(+) H. pylori effectively colonizes gastric mucosa and impairs endothelial function, leading to increased atherosclerosis through exosomes-mediated ROS formation.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Gastroenterology & Hepatology

Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report

Peter Malfertheiner et al.

Summary: Helicobacter pylori infection is recognized as an infectious disease and requires optimized management to prevent complications and gastric cancer. Continuous updates in treatment strategies and testing methods are necessary due to rising antibiotic resistance and the impact on gut microbiota.

GUT (2022)

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Article Multidisciplinary Sciences

Helicobacter pylori infection eradication for nonalcoholic fatty liver disease: a randomized controlled trial

Ying-ying Yu et al.

Summary: This study investigated the effect of H. pylori eradication treatment on NAFLD patients. The results showed that after 1 year of treatment, the metabolic and inflammatory indicators improved significantly in the treatment group, indicating that H. pylori infection may worsen the development of NAFLD, and eradication treatment can improve metabolic indicators and the degree of liver steatosis.

SCIENTIFIC REPORTS (2022)

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Article Multidisciplinary Sciences

Community prevalence of Helicobacter pylori and dyspepsia and efficacy of triple therapy in a rural district of eastern Uganda

Yang Jae Lee et al.

Summary: This study investigated the prevalence of H. pylori and chronic dyspepsia in eastern Uganda, as well as evaluated the efficacy of standard triple therapy for H. pylori eradication. The results showed that chronic dyspepsia did not predict H. pylori infection, but a higher level of education was an independent predictor. Standard triple therapy had a 90% eradication rate in the region.

HELIYON (2022)

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Article Microbiology

Helicobacter pylori pathogen inhibits cellular responses to oncogenic stress and apoptosis

Manikandan Palrasu et al.

Summary: H. pylori infection is a major risk factor for gastric cancer. This study investigates the impact of H. pylori bacterial factors on the host ubiquitin proteasome system and uncovers the regulatory mechanism associated with the tumor suppressor ARF.

PLOS PATHOGENS (2022)

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Article Oncology

Vacuolating Cytotoxin A Triggers Mitophagy in Helicobacter pylori-Infected Human Gastric Epithelium Cells

Li Wang et al.

Summary: The study revealed that Helicobacter pylori's VacA induces autophagy in gastric epithelial cells and promotes mitophagy by damaging mitochondrial membrane potential, leading to PINK1 accumulation and Parkin recruitment.

FRONTIERS IN ONCOLOGY (2022)

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Article Pediatrics

Inverse association between Helicobacter pylori infection and childhood asthma in a physical examination population: a cross-sectional study in Chongqing, China

Donghai Wang et al.

Summary: This study evaluates the relationship between Helicobacter pylori infection and pediatric asthma in Chongqing, China, and finds a significant inverse association between the two. Further research is needed to determine the causal relationship and mechanisms for preventing and controlling childhood asthma.

BMC PEDIATRICS (2022)

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Review Pharmacology & Pharmacy

Berberine for gastric cancer prevention and treatment: Multi-step actions on the Correa's cascade underlie its therapeutic effects

Qingsong Liu et al.

Summary: Berberine (BBR) has shown multi-step actions on the Correa's cascade, contributing to the prevention and treatment of gastric cancer. Its mechanisms include suppression of H. pylori infection, control of mucosal inflammation, promotion of ulcer healing, and regulation of inflammatory cytokines.

PHARMACOLOGICAL RESEARCH (2022)

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Article Gastroenterology & Hepatology

Chinese herbal formula shen-ling-bai-zhu-san to treat chronic gastritis: Clinical evidence and potential mechanisms

Wei Jin et al.

Summary: This study systematically evaluated the clinical evidence and potential mechanisms of Shen-ling-bai-zhu san (SLBZS) for the treatment of chronic gastritis (CG). Meta-analysis showed that SLBZS was more effective than conventional therapies for CG, but its safety remains unclear. Network pharmacology analysis suggested that SLBZS may treat CG by acting on related targets and pathways.

WORLD JOURNAL OF GASTROENTEROLOGY (2022)

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Article Pharmacology & Pharmacy

Pharmacological and molecular analysis of the effects of Huangqi Jianzhong decoction on proliferation and apoptosis in GES-1 cells infected with H. pylori

Jingnan Hu et al.

Summary: Huangqi Jianzhong decoction (HQJZD) exhibits anti-Helicobacter pylori activity and promotes the proliferation of human gastric epithelial cells while reducing apoptosis. The effect of HQJZD on H. pylori is dose-dependent.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Gastroenterology & Hepatology

Helicobacter pylori employs a general protein glycosylation system for the modification of outer membrane adhesins

Kai-Wen Teng et al.

Summary: Helicobacter pylori infection is associated with gastric diseases, including gastric cancer. The key adhesins AlpA/B and BabA/B in H. pylori are modified by glycans and show a two-step molecular weight upshift pattern. The glycosylation process is shared with LPS biosynthesis. Loss of adhesin glycosylation reduces stability, protease resistance, and adhesion ability. Mutations in LPS biosynthesis significantly reduce bacterial adhesion in vitro.

GUT MICROBES (2022)

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Review Veterinary Sciences

Gastric Helicobacter species associated with dogs, cats and pigs: significance for public and animal health

Emily Taillieu et al.

Summary: This article discusses the importance of Helicobacter species in dogs, cats, and pigs and their potential to infect humans. The article highlights the association of Helicobacter suis with gastritis and decreased weight gain in pigs, as well as its potential to cause disease in humans. It also mentions that multiple Helicobacter species can colonize the stomachs of dogs and cats, but their pathogenic significance is likely low. The article concludes that besides H. pylori, gastric Helicobacter species associated with these animals are also clinically relevant in humans.

VETERINARY RESEARCH (2022)

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Review Allergy

The Protective Effects of Helicobacter pylori Infection on Allergic Asthma

Zhi Tong Zuo et al.

Summary: H. pylori may protect against allergic asthma by regulating T cell ratios, targeting dendritic cells for immune tolerance, and depending on highly suppressed Tregs for its protective effects. It may also protect against asthma by altering stomach hormone levels, affecting the autonomic nervous system, and reducing heat shock protein 70 expression.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2021)

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Article

Helicobacter pylori and Gastric Cancer

Judith Kim et al.

Gastrointestinal Endoscopy Clinics of North America (2021)

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Review Medicine, General & Internal

Recent Advances and Implication of Bioengineered Nanomaterials in Cancer Theranostics

Ayushi Rai et al.

Summary: Cancer is a leading cause of death, with infectious agents playing a significant role in its incidence. Nanotechnology shows promise in improving cancer diagnosis, imaging, and treatment, enhancing anti-cancer efficacy potential.

MEDICINA-LITHUANIA (2021)

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Article Biology

Asymmetric random walks reveal that the chemotaxis network modulates flagellar rotational bias in Helicobacter pylori

Jyot D. Antani et al.

Summary: The chemotaxis network in Helicobacter pylori regulates the direction of rotation in the bacterial flagellar motor to facilitate cell migration towards favorable chemical environments. This modulation results in cells swimming faster or slower depending on the direction of flagellar rotation. Exposure to a chemo-attractant decreases the rotational bias, leading to cells swimming exclusively in the faster mode, while the absence of the chemotaxis protein CheY results in a zero bias. The relationship between reversal frequency and rotational bias is unimodal in this species.

ELIFE (2021)

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Article Engineering, Biomedical

Helicobacter pylori-targeting multiligand photosensitizer for effective antibacterial endoscopic photodynamic therapy

Byeong Nam Im et al.

Summary: The study proposes an H. pylori-targeting photodynamic therapy system, p3SLP, which demonstrates significant antibacterial effects and anti-inflammatory response in infected mice, showing great potential for replacing antibiotic-based therapy.

BIOMATERIALS (2021)

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Article Medicine, General & Internal

Frequency of iron deficiency anemia (IDA) among patients with Helicobacter pylori infection

Adeel Rahat et al.

Summary: The study revealed an association between H. Pylori infection and iron deficiency anemia, with 37.5% of the patients in the study population experiencing iron deficiency anemia.

PAKISTAN JOURNAL OF MEDICAL SCIENCES (2021)

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Review Gastroenterology & Hepatology

Treatment of Helicobacter pylori infection in the presence of penicillin allergy

Amit Kumar Dutta et al.

Summary: Treatment options for H.pylori infection in patients with penicillin allergy include first-line Bismuth-based quadruple therapy for 10-14 days, and second-line Levoflaxacin-based triple therapy for 10 days. Patients with persistent infection after 2 treatment courses should be tested for penicillin allergy, and treatment should be guided by H.pylori culture and sensitivity testing results.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

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Review Gastroenterology & Hepatology

DNA diagnostics for reliable and universal identification of Helicobacter pylori

Pavol Sulo et al.

Summary: Reliable diagnostics are crucial for detecting and treating Helicobacter pylori infection, with non-invasive urea breath test (UBT) and stool antigen test (SAT) currently leading the way. Nested PCR (NPCR) can achieve DNA amplification specificity by involving two rounds of PCR. Properly designed primers for the 16S rRNA gene can facilitate the development of an NPCR assay for unambiguous identification of H. pylori.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

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Article Biochemistry & Molecular Biology

Structural basis of assembly and torque transmission of the bacterial flagellar motor

Jiaxing Tan et al.

Summary: This study provides detailed molecular insights into the structure, assembly, and torque transmission mechanisms of the bacterial flagellar motor.

CELL (2021)

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Article Microbiology

Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis

Satoshi Imai et al.

Summary: Infection with CagA-producing H. pylori leads to gastric cancer development through disrupting DNA repair mechanisms, inhibiting apoptosis of damaged cells, and promoting somatic mutation. This hit-and-run mechanism creates a favorable environment for the initiation and progression of gastric carcinogenesis.

CELL HOST & MICROBE (2021)

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Article Gastroenterology & Hepatology

Comparative Effectiveness of Multiple Different First-Line Treatment Regimens for Helicobacter pylori Infection: A Network Meta-analysis

Theodore Rokkas et al.

Summary: The study compared the effectiveness of different first-line regimens for Helicobacter pylori infection through a network meta-analysis. Results showed that vonoprazan triple therapy and reverse hybrid therapy achieved high eradication rates above 90%, with levofloxacin triple therapy performing best in Western countries. Standard triple therapy was found to be the least efficacious in this analysis.

GASTROENTEROLOGY (2021)

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Article Biochemistry & Molecular Biology

Evodiamine Inhibits Helicobacter pylori Growth and Helicobacter pylori-Induced Inflammation

Ji Yeong Yang et al.

Summary: Evodiamine inhibits the growth of H. pylori by downregulating gene expressions related to replication and transcription machineries of the bacteria. Moreover, evodiamine also suppresses urease expression, leading to reduced translocation of CagA and VacA proteins into AGS cells. Additionally, evodiamine inhibits the activation of signaling proteins induced by H. pylori infection, contributing to reduction of IL-8 production in AGS cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Gastroenterology & Hepatology

Helicobacter pylori infection and antibiotic resistance - from biology to clinical implications

Evariste Tshibangu-Kabamba et al.

Summary: Helicobacter pylori is a major human pathogen with increasing antibiotic resistance posing a serious threat to human health. The resistance mechanisms include single drug resistance, multidrug resistance, and heteroresistance, primarily related to mutational changes and target-mediated mechanisms. Further research is needed to explore additional biological attributes driving drug resistance in H. pylori for better treatment outcomes.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Pharmacology & Pharmacy

Clinical Strains of Helicobacter pylori With Strong Cell Invasiveness and the Protective Effect of Patchouli Alcohol by Improving miR-30b/C Mediated Xenophagy

Yifei Xu et al.

Summary: The study revealed that drug-resistant strains of Helicobacter pylori exhibit stronger invasive ability, but patchouli alcohol can effectively combat intracellular H. pylori. This compound enhances xenophagy by regulating miR-30b/c and upregulating xenophagy-related gene expression, thereby inhibiting the invasion of H. pylori.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Cell Biology

Efficacy of immunohistochemical staining in detecting Helicobacter pylori in Saudi patients with minimal and atypical infection

Mohammed Akeel et al.

Summary: This study demonstrates that immunohistochemical staining shows higher sensitivity and specificity in detecting Helicobacter pylori infection in gastric biopsies, with the highest diagnostic accuracy among different staining methods.

EUROPEAN JOURNAL OF HISTOCHEMISTRY (2021)

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Article Gastroenterology & Hepatology

CagA+ Helicobacter pylori infection and N-nitrosodimethylamine administration induce cholangiocarcinoma development in hamsters

Rungtiwa Dangtakot et al.

Summary: The study found that H. pylori infection and exposure to carcinogens can induce the development of cholangiocarcinoma (CCA) with slow progression.

HELICOBACTER (2021)

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Article Medicine, General & Internal

Prevalence of Helicobacter pylori Infection Among Rosacea and Chronic Spontaneous Urticaria Patients in a Tertiary Hospital in Riyadh, Saudi Arabia

Amal AlBalbeesi et al.

Summary: The study highlights the significant association of H. pylori with rosacea and CSU, regardless of the presence of gastrointestinal symptoms. The inclusion of H. pylori testing in the routine workup of CSU and rosacea patients is recommended based on the findings.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Article Gastroenterology & Hepatology

Accuracies of Endoscopic Diagnosis ofHelicobacter pylori-Gastritis: Multicenter Prospective Study Using White Light Imaging and Linked Color Imaging

Shoko Ono et al.

DIGESTION (2020)

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Article Gastroenterology & Hepatology

Risk Factors and Incidence of Gastric Cancer After Detection of Helicobacter pylori Infection: A Large Cohort Study

Shria Kumar et al.

GASTROENTEROLOGY (2020)

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Review Immunology

Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis

Atsushi Takahashi-Kanemitsu et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Review Pharmacology & Pharmacy

Phospholipids and cholesterol: Inducers of cancer multidrug resistance and therapeutic targets

Joanna Kopecka et al.

DRUG RESISTANCE UPDATES (2020)

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Article Gastroenterology & Hepatology

Prospective, study comparing the accuracy of two different stool antigen tests (Premier Platinum HpSA and novel ImmunoCard STATI rapid test) for the diagnosis of Helicobacter pylori infection

Adrian G. McNicholl et al.

GASTROENTEROLOGIA Y HEPATOLOGIA (2020)

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Article Gastroenterology & Hepatology

Seven-day vonoprazan and low-dose amoxicillin dual therapy as first-line Helicobacter pylori treatment: a multicentre randomised trial in Japan

Sho Suzuki et al.

GUT (2020)

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Review Biochemistry & Molecular Biology

Using Probiotics as Supplementation for Helicobacter pylori Antibiotic Therapy

Jianfu Ji et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Gastroenterology & Hepatology

Sequential Helicobacter pylori eradication therapy in Myanmar; a randomized clinical trial of efficacy and tolerability

Nan Phyu Sin Toe Myint et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Eradication of Helicobacter pylori: the power of nanosized formulations

Qianyu Zhang et al.

NANOMEDICINE (2020)

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Article Oncology

Helicobacter pylori CagA oncoprotein interacts with SHIP2 to increase its delivery into gastric epithelial cells

Yumiko Fujii et al.

CANCER SCIENCE (2020)

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Review Biochemistry & Molecular Biology

The Helicobacter pylori Cag Type IV Secretion System

Timothy L. Cover et al.

TRENDS IN MICROBIOLOGY (2020)

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Review Infectious Diseases

Role of vacuolating cytotoxin A inHelicobacter pyloriinfection and its impact on gastric pathogenesis

Shamshul Ansari et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2020)

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Article Gastroenterology & Hepatology

The role ofHelicobacter pyloriin vitamin-B12deficiency due to metformin use

Melih Tansel Gokisik et al.

HELICOBACTER (2020)

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Article Oncology

VacAgenotypes andcagA-EPIYA-Cmotifs ofHelicobacter pyloriand gastric histopathological lesions

Mounia El Khadir et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

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Article Biotechnology & Applied Microbiology

Genetic requirements and transcriptomics of Helicobacter pylori biofilm formation on abiotic and biotic surfaces

Skander Hathroubi et al.

NPJ BIOFILMS AND MICROBIOMES (2020)

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Article Biochemistry & Molecular Biology

The relationship between gastric cancer and Helicobacter pylori cytotoxin-related gene A genotypes

Huai Kun Ni et al.

CELLULAR AND MOLECULAR BIOLOGY (2020)

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Article Dermatology

Association between Chronic Urticaria andHelicobacter pyloriInfection among Patients Attending a Tertiary Hospital in Tanzania

Magdalena F. Dennis et al.

DERMATOLOGY RESEARCH AND PRACTICE (2020)

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Review Gastroenterology & Hepatology

High dose PPI-amoxicillin dual therapy for the treatment ofHelicobacter pyloriinfection: a systematic review with meta-analysis

Yang-Jie Zhu et al.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2020)

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Article Gastroenterology & Hepatology

Helicobacter pylori urease induces pro-inflammatory effects and differentiation of human endothelial cells: Cellular and molecular mechanism

Mariele de Jesus Souza et al.

HELICOBACTER (2019)

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Review Cell Biology

Current information on the association of Helicobacter pylori with autophagy and gastric cancer

Majid Eslami et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Helicobacter pylori VacA Targets Myeloid Cells in the Gastric Lamina Propria To Promote Peripherally Induced Regulatory T-Cell Differentiation and Persistent Infection

Aleksandra Altobelli et al.

MBIO (2019)

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Review Gastroenterology & Hepatology

Proton pump inhibitor: The dual role in gastric cancer

Moon Kyung Joo et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

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Review: Epidemiology of Helicobacter pylori infection

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HELICOBACTER (2019)

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Helicobacter pylori recrudescence and its influencing factors

Yan Sun et al.

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The influence of the microbiome on respiratory health

Tomasz P. Wypych et al.

NATURE IMMUNOLOGY (2019)

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Review Gastroenterology & Hepatology

Helicobacter pylori virulence genes

Anja Sterbenc et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

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Review Medicine, General & Internal

Effects of Helicobacter pylori treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial

Wen-Qing Li et al.

BMJ-BRITISH MEDICAL JOURNAL (2019)

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Article Microbiology

Helicobacter pylori and colorectal cancer-A bacterium going abroad?

Julia Butt et al.

PLOS PATHOGENS (2019)

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Article Gastroenterology & Hepatology

Serologic Response to Helicobacter pylori Proteins Associated With Risk of Colorectal Cancer Among Diverse Populations in the United States

Julia Butt et al.

GASTROENTEROLOGY (2019)

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Review Medicine, General & Internal

Gastric MALT lymphoma and Helicobacter pylori

Antonio Salar

MEDICINA CLINICA (2019)

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Article Gastroenterology & Hepatology

Eradication Efficacy of Modified Dual Therapy Compared with Bismuth-Containing Quadruple Therapy as a First-Line Treatment of Helicobacter pylori

Jing Yang et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2019)

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Article Biotechnology & Applied Microbiology

The Relation of Cytotoxin-Associated Gene-A Seropositivity with Vitamin B12 Deficiency in Helicobacter pylori-Positive Patients

Celal Ulasoglu et al.

BIOMED RESEARCH INTERNATIONAL (2019)

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Article Clinical Neurology

Helicobacter pylori seropositivity and its association with incident all-cause and Alzheimer's disease dementia in large national surveys

May A. Beydoun et al.

ALZHEIMERS & DEMENTIA (2018)

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Article Biochemistry & Molecular Biology

Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs

Kristof Moonens et al.

EMBO JOURNAL (2018)

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Review Gastroenterology & Hepatology

Prevalence of Antibiotic Resistance in Helicobacter pylori: A Systematic Review and Meta-analysis in World Health Organization Regions

Alessia Savoldi et al.

GASTROENTEROLOGY (2018)

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Article Gastroenterology & Hepatology

Effects of Helicobacter pylori eradication for metachronous gastric cancer prevention: a randomized controlled trial

Ji Min Choi et al.

GASTROINTESTINAL ENDOSCOPY (2018)

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Article Microbiology

vacA s1m1 genotype and cagA EPIYA-ABC pattern are predominant among Helicobacter pylori strains isolated from Mexican patients with chronic gastritis

Josefina Atrisco-Morales et al.

JOURNAL OF MEDICAL MICROBIOLOGY (2018)

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Review Gastroenterology & Hepatology

Characteristics and predictors of gastric cancer after Helicobacter pylori eradication

Satoki Shichijo et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

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Article Microbiology

&ITHelicobacter pylori&IT Infection Is Not Associated with Non-alcoholic Fatty Liver Disease: A Cross-Sectional Study in China

Nengguang Fan et al.

FRONTIERS IN MICROBIOLOGY (2018)

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Review Infectious Diseases

Understanding treatment guidelines with bismuth and non-bismuth quadruple Helicobacter pylori eradication therapies

David Y. Graham et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2018)

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Article Gastroenterology & Hepatology

Real-time PCR for Helicobacter pylori diagnosis. The best tools available

Lucie Benejat et al.

HELICOBACTER (2018)

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Article Biochemistry & Molecular Biology

Coptisine-induced inhibition of Helicobacter pylori: elucidation of specific mechanisms by probing urease active site and its maturation process

Cailan Li et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2018)

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Review Gastroenterology & Hepatology

Helicobacter pylori infection and liver diseases: Epidemiology and insights into pathogenesis

Kazuya Okushin et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

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Review Clinical Neurology

H-pylori and Parkinson's disease: Meta-analyses including clinical severity

Efthimios Dardiotis et al.

CLINICAL NEUROLOGY AND NEUROSURGERY (2018)

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Review Gastroenterology & Hepatology

Helicobacter pylori infection in Africa: 2018 literature update

Stella I. Smith et al.

MINERVA GASTROENTEROLOGICA E DIETOLOGICA (2018)

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Review Medicine, General & Internal

Non-invasive diagnostic tests for Helicobacter pylori infection

Lawrence M. J. Best et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2018)

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Review Gastroenterology & Hepatology

Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis

James K. Y. Hooi et al.

GASTROENTEROLOGY (2017)

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Review Dermatology

Rosacea is associated with Helicobacter pylori: a systematic review and meta-analysis

A-H R. Jorgensen et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2017)

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Review Pharmacology & Pharmacy

Role of Bismuth in the Eradication of Helicobacter pylori

Huseyin Alkim et al.

AMERICAN JOURNAL OF THERAPEUTICS (2017)

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Review Gastroenterology & Hepatology

Systematic review with meta-analysis: the global recurrence rate of Helicobacter pylori

Y. Hu et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2017)

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Review Medicine, General & Internal

Asthma and gastroesophageal reflux disease: a multidisciplinary point of view

Paolo Solidoro et al.

MINERVA MEDICA (2017)

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Article Oncology

Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia: evidence from a meta-analysis

Hai-Ning Chen et al.

GASTRIC CANCER (2016)

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Article Oncology

Impact of Helicobacter pylori on the growth of hepatic orthotopic graft tumors in mice

Junwei Wang et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2015)

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Article Gastroenterology & Hepatology

Correlation of Helicobacter pylori Genotypes with Gastric Histopathology in the Central Region of a South-European Country

Nuno Almeida et al.

DIGESTIVE DISEASES AND SCIENCES (2015)

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Article Oncology

Global burden of gastric cancer attributable to Helicobacter pylori

Martyn Plummer et al.

INTERNATIONAL JOURNAL OF CANCER (2015)

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Article Gastroenterology & Hepatology

Eradication of Helicobacter pylori After Endoscopic Resection of Gastric Tumors Does Not Reduce Incidence of Metachronous Gastric Carcinoma

Jeongmin Choi et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2014)

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Article Medicine, General & Internal

The use of a second biopsy from the gastric body for the detection of Helicobacter pylori using rapid urease test

Andrew Wong et al.

SINGAPORE MEDICAL JOURNAL (2014)

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Article Gastroenterology & Hepatology

Accuracy of stool antigen test for the diagnosis of Helicobacter pylori infection in children: A meta-analysis

Xiaoying Zhou et al.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2014)

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Article Gastroenterology & Hepatology

Diagnosis of Helicobacter pylori infection in gastric mucosa by endoscopic features: A multicenter prospective study

Takahiro Kato et al.

DIGESTIVE ENDOSCOPY (2013)

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Article Gastroenterology & Hepatology

Stool antigen tests for the management of Helicobacter pylori infection

Tadashi Shimoyama

WORLD JOURNAL OF GASTROENTEROLOGY (2013)

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Article Gastroenterology & Hepatology

Vacuolating Cytotoxin and Variants in Atg16L1 That Disrupt Autophagy Promote Helicobacter pylori Infection in Humans

Deepa Raju et al.

GASTROENTEROLOGY (2012)

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Review Gastroenterology & Hepatology

Management of Helicobacter pylori infection-the Maastricht IV/ Florence Consensus Report

Peter Malfertheiner et al.

GUT (2012)

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Review Respiratory System

The role of Helicobacter pylori infection in the development of allergic asthma

Christian Taube et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2012)

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Article Clinical Neurology

The relationship between Helicobacter pylori infection and Alzheimer's disease in Japan

Seiji Shiota et al.

JOURNAL OF NEUROLOGY (2011)

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Article Multidisciplinary Sciences

Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells

Isabella M. Toller et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Article Infectious Diseases

Phenotypic and genotypic Helicobacter pylori clarithromycin resistance and therapeutic outcome: benefits and limits

Vincenzo De Francesco et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2010)

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Article Gastroenterology & Hepatology

Iron deficiency anemia in Helicobacter pylori infection: meta-analysis of randomized controlled trials

Yuan Wenzhen et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2010)

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Article Gastroenterology & Hepatology

The Relationship Between Virulence Factors of Helicobacter pylori and Severity of Gastritis in Infected Patients

Hasan Umit et al.

DIGESTIVE DISEASES AND SCIENCES (2009)

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Article Gastroenterology & Hepatology

Corpus-predominant gastritis as a risk factor for false-negative 13C-urea breath test results

G. Capurso et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2006)

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Article Gastroenterology & Hepatology

Antigen stool test for assessment of Helicobacter pylori infection in patients with upper gastrointestinal bleeding

U Peitz et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2003)

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Article Dermatology

The link between Helicobacter pylori infection and rosacea

A Szlachcic

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2002)

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Article Immunology

The Helicobacter pylori blood group antigen-binding adhesin facilitates bacterial colonization and augments a nonspecific immune response

R Rad et al.

JOURNAL OF IMMUNOLOGY (2002)

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