期刊
NANOSCALE
卷 8, 期 20, 页码 10570-10575出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6nr00843g
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资金
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Major Program of Development Foundation of Hefei Center for Physical Science and Technology, Hefei Science Center CAS [2015HSC-UP012]
- National Natural Science Foundation of China [U1532144, 21375121, 81201364, 81572167]
Osteoporosis (OP) is an important aging-related disease and the effective prevention/treatment of this disease remains challenging. Considering the acidic microenvironment of bone resorption lacunae, herein, we rationally designed two pamidronate (Pami)-derivative and alendronate (Alen)-derivative hydrogelators Pami-D and Alen-D which self-assemble into nanofibers to form supramolecular hydrogels under acidic conditions. Cell viability assay, osteoclastogenesis, osteoclastic gene expression, and in vitro bone resorption results indicated that both Pami-D and Alen-D have better inhibitory effects on osteoclastic formation and bone resorption than Pami and Alen, respectively. We anticipate that our new drugs Pami-D and Alen-D could smartly self-assemble and locally concentrate the drugs at bone resorption lacunae in vivo and subsequently prevent/treat osteoporosis more efficiently.
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