相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。An atlas of substrate specificities for the human serine/threonine kinome
Jared L. Johnson et al.
NATURE (2023)
PKD autoinhibition in trans regulates activation loop autophosphorylation in cis
Ronja Reinhardt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2023)
Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization
Pragya Pathak et al.
ACS CHEMICAL NEUROSCIENCE (2023)
Structure and regulation of the myotonic dystrophy kinase-related Cdc42-binding kinase
Linda Truebestein et al.
STRUCTURE (2023)
ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt1
Alexandria L. Shaw et al.
STRUCTURE (2023)
Reconfigurable asymmetric protein assemblies through implicit negative design
Danny D. Sahtoe et al.
SCIENCE (2022)
Protein-Small Molecule Interactions in Native Mass Spectrometry
Jack L. Bennett et al.
CHEMICAL REVIEWS (2022)
Design of protein-binding proteins from the target structure alone
Longxing Cao et al.
NATURE (2022)
Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation
Aleksandra Levina et al.
NATURE COMMUNICATIONS (2022)
Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers
Vladislav Belyy et al.
ELIFE (2022)
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction
John T. Happ et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2022)
Bioprinting for the Biologist
Andrew C. Daly et al.
CELL (2021)
Mass photometry enables label-free tracking and mass measurement of single proteins on lipid bilayers
Eric D. B. Foley et al.
NATURE METHODS (2021)
Mass-sensitive particle tracking to elucidate the membrane-associated MinDE reaction cycle
Tamara Heermann et al.
NATURE METHODS (2021)
Probing membrane protein-lipid interactions
Mark T. Agasid et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2021)
In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate
Daniel Pokorny et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2021)
Highly accurate protein structure prediction with AlphaFold
John Jumper et al.
NATURE (2021)
Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation
Linda Truebestein et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation
Bence Hajdusits et al.
ELIFE (2021)
A systematic approach to quantitative Western blot analysis
Lakshmi Pillai-Kastoori et al.
ANALYTICAL BIOCHEMISTRY (2020)
Improved protein structure prediction using potentials from deep learning
Andrew W. Senior et al.
NATURE (2020)
Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation
Lingfeng Chen et al.
NATURE CHEMICAL BIOLOGY (2020)
Antibodies recognizing the C terminus of PP2A catalytic subunit are unsuitable for evaluating PP2A activity and holoenzyme composition
Ingrid E. Frohner et al.
SCIENCE SIGNALING (2020)
The Myc tag monoclonal antibody 9E10 displays highly variable epitope recognition dependent on neighboring sequence context
Stefan Schuechner et al.
SCIENCE SIGNALING (2020)
Ndr/Lats Kinases Bind Specific Mob-Family Coactivators through a Conserved and Modular Interface
Benjamin W. Parker et al.
BIOCHEMISTRY (2020)
Covalent Aurora A regulation by the metabolic integrator coenzyme A
Yugo Tsuchiya et al.
REDOX BIOLOGY (2020)
Characterization of CaMKIIα holoenzyme stability
Ana P. Torres-Ocampo et al.
PROTEIN SCIENCE (2020)
Macromolecular modeling and design in Rosetta: recent methods and frameworks
Julia Koehler Leman et al.
NATURE METHODS (2020)
Redox priming promotes Aurora A activation during mitosis
Daniel C. Lim et al.
SCIENCE SIGNALING (2020)
Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity
Dominic P. Byrne et al.
SCIENCE SIGNALING (2020)
MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases
Peter Sok et al.
STRUCTURE (2020)
Structural basis of STING binding with and phosphorylation by TBK1
Conggang Zhang et al.
NATURE (2019)
High-resolution structure determination of sub-100 kDa complexes using conventional cryo-EM
Mark A. Herzik et al.
NATURE COMMUNICATIONS (2019)
Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex
Oksana Gerlits et al.
SCIENCE ADVANCES (2019)
Custom-Size, Functional, and Durable DNA Origami with Design-Specific Scaffolds
Floris A. S. Engelhardt et al.
ACS NANO (2019)
A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1
Baoyu Zhao et al.
NATURE (2019)
Switch-like activation of Bruton's tyrosine kinase by membrane-mediated dimerization
Jean K. Chung et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Structural Basis of Protein Kinase R Autophosphorylation
Christopher B. Mayo et al.
BIOCHEMISTRY (2019)
Autophosphorylation activates c-Src kinase through global structural rearrangements
Edgar E. Boczek et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Best practices and benchmarks for intact protein analysis for top-down mass spectrometry
Daniel P. Donnelly et al.
NATURE METHODS (2019)
A ubiquitin-like domain controls protein kinase D dimerization and activation by trans-autophosphorylation
Daniel J. Elsner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes
Eunyoung Park et al.
NATURE (2019)
Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer
Ping Wu et al.
STRUCTURE (2019)
Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure
T. P. Hughes et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
A Structurally-Validated Multiple Sequence Alignment of 497 Human Protein Kinase Domains
Vivek Modi et al.
SCIENTIFIC REPORTS (2019)
Structural characterization of the catalytic and regulatory subunits of phosphorylase kinase in the context of the hexadecameric enzyme complex
Mary Ashley Rimmer et al.
PROTEIN SCIENCE (2018)
Protein kinase D displays intrinsic Tyr autophosphorylation activity: insights into mechanism and regulation
Mathias Cobbaut et al.
FEBS LETTERS (2018)
Conformational sampling of membranes by Akt controls its activation and inactivation
Iva Lucic et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Homing in: Mechanisms of Substrate Targeting by Protein Kinases
Chad J. Miller et al.
TRENDS IN BIOCHEMICAL SCIENCES (2018)
Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1
Joseph Schoepfer et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Structural insights into the functional diversity of the CDK-cyclin family
Daniel J. Wood et al.
OPEN BIOLOGY (2018)
Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension
Douglas Marcotte et al.
PROTEIN SCIENCE (2017)
The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1
Andrew A. Wylie et al.
NATURE (2017)
Crystal structure of human IRAK1
Li Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Local protein kinase A action proceeds through intact holoenzymes
F. Donelson Smith et al.
SCIENCE (2017)
DNA NANOTECHNOLOGY Self-assembly of genetically encoded DNA-protein hybrid nanoscale shapes
Florian Praetorius et al.
SCIENCE (2017)
A switch in nucleotide affinity governs activation of the Src and Tec family kinases
Freia von Rauendorf et al.
SCIENTIFIC REPORTS (2017)
cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometry
Dominic P. Byrne et al.
BIOCHEMICAL JOURNAL (2016)
Novel Features of DAG-Activated PKC Isozymes Reveal a Conserved 3-D Architecture
Iva Lucic et al.
JOURNAL OF MOLECULAR BIOLOGY (2016)
Enzymatic reactions in confined environments
Andreas Kuchler et al.
NATURE NANOTECHNOLOGY (2016)
Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites
Bertrand Simon et al.
STRUCTURE (2016)
How Do Protein Kinases Take a Selfie (Autophosphorylate)?
Jonah Beenstock et al.
TRENDS IN BIOCHEMICAL SCIENCES (2016)
Mass Spectrometry of Protein Complexes: From Origins to Applications
Shahid Mehmood et al.
ANNUAL REVIEW OF PHYSICAL CHEMISTRY, VOL 66 (2015)
Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK
Clinton A. Taylor et al.
BIOCHEMISTRY (2015)
Activation of transmembrane cell-surface receptors via a common mechanism? The rotation model''
Ichiro N. Maruyama
BIOESSAYS (2015)
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances
Marco Y. Hein et al.
CELL (2015)
Phosphoryl Transfer Reaction Snapshots in Crystals: INSIGHTS INTO THE MECHANISM OF PROTEIN KINASE A CATALYTIC SUBUNIT
Oksana Gerlits et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Identification of Purines and 7-Deazapurines as Potent and Selective Type I Inhibitors of Troponin I-Interacting Kinase (TNNI3K)
Brian G. Lawhorn et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases
Qifang Xu et al.
SCIENCE SIGNALING (2015)
Ligand regulation of a constitutively dimeric EGF receptor
Daniel M. Freed et al.
NATURE COMMUNICATIONS (2015)
A molecular ruler regulates cytoskeletal remodelling by the Rho kinases
Linda Truebestein et al.
NATURE COMMUNICATIONS (2015)
Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate
Qi Wang et al.
ELIFE (2015)
Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases
Qifang Xu et al.
SCIENCE SIGNALING (2015)
Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling
Jacob R. Haling et al.
CANCER CELL (2014)
Structural basis of Rad53 kinase activation by dimerization and activation segment exchange
Leanne E. Wybenga-Groot et al.
CELLULAR SIGNALLING (2014)
Activation of Protein Kinase PKR Requires Dimerization-induced cis-Phosphorylation within the Activation Loop
Madhusudan Dey et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
A Proteomic Ruler for Protein Copy Number and Concentration Estimation without Spike-in Standards
Jacek R. Wisniewski et al.
MOLECULAR & CELLULAR PROTEOMICS (2014)
IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly
Ryan Ferrao et al.
MOLECULAR CELL (2014)
Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2
Adelajda Zorba et al.
ELIFE (2014)
A Kinetic Test Characterizes Kinase Intramolecular and Intermolecular Autophosphorylation Mechanisms
Charlotte A. Dodson et al.
SCIENCE SIGNALING (2013)
Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1
Daqi Tu et al.
CELL REPORTS (2013)
Crystal Structure and Mechanism of Activation of TANK-Binding Kinase 1
Amede Larabi et al.
CELL REPORTS (2013)
The Structural Basis for Control of Eukaryotic Protein Kinases
Jane A. Endicott et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)
Structural Basis of the Unfolded Protein Response
Alexei Korennykh et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 28 (2012)
Structure and Location of the Regulatory β Subunits in the (αβγδ)4 Phosphorylase Kinase Complex
Owen W. Nadeau et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
The structure of the PERK kinase domain suggests the mechanism for its activation
Wenjun Cui et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2011)
Biological Phosphoryl-Transfer Reactions: Understanding Mechanism and Catalysis
Jonathan K. Lassila et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80 (2011)
Structure of the Dimeric Autoinhibited Conformation of DAPK2, a Pro-Apoptotic Protein Kinase
Ashok K. Patel et al.
JOURNAL OF MOLECULAR BIOLOGY (2011)
Crystal structure of inhibitor of κB kinase β
Guozhou Xu et al.
NATURE (2011)
Co-Crystal Structures of Inhibitors with MRCKβ, a Key Regulator of Tumor Cell Invasion
Timo Heikkila et al.
PLOS ONE (2011)
Structural Insights into the Autoactivation Mechanism of p21-Activated Protein Kinase
Jue Wang et al.
STRUCTURE (2011)
Design of Potent IGF1-R Inhibitors Related to Bis-azaindoles
Conception Nemecek et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2010)
Crystal Contacts as Nature's Docking Solutions
Evgeny Krissinel
JOURNAL OF COMPUTATIONAL CHEMISTRY (2010)
The nuts and bolts of AGC protein kinases
Laura R. Pearce et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation
Peter Rellos et al.
PLOS BIOLOGY (2010)
Mode of Action of cGMP-dependent Protein Kinase-specific Inhibitors Probed by Photoaffinity Cross-linking Mass Spectrometry
Martijn W. H. Pinkse et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9
Mark W. Richards et al.
MOLECULAR CELL (2009)
Structure and Activation Mechanism of the CHK2 DNA Damage Checkpoint Kinase
Zhenjian Cai et al.
MOLECULAR CELL (2009)
The unfolded protein response signals through high-order assembly of Ire1
Alexei V. Korennykh et al.
NATURE (2009)
A dimerization-dependent mechanism drives RAF catalytic activation
Thanashan Rajakulendran et al.
NATURE (2009)
Structure of dystrophia myotonica protein kinase
Jonathan M. Elkins et al.
PROTEIN SCIENCE (2009)
The Precise Sequence of FGF Receptor Autophosphorylation Is Kinetically Driven and Is Disrupted by Oncogenic Mutations
Erin D. Lew et al.
SCIENCE SIGNALING (2009)
Structure of the dual enzyme ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing
Kenneth P. K. Lee et al.
CELL (2008)
Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor
Jinhua Wu et al.
EMBO JOURNAL (2008)
Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure
David Komander et al.
EMBO JOURNAL (2008)
Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites
Ashley C. W. Pike et al.
EMBO JOURNAL (2008)
Chk2 Oligomerization Studied by Phosphopeptide Ligation IMPLICATIONS FOR REGULATION AND PHOSPHODEPENDENT INTERACTIONS
Jiejin Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Substrate discrimination among mitogen-activated protein kinases through distinct docking sequence motifs
Douglas L. Sheridan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
PKCγ mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling
Dineke S. Verbeek et al.
JOURNAL OF CELL SCIENCE (2008)
A helix scaffold for the assembly of active protein kinases
Alexandr P. Kornev et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation
Choel Kim et al.
CELL (2007)
Activation segment exchange: a common mechanism of kinase autophosphorylation?
Antony W. Oliver et al.
TRENDS IN BIOCHEMICAL SCIENCES (2007)
Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation
Camilla Hauge et al.
EMBO JOURNAL (2007)
The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module
Natarajan Kannan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop
Hong Cheng et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism
Alexandr P. Kornev et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases
Michelle Pirruccello et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange
Antony W. Oliver et al.
EMBO JOURNAL (2006)
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
Xuewu Zhang et al.
CELL (2006)
Molecular insights into the self-assembly mechanism of dystrophia myotonica kinase
Pilar Garcia et al.
FASEB JOURNAL (2006)
Molecular mechanism for the regulation of Rho-kinase by dimerization and its inhibition by fasudil
H Yamaguchi et al.
STRUCTURE (2006)
Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme
OS Rosenberg et al.
CELL (2005)
Higher-order substrate recognition of elF2α by the RNA-dependent protein kinase PKR
AC Dar et al.
CELL (2005)
Mechanistic link between PKR dimerization, autophosphorylation, and elF2α substrate recognition
M Dey et al.
CELL (2005)
Catalytic independent functions of a protein kinase as revealed by a kinase-dead mutant: Study of the Lys72His mutant of cAMP-dependent kinase
GH Iyer et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Regulation of the G2/M transition in Xenopus oocytes by the cAMP-dependent protein kinase
PA Eyers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs
PA Lochhead et al.
CELL (2005)
Mechanism of Aurora B activation by INCENP and inhibition by Hesperadin
F Sessa et al.
MOLECULAR CELL (2005)
Stochastic model of protein-protein interaction: Why signaling proteins need to be colocalized
NN Batada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Regulation of protein kinases: Controlling activity through activation segment conformation
B Nolen et al.
MOLECULAR CELL (2004)
New insights into the structure-function relationships of Rho-associated kinase: a thermodynamic and hydrodynamic study of the dimer-to-monomer transition and its kinetic implications
JD Doran et al.
BIOCHEMICAL JOURNAL (2004)
Human mob proteins regulate the NDR1 and NDR2 serine-threonine kinases
E Devroe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event
A Cole et al.
BIOCHEMICAL JOURNAL (2004)
A family with severe insulin resistance and diabetes due to a mutation in AKT2
S George et al.
SCIENCE (2004)
Identification of novel phosphorylation sites on Xenopus laevis aurora A and analysis of phosphopeptide enrichment by immobilized metal-affinity chromatography
CE Haydon et al.
MOLECULAR & CELLULAR PROTEOMICS (2003)
Keeping G proteins at bay:: A complex between G protein-coupled receptor kinase 2 and Gβγ
DT Lodowski et al.
SCIENCE (2003)
Structural basis for the autoinhibition of c-Abl tyrosine kinase
B Nagar et al.
CELL (2003)
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP
J Yang et al.
NATURE STRUCTURAL BIOLOGY (2002)
The conformational plasticity of protein kinases
M Huse et al.
CELL (2002)
Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase
Madhusudan et al.
NATURE STRUCTURAL BIOLOGY (2002)
Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1
MC Parrini et al.
MOLECULAR CELL (2002)
Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain
T Moriki et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
Activation loop Ser744 and Ser748 in protein kinase D are transphosphorylated in vivo
RT Waldron et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with PhosphoCDK2
HW Song et al.
MOLECULAR CELL (2001)
分享论文
