期刊
NANOSCALE
卷 8, 期 1, 页码 492-499出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr06261f
关键词
-
类别
资金
- China National Key Basic Research Program (973 Project) [2010CB933902, 2015CB931802]
- National Natural Scientific Fund [81225010, 81327002, 31170961, 20771075, 20803040]
- National 863 Hi-tech Project [2012AA022703, 2014AA020700]
- Shanghai Science and Technology Fund [13NM1401500]
- China Postdoctoral Science Foundation, Shanghai 1000 People Plan Program
- ERC [239931-NANOPUZZLE]
- Fondo Social Europeo (FSE
- Gobierno de Aragon)
Targeted imaging and tumor therapy using nanomaterials has stimulated research interest recently, but the high cytotoxicity and low cellular uptake of nanomaterials limit their bioapplication. In this paper, glucose (Glc) was chosen to functionalize Au nanoprisms (NPrs) for improving the cytotoxicity and cellular uptake of Au@PEG-Glc NPrs into cancer cells. Glucose is a primary source of energy at the cellular level and at cellular membranes for cell recognition. A coating of glucose facilitates the accumulation of Au@PEG-Glc NPrs in a tumor region much more than Au@PEG NPrs. Due to the high accumulation and excellent photoabsorbing property of Au@PEG-Glc NPrs, enhanced optoacoustic imaging of a tumor in vivo was achieved, and visualization of the tumor further guided cancer treatment. Based on the optical-thermal conversion performance of Au@PEG-Glc NPrs, the tumor in vivo was effectively cured through photothermal therapy. The current work demonstrates the great potential of Au@PEG-Glc NPrs in optoacoustic imaging and photothermal cancer therapy in future.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据