期刊
TOXINS
卷 15, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/toxins15070451
关键词
venoms; transcriptomics; RNA-Seq; translational bioinformatics; systems biology; drug discovery
VenomSeq is a new platform that systematically identifies associations between venoms and drugs/diseases using high-throughput transcriptomics and perturbational differential gene expression analysis. By integrating comparisons to public repositories of differential expression, associations between regulatory networks and disease, and existing knowledge of venom activity, it provides new therapeutic hypotheses linking venoms to human diseases supported by multiple layers of preliminary evidence.
Venoms are a diverse and complex group of natural toxins that have been adapted to treat many types of human disease, but rigorous computational approaches for discovering new therapeutic activities are scarce. We have designed and validated a new platform-named VenomSeq-to systematically identify putative associations between venoms and drugs/diseases via high-throughput transcriptomics and perturbational differential gene expression analysis. In this study, we describe the architecture of VenomSeq and its evaluation using the crude venoms from 25 diverse animal species and 9 purified teretoxin peptides. By integrating comparisons to public repositories of differential expression, associations between regulatory networks and disease, and existing knowledge of venom activity, we provide a number of new therapeutic hypotheses linking venoms to human diseases supported by multiple layers of preliminary evidence.
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