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Review
Pharmacology & Pharmacy
Kristopher Amaro-Hosey et al.
Summary: This study systematically reviewed epidemiological studies on drug-induced sudden death, summarized their methodologies, and presented the results. A total of 74 articles were included from the Medline electronic database. The majority of the studies originated from North America (40.5%) or Europe (39.2%). Case-control (47.3%) and cohort (40.5%) studies were the most common designs. The most frequently used endpoint was sudden death or sudden cardiac death, mainly with ventricular arrhythmia. The results were heterogeneous and inconclusive, highlighting the need for improved methodologies to determine the risk of sudden cardiac death associated with drug use.
CURRENT DRUG SAFETY
(2023)
Article
Microbiology
Shadi Aghamohammad et al.
Summary: From the introduction of the first antibiotic to the present day, antibiotic resistance has become a challenging problem in medicine. The presence of resistant isolates in clinical and even asymptomatic fecal carriers has become a difficult public health issue. Therefore, the use of new antimicrobial combination therapies or alternative agents with antimicrobial activity, such as plant-, metal-, and nanoparticle-based agents, may be crucial. Recently, probiotics have gained attention as a potential candidate to combat infectious disease control and antimicrobial resistance by restoring the balance of the microbial population.
MICROBIOLOGICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Xuezheng Lin et al.
Summary: Chitosan, a biocompatible and biodegradable polymer derived from chitin polysaccharide, is widely used in medical and pharmaceutical fields due to its antimicrobial activities against various pathogens. It also has beneficial effects on animals and can be applied in agriculture and environmental protection. However, its water solubility affects its antimicrobial capabilities, limiting its application. This review updates the preparation, factors affecting antimicrobial activity, structure, mechanism, and potential applications of chitosan derivatives in the antimicrobial field.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Renato Kovacs et al.
Summary: The antimicrobial effect of chitosan and its derivatives has been confirmed on various bacteria and fungi. The tests conducted on pathogenic microorganisms revealed the inhibitory effect mechanism and concentration dependence of chitosan. By adding commercially available chitosan derivatives to a probiotic strain, it was determined that chitosan has a viabilty decreasing effect at concentrations above the minimum inhibitory concentration (MIC). The study also identified increased cell membrane permeability and irreversible interaction between low molecular weight chitosan and bacterial cells.
Article
Chemistry, Medicinal
Feng Cao et al.
Summary: A collection of small molecule compounds was screened against drug-resistant bacterial pathogens, and compound 1 was found to be a potent inhibitor of Staphylococcus aureus and methicillin-resistant S. aureus. However, it showed no activity against Gram-negative bacteria. Further analysis revealed that the N-propyl imidazole moiety was critical for the antibacterial activity.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Wen Tang et al.
Summary: Chitin is a natural polysaccharide derived from marine crustaceans, and chitosan is a modified form of chitin with a reduced acetyl group. Chitosan has gained significant attention for its biodegradability, biocompatibility, hypoallergenic properties, and various biological activities. However, its limited solubility in water and organic solvents has restricted its application range. Consequently, extensive chemical modifications and the development of chitosan derivatives have expanded its potential applications, particularly in the pharmaceutical field. This review paper summarizes the recent applications of chitosan and its derivatives in medical materials.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Divakar Dahiya et al.
Summary: Antibiotic therapy can harm the normal microbiota of the gastrointestinal tract, resulting in decreased diversity, changed metabolic activity, and the emergence of antibiotic-resistant strains. This can lead to antibiotic-associated diarrhoea and recurrent infections. Different classes of antibiotics can also cause gastrointestinal, immunologic, and neurocognitive conditions. Restoring the imbalanced gut microbiota to a healthy state is crucial for overall well-being. Probiotic strains, consumed through food, beverages, or supplements, can help establish a beneficial gut-brain relationship.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Pan-Long Chu et al.
Summary: The anti-quorum sensing activity of 53 newly prepared benzothiazole derivatives containing an isopropanolamine moiety was analyzed, and structure-activity relationships were examined. Compound D3 exhibited the strongest antibacterial activity, with an EC50 of 1.54 μg/mL against Xanthomonas oryzae pv oryzae (Xoo). Compound D3 inhibited QS-regulated virulence factors to suppress bacterial infection. In vivo assays showed good control efficiency against Xoo, and addition of organic silicone or orange peel essential oil further enhanced the control efficiency. The potent anti-QS activity of these benzothiazole derivatives is significant for the development of novel bactericidal compounds.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Polymer Science
Jeong-Hye Seo et al.
Summary: The purpose of this study was to prepare orthodontic resin cement containing halloysite nanotubes (HNTs) loaded with zinc oxide (ZnO) and investigate its mechanical, physical, chemical, and antibacterial properties. The results showed that the developed nanocomposite exhibited antimicrobial activity, while maintaining the mechanical and chemical properties of orthodontic resin cement, making it a potential solution for preventing demineralized white lesions.
Review
Polymer Science
Andre Jiang et al.
Summary: The development of biobased polymer packaging films has gained attention due to the environmental hazards of petroleum-based, nonbiodegradable packaging materials. Chitosan is a popular biopolymer for food packaging due to its biocompatibility, biodegradability, antibacterial properties, and ease of use. This review summarizes chitosan composites that exhibit active packaging, improving food storage conditions and extending shelf life, by incorporating active compounds such as essential oils and phenolic compounds. Additionally, composites with polysaccharides and various nanoparticles are also discussed. This review provides valuable information for selecting an enhanced composite with chitosan and offers directions for the development of novel biodegradable food packaging materials.
Article
Polymer Science
Young-Soo Sohn et al.
Summary: In this study, the surface of non-woven polypropylene (NW-PP) fabric was modified to form carbon-nitrogen (CN) layers using a modified DC-pulsed sputtering technique. The CN-formed NW-PP fabrics exhibited strong hydrophobicity and full-wetting characteristics. Additionally, the CN-formed NW-PP showed enhanced antibacterial properties against both Gram-positive and Gram-negative bacteria. The study presents a one-step, damage-free, mass-productive, and eco-friendly method for the mass production of antibacterial fabrics.
Article
Polymer Science
Yassine EL-Ghoul et al.
Summary: In this study, a new crosslinked biopolymer was synthesized and complexed with different metal salts. The structures and properties of the four complexes were characterized. The results showed that these complexes exhibited significant antibacterial and antifungal activities against various pathogenic strains. Additionally, the complexes demonstrated high antioxidant activity and potential anticancer effects.
Article
Polymer Science
Xuemei Bai et al.
Summary: A series of chitosan (CS)-grafted carbon oxynitride (OCN) nanoparticles (denoted as CS-OCN) were successfully synthesized by thermal polycondensation and subsequent esterification. The structure and photocatalytic performance of CS-OCN nanoparticles were investigated. The optimized CS-OCN-3 showed a photocatalytic degradation efficiency of 94.3% within 390 min, with a photocurrent response intensity about 150% higher compared to pure OCN. The enhanced photocatalytic performance was attributed to improved photogenerated carrier's separation and transportation as well as stronger visible light response after CS grafting.
Article
Polymer Science
Alexey Lunkov et al.
Summary: Quaternary chitosan derivative with covalently bonded antioxidant was used to synthesize selenium nanoparticles, which were characterized using AFM, TEM, and DLS methods. The results showed the formation of stable nanoparticles with a positive charge and a size in a specific range. The SeNPs exhibited antibacterial and fungicidal activity, with the highest activity against C. albicans. The modified SeNPs showed significantly higher toxicity to eukaryotic cells, particularly those synthesized at 55 degrees C, and SeNPs loaded with DOX demonstrated effective inhibition of hepatocarcinoma and keratinocytes.
Review
Infectious Diseases
Kai Tang et al.
Summary: The clinical application of quinolone antibiotics is extensive, but it comes with hidden dangers and side effects, particularly drug resistance. This review focuses on the history, structure, and bactericidal mechanism of quinolone antibiotics, and summarizes the latest clinical studies to lay a theoretical foundation for understanding bacterial response to quinolone treatment.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Pharmacology & Pharmacy
Aura Rusu et al.
Summary: The value of antibacterial fluoroquinolones (FQs) is debatable due to their severe adverse effects (AEs), resulting in their withdrawal from the market. New systemic FQs with potent antibacterial activity have been approved, but require more clinical studies to meet regulatory requirements. Post-marketing surveillance will confirm the safety profile of these new drugs. The management of AEs, rational use, and caution of FQs were also outlined.
Article
Chemistry, Inorganic & Nuclear
Hussein Ali Kadhim Kyhoiesh et al.
Summary: A new tridentate azo dye ligand and its metal complexes with Pt(IV) and Au(III) have been synthesized. The structures were determined through various spectroscopic and analytical techniques, and the complexes showed significant antimicrobial and anticancer activities.
INORGANICA CHIMICA ACTA
(2023)
Review
Biochemistry & Molecular Biology
Ke-Xin Huang et al.
Summary: In recent years, there has been an increasing focus on natural polysaccharides due to their low cost, biocompatibility, and biodegradability. Quaternization is a modification method that enhances the solubility and antibacterial ability of natural polysaccharides. Water-soluble derivatives of cellulose, chitin, and chitosan have diverse applications in fields such as antibacterial products, drug delivery, wound healing, sewage treatment, and ion exchange membranes. By combining the inherent properties of these polysaccharides with quaternary ammonium groups, new products with multiple functions and properties can be obtained. This review summarizes the research progress in the applications of quaternized cellulose, chitin, and chitosan in the past five years and discusses the challenges and future perspectives in this promising field.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Inorganic & Nuclear
Raul Colorado-Peralta et al.
Summary: This article summarizes the efficient antimicrobial activity of copper complexes using thiazole and benzothiazole as ligands against different bacteria and fungi.
Review
Chemistry, Applied
Usha D. Hemraz et al.
Summary: In recent years, there has been a growing interest in designing modified cellulose nanocrystals (CNCs) as nanoscale antimicrobial agents for various applications such as food preservation, additive manufacturing, biomedical, and water purification. CNCs are derived from renewable bioresources and possess excellent physicochemical properties, including rod-like structures, large surface area, low toxicity, biocompatibility, biodegradability, and sustainability. Their abundant surface hydroxyl groups also enable easy chemical modifications for advanced functional CNCs-based antimicrobial materials. This review focuses on the recent progress in CNC-inorganic and CNC-organic hybrid-based materials and discusses their design, synthesis, applications, and modes of antimicrobial action.
CARBOHYDRATE POLYMERS
(2023)
Article
Polymer Science
Ana Isabel Moreno et al.
Summary: This study developed a scaffold composed of polylactic acid and wollastonite particles enriched with propolis extracts for bone tissue repair and regeneration. The scaffold exhibited antibacterial activity against pathogens causing osteomyelitis and showed good physical, mechanical, and thermal properties. It also had high cell viability and strong bactericidal properties.
Review
Cell Biology
Peiyu Zhu et al.
Summary: Hand-foot-and-mouth disease (HFMD) is a viral illness commonly seen in young children under 5 years of age, characterized by oral herpes and rashes on the hands and feet. It is important to note that HFMD may be associated with fatal neurological complications, but currently, there is no specific pharmaceutical intervention for HFMD.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Review
Polymer Science
Nguyen Huy Hoang et al.
Summary: By 2050, the demand for food and water will increase due to population growth and climate change. Nanoparticles (NPs), especially those based on chitosan (CS), can be used in agriculture to achieve sustainable agricultural production. CS-NPs or CS-NPs loaded with active ingredients have shown promising results in controlling plant diseases and enhancing plant growth, attracting significant attention in recent years.
Article
Biochemistry & Molecular Biology
Anton R. Egorov et al.
Summary: An ultrasonic approach has been developed for the synthesis of selenium-containing derivatives of chitin and chitosan. The synthetic procedure is simple, efficient, and environmentally friendly. The derivatives show high antibacterial and antifungal activity, surpassing the effect of classic antibiotics. Furthermore, they exhibit promising transfection activity and act as efficient catalysts for alcohol oxidation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Anton R. Egorov et al.
Summary: This study focuses on the development of new ciprofloxacin releasing systems (CRS) that can reduce the toxicity of ciprofloxacin by conjugating it with chitosan to form self-assembled nanoparticles (SANPs). The CRS demonstrated high loading and encapsulation efficiency, and a prolonged release profile. In vivo testing in rats showed that the antibacterial effect of the CRS was superior to that of the starting ciprofloxacin, and the toxicity of the nanoparticles was similar to that of chitosan.
Review
Chemistry, Multidisciplinary
Jian He et al.
Summary: Drug-resistant bacterial infections are becoming more severe, but nanomaterials-based therapy shows promise in replacing antimicrobial agents and enhancing antibiotics activity. This review analyzes the current situation, resistance mechanisms, and treatment difficulties, as well as the efficacy and mechanisms of nanomaterials against resistant bacteria. Factors affecting antibacterial efficacy and emerging challenges are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Mahshid Ghasemi et al.
Summary: The MTT assay is commonly used in studies of cell toxicity, but it is often misinterpreted. Our research found that the assay measurements are influenced by various factors and require optimization and rational interpretation of the data to avoid misleading conclusions. While the assay can be a powerful tool, it also has limitations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Dazhong Yan et al.
Summary: Chitosan, a natural antimicrobial polymer, has potential as an alternative for antibiotics in therapy and disinfection due to its ability to kill microbes by neutralizing their negative charges on the surface. Chemically modified chitosan derivatives have better water solubility and antimicrobial properties, offering promise for improvement in the treatment of enteric infections.
Article
Chemistry, Multidisciplinary
Andreii S. Kritchenkov et al.
Summary: The pyridoxal derivatives of chitosan with various degrees of substitution were synthesized and tested for antibacterial activity. The derivative with moderate molecular weight and high DS showed the highest activity against S. aureus and E. coli, with nanoparticles of this derivative having a slightly higher in vitro antibacterial effect than ampicillin and gentamicin.
MENDELEEV COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Andreii S. Kritchenkov et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Review
Polymer Science
Seidy Pedroso-Santana et al.
POLYMER INTERNATIONAL
(2020)
Article
Biochemistry & Molecular Biology
Andreii S. Kritchenkov et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Chemistry, Applied
Andreii S. Kritchenkov et al.
CARBOHYDRATE POLYMERS
(2020)
Review
Polymer Science
Jianhui Li et al.
EUROPEAN POLYMER JOURNAL
(2020)
Article
Food Science & Technology
Andreii S. Kritchenkov et al.
FOOD PACKAGING AND SHELF LIFE
(2020)
Review
Engineering, Chemical
Murugesan Chandrasekaran et al.
Article
Materials Science, Multidisciplinary
Yalin Ma et al.
JOURNAL OF MATERIALS CHEMISTRY C
(2020)
Article
Biochemistry & Molecular Biology
Andreii S. Kritchenkov et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Biochemistry & Molecular Biology
Andreii S. Kritchenkov et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Chemistry, Applied
Andreii S. Kritchenkov et al.
Review
Biochemistry & Molecular Biology
Marina Gjorgjieva et al.
CURRENT MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
A. S. Kritchenkov et al.
RUSSIAN CHEMICAL BULLETIN
(2018)
Article
Biochemistry & Molecular Biology
Priyanka Sahariah et al.
Article
Pharmacology & Pharmacy
Mounyr Balouiri et al.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2016)
Article
Engineering, Chemical
Konstantin N. Semenov et al.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2013)
Review
Pharmacology & Pharmacy
Jarmila Vinsova et al.
CURRENT PHARMACEUTICAL DESIGN
(2011)
Review
Food Science & Technology
Ming Kong et al.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2010)
Article
Polymer Science
Rejane C. Goy et al.
POLIMEROS-CIENCIA E TECNOLOGIA
(2009)
Review
Biochemistry & Molecular Biology
EI Rabea et al.
