期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 12, 期 3, 页码 789-799出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2015.11.016
关键词
Silver nanoparticles; Antibacterial; Toxicity; Bacterial resistance
资金
- FAPESP
- CNPq
- INOMAT (MCTI/CNPq)
- NanoBioss (MCTI)
- Brazilian Network on Nanotoxicology (MCTI/CNPq)
Silver nanoparticles are well known potent antimicrobial agents. Although significant progresses have been achieved on the elucidation of antimicrobial mechanism of silver nanoparticles, the exact mechanism of action is still not completely known. This overview incorporates a retrospective of previous reviews published and recent original contributions on the progress of research on antimicrobial mechanisms of silver nanoparticles. The main topics discussed include release of silver nanoparticles and silver ions, cell membrane damage, DNA interaction, free radical generation, bacterial resistance and the relationship of resistance to silver ions versus resistance to silver nanoparticles. The focus of the overview is to summarize the current knowledge in the field of antibacterial activity of silver nanoparticles. The possibility that pathogenic microbes may develop resistance to silver nanoparticles is also discussed.
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