期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 12, 期 5, 页码 1397-1407出版社
ELSEVIER
DOI: 10.1016/j.nano.2016.01.009
关键词
Bionanotechnology; Self-assembly; Cancer; Supramolecular materials; Hydrogels; Tissue engineering
资金
- Australian Research Council (ARC) Discovery Project [DP130103131]
- ARC [LE110100141]
- NHMRC Career Development Fellowship [APP1050684]
- Alfred Deakin Research Fellowship
- Australian Microscopy and Microanalysis Research Facility (AMMRF)
- Swedish Research Council VR
- Institut Laue-Langevin user access programme [8-03-826]
The local inflammatory environment of the cell promotes the growth of epithelial cancers. Therefore, controlling inflammation locally using a material in a sustained, non-steroidal fashion can effectively kill malignant cells without significant damage to surrounding healthy cells. A promising class of materials for such applications is the nanostructured scaffolds formed by epitope presenting minimalist self-assembled peptides; these are bioactive on a cellular length scale, while presenting as an easily handled hydrogel. Here, we show that the assembly process can distribute an anti- inflammatory polysaccharide, fucoidan, localized to the nanofibers within the scaffold to create a biomaterial for cancer therapy. We show that it supports healthy cells, while inducing apoptosis in cancerous epithelial cells, as demonstrated by the significant down-regulation of gene and protein expression pathways associated with epithelial cancer progression. Our findings highlight an innovative material approach with potential applications in local epithelial cancer immunotherapy and drug delivery. (C) 2016 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据