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Building the synaptonemal complex: Molecular interactions between the axis and the central region

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PLOS GENETICS
卷 19, 期 7, 页码 -

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PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1010822

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The successful delivery of genetic material to gametes relies on tightly regulated interactions between parental chromosomes, which are brought in close proximity along their length by a conserved chromosomal interface called the synaptonemal complex (SC). Despite known components, the interfaces responsible for SC assembly remain unknown. This study surveys findings from various model systems, with a focus on insights gained from the nematode C. elegans, to synthesize our current understanding of SC structure, dynamics, and biophysical properties, and propose mechanisms for SC assembly.
The successful delivery of genetic material to gametes requires tightly regulated interactions between the parental chromosomes. Central to this regulation is a conserved chromosomal interface called the synaptonemal complex (SC), which brings the parental chromosomes in close proximity along their length. While many of its components are known, the interfaces that mediate the assembly of the SC remain a mystery. Here, we survey findings from different model systems while focusing on insight gained in the nematode C. elegans. We synthesize our current understanding of the structure, dynamics, and biophysical properties of the SC and propose mechanisms for SC assembly.

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