期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 12, 期 6, 页码 1471-1477出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2016.03.008
关键词
Antimicrobial nanosurface; Antibiotic; Microbial fuel cell; Biofilm; E.coli
资金
- biotechnet Switzerland
A novel method was developed to assay the antimicrobial capacity of nanostructured surfaces for medical implants in a bicathodic microbial fuel cell. Nano-structured gold surfaces with protruding nanopillars and nanorings were investigated. Escherichia coli K12 were used as a model microbe to record electronic effects caused by the interaction with nanosurfaces. The nanostructured gold surfaces enabled power density maxima up to 1910 mW/m(2), indicating fair vivacity, while flat surfaces on the nanoscale provided almost no power 0.35 mW/m(2). The biofilm presence on antimicrobial nanosurfaces was confirmed by the addition of ampicillin and its bactericidal effect resulted in oscillating and declining potentiometric signals. Current density experiments showed that biofilms on antimicrobial nanostructured electrodes caused low currents, indicating that E.coli biofilm remained functional before destruction. The bicathodic microbial fuel cell sensor is a novel tool for evaluating antimicrobial effects caused by nanosurfaces and antibiotics. (C) 2016 Elsevier Inc. All rights reserved.
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