期刊
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
卷 136, 期 1, 页码 80-90出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.oooo.2023.04.001
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The aim of this study was to categorize the risk groups of patients with oropharyngeal carcinoma based on p16 and p53 status, smoking/alcohol consumption history, and other prognostic factors. The results showed that p16 negativity was an important prognostic factor for oropharyngeal cancer patients, especially for those with lower p53 expression and not smoking/consuming alcohol.
Objective. The aim of this study is to categorize the risk groups of patients with oropharyngeal carcinoma (OPC) according to p16 and p53 status, smoking/alcohol consumption history, and other prognostic factors.Study Design. The immunostaining of p16 and p53 of 290 patients was retrospectively evaluated. The history of smoking/alcohol consumption of each patient was noted. p16 and p53 staining patterns were reviewed. The results were compared with demo-graphic findings and prognostic factors. Risk groups have been classified for the p16 status of patients.Results. The median follow-up was 47 months (range 6-240). Five-year disease-free survival (DFS) rates for patients with p16 (+) and (-) were 76% and 36%, and overall survival rates were 83% vs 40%, respectively (HR = 0.34 [0.21-0.57], P < .0001), HR = 0.22 [0.12-0.40] P < .0001, respectively). p16(-), p53(+), heavy smoking/alcohol consumption, performance status; advanced T and N stages in patients with p16(-), and continuing smoking/alcohol consumption after treatment were found to be unfavorable risk factors. Five-year overall survival rates were 95%, 78%, and 36% for low, intermediate, and high-risk groups, respectively.Conclusions. The results of our study have shown that p16 negativity in patients with oropharyngeal cancer was found to be an important prognostic factor, especially for those with lower p53 expression and not smoking/consuming alcohol. (Oral Surg Oral Med Oral Pathol Oral Radiol 2023;136:80-90)
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