期刊
NANOMEDICINE
卷 11, 期 18, 页码 2399-2404出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0246
关键词
calcium granules; kidney stones; nanoparticle translocation
资金
- Primordia Institute of New Sciences and Medicine
- Chang Gung Medical Research Project [FMRPD2T02, EMRPD1A0961]
- Ming Chi University of Technology [0XB0]
- National Science Council of Taiwan [101-2632-B-182-001-MY3]
Recent studies indicate that mineralo-organic nanoparticles form in various human body fluids, including blood and urine. These nanoparticles may form within renal tubules and increase in size in supersaturated urine, eventually leading to the formation of kidney stones. Here, we present observations suggesting that mineralo-organic nanoparticles found in blood may induce kidney stone formation via an alternative mechanism in which the particles translocate through endothelial and renal epithelial cells to reach urine. We propose that this alternative mechanism of kidney stone formation and the study of mineralo-organic nanoparticles in general may provide novel strategies for the early detection and treatment of ectopic calcifications and kidney stones.
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