期刊
NANOMEDICINE
卷 11, 期 10, 页码 1193-1205出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0010
关键词
flexing; human skin in vivo; imaging; massage; nanoparticle penetration; zinc oxide
资金
- National Health & Medical Research Council of Australia
Aim: We assessed the effects of flexing and massage on human skin penetration and toxicity of topically applied coated and uncoated zinc oxide nanoparticles (similar to 75 nm) in vivo. Materials & methods: Noninvasive multiphoton tomography with fluorescence lifetime imaging was used to evaluate the penetration of nanoparticles through the skin barrier and cellular apoptosis in the viable epidermis. Results: All nanoparticles applied to skin with flexing and massage were retained in the stratum corneum or skin furrows. No significant penetration into the viable epidermis was seen and no cellular toxicity was detected. Conclusion: Exposure of normal in vivo human skin to these nanoparticles under common in-use conditions of flexing or massage is not associated with significant adverse events.
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