期刊
NANOMEDICINE
卷 11, 期 18, 页码 2405-2417出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0203
关键词
clinical 6-MV radiation therapy; MRI-guided radiation therapy; radiosensitizing nanoparticles
资金
- Nano-H
- ANR [ANR-11-NANO-017, ANR-12-RPIB-0010]
- French program 'Investissement d'Avenir' by the 'Agence Nationale pour la Recherche' [ANR-11-IN-BS-0006]
Aim: This study reports the use of gadolinium-based AGuIX nanoparticles (NPs) as a theranostic tool for both image-guided radiation therapy and radiosensitization of brain tumors. Materials & methods: Pharmacokinetics and regulatory toxicology investigations were performed on rodents. The AGuIX NPs' tumor accumulation was studied by MRI before 6-MV irradiation. Results: AGuIX NPs exhibited a great safety profile. A single intravenous administration enabled the tumor delineation by MRI with a T-1 tumor contrast enhancement up to 24 h, and the tumor volume reduction when combined with a clinical 6-MV radiotherapy. Conclusion: This study demonstrates the efficacy and the potential of AGuIX NPs for image-guided radiation therapy, promising properties that will be assessed in the upcoming Phase I clinical trial.
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