期刊
NANOMEDICINE
卷 11, 期 9, 页码 1153-1167出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm.16.34
关键词
mesenchymal stem cells; Scleraxis; tendon healing; tendon progenitors
资金
- AO Research Fund of the AO Foundation [S-10-74D]
- DAAD PhD stipendship program
Aim: Currently there is no effective approach to enhance tendon repair, hence we aimed to identify a suitable cell source for tendon engineering utilizing an established clinically relevant animal model for tendon injury. Materials & methods: We compared, by in-depth histomorphometric evaluation, the regenerative potential of uncommitted human mesenchymal stem cells (hMSC) and Scleraxis (Scx)-programmed tendon progenitors (hMSC-Scx) in the healing of a full-size of rat Achilles tendon defect. Results: Our analyses clearly demonstrated that implantation of hMSC-Scx, in contrast to hMSC and empty defect, results in smaller diameters, negligible ectopic calcification and advanced cellular organization and matrix maturation in the injured tendons. Conclusion: Scaffold-free delivery of hMSC-Scx aids in enhanced repair in a clinically translatable Achilles tendon injury model.
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