期刊
NANOMEDICINE
卷 11, 期 20, 页码 2735-2751出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0208
关键词
cancer therapy; dendritic cells; macrophages; MDSC; myeloid cells; nanomedicine; nanoparticles; polarization; siRNA; targeting
资金
- Germant Research Foundation [SFB 1066]
Macrophages, myeloid-derived suppressor cells and tolerogenic dendritic cells are central players of a heterogeneous myeloid cell population, with the ability to suppress innate and adaptive immune responses and thus to promote tumor growth. Their influx and local proliferation are mainly induced by the cancers themselves, and their numbers in the tumor microenvironment and the peripheral blood correlate with decreased survival. Therapeutic targeting these innate immune cells, either aiming at their elimination or polarization toward tumor suppressive cells is an attractive novel approach to control tumor progression and block metastasis. We review the current understanding of cancer immunology including immune surveillance and immune editing in the context of these prominent innate suppressor cells, and their targetability by nanoparticular immunotherapy with small molecules or siRNA
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据