期刊
NANOMEDICINE
卷 11, 期 19, 页码 2581-2602出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0204
关键词
diabetes; GSH; insulin; MDA; Nkx6.1; Pdx-1; silymarin-loaded pluronic nanoparticles; silymarin; SOD; STZ
Aim: This study aimed to develop a new stable nanoformulation of silymarin (SM) with optimum enhanced oral bioavailability and to evaluate its effect as well as mechanism of action as a superior antidiabetic agent over native SM using streptozotocin-induced diabetic rats. Materials and methods: SM-loaded pluronic nanomicelles (SMnp) were prepared and fully characterized. Biochemical parameters were performed as well as histological, confocal and reverse-transcription polymerase chain reaction studies on pancreatic target tissues. Results & conclusion: SMnp were found to improve significantly the antihyperglycemic, antioxidant and antihyperlipidemic properties as compared with native SM. In addition, SMnp was found to be a more efficient agent over SM in the management of diabetes and its associated complications due to its superior bioavailability in vivo, and the controlled release profile of SM.
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