期刊
NANOMEDICINE
卷 11, 期 15, 页码 1929-1946出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0150
关键词
biomimetic peptides; carbon nanotubes; human circulating multipotent cells; nanocomposite scaffold; neuronal differentiation; regenerative medicine
资金
- CaRiPaRo Foundation (Excellence Research Project)
- Italian Ministry of Education, Universities and Research - MIUR [PRIN-20104XET32]
- University of Padova, Italy [PRAT2015 CPDA151948]
- [CPDR137224/13]
Aim: We aimed to set up a self-standing, biomimetic scaffold system able to induce and support per se neuronal differentiation of autologous multipotent cells. Materials & methods: We isolated a population of human circulating multipotent cells (hCMCs), and used carbon nanotube/polymer nanocomposite scaffolds to mimic electrical/nanotopographical features of the neural environment, and biomimetic peptides reproducing axon guidance cues from neural proteins. Results: hCMCs showed high degree of stemness and multidifferentiative potential; stimuli from the scaffolds and biomimetic peptides could induce and boost hCMC differentiation toward neuronal lineage despite the absence of exogenously added, specific growth factors. Conclusion: This work suggests the scaffold-peptides system combined with autologous hCMCs as a functional biomimetic, self-standing prototype for neural regenerative medicine applications.
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