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Impact of common ALDH2 inactivating mutation and alcohol consumption on Alzheimer's disease

FRONTIERS IN AGING NEUROSCIENCE (2023)

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SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant

Hongchao Guo et al.

Summary: The common ALDH2*2 variant affects around 8% of the global population and is associated with a severe loss of ALDH2 enzymatic activity and an increased risk of CAD. Empagliflozin, an SGLT2 inhibitor, has been shown to improve EC dysfunction caused by ALDH2*2, suggesting a potential preventive measure against CAD.

SCIENCE TRANSLATIONAL MEDICINE (2023)

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Review Biochemistry & Molecular Biology

Hsp70.1 carbonylation induces lysosomal cell death for lifestyle-related diseases

Tetsumori Yamashima et al.

Summary: Alzheimer's disease, type 2 diabetes, and NASH are increasingly common disorders. Individuals with type 2 diabetes are prone to Alzheimer's disease. The pathogenesis of these disorders is multifactorial, but oxidative damage caused by reactive oxygen species (ROS) may play a common role. The lipid peroxidation product hydroxynonenal has been implicated in cell degeneration and death in the brain, pancreas, and liver.

FRONTIERS IN MOLECULAR BIOSCIENCES (2023)

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Article Medicine, General & Internal

Changes in Alcohol Consumption and Risk of Dementia in a Nationwide Cohort in South Korea

Keun Hye Jeon et al.

Summary: This retrospective cohort study investigated the impact of changes in alcohol consumption on dementia risk. The findings suggest that maintaining mild to moderate alcohol consumption, reducing heavy drinking to moderate levels, and initiating mild alcohol consumption are associated with a decreased risk of dementia.

JAMA NETWORK OPEN (2023)

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Article Cardiac & Cardiovascular Systems

ALDH2 rs671 and MTHFR rs1801133 polymorphisms are risk factors for arteriosclerosis in multiple arteries

Nan Cai et al.

Summary: This study investigated the relationship between ALDH2 and MTHFR gene polymorphisms and arteriosclerosis in multiple arteries. The results showed that ALDH2 rs671 A/A and MTHFR rs1801133 T/T genotypes may be independent risk factors for arteriosclerosis in multiple arteries.

BMC CARDIOVASCULAR DISORDERS (2023)

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Article Clinical Neurology

Changes of neurofilament light chain in patients with alcohol dependence following withdrawal and the genetic effect from ALDH2 Polymorphism

Ming-Chyi Huang et al.

Summary: Blood NFL levels are increased in patients with alcohol dependence and decrease after early abstinence. The ALDH2 rs671 polymorphism is associated with NFL levels. Reduction in NFL levels correlates with improvement of clinical symptoms.

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2023)

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Article Neurosciences

Machine Learning Selection of Most Predictive Brain Proteins Suggests Role of Sugar Metabolism in Alzheimer's Disease

Raghav Tandon et al.

Summary: The study aimed to identify protein subsets that can accurately classify subjects into control, AsymAD, and AD. Results showed that a 29-protein subset accurately classified AD, while an 88-protein subset best predicted AsymAD or control. Biomarkers across different disease stages were dynamically separable, and predictive proteins were significantly enriched in sugar metabolism.

JOURNAL OF ALZHEIMERS DISEASE (2023)

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Article Clinical Neurology

Blood-Brain Barrier Dysfunction in Normal Aging and Neurodegeneration: Mechanisms, Impact, and Treatments

Anuska V. Andjelkovic et al.

Summary: Cerebral endothelial cells and their tight junctions form the blood-brain barrier (BBB), which is a unique, dynamic, and multi-functional interface. This review focuses on the changes in BBB and the neurovascular unit in normal aging and neurodegenerative disorders, particularly Alzheimer's disease, cerebral amyloid angiopathy, and vascular dementia. Evidence suggests that BBB dysfunction contributes to neurodegeneration. The mechanisms underlying BBB dysfunction and its potential as a therapeutic target, including enhancing drug delivery, clearance of neurotoxic compounds, and preventing BBB dysfunction, are discussed. The need for novel biomarkers of BBB dysfunction is also addressed.

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Formaldehyde toxicity in age-related neurological dementia

Yiduo Kou et al.

Summary: Research suggests that the accumulation of formaldehyde (FA) in the brain may have a negative impact on cognitive function, especially in aging and Alzheimer's disease progression. Additionally, there is a vicious circle between the deposition of amyloid-beta (A beta) and the generation of FA, accelerating the progression of the disease.

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In Situ Imaging of Formaldehyde in Live Mice with High Spatiotemporal Resolution Reveals Aldehyde Dehydrogenase-2 as a Potential Target for Alzheimer's Disease Treatment

Rongrong Tao et al.

Summary: The study re-engineered phenylhydrazines to create a selective, rapid, and reversible fluorescent probe named PFM309 for tracking formaldehyde flux. PFM309 identified the crucial role of ALDH2 in AD pathology, showcasing its potential as a target for AD drug development.

ANALYTICAL CHEMISTRY (2022)

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Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer's disease via inhibition of ACSL4-dependent ferroptosis

Zhi-yun Zhu et al.

Summary: The study demonstrated that ALDH2 overexpression significantly improved cognitive function, cardiac function, and morphological properties in an Alzheimer's disease mouse model, attenuating oxidative stress, apoptosis, and inflammation in the myocardium. ALDH2 played a crucial role in protecting against cardiac anomalies induced by Alzheimer's disease through regulation of lipid peroxidation and ferroptosis.

ACTA PHARMACOLOGICA SINICA (2022)

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Alcohol-Induced Neuroinflammatory Response and Mitochondrial Dysfunction on Aging and Alzheimer's Disease

Brandon Emanuel Leon et al.

Summary: Mitochondria play a crucial role in various cellular functions and are essential for maintaining energy homeostasis in neurons. Chronic and heavy alcohol use can accelerate brain aging and increase the risk of dementia, especially Alzheimer's disease. Alcohol-induced mitochondrial dysfunction is associated with neuroimmune responses, including pro-inflammatory cytokines. This review focuses on how alcohol affects the aging process and exacerbates Alzheimer's disease by impairing mitochondrial function.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2022)

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Alcohol Consumption: Medical Implications, the Liver and Beyond

Victor Meza et al.

Summary: Alcohol use disorder is a major contributor to disease and death. Alcohol-related liver disease is one of the most extensively studied consequences of alcohol use, but it also affects multiple systems and increases the risk of infections and specific types of cancer. Alcohol consumption has wide-ranging adverse effects on nearly every organ system and is the fifth-leading cause of death in both men and women, resulting in up to 139 million disability-adjusted life years. The risk is strongly correlated with the duration and amount of alcohol consumed. The term "alcohol-related liver disease" encompasses a spectrum of progressive stages that account for almost half of the global liver-related mortality.

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Isotope-labeled amyloid-β does not transmit to the brain in a prion-like manner after peripheral administration

Mirjam Brackhan et al.

Summary: Using stable isotope labeling and targeted mass spectrometry, the study shows that amyloid-beta does not reach the brain from the periphery, contradicting the theory of transmissibility in Alzheimer's disease.

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Association Study and Meta-Analysis of Polymorphisms and Blood mRNA Expression of the ALDH2 Gene in Patients with Alzheimer's Disease

Mariko Ueno et al.

Summary: The expression level of ALDH2 in the blood of LOAD patients was significantly increased, and there was a genetic association with ALDH2*2 in LOAD. ALDH2 may have significant roles in the pathogenesis of LOAD in the Asian population.

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Associations of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Polymorphism With Cognitive Impairment Among the Oldest-Old in China

Xurui Jin et al.

Summary: Recent study found that carrying ALDH2 rs671 mutation is associated with higher odds of cognitive impairment among the oldest-old, independent of alcohol consumption.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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ALDH2 variance in disease and populations

Che-Hong Chen et al.

Summary: The ALDH2*2 variant is a genetic polymorphism that commonly leads to alcohol flushing reactions and is associated with the largest number of traits in humans. It affects nearly 8% of the world population, especially East Asians. Carriers of the ALDH2*2 variant present alterations in multiple blood biomarkers, clinical measurements, drug prescriptions, dietary habits, and lifestyle behaviors. They are also more susceptible to aldehyde-associated diseases. However, the interaction between alcohol and ALDH2-related pathology and the possible beneficial effects of ALDH2 deficiency are not well understood.

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Fan Chen et al.

Summary: The study found that urine FA levels are significantly increased in AD patients and may have good diagnostic value. Urine FA levels are involved in the pathological process of AD and may serve as a potential biomarker for clinical auxiliary diagnosis.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Preclinical Models for Alzheimer?s Disease: Past, Present, and Future Approaches

Ansab Akhtar et al.

Summary: A robust preclinical disease model is crucial for understanding the mechanisms, pathways, and drug screening for human diseases. However, there is a lack of developed and accurate clinical models for Alzheimer's disease (AD), which limits the ability to mimic human pathology and translate potential therapies.

ACS OMEGA (2022)

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Hydroxynonenal Causes Hepatocyte Death by Disrupting Lysosomal Integrity in Nonalcoholic Steatohepatitis

Takuya Seike et al.

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CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Nutrients and amyloid ? status in the brain: A narrative review

Gustavo Diaz et al.

Summary: Certain dietary patterns and nutrients are associated with brain Aβ status. The Mediterranean diet, ketogenic diet, low intake of saturated fat, high-glycemic-index food, sodium, and junk/fast food are associated with reduced levels of Aβ in the brain. On the other hand, high levels of Aβ in the brain are related to a higher intake of total cholesterol, triglycerides, LDL cholesterol, saturated fat, sucrose, and fructose. Higher density lipoproteins (HDL) cholesterol and polyunsaturated fatty acids consumption are associated with low Aβ status in the brain.

AGEING RESEARCH REVIEWS (2022)

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Review Neurosciences

Innate immune activation: Parallels in alcohol use disorder and Alzheimer's disease

Adriana Ramos et al.

Summary: Alcohol use disorder is associated with systemic inflammation and organ dysfunction, particularly in the liver and brain. Studies have shown that alcohol abuse impairs brain function and accelerates neurodegeneration through inflammatory mechanisms involving innate immune cells. Recent research also suggests shared genetic risk factors between alcohol use and neurodegenerative disorders related to innate immunity.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)

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Article Clinical Neurology

Alcohol use disorder is associated with higher risks of Alzheimer's and Parkinson's diseases: A study of US insurance claims data

Pengyue Zhang et al.

Summary: This study found that alcohol use disorder (AUD) is associated with an increased risk of Alzheimer's disease and Parkinson's disease. Specifically, in the White population, AUD was significantly associated with an elevated risk of Parkinson's disease. In Black, White, and Hispanic individuals, AUD was associated with a higher risk of Alzheimer's disease.

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING (2022)

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Alcohol use disorder is associated with higher risks of Alzheimer's and Parkinson's diseases: A study of US insurance claims data

Pengyue Zhang et al.

Summary: The study found a strong association between AUD and Alzheimer's disease, as well as an increased risk of Parkinson's disease in White individuals. Cognitive screening and neurological examination in older adults with AUD can lead to early detection of these diseases.

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING (2022)

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Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5/ALDH2 deficiency

Anfeng Mu et al.

Summary: A novel Fanconi anemia-like inherited bone marrow failure syndrome has been discovered in Japanese children and is associated with variants in the ADH5 and ALDH2 genes. ADH5 is identified as the primary defense against formaldehyde, with ALDH2 providing a backup mechanism. Patient-derived fibroblasts displayed normal levels of DNA repair, whereas disease model iPSCs showed defective cell expansion during hematopoietic differentiation in vitro, which could be partially reversed by treatment with a new small molecule called C1.

BLOOD (2021)

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Review Psychiatry

Alcohol use and dementia: new research directions

Rachel Visontay et al.

Summary: Recent evidence suggests that low-to-moderate alcohol consumption may have protective effects on dementia and cognitive function, but the methodological limitations of existing observational studies have been highlighted. Chronic heavy alcohol use can cause alcohol-related brain damage through various neurotoxic pathways, including thiamine deficiency, ethanol, and acetaldehyde. Future research should focus on robust analytical and design-based approaches to better understand the relationship between alcohol use and dementia in the general population.

CURRENT OPINION IN PSYCHIATRY (2021)

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Article Neurosciences

Age-Related Neuronal Deterioration Specifically Within the Dorsal CA1 Region of the Hippocampus in a Mouse Model of Late Onset Alzheimer's Disease

Rasha H. Mehder et al.

Summary: This study investigated the relationship between oxidative damage in the dorsal hippocampal CA1 region and progressive cognitive impairment in a mouse model of Alzheimer's disease. Results showed that increased oxidative damage preceded synaptic trimming and may be associated with alterations in neuronal structure leading to cognitive decline.

JOURNAL OF ALZHEIMERS DISEASE (2021)

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Article Neurosciences

Association Study of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Polymorphism With Alzheimer Disease in the Taiwanese Population

Yah-Yuan Wu et al.

Summary: This study suggested a potential negative association between ADH1C rs2241894 genotype and female AD, as well as an interaction effect between AD and plasma ADH1C level. However, this finding was not confirmed in the extension study. Further research with age-matched and large sample size case-control studies is needed to verify the protective genetic factor of AD related to rs2241894.

FRONTIERS IN NEUROSCIENCE (2021)

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Synaptic dysfunction of Aldh1a1 neurons in the ventral tegmental area causes impulsive behaviors

Xinyan Li et al.

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MOLECULAR NEURODEGENERATION (2021)

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The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment

Hong Zhang et al.

Summary: ALDH2 plays a crucial role in tumorigenesis and progression, with the ALDH2*2 polymorphism associated with tumor development. This study summarizes the essential functions and potential mechanisms of ALDH2 in cancer. Therefore, ALDH2 is considered a potential therapeutic target for cancer treatment.

ACTA PHARMACEUTICA SINICA B (2021)

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Impact of mitochondrial aldehyde dehydrogenase 2 on cognitive impairment in the AD model mouse

Ying Yang et al.

Summary: ALDH2 overexpression significantly improves cognitive function in AD mice and protects against A beta hippocampal neuronal toxicity by reducing toxic aldehydes, ROS, and increasing ATP production.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2021)

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AGEING RESEARCH REVIEWS (2021)

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Synthesis of human amyloid restricted to liver results in an Alzheimer disease-like neurodegenerative phenotype

Virginie Lam et al.

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Formaldehyde and De/Methylation in Age-Related Cognitive Impairment

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Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence

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GENETICS AND MOLECULAR RESEARCH (2016)

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Homocysteine and Alzheimer's Disease: Evidence for a Causal Link from Mendelian Randomization

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A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease

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MOLECULAR NEURODEGENERATION (2016)

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From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery

William A. Banks

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Amyloid pore-channel hypothesis: effect of ethanol on aggregation state using frog oocytes for an Alzheimer's disease study

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Age-related formaldehyde interferes with DNA methyltransferase function, causing memory loss in Alzheimer's disease

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Oxidative stress accelerates amyloid deposition and memory impairment in a double-transgenic mouse model of Alzheimer's disease

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Characterization of Aldh2-/- mice as an age-related model of cognitive impairment and Alzheimer's disease

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MOLECULAR BRAIN (2015)

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Metabolic Risk Factors of Sporadic Alzheimer's Disease: Implications in the Pathology, Pathogenesis and Treatment

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Alcohol Consumption, Dementia and Cognitive Decline: An Overview of Systematic Reviews

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Disturbance of endogenous hydrogen sulfide generation and endoplasmic reticulum stress in hippocampus are involved in homocysteine-induced defect in learning and memory of rats

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BEHAVIOURAL BRAIN RESEARCH (2014)

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Severe Psychiatric Disorders in Mid-Life and Risk of Dementia in Late-Life (Age 65-84 Years): A Population Based Case-Control Study

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Polymorphisms in the aldehyde dehydrogenase 2 and dopamine β hydroxylase genes are not associated with Alzheimer's disease

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Andras Bilkei-Gorzo

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Accumulated hippocampal formaldehyde induces age-dependent memory decline

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Ethanol Reduces Amyloid Aggregation In Vitro and Prevents Toxicity in Cell Lines

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Formaldehyde induces hyperphosphorylation and polymerization of Tau protein both in vitro and in vivo

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Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

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Characterization of the APP/PS1 mouse model of Alzheimer's disease in senescence accelerated background

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Aging-associated excess formaldehyde leads to spatial memory deficits

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Oxidative lipid modification of nicastrin enhances amyloidogenic ?-secretase activity in Alzheimer's disease

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4-Hydroxy-2-Nonenal, a Reactive Product of Lipid Peroxidation, and Neurodegenerative Diseases: A Toxic Combination Illuminated by Redox Proteomics Studies

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Effects of chronic alcohol consumption on expression levels of APP and Aβ-producing enzymes

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Role of aldehyde dehydrogenase 2 Glu504lys polymorphism in acute coronary syndrome

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Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia

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Ethanol protects cultured neurons against amyloid-β and α-synuclein-induced synapse damage

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Overexpression of Aldehyde Dehydrogenase-2 Attenuates Neurotoxicity Induced by 4-Hydroxynonenal in Cultured Primary Hippocampal Neurons

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DNA Cross-Link Induced by trans-4-Hydroxynonenal

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Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease Implications for Aβ accumulation in AD brain

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Cortical DNA methylation maintains remote memory

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Absence of association on aldehyde dehydrogenase 2 (ALDH2) polymorphism with Mongolian Alzheimer patients

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Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis

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Alcohol Consumption as a Risk Factor for Dementia and Cognitive Decline: Meta-Analysis of Prospective Studies

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Hyperhomocysteinemia Increases beta-Amyloid by Enhancing Expression of gamma-Secretase and Phosphorylation of Amyloid Precursor Protein in Rat Brain

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Review Geriatrics & Gerontology

Hyperhomocysteinemia and Alzheimer's disease: A systematic review

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Elevated levels of 4-hydroxynonenal-histidine Michael adduct in the hippocampi of patients with Alzheimer's disease

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Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD

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Effects of HNE-modification induced by Aβ on neprilysin expression and activity in SH-SY5Y cells

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Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele

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Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis

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The Alcohol Flushing Response: An Unrecognized Risk Factor for Esophageal Cancer from Alcohol Consumption

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Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype

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Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily

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Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

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Promotion of amyloid β protein misfolding and fibrillogenesis by a lipid oxidation product

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Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity

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The association of mitochondrial aldehyde dehydrogenase gene (ALDH2) polymorphism with susceptibility to late-onset Alzheimer's disease in Chinese

Binbin Wang et al.

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Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart

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Oxidative stress hypothesis in Alzheimer's disease: a reappraisal

Domenico Pratico

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Mixed brain pathologies account for most dementia cases in community-dwelling older persons

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Formaldehyde at Low Concentration Induces Protein Tau into Globular Amyloid-Like Aggregates In Vitro and In Vivo

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The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation

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Effects of chronic ethanol drinking on the bloodbrain barrier and ensuing neuronal toxicity in alcohol-preferring rats subjected to intraperitoneal LPS injection

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Potential implications of endogenous aldehydes in β-amyloid misfolding, oligomerization and fibrillogenesis

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Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease

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Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment

DA Butterfield et al.

NEUROSCIENCE LETTERS (2006)

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Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction

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Reduction of NRI and phosphorylated Ca2+/calmodulin-dependent protein kinase II levels in Alzheimer's disease

N Amada et al.

NEUROREPORT (2005)

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Mitochondrial aldehyde dehydrogenase polymorphism is not associated with incidence of Alzheimer's disease

IS Shin et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2005)

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Evidence of increased oxidative damage in subjects with mild cognitive impairment

JN Keller et al.

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β-Site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways

E Tamagno et al.

JOURNAL OF NEUROCHEMISTRY (2005)

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Alzheimer's disease: the two-hit hypothesis

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LANCET NEUROLOGY (2004)

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Sulindac improves memory and increases NMDA receptor subunits in aged Fischer 344 rats

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NEUROBIOLOGY OF AGING (2004)

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Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer's disease in an older Korean population

JM Kim et al.

NEUROBIOLOGY OF AGING (2004)

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4-Hydroxynonenal oxidatively modifies histones: implications for Alzheimer's disease

J Drake et al.

NEUROSCIENCE LETTERS (2004)

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Differential expression of N-methyl-D-aspartate receptor NR2 isoforms in Alzheimer's disease

MR Hynd et al.

JOURNAL OF NEUROCHEMISTRY (2004)

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Article Biochemistry & Molecular Biology

Oxidized neprilysin in aging and Alzheimer's disease brains

DS Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)

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Evaluation of aldehyde dehydrogenase 1 promoter polymorphisms identified in human populations

JP Spence et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2003)

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Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells

I Ohsawa et al.

JOURNAL OF NEUROCHEMISTRY (2003)

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Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma

A Yokoyama et al.

CARCINOGENESIS (2002)

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Oxidative stress increases expression and activity of BACE in NT2 neurons

E Tamagno et al.

NEUROBIOLOGY OF DISEASE (2002)

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Review Biochemistry & Molecular Biology

Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells

VA Bohr

FREE RADICAL BIOLOGY AND MEDICINE (2002)

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Involvement of glycogen synthase kinase-3β and tau phosphorylation in neuronal Golgi disassembly

W Elyaman et al.

JOURNAL OF NEUROCHEMISTRY (2002)

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Article Medicine, General & Internal

Plasma homocysteine as a risk factor for dementia and Alzheimer's disease.

S Seshadri et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

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Article Neurosciences

Ethanol induced changes in cyclin-dependent kinase-5 activity and its activators, P35, P67 (Munc-18) in rat brain

Y Rajgopal et al.

NEUROSCIENCE LETTERS (2001)

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Article Neurosciences

Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis

D Praticò et al.

JOURNAL OF NEUROSCIENCE (2001)

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The formaldehyde metabolic detoxification enzyme systems and molecular cytotoxic mechanism in isolated rat hepatocytes

S Teng et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2001)

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Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease

T Kawarabayashi et al.

JOURNAL OF NEUROSCIENCE (2001)

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Article Geriatrics & Gerontology

Deficits in the expression of the NR2B subunit in the hippocampus of aged Fisher 344 rats

DA Clayton et al.

NEUROBIOLOGY OF AGING (2001)

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Article Multidisciplinary Sciences

NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation

E Shimizu et al.

SCIENCE (2000)

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Article Biochemistry & Molecular Biology

4-hydroxynonenal-modified amyloid-β peptide inhibits the proteasome:: possible importance in Alzheimer's disease

R Shringarpure et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2000)

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Article Biochemistry & Molecular Biology

Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in the Japanese population

K Kamino et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)

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