期刊
NANO TODAY
卷 11, 期 6, 页码 817-832出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2016.10.005
关键词
Nanoparticles; Protein corona; Targeting; Therapeutic efficacy
资金
- US National Institutes of Health (NIH) [CA151884, EB015419]
- US Department of Defense (DoD) Prostate Cancer Research Program (PCRP) Synergistic Idea Development Award [W81XWH 15 1 0728]
- David Koch Prostate Cancer Foundation (PCF) Award in Nanotherapeutics
- Movember PCF Challenge Award
- National Research Foundation of Korea [K1A1A2048701]
Upon entering the physiological environment, nanoparticles (NPs) are immediately surrounded by a complex and tightly bound layer of biomolecules, or '(hard) protein corona'. The corona controls NP fate in vivo and becomes the interface with cells. One of nanomedicine's central goals is to make NPs capable of active targeting in both imaging and therapy. If the NP is not designed correctly, the resulting corona can cause mistargeting and aberrant biodistribution, unanticipated toxicity, and low therapeutic efficacy. Here we present groundbreaking concepts about nanobio interactions and discuss approaches to bypass protein corona issues and thus enhance the efficacy of NPs. (C) 2016 Elsevier Ltd. All rights reserved.
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