期刊
NANO RESEARCH
卷 10, 期 1, 页码 37-48出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-016-1264-x
关键词
graphene oxide/gold nanorods; in situ growth; computed tomography imaging; photothermal therapy
类别
资金
- National Natural Science Foundation of China [51302190]
- Shanghai Natural Science Foundation [16ZR1400700]
- Shanghai Health and Family Planning Commission Project [20144Y0248, 2012y193]
Graphene oxide/gold nanorod (GO/GNR) nanohybrids were synthesized with a GO- and gold-seed-mediated in situ growth method at room temperature by mixing polystyrene sulfonate (PSS) functionalized GO, secondary growth solution, and gold seeds. Compared with ex situ preparation methods of GO/GNRs or graphene (G)/GNRs, the in situ synthesis of GO/GNRs addressed the issue of the aggregation of the GNRs before their attachment onto the GO. The method is straightforward and environment-friendly. The GO/GNRs showed a remarkable photothermal effect in vitro. The temperature of the GO/GNR nanohybrids increased from 25 to 49.9 A degrees C at a concentration of 50 mu g/mL after irradiation with an 808-nm laser (0.4 W/cm(2)) for 6 min. Additionally, the GO/GNRs exhibited good optical and morphological stability and photothermal properties after six cycles of laser irradiation. Upon injection of the GO/GNRs into xenograft tumors, excellent computed tomography (CT) imaging properties and photothermal effect were obtained. The preclinical CT agent iohexol was combined with the GO/GNRs and further enhanced CT imaging. Therefore, the GO/GNR nanohybrids have great potential for precise CT-image-guided tumor photothermal treatment.
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