期刊
NANO RESEARCH
卷 9, 期 5, 页码 1236-1243出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-016-1019-8
关键词
photothermal therapy; titanium oxides; biocompatibility; photothermal conversion
类别
资金
- National Natural Science Foundation of China [51302180, 51222203, 51002100, 51132006]
- National Basic Research Program of China [2011CB911002, 2012CB932601]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
The photothermal therapy (PTT) technique is regarded as a promising method for cancer treatment. However, one of the obstacles preventing its clinical application is the non-degradability and biotoxicity of the existing heavy-metal and carbon-based therapeutic agents. Therefore, a PTT material with a high photothermal efficiency, low toxicity, and good biocompatibility is urgently wanted. Herein, we report a titanium oxide-based therapeutic agent with a high efficacy and low toxicity for the PTT process. We demonstrated that Magn,li-phase Ti8O15 nanoparticles fabricated by the arc-melting method exhibit > 98% absorption of near infrared light and a superior photothermal therapy effect in the in vivo mouse model. The Ti8O15 nanoparticle PTT material also shows a good biocompatibility and biosafety. Our study reveals Magn,li-phase titanium oxide as a new family of PTT agents and introduces new applications of titanium oxides for photothermal conversion.
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