期刊
NANO RESEARCH
卷 10, 期 1, 页码 145-156出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-016-1273-9
关键词
aptamer; adsorbent; selectivity; separation; extraction
类别
资金
- National Natural Science Foundation of China [51272186, 21422105]
- Foundation for the Author of National Excellent Doctoral Dissertation of P. R. China [201220]
- Ten Thousand Talents Program for Young Talents
Adsorbents are widely employed in both fundamental and applied research areas such as separation technology, biotechnology, and environmental science. Selectivity and reusability are two most important requirements for adsorbents. Aptamers exhibit perfect selectivity and easy regeneration, which make them uniquely effective adsorption materials. Herein, we have rationally designed novel aptamer-based adsorbents and investigated their performance in extraction/separation of targets from an aqueous solution. These adsorbents can selectively extract targets from complicated sample matrices containing background compounds. Moreover, they can also be easily recycled without a significant loss of adsorption capacity. Notably, the adsorbents did not affect the activity of isolated biological samples, revealing their potential for the purification/separation of biomolecules. Composite adsorbents were constructed using aptamer-based adsorbents and a porous polymer, displaying highly efficient target separation from aqueous solution. Finally, separation columns were constructed, and targets in the aqueous solution were efficiently separated by these columns. The aptamerbased adsorbents described here exhibit great promise for potential applications in separation technology, biotechnology, and environment-related areas.
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