期刊
NANO RESEARCH
卷 9, 期 4, 页码 1079-1090出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-016-1000-6
关键词
polyoxometalates; nanozymes; protease activities; superoxide dismutase (SOD) activities; Alzheimer's disease
类别
资金
- National Basic Research Program of China [2011CB936004, 2012CB720602]
- National Natural Science Foundation of China [21210002, 21431007, 21402183, 21533008]
Proteolytic degradation of amyloid-beta (A beta) aggregates and clearance of A beta-induced reactive oxygen species (ROS) have received significant attention for the treatment of Alzheimer's disease (AD). However, it is difficult, and often unfeasible, to directly upregulate or transport intracellular native enzymes. More importantly, penetration of the blood-brain barrier (BBB) has presented a major impediment. Herein, we report on the rational design of a polyoxometalatebased nanozyme with both protease-like activity for depleting A beta aggregates, and superoxide dismutase (SOD)-like activity for scavenging A beta-mediated ROS. Furthermore, this nanozyme acts as a metal chelator to remove Cu from Cu-induced A beta oligomers. More intriguingly, the nanozyme can cross the BBB and exhibits low toxicity. This work provides new insights into the design and synthesis of inorganic nanozymes as multifunctional therapeutic agents in the treatment of AD.
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