Recent Advances in Acoustofluidics for Point-of-Care Testing

Point-of-care testing (POCT) has played important role in clinical diagnostics, environmental assessment, chemical and biological analyses, and food and chemical processing due to its faster turnaround compared to laboratory testing. Dedicated manipulations of solutions or particles are generally required to develop POCT technologies that achieve a sample-in-answer-out operation. With the development of micro- and nanotechnology, many tools have been developed for sample preparation, on-site analysis and solution manipulations (mixing, pumping, valving, etc.). Among these approaches, the use of acoustic waves to manipulate fluids and particles (named acoustofluidics) has been applied in many researches. This review focuses on the recent developments in acoustofluidics for POCT. It starts with the fundamentals of different acoustic manipulation techniques and then lists some of representative examples to highlight each method in practical POC applications. Looking toward the future, a compact, portable, highly integrated, low power, and biocompatible technique is anticipated to simultaneously achieve precise manipulation of small targets and multimodal manipulation in POC applications.

Automated summary

Point-of-care testing (POCT) has played a crucial role in various fields due to its faster turnaround compared to laboratory testing. The development of micro- and nanotechnology has led to the emergence of acoustofluidics, which utilizes acoustic waves to manipulate fluids and particles, and has been widely applied in POCT research.