This study investigates the role of the lateral entorhinal cortex (LEC) and the posterior piriform cortex (PPC) in aversive olfactory learning. The findings suggest that LEC is involved in the acquisition of negative odor value, while PPC is involved in the memory-retrieval phase. Inhibition of LEC CaMKIIa+ neurons affects fear encoding, fear memory recall, and PPC responses to a conditioned odor, providing evidence for the involvement of LEC CaMKIIa+ neurons in negative valence encoding.
Olfactory learning is widely regarded as a substrate for animal survival. The exact brain areas involved in olfactory learning and how they function at various stages during learning remain elusive. Here, we investigate the role of the lateral entorhinal cortex (LEC) and the posterior piriform cortex (PPC), two important olfactory areas, in aversive olfactory learning. We find that the LEC is involved in the acquisition of negative odor value during olfactory fear conditioning, whereas the PPC is involved in the memory-retrieval phase. Furthermore, inhibition of LEC CaMKIIa+ neurons affects fear encoding, fear memory recall, and PPC responses to a conditioned odor. These findings provide direct evidence for the involvement of LEC CaMKIIa+ neurons in negative valence encoding.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据