Antibiotic prophylaxis and surgical site infections in orthognathic surgery - a retrospective analysis

BackgroundThis study was conducted to determine surgical site infection (SSI) rates and potential risk factors as well as to evaluate antibiotic prophylaxis in orthognathic surgery.MethodsThis retrospective observational study included patients who received orthognathic surgery. SSIs and their management were assessed for up to one year post-operatively. The applied antibiotic regime and other possible influencing factors (smoking, age, site of infection, drainage, duration of surgery, displacement distances, craniofacial malformations) were assessed.ResultsIn total 291 patient met the inclusion criteria (56.7% female). The mean age at surgery was 25.5 & PLUSMN; 8.5 years. Fifty-four patients (18.6%) were diagnosed with a craniofacial malformation. Relevant previous surgeries were documented in about one quarter of included patients (n = 75). Ninety-two percent of patients (n = 267) received intraoperative single-dose antibiotic prophylaxis. Surgical site infections occurred in 12.4% (n = 36) of patients. There was a significant association between postoperative infections and type of surgery (P = .037) as well as type of drainage (P = .002). Statistical analyses also revealed a higher prevalence of smokers (P = .036) and previous surgically assisted rapid palatal expansion (SARPE) (P = .018) in the infection group. Furthermore, no significant relationships were observed between postoperative infections and various co-factors (i.e. antibiotic regime, age at surgery, gender, associated craniofacial malformations, surgery duration, displacement distances, mandibular setback vs. advancement).ConclusionLow rates of SSIs occurred following an intraoperative single-dose antibiotic regime. None of the SSIs had a significant effect on the final surgical outcome. Present data do not warrant escalation of the antibiotic regimen. Postoperative smoking and capillary drainage should be avoided.

Automated summary

This retrospective study evaluated the incidence of surgical site infections (SSI) and associated risk factors in orthognathic surgery. Low rates of SSIs were found following an intraoperative single-dose antibiotic prophylaxis. Postoperative infections were significantly associated with type of surgery, type of drainage, smoking, and previous surgically assisted rapid palatal expansion (SARPE). No significant relationships were observed between infections and antibiotic regime, age at surgery, gender, craniofacial malformations, surgery duration, displacement distances, and mandibular setback vs. advancement.