期刊
NANO LETTERS
卷 16, 期 7, 页码 4472-4476出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.6b01648
关键词
DNA aptamers; biosensors; cancer diagnosis; memristive behavior; silicon nanowires
类别
资金
- European Commission FP7 Programme through the Marie Curie Initial Training Network PROSENSE [317420]
We present the very first worldwide ever-reported electrochemical biosensor based on a memristive effect and DNA aptamers. This novel device is developed to propose a completely new approach in cancer diagnostics. In this study, an affinity-based technique is presented for the detection of the prostate specific antigen (PSA) using DNA aptamers. The hysteretic properties of memristive silicon nanowires functionalized with these DNA aptamers provide a label-free and ultrasensitive biodetection technique. The ultrasensitive detection is hereby demonstrated for PSA with a limit of detection down to 23 aM, best ever published value for electrochemical biosensors in PSA detection. The effect of polyelectrolytes on our memristive devices is also reported to further show how positive or negative charges affect the memristive hysteresis. With such an approach, combining memristive nanowires and aptamers, memristive aptamer-based biosensors can be proposed to detect a wide range of cancer markers with unprecedent ultrasensitivities to also address the issue of an early detection of cancer.
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