☆ 4.6 Review

The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update

ADVANCES IN NUTRITION (2023)

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Article Geriatrics & Gerontology

MIB-626, an Oral Formulation of a Microcrystalline Unique Polymorph of β-Nicotinamide Mononucleotide, Increases Circulating Nicotinamide Adenine Dinucleotide and its Metabolome in Middle-Aged and Older Adults

Karol Pencina et al.

Summary: This study investigated the pharmacokinetics and pharmacodynamics of MIB-626, a microcrystalline unique polymorph beta NMN formulation. The results showed that MIB-626 treatment was associated with substantial dose-related increases in blood NAD levels and its metabolome. These foundational data can facilitate the design of efficacy trials in disease conditions.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2023)

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Article Biochemistry & Molecular Biology

Distribution of Nicotinamide Mononucleotide after Intravenous Injection in Normal and Ischemic Stroke Mice

Si-Li Zheng et al.

Summary: This study investigated the distribution of intravenous NMN in normal and ischemic stroke mice, its therapeutic effect on ischemic brain infarction, and the acute toxicity after injection. The results showed that NMN can distribute to various tissues, enter the brain to boost NAD levels, and exhibit therapeutic effect without acute toxicity. The kidney was found to have the highest distribution of NMN.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2023)

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Article Biotechnology & Applied Microbiology

An artificial multi-enzyme cascade biocatalysis for biomanufacturing of nicotinamide mononucleotide from starch and nicotinamide in one-pot

Qiangzi Li et al.

Summary: An artificial in vitro multi-enzyme cascade biocatalysis was developed to synthesize NMN using starch and nicotinamide as substrates, achieving high yields and molar yields. This method offers an environmentally friendly and cost-effective approach for NMN production, showing great potential as an alternative method.

ENZYME AND MICROBIAL TECHNOLOGY (2023)

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Article Multidisciplinary Sciences

Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study

Helena A. K. Lapatto et al.

Summary: Nicotinamide riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD(+)), has shown promise in improving obesity-associated mitochondrial dysfunction and metabolic syndrome. However, short-term clinical trials have not yielded positive results. This study aimed to investigate the long-term effects of NR supplementation on mitochondrial biogenesis and metabolic health in humans. The results showed that NR improved NAD(+) metabolism, muscle mitochondrial number, myoblast differentiation, gut microbiota composition, and epigenetic control of gene expression. However, it did not improve adiposity or metabolic health.

SCIENCE ADVANCES (2023)

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Article Cell Biology

Oral nicotinamide riboside raises NAD plus and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin

Michael Vreones et al.

Summary: NR supplementation can increase NAD(+) levels in the brain and modify biomarkers related to neurodegenerative pathology, indicating its potential therapeutic benefits.

AGING CELL (2023)

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Article Biochemistry & Molecular Biology

Host-microbiome interactions in nicotinamide mononucleotide (NMN) deamidation

Lynn-Jee Kim et al.

Summary: Research has found that orally administered nicotinamide mononucleotide (NMN) can undergo deamidation and incorporation in mammalian tissue via the de novo pathway, which is reduced in animals treated with antibiotics to ablate the gut microbiome. Antibiotics increase the availability of NAD(+) metabolites, suggesting that the microbiome may compete with the host for dietary NAD(+) precursors. These findings highlight new interactions between NMN and the gut microbiome.

FEBS LETTERS (2023)

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Review Biochemistry & Molecular Biology

Long Non-Coding RNA GAS5 in Age-Related Diseases

Yaqi Wang et al.

Summary: This study summarizes the regulatory effect of lncRNA GAS5 on age-related diseases, finding that it can inhibit cancer growth, invasion, and metastasis, enhance cell sensitivity to chemotherapy drugs, and has close relationships with multiple miRNAs.

CURRENT MEDICINAL CHEMISTRY (2022)

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Article Immunology

Reduced Levels of NAD in Skeletal Muscle and Increased Physiologic Frailty Are Associated With Viral Coinfection in Asymptomatic Middle-Aged Adults

Thanh Tran et al.

Summary: This study found that levels of total NAD decreased in skeletal muscle of HIV-infected individuals, and coinfections with hepatitis C virus and cytomegalovirus exacerbated this decline. Additionally, coinfections were associated with increased inflammation, immune activation, and physiologic frailty.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2022)

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Review Behavioral Sciences

Path integration in normal aging and Alzheimer's disease

Viadislava Segen et al.

Summary: In this review, we discuss the impairment of path integration (PI) in healthy aging and Alzheimer's disease (AD), and the underlying neural mechanisms. We highlight the importance of the grid cell network in the entorhinal cortex for PI, the presence of PI deficits in healthy aging and their increased severity in early-stage AD patients, the link between compromised entorhinal grid cell computations and PI deficits in healthy older adults and young adults at risk of AD, and the potential of PI and grid cell deficits as sensitive markers for pathological decline in early AD.

TRENDS IN COGNITIVE SCIENCES (2022)

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Article Nutrition & Dietetics

Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study

Mijin Kim et al.

Summary: This study investigated the effects of time-dependent intake of nicotinamide mononucleotide (NMN) on sleep quality, fatigue, and physical performance in older adults. The results showed that afternoon intake of NMN significantly improved lower limb function and reduced drowsiness in older adults. These findings suggest the potential of NMN in preventing physical decline and improving fatigue in older adults.

NUTRIENTS (2022)

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Article Nutrition & Dietetics

Oral Administration of Nicotinamide Mononucleotide Increases Nicotinamide Adenine Dinucleotide Level in an Animal Brain

Chidambaram Ramanathan et al.

Summary: Oral administration of NMN has shown to increase brain NAD(+) levels in mice.

NUTRIENTS (2022)

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Article Biology

New insight into dyslipidemia-induced cellular senescence in atherosclerosis

Qunyan Xiang et al.

Summary: Atherosclerosis is an age-related disease and a leading cause of mortality worldwide. Recent studies have shown that cellular senescence contributes to the development of atherosclerosis. Dyslipidemia plays a critical role in both cellular senescence and atherosclerosis.

BIOLOGICAL REVIEWS (2022)

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Article Cell Biology

The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease

Brage Brakedal et al.

Summary: In this study, we found that oral intake of nicotinamide riboside (NR) in Parkinson's disease (PD) patients was safe and increased cerebral NAD levels, leading to altered cerebral metabolism and mild clinical improvement. NR also upregulated processes related to mitochondrial, lysosomal, and proteasomal function in blood cells and/or skeletal muscle, and decreased the levels of inflammatory cytokines.

CELL METABOLISM (2022)

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Article Cell Biology

Association between NAD+ levels and anaemia among women in community-based study

Fan Yang et al.

Summary: This study examined the association between NAD(+) levels and anemia in women. The findings showed that higher NAD(+) levels were significantly associated with a lower prevalence of anemia, particularly microcytic anemia and normocytic anemia.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

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Article Dermatology

Nicotinamide mononucleotide reduces melanin production in aged melanocytes by inhibiting cAMP/Wnt signaling

Sofia Brito et al.

Summary: NMN reduces melanogenesis in aged melanocytes by downregulating the signaling of melanogenesis-associated receptors. Therefore, NMN is a human-friendly anti-melanogenic agent with the potential to aid in aging-related hyperpigmentation therapy.

JOURNAL OF DERMATOLOGICAL SCIENCE (2022)

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Article Food Science & Technology

Nicotinamide mononucleotide (NMN) and NMN-rich product supplementation alleviate p-chlorophenylalanine-induced sleep disorders

Chun-Yan Shen et al.

Summary: The study found that Nicotinamide mononucleotide (NMN) and NMN-rich products (NMNP) can alleviate depression-like behavior and promote sleep by simultaneously regulating multiple systems.

JOURNAL OF FUNCTIONAL FOODS (2022)

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Article Multidisciplinary Sciences

Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing

Xiao-Ru Ma et al.

Summary: Age-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). The authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in mouse OPCs. beta-nicotinamide mononucleotide (beta-NMN) supplement delays myelin aging and enhances remyelination in the aged mice.

NATURE COMMUNICATIONS (2022)

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Article Endocrinology & Metabolism

Association of Human Whole Blood NAD+ Contents With Aging

Fan Yang et al.

Summary: The association between whole blood NAD(+) contents and aging differed significantly between males and females, with a loss of blood NAD(+) observed only in males, especially in the male middle-aged population. Considering gender differences is crucial in future studies related to NAD(+).

FRONTIERS IN ENDOCRINOLOGY (2022)

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Article Nutrition & Dietetics

Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects

Keisuke Okabe et al.

Summary: Nicotinamide mononucleotide (NNM), an orally bioavailable NAD(+) precursor, has shown beneficial effects against aging and aging-associated diseases. In a trial with healthy subjects, oral supplementation of NMN for 12 weeks caused no adverse effects and significantly increased NAD(+) levels in whole blood.

FRONTIERS IN NUTRITION (2022)

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Article Biochemical Research Methods

Nicotinamide Mononucleotide Administration Restores Redox Homeostasis via the Sirt3-Nrf2 Axis and Protects Aged Mice from Oxidative Stress-Induced Liver Injury

Chengting Luo et al.

Summary: In this study, the researchers found that the oxidation-reduction process was associated with aging in the mouse liver. They also discovered that oxidative stress activates Nrf2 and its downstream genes, but supplementation of NMN reduced oxidative stress and restored adaptive homeostasis through the Sirt3-Nrf2 axis.

JOURNAL OF PROTEOME RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Protective Role of Mitochondrial Uncoupling Proteins against Age-Related Oxidative Stress in Type 2 Diabetes Mellitus

Masa Cater et al.

Summary: Accumulation of oxidative damage to DNA and biomolecules is crucial in aging and age-related diseases. Mitochondrial DNA is highly vulnerable to oxidative stress, leading to dysfunction and bioenergetic crisis. Mitochondrial uncoupling proteins (UCPs) protect cells from damage by dissipating the proton gradient required for oxidative phosphorylation. Understanding UCPs' roles is critical in developing strategies to combat type 2 diabetes.

ANTIOXIDANTS (2022)

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Article Pharmacology & Pharmacy

Improvement of tissue-specific distribution and biotransformation potential of nicotinamide mononucleotide in combination with ginsenosides or resveratrol

Long-Bo Bai et al.

Summary: Decreased NAD(+) level plays a critical role in many diseases and aging. Research shows that supplementing NMN can improve NAD(+) levels, but it is unclear if combining with other nutrients can improve NAD(+) levels in specific tissues. This study validates the efficacy of drug combinations in mice and provides new treatment ideas for aging or diseases caused by decreased NAD(+) levels.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2022)

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Review Cell Biology

New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary

Tomas Schmauck-Medina et al.

Summary: The nine original hallmarks of aging, along with new emerging ones, have played a crucial role in guiding and advancing research on the biology of aging. Understanding and studying these hallmarks can provide a more comprehensive explanation of aging and age-related diseases, leading to interventions and therapeutics for healthy, happy, and productive lives in the elderly.

AGING-US (2022)

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Article Cell Biology

Coordinated metabolic transitions and gene expression by NAD+ during adipogenesis

Edgar Sanchez-Ramirez et al.

Summary: This study reveals the role of NAD(+) and SIRT1 in adipogenic differentiation, demonstrating that NAD(+) inhibits adipocyte commitment while SIRT1 is essential for terminal differentiation of pre-adipocytes and regulates subcellular compartmentalization of redox metabolism.

JOURNAL OF CELL BIOLOGY (2022)

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Review Biology

The landscape of aging

Yusheng Cai et al.

Summary: This article discusses the aging process and age-associated diseases, emphasizing the importance of aging and healthy aging, and revealing the role of evolutionarily conserved genetic pathways and biological processes in controlling the rate of aging. It reviews the descriptive, conceptual, and interventive aspects of aging research at multiple levels.

SCIENCE CHINA-LIFE SCIENCES (2022)

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Review Nutrition & Dietetics

Emerging Role of Nicotinamide Riboside in Health and Diseases

Chiranjeev Sharma et al.

Summary: Nicotinamide riboside (NR), as a potent NAD(+) enhancement agent, has shown promising results in protecting against various pathological conditions such as neurodegenerative diseases, diabetes, and hearing loss.

NUTRIENTS (2022)

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Article Multidisciplinary Sciences

Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women

Yuichiro Fukamizu et al.

Summary: Studies have shown that daily oral administration of 1250 mg beta-NMN for up to 4 weeks is safe and well-tolerated in healthy adult men and women, with no adverse events reported.

SCIENTIFIC REPORTS (2022)

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Article Urology & Nephrology

Relationship between sperm NAD plus concentration and reproductive aging in normozoospermia men:A Cohort study

Xueyan Bai et al.

Summary: This study investigated the relationship between sperm NAD+ levels, paternal age, and semen quality. The results showed that sperm NAD+ levels are not dependent on age, but are negatively correlated with sperm quality parameters. This suggests a unique role of NAD+ in spermatogenesis and potential opportunities for treating oligozoospermia.

BMC UROLOGY (2022)

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Article Cell Biology

Healthy aging and muscle function are positively associated with NAD+ abundance in humans

Georges E. Janssens et al.

Summary: This study reveals the impact of aging on skeletal muscle function and metabolism, as well as the association between (lack of) physical activity and age-related decline in muscle function. The levels of nicotinamide adenine dinucleotide (NAD(+)) were found to be significantly lower in older adults, and this decrease was more pronounced in physically impaired individuals. However, exercise-trained older individuals had NAD(+) levels similar to those of younger individuals, indicating a positive effect of physical activity on NAD(+) abundance and muscle functioning.

NATURE AGING (2022)

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Article Geriatrics & Gerontology

Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men

Masaki Igarashi et al.

Summary: The study investigated the effects of chronic oral supplementation of NMN on blood NAD+ levels and physiological dysfunctions in older individuals. The results showed that NMN significantly increased NAD+ concentrations and improved certain aspects of physical performance, but had no significant effect on body composition.

NPJ AGING (2022)

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Article Biochemistry & Molecular Biology

Nicotinamide mononucleotide supplementation protects the intestinal function in aging mice and d-galactose induced senescent cells

Meng Ru et al.

Summary: The study suggests that supplementation of NMN has the potential to improve the structural and functional decline in the intestine during aging, as well as enhance cell viability and antioxidant capacity in senescent cells.

FOOD & FUNCTION (2022)

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Article Geriatrics & Gerontology

A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults

Hao Huang

Summary: This study evaluated the anti-aging effect and safety of NMN in a double-blind, parallel, randomized controlled clinical trial. The results showed that NMN could increase NAD+ levels in cells, leading to higher energy levels and an anti-aging effect. The SF 36 scores and HOMA IR index were significantly improved in the NMN group compared to the placebo group.

FRONTIERS IN AGING (2022)

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Article Medicine, Research & Experimental

Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes

Jing Wu et al.

Summary: This study reveals that nicotinamide riboside (NR) can suppress autophagy and attenuate type I interferon (IFN-beta) release in myeloid cells, exerting anti-inflammatory effects. The mechanism of action involves NR's dependency on NAD(+) and its modulation of inosine signaling. These findings suggest NR as a potential adjunct for the management of systemic lupus erythematosus (SLE).

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Pharmacology & Pharmacy

Nicotinamide supplementation in diabetic nonalcoholic fatty liver disease patients: randomized controlled trial

Rasha R. El-Kady et al.

Summary: Nicotinamide supplementation did not show significant improvements in liver fibrosis or steatosis in diabetic NAFLD patients. However, it did lead to a reduction in liver enzymes, improvement in lipid metabolism abnormalities and insulin resistance, and an increase in patients' quality of life.

THERAPEUTIC ADVANCES IN CHRONIC DISEASE (2022)

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Article Cell Biology

Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment

Xiaohong Chen et al.

Aging-US (2021)

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Article Biochemistry & Molecular Biology

CD38 downregulation modulates NAD+ and NADP(H) levels in thermogenic adipose tissues

Andrea Benzi et al.

Summary: Different strategies to increase NAD(+) levels offer promising means for healthy aging and regulating metabolism. CD38, a NAD(+) -dependent enzyme, plays a crucial role in modulating thermogenic responses in cold-activated BAT and WAT.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2021)

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Review Biotechnology & Applied Microbiology

Biological synthesis of nicotinamide mononucleotide

Qi Shen et al.

Summary: NMN is a nucleotide that can be converted into NAD in human cells, and has attracted attention as a potential anti-aging drug. The chemical synthesis of NMN is challenging, involving the use of the intermediate PRPP and enzymes for conversion.

BIOTECHNOLOGY LETTERS (2021)

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Review Cardiac & Cardiovascular Systems

NAD+ Metabolism in Cardiac Health, Aging, and Disease

Mahmoud Abdellatif et al.

Summary: NAD(+) plays a crucial role in metabolic health and age-related diseases, with supplementation showing positive effects. Decline in NAD(+) pools is associated with cardiovascular disease risk factors, and replenishment can improve related conditions.

CIRCULATION (2021)

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Review Cell Biology

NAD+ metabolism and its roles in cellular processes during ageing

Anthony J. Covarrubias et al.

Summary: NAD(+) is a crucial coenzyme in redox reactions and plays a pivotal role in energy metabolism. Its levels decline with age, and raising NAD(+) levels is being explored as a potential strategy to extend human lifespan and healthspan. NAD(+) influences key cellular processes and functions, including metabolic pathways, DNA repair, and cellular senescence, with implications for healthy aging and age-related diseases.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Cell Biology

Preclinical and clinical evidence of NAD plus precursors in health, disease, and ageing

Ole Kristian Reiten et al.

Summary: NAD+ is a crucial molecule in human life and health, with age-related decline in cellular NAD+ levels. However, NAD+ precursor supplementation can potentially extend lifespan, mitigate diseases, and have therapeutic potential for aging-related conditions.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

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Article Biochemistry & Molecular Biology

Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells

Andrey Kropotov et al.

Summary: Nicotinamide riboside can be imported into cells by equilibrative nucleoside transporters, while nicotinic acid riboside requires active utilization in the cytosol before being taken up by HEK293 cells. Concentrative nucleoside transporters do not mediate the uptake of nicotinamide riboside.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications

Nan Xiao et al.

Summary: Metabolomic data and cytokine/chemokine profiling from stratified COVID-19 patients suggest a correlation between arginine, tryptophan, and purine metabolic pathways with hyperinflammation, potentially offering therapeutic targets for severe COVID-19 patients. Modulating metabolism can significantly impact the release of proinflammatory cytokines by peripheral blood mononuclear cells, indicating a potential strategy for treating fatal cytokine release syndrome in COVID-19.

NATURE COMMUNICATIONS (2021)

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Article Biochemical Research Methods

Biosynthesis of a Therapeutically Important Nicotinamide Mononucleotide through a Phosphoribosyl Pyrophosphate Synthetase 1 and 2 Engineered Strain of Escherichia coli

Anoth Maharjan et al.

Summary: The study successfully constructed a recombinant strain of E. coli with inserted NAMPT, PRPS1, and PRPS2 genes, achieving efficient NMN production in batch fermentation studies. Further investigation showed that supplementation of ribose, Mg2+, phosphate, nicotinamide, and lactose inducer led to a significant increase in NMN production levels.

ACS SYNTHETIC BIOLOGY (2021)

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Review Pharmacology & Pharmacy

Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer

Giorgia Colombo et al.

Summary: Tumor cells modify their cellular metabolism in order to sustain uncontrolled proliferation, requiring adequate amounts of NAD and NADPH to support overexpressed enzymes. This review explores the rationale for targeting key enzymes that maintain the cellular NAD/NADPH pool in colorectal cancer and enzymes that consume or use NADP(H).

FRONTIERS IN PHARMACOLOGY (2021)

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Article Peripheral Vascular Disease

Age-related alterations in cardiac and arterial structure and function in hypertensive women and men

Anping Cai et al.

Summary: This study compared age-related alterations in cardiac and arterial structures and functions by sex, and explored the impacts of achieved systolic blood pressure levels on these alterations in hypertensive women and men. It was found that in women, there were greater associations between age and cardiac/arterial indices compared to men, especially when systolic blood pressure was below 130 mm Hg.

JOURNAL OF CLINICAL HYPERTENSION (2021)

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Article Biochemistry & Molecular Biology

Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD+

Jureepon Roboon et al.

Summary: Neuroinflammation is a critical pathological process in various neurological conditions, and the direct impact of brain NAD(+) levels and CD38 gene on neuroinflammation has been demonstrated. Inhibiting CD38 and supplementing NAD(+) can effectively suppress neuroinflammation.

JOURNAL OF NEUROCHEMISTRY (2021)

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Article Immunology

β-Nicotinamide Mononucleotide (NMN) Administrated by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice

Xianrong Zhou et al.

Summary: Intraperitoneal injection of NMN monomers protected mice from UVB-induced photodamage by maintaining normal skin structure and collagen fibers, reducing mast cell production, increasing antioxidant ability, and regulating the inflammatory response in both skin and liver tissues.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Article Biotechnology & Applied Microbiology

Metabolic design for selective production of nicotinamide mononucleotide from glucose and nicotinamide

Shinichiro Shoji et al.

Summary: A whole-cell biocatalyst using Escherichia coli was developed for efficient production of Nicotinamide mononucleotide (NMN) from inexpensive substrates glucose and nicotinamide, achieving high yields and selectivity. The approach identified functional transporters and key enzymes allowing for intracellular uptake, conversion, and extracellular excretion of NMN. This method shows promise for low-cost, high-quality industrial production of NMN and other nucleotide compounds using microorganisms.

METABOLIC ENGINEERING (2021)

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Article Nutrition & Dietetics

The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase

Kai-Min Niu et al.

Summary: Nicotinamide mononucleotide can retard the aging process by reshaping gut microbiota and metabolomes, especially by increasing telomere length to extend cell lifespan. Oral NMN supplementation might be an effective strategy to delay aging.

FRONTIERS IN NUTRITION (2021)

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Article Multidisciplinary Sciences

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

Mihoko Yoshino et al.

Summary: The study demonstrates that NMN supplementation can enhance insulin sensitivity, insulin signaling, and remodeling in women with prediabetes who are overweight or obese, improving their metabolic function.

SCIENCE (2021)

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Article Chemistry, Medicinal

Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators

Anthony B. Pinkerton et al.

Summary: NAD(+) is a crucial cellular factor with roles in various biological processes, low levels of which are associated with diseases. Activating NAMPT is a novel strategy to increase NAD(+) levels, and a newly discovered compound shows more potent activation.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)

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Review Medicine, Research & Experimental

NAD+ homeostasis in human health and disease

Ruben Zapata-Perez et al.

Summary: Depletion of NAD(+) can lead to various pathological phenotypes, from rare inherited defects to more common age-related diseases. Therapeutic implications of NAD(+) repletion for boosting health and treating diseases are discussed, along with the potential use of NAD(+)-enhancing agents.

EMBO MOLECULAR MEDICINE (2021)

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Article Immunology

Nicotinamide mononucleotide-elicited NAMPT signaling activation aggravated adjuvant-induced arthritis in rats by affecting peripheral immune cells differentiation

Qi-Hai Wang et al.

Summary: Supplementation of NMN exacerbated the severity of AIA in rats, deteriorated MMP3-controlled tissue damages, and altered the immune profile by increasing Th17/Treg cells ratio. Up-regulation of NAMPT in PBMCs from NMN-treated rats was accompanied by significant increase in iNOS, MCP-1, and IL-1 beta expression.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Nutrition & Dietetics

NAD(+)-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults

N. J. Connell et al.

Summary: The study showed that NAD(+) precursor supplementation with L-tryptophan, nicotinic acid, and nicotinamide did not improve mitochondrial or skeletal muscle function in physically compromised older adults living in the community.

JOURNAL OF NUTRITION (2021)

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Article Nutrition & Dietetics

Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study

Bagen Liao et al.

Summary: The study conducted a six-week randomized, double-blind, placebo-controlled, four-arm clinical trial, finding that supplementation with NMN during exercise training significantly increased cardiovascular fitness in healthy amateur runners, likely due to enhanced oxygen utilization in skeletal muscle.

JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION (2021)

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Review Geriatrics & Gerontology

Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors

Jing She et al.

Summary: Coenzyme I (NAD(+)/NADH) and coenzyme II (NADP(+)/NADPH) play important roles in biological processes, with NAD(+) synthesized through de novo and salvage pathways and NADH levels increasing in aged brain tissue. The ratio of NAD+/NADH affects cellular metabolism, ATP production, and other functions.

AGING AND DISEASE (2021)

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Article Medicine, Research & Experimental

Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells

Tingting Fang et al.

Summary: By supplementing NAD+ intermediates, it is possible to activate sirtuin deacylases and improve cell aging. Research has shown that nicotinamide mononucleotide can effectively alleviate age-related physiological decline in the lung of mice, as well as pulmonary fibrosis induced by bleomycin in young mice. In vitro experiments have demonstrated that nicotinamide mononucleotide can significantly improve the senescence phenotype of alveolar epithelial cells.

MEDCOMM (2021)

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Review Biochemistry & Molecular Biology

The role of mTOR in age-related diseases

Zofia Chrienova et al.

Summary: The aging population is a significant socio-economic issue, with the mTOR pathway playing a key role in age-related diseases and influencing cellular aging characteristics through its regulation.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2021)

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Article Nutrition & Dietetics

NAD(+)-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults

N. J. Connell et al.

Summary: Supplementation with NAD(+) precursors such as tryptophan, nicotinic acid, and nicotinamide did not improve mitochondrial or skeletal muscle function in physically compromised older adults, indicating that boosting NAD(+) may not be an effective modality for promoting healthy aging.

JOURNAL OF NUTRITION (2021)

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Article Nutrition & Dietetics

Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study

C. F. Dolopikou et al.

EUROPEAN JOURNAL OF NUTRITION (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Single-Voxel 1H MR spectroscopy of cerebral nicotinamide adenine dinucleotide (NAD+) in humans at 7T using a 32-channel volume coil

Puneet Bagga et al.

MAGNETIC RESONANCE IN MEDICINE (2020)

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Article Neurosciences

Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin-resistant men

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JOURNAL OF PHYSIOLOGY-LONDON (2020)

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Article Geriatrics & Gerontology

Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects

Tamas Kiss et al.

GEROSCIENCE (2020)

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Article Multidisciplinary Sciences

Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity

Anna Wilk et al.

SCIENTIFIC REPORTS (2020)

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Article Nutrition & Dietetics

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

Carlijn M E Remie et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2020)

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Article Pharmacology & Pharmacy

Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside

Lukasz Mateuszuk et al.

BIOCHEMICAL PHARMACOLOGY (2020)

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Review Geriatrics & Gerontology

NAD plus therapy in age-related degenerative disorders: A benefit/risk analysis

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EXPERIMENTAL GERONTOLOGY (2020)

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Article Multidisciplinary Sciences

Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration

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NATURE COMMUNICATIONS (2020)

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Impaired nicotinamide adenine dinucleotide (NAD+) metabolism in diabetes and diabetic tissues: Implications for nicotinamide-related compound treatment

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JOURNAL OF DIABETES INVESTIGATION (2020)

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Review Nutrition & Dietetics

Nicotinamide Riboside-The Current State of Research and Therapeutic Uses

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NUTRIENTS (2020)

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Article Biochemistry & Molecular Biology

NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging

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MOLECULAR CELL (2020)

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Article Neurosciences

Nicotinamide riboside protects noise-induced hearing loss by recovering the hair cell ribbon synapses

Shuguang Han et al.

NEUROSCIENCE LETTERS (2020)

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Review Geriatrics & Gerontology

Age-related NAD(+) decline

Melanie R. McReynolds et al.

EXPERIMENTAL GERONTOLOGY (2020)

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Article Biochemistry & Molecular Biology

Depot-specific regulation of NAD+/SIRTs metabolism identified in adipose tissue of mice in response to high-fat diet feeding or calorie restriction

Xiaojing Wei et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2020)

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Metabolic engineering of Escherichia coli for optimized biosynthesis of nicotinamide mononucleotide, a noncanonical redox cofactor

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MICROBIAL CELL FACTORIES (2020)

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Article Cell Biology

Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes

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Boosting NAD level suppresses inflammator activation of PBMCs in heart failure

Bo Zhou et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Review Cell Biology

Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD+ Amount at the Cellular Level?

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Geriatrics & Gerontology

Brain NAD Is Associated With ATP Energy Production and Membrane Phospholipid Turnover in Humans

Bernard Cuenoud et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

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Article Endocrinology & Metabolism

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

Junichiro Irie et al.

ENDOCRINE JOURNAL (2020)

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Article Geriatrics & Gerontology

The Plasma NAD+ Metabolome Is Dysregulated in Normal Aging

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REJUVENATION RESEARCH (2019)

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Correction Biochemistry & Molecular Biology

Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (vol 173, pg 74 2018)

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Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease

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CELL METABOLISM (2019)

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Article Dermatology

Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety

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EXPERIMENTAL DERMATOLOGY (2019)

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Article Cell Biology

NAD+ metabolism governs the proinflammatory senescence-associated secretome

Timothy Nacarelli et al.

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Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease

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NATURE NEUROSCIENCE (2019)

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Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model

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NATURE NEUROSCIENCE (2019)

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Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults

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SCIENTIFIC REPORTS (2019)

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Direct Gating of the TRPM2 Channel by cADPR via Specific Interactions with the ADPR Binding Pocket

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CELL REPORTS (2019)

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Article Biochemistry & Molecular Biology

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice

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REDOX BIOLOGY (2019)

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Article Cell Biology

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

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CELL REPORTS (2019)

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Article Geriatrics & Gerontology

A Pilot Study Investigating Changes in the Human Plasma and Urine NAD plus Metabolome During a 6 Hour Intravenous Infusion of NAD

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FRONTIERS IN AGING NEUROSCIENCE (2019)

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Article Geriatrics & Gerontology

Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects

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GEROSCIENCE (2019)

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Article Biology

Endurance exercise resistance to lipotoxic cardiomyopathy is associated with cardiac NAD+/dSIR2/PGC-1α pathway activation in old Drosophila

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BIOLOGY OPEN (2019)

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Article Immunology

Macrophage de novo NAD(+) synthesis specifies immune function in aging and inflammation

Paras S. Minhas et al.

NATURE IMMUNOLOGY (2019)

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Article Pharmacology & Pharmacy

Nicotinamide mononucleotide alleviates Aluminum induced bone loss by inhibiting the TXNIP-NLRP3 inflammasome

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TOXICOLOGY AND APPLIED PHARMACOLOGY (2019)

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Nicotinamide Mononucleotide and Melatonin Alleviate Aging-induced Cognitive Impairment via Modulation of Mitochondria! Function and Apoptosis in the Prefrontal Cortex and Hippocampus

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NEUROSCIENCE (2019)

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A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death

Zhi Ying Zhao et al.

ISCIENCE (2019)

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Article Endocrinology & Metabolism

Slc12a8 is a nicotinamide mononucleotide transporter

Alessia Grozio et al.

NATURE METABOLISM (2019)

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Article Nutrition & Dietetics

A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

Ole L. Dollerup et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2018)

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Review Cell Biology

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

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CELL METABOLISM (2018)

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Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

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CELL METABOLISM (2018)

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NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR

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CELL METABOLISM (2018)

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NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Multidisciplinary Sciences

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

Christopher R. Martens et al.

NATURE COMMUNICATIONS (2018)

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Article Cardiac & Cardiovascular Systems

Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases

Alice E. Kane et al.

CIRCULATION RESEARCH (2018)

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β-nicotinamide mononucleotide (NMN) production in Escherichia coli

George Catalin Marinescu et al.

SCIENTIFIC REPORTS (2018)

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PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 activity

Siyuan Zha et al.

STEM CELL RESEARCH & THERAPY (2018)

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Review Physiology

NAD(H) in mitochondrial energy transduction: implications for health and disease

Matthew A. Walker et al.

CURRENT OPINION IN PHYSIOLOGY (2018)

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Nicotinamide mononucleotide preserves mitochondrial function and increases survival in hemorrhagic shock

Carrie A. Sims et al.

JCI INSIGHT (2018)

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Article Cardiac & Cardiovascular Systems

Short-term administration of Nicotinamide Mononucleotide preserves cardiac mitochondrial homeostasis and prevents heart failure

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JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2017)

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Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

Vincenzo Sorrentino et al.

NATURE (2017)

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Article Neurosciences

Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease

Zhiwen Yao et al.

NEUROSCIENCE LETTERS (2017)

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Article Biophysics

PARP inhibitor rucaparib induces changes in NAD levels in cells and liver tissues as assessed by MRS

Gilberto S. Almeida et al.

NMR IN BIOMEDICINE (2017)

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Review Biochemistry & Molecular Biology

NAD+ in Aging: Molecular Mechanisms and Translational Implications

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TRENDS IN MOLECULAR MEDICINE (2017)

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Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway

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SCIENTIFIC REPORTS (2017)

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Article Endocrinology & Metabolism

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells

Rachel S. Fletcher et al.

MOLECULAR METABOLISM (2017)

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Article Multidisciplinary Sciences

An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD plus levels in healthy volunteers

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PLOS ONE (2017)

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Article Pharmacology & Pharmacy

NAD replenishment with nicotinamide mononucleotide protects blood-brain barrier integrity and attenuates delayed tissue plasminogen activator-induced haemorrhagic transformation after cerebral ischaemia

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BRITISH JOURNAL OF PHARMACOLOGY (2017)

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Article Medicine, Research & Experimental

Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model

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JCI INSIGHT (2017)

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Article Biochemistry & Molecular Biology

NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In Vivo

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CURRENT BIOLOGY (2017)

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Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner

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CELL DEATH AND DIFFERENTIATION (2016)

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Article Cell Biology

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

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AGING CELL (2016)

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Review Biochemistry & Molecular Biology

NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy

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BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2016)

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Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death

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BRAIN RESEARCH (2016)

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Hepatic NAD+ deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing

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BRITISH JOURNAL OF PHARMACOLOGY (2016)

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Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

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Cell Metabolism (2016)

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CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

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CELL METABOLISM (2016)

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Article Cardiac & Cardiovascular Systems

Normalization of NAD+ Redox Balance as a Therapy for Heart Failure

Chi Fung Lee et al.

CIRCULATION (2016)

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Article Nutrition & Dietetics

β-Nicotinamide Mononucleotide, an Anti-Aging Candidate Compound, Is Retained in the Body for Longer than Nicotinamide in Rats

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JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY (2016)

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Article Neurosciences

Nicotinamide mononucleotide inhibits post-ischemic NAD+ degradation and dramatically ameliorates brain damage following global cerebral ischemia

Ji H. Park et al.

NEUROBIOLOGY OF DISEASE (2016)

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Article Multidisciplinary Sciences

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

Joanna Ratajczak et al.

NATURE COMMUNICATIONS (2016)

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Article Multidisciplinary Sciences

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

Samuel A. J. Trammell et al.

NATURE COMMUNICATIONS (2016)

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NAD plus regulates Treg cell fate and promotes allograft survival via a systemic IL-10 production that is CD4+ CD25+ Foxp3+ T cells independent

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SCIENTIFIC REPORTS (2016)

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Article Pharmacology & Pharmacy

Head to Head Comparison of Short-Term Treatment with the NAD+ Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice

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Frontiers in Pharmacology (2016)

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Article Clinical Neurology

Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer's disease-relevant murine model

Aaron N. Long et al.

BMC NEUROLOGY (2015)

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Review Cell Biology

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

Carles Canto et al.

CELL METABOLISM (2015)

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Article Multidisciplinary Sciences

In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

Xiao-Hong Zhu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Review Multidisciplinary Sciences

NAD+ in aging, metabolism, and neurodegeneration

Eric Verdin

SCIENCE (2015)

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Article Biochemistry & Molecular Biology

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

M. Di Stefano et al.

CELL DEATH AND DIFFERENTIATION (2015)

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Article Cell Biology

Dietary restriction involves NAD+-dependent mechanisms and a shift toward oxidative metabolism

Natalie Moroz et al.

AGING CELL (2014)

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P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage

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CELL (2014)

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Article Cell Biology

A High-Fat Diet and NAD+ Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

Morten Scheibye-Knudsen et al.

CELL METABOLISM (2014)

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Article Cell Biology

Activation of SIRT3 by the NAD+ Precursor Nicotinamide Riboside Protects from Noise-Induced Hearing Loss

Kevin D. Brown et al.

CELL METABOLISM (2014)

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Article Biochemistry & Molecular Biology

Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in Aβ (1-42)-induced rat model of Alzheimer's disease

E. Turunc Bayrakdar et al.

FREE RADICAL RESEARCH (2014)

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Effects of Poly (ADP-ribose) Polymerase Inhibitor 3-Aminobenzamide on Blood-Brain Barrier and Dopaminergic Neurons of Rats with Lipopolysaccharide-Induced Parkinson's Disease

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JOURNAL OF MOLECULAR NEUROSCIENCE (2014)

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Review Cell Biology

NAD+ and sirtuins in aging and disease

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TRENDS IN CELL BIOLOGY (2014)

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Review Dermatology

A review of nicotinamide: treatment of skin diseases and potential side effects

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JOURNAL OF COSMETIC DERMATOLOGY (2014)

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Article Biochemistry & Molecular Biology

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Ana P. Gomes et al.

CELL (2013)

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Review Endocrinology & Metabolism

Nicotinamide riboside, a trace nutrient in foods, is a Vitamin B3 with effects on energy metabolism and neuroprotection

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CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2013)

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Article Biochemistry & Molecular Biology

Nicotinamide Adenine Dinucleotide (NAD+) Repletion Attenuates Bupivacaine-Induced Neurotoxicity

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NEUROCHEMICAL RESEARCH (2013)

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Article Cell Biology

(ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neuronal degeneration in a mouse model of Parkinson's disease

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CELL DEATH & DISEASE (2013)

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Review Immunology

Adenine dinucleotide second messengers and T-lymphocyte calcium signaling

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FRONTIERS IN IMMUNOLOGY (2013)

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Review Pharmacology & Pharmacy

Nicotinic acid: clinical considerations

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EXPERT OPINION ON DRUG SAFETY (2012)

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Editorial Material Cell Biology

Exploring the therapeutic space around NAD+

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Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

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PLOS ONE (2012)

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Article Multidisciplinary Sciences

The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Review Biochemistry & Molecular Biology

NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns

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REDOX REPORT (2012)

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Altered behavioral and metabolic circadian rhythms in mice with disrupted NAD+ oscillation

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AGING-US (2011)

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Article Cell Biology

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

Jun Yoshino et al.

CELL METABOLISM (2011)

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Article Immunology

Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β

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Article Chemistry, Multidisciplinary

Factors Controlling the Mechanism of NAD+ Non-Redox Reactions

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

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Article Oncology

Oral nicotinamide protects against ultraviolet radiation-induced immunosuppression in humans

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CARCINOGENESIS (2009)

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Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

Yasukazu Nakahata et al.

SCIENCE (2009)

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Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD(+) Biosynthesis

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SCIENCE (2009)

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Synthesis of phosphodiester-type nicotinamide adenine dinucleotide analogs

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TETRAHEDRON (2009)

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Review Immunology

CD28- T cells: their role in the age-associated decline of immune function

Nan-ping Weng et al.

TRENDS IN IMMUNOLOGY (2009)

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Review Nutrition & Dietetics

Nicotinic acid nicotinamide and nicotinamide riboside: A molecular evaluation of NAD(+) precursor vitamins in human nutrition

Katrina L. Bogan et al.

ANNUAL REVIEW OF NUTRITION (2008)

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Article Cell Biology

IRS1-independent defects define major nodes of insulin resistance

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CELL METABOLISM (2008)

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High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease

Haiqun Jia et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2008)

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Article Cell Biology

Nampt/PBEF/Visfatin regulates insulin secretion in β cells as a systemic NAD biosynthetic enzyme

Javier R. Revollo et al.

CELL METABOLISM (2007)

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Review Chemistry, Organic

Nicotinamide adenine dinucleotide: beyond a redox coenzyme

Hening Lin

ORGANIC & BIOMOLECULAR CHEMISTRY (2007)

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Article Biochemistry & Molecular Biology

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Review Nutrition & Dietetics

The treatment of migraines and tension-type headaches with intravenous and oral niacin (nicotinic acid): systematic review of the literature

Jonathan Prousky et al.

NUTRITION JOURNAL (2005)

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Article Medicine, General & Internal

European Nicotinamide Diabetes Intervention Trial (ENDIT):: a randomised controlled trial of intervention before the onset of type 1 diabetes

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LANCET (2004)

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Article Chemistry, Medicinal

Stereoselective synthesis of nicotinamide β-riboside and nucleoside analogs

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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)

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Article Cell Biology

Calorie restriction extends yeast life span by lowering the level of NADH

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GENES & DEVELOPMENT (2004)

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Article Biochemistry & Molecular Biology

Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans

P Bieganowski et al.

CELL (2004)

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Article Biochemistry & Molecular Biology

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1

KJ Bitterman et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Article Chemistry, Medicinal

An efficient chemical synthesis of nicotinamide riboside (NAR) and analogues

S Tanimori et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002)

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Article Biochemistry & Molecular Biology

PDGF-induced Akt phosphorylation does not activate NF-κB in human vascular smooth muscle cells and fibroblasts

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FEBS LETTERS (2000)

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