4.7 Article

A Dual Stimuli-Responsive Nanoplatform Loaded PtIV-Triptolide Prodrug for Achieving Synergistic Therapy toward Breast Cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

A positive self-amplified H2O2 and acidity circulation for boosting CDT-PTT-starvation therapy

Yiming Rao et al.

Summary: A pH-sensitive nanoplatform is designed to enhance the therapeutic effect of chemodynamic therapy by increasing intracellular H2O2 and acidity. The nanoplatform releases loaded TAM and ICG under acidic conditions and increases the content of O2 and H2O2 through a synergistic effect. It also promotes the collapse of nanoparticles and the accumulation of intracellular H2O2 through a positive circulation. In addition, the nanoplatform combines photothermal therapy and starvation therapy with chemodynamic therapy.

JOURNAL OF CONTROLLED RELEASE (2023)

Article Chemistry, Multidisciplinary

Photo-Reduction with NIR Light of Nucleus-Targeting PtIV Nanoparticles for Combined Tumor-Targeted Chemotherapy and Photodynamic Immunotherapy

Dengshuai Wei et al.

Summary: This study reports the use of Pt-IV-functionalized nanoparticles that can be excited within the MR region for multi-modal treatment. These nanoparticles selectively accumulate in tumor tissue and successfully eradicate breast cancer tumors.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Article Chemistry, Multidisciplinary

A Fe(III)-porphyrin-oxaliplatin(IV) nanoplatform for enhanced ferroptosis and combined therapy

Xiaochun Hu et al.

Summary: This study successfully developed a nanotheranostics that promotes the synergistic effect of chemotherapy/ferroptosis/immunomodulation in cancer. The nanotheranostics utilize the characteristics of drug prodrug and metal-organic frameworks to achieve controllable chemotherapy and ferroptosis in the tumor microenvironment.

JOURNAL OF CONTROLLED RELEASE (2022)

Article Chemistry, Medicinal

Pt(IV) Prodrugs with Non-Steroidal Anti-inflammatory Drugs in the Axial Position

Daniil V. Spector et al.

Summary: In this study, a series of novel Pt(IV) prodrugs with nonsteroidal anti-inflammatory drugs were designed and synthesized. By tuning the drug lipophilicity via variation of the axial ligands, the most potent Pt(IV) prodrug was obtained, showing enhanced cellular accumulation and cytotoxicity. The prodrugs exhibited superior antiproliferative activity compared to cisplatin and overcame tumor cell line resistance.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Article Chemistry, Multidisciplinary

Heavy-Metal Trojan Horse: Enterobactin-Directed Delivery of Platinum(IV) Prodrugs to Escherichia coli

Chuchu Guo et al.

Summary: This study repurposes the clinically approved anticancer drug cisplatin into a targeted antibiotic by conjugating it with a siderophore employed by Enterobacteriaceae. The conjugate shows antibacterial activity against Escherichia coli and is delivered into the bacterial cytoplasm by the siderophore uptake machinery.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Article Engineering, Biomedical

NIR-light-controlled G-quadruplex hydrogel for synergistically enhancing photodynamic therapy via sustained delivery of metformin and catalase-like activity in breast cancer

Yanting Sun et al.

Summary: In this report, a smart G-quadruplex hydrogel named HMI@GEL was constructed for breast cancer treatment. This platform exhibited excellent characteristics of NIR-light-triggered and persistent drug delivery to maintain high intratumoral concentration of metformin. The combination of PTT and synergistically enhanced PDT as well as the activated tumour immunotherapy achieved remarkable apoptosis and necrosis.

MATERIALS TODAY BIO (2022)

Article Chemistry, Multidisciplinary

Photo-Reduction with NIR Light of Nucleus-Targetingt Pt-IV Nanoparticles for Combined Tumor-Targeted Chemotherapy and Photodynamic Immunotherapy

Dengshuai Wei et al.

Summary: The development of Pt-IV prodrugs selectively reduced into their Pt-II active species within cancerous cells has gained increasing attention. Despite progress, compounds are mostly excited using UV or blue light, limiting treatment for deep or large tumors. Pt-IV-functionalized nanoparticles excited at 808 nm within the MR region show potential for multi-modal treatment in eradicating tumors.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Review Chemistry, Multidisciplinary

Recent Advances in the Design and Sensing Applications of Hemin/Coordination Polymer-Based Nanocomposites

Amir M. Alsharabasy et al.

Summary: This article discusses the preparation of biomimetic catalysts and their research status and development direction in biological sensing applications, focusing on the importance and potential of hemin/coordination polymer nanocomposites in biomimetic catalysis.

ADVANCED MATERIALS (2021)

Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Review Oncology

Broadening horizons: the role of ferroptosis in cancer

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Review Biotechnology & Applied Microbiology

Natural products in drug discovery: advances and opportunities

Atanas G. Atanasov et al.

Summary: Natural products and their analogues have historically played a significant role in pharmacotherapy, however, they also present challenges. Recent technological and scientific developments are addressing these challenges and revitalizing interest in natural products as drug leads, particularly for combating antimicrobial resistance.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Biotechnology & Applied Microbiology

A self-amplified nanocatalytic system for achieving 1+1+1 > 3 chemodynamic therapy on triple negative breast cancer

Lulu Zhou et al.

Summary: The self-amplified nanocatalytic system (ZIF67/Ola/Lapa) effectively delivers the PARP inhibitor and NQO1-bioactivatable drug, offering a new paradigm for tumor-specific self-amplified chemodynamic therapy.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Review Medicine, Research & Experimental

Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives

Jie Gao et al.

Summary: Triptolide, as a diterpenoid compound isolated from Tripterygium wilfordii Hook. F., has shown significant inhibitory effects on solid tumors and is being considered as a potential blockbuster drug candidate. Researchers have developed synthesis methods for triptolide to meet clinical needs and connect different disciplines efficiently for further study.

THERANOSTICS (2021)

Review Chemistry, Multidisciplinary

Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

Mauro Sousa de Almeida et al.

Summary: Nanoparticles have diverse applications, particularly in nanomedicine for detecting and treating diseases like cancer and inflammation. Understanding the mechanisms of cellular uptake and intracellular localization of nanoparticles is crucial for therapeutic applications. Factors such as physicochemical properties, endocytic pathways, and cellular uptake regulators play key roles in the application of nanoparticles in medicine.

CHEMICAL SOCIETY REVIEWS (2021)

Review Biochemistry & Molecular Biology

Ferroptosis: mechanisms and links with diseases

Hong-fa Yan et al.

Summary: Ferroptosis is a form of cell death that is iron-dependent and involves accumulation of lethal lipid species from lipid peroxidation. This review discusses the regulatory mechanisms of ferroptosis and its connections with iron, lipid, and cysteine metabolism pathways. Additionally, it explores the role of ferroptosis in diseases such as cancer, ischemia/reperfusion, Alzheimer's disease, and Parkinson's disease, and evaluates the potential therapeutic applications of ferroptosis inhibitors in clinical settings.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Chemistry, Multidisciplinary

MOF-Derived Double-Layer Hollow Nanoparticles with Oxygen Generation Ability for Multimodal Imaging-Guided Sonodynamic Therapy

Xueting Pan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Multidisciplinary Sciences

Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism

Di Yu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Oncology

Clinical development and potential of photothermal and photodynamic therapies for cancer

Xingshu Li et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Article Chemistry, Medicinal

Platinum-Based Combination Therapy: Molecular Rationale, Current Clinical Uses, and Future Perspectives

Chunqiu Yu et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Pharmacology & Pharmacy

Triptolide and Its Derivatives as Cancer Therapies

Pawan Noel et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2019)

Article Chemistry, Multidisciplinary

Recent Progress in Ferroptosis Inducers for Cancer Therapy

Chen Liang et al.

ADVANCED MATERIALS (2019)

Review Materials Science, Biomaterials

Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer

Dnyaneshwar Kalyane et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

Review Multidisciplinary Sciences

Platinum drugs: from Pt(II) compounds, Pt(IV) prodrugs, to Pt nanocrystals/nanoclusters

Xi Hu et al.

SCIENCE BULLETIN (2017)

Review Biochemistry & Molecular Biology

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell et al.

Article Chemistry, Multidisciplinary

Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation

Qing-Li He et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Review Chemistry, Multidisciplinary

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

Timothy C. Johnstone et al.

CHEMICAL REVIEWS (2016)

Article Chemistry, Inorganic & Nuclear

Platinum(IV) anticancer prodrugs - hypotheses and facts

Dan Gibson

DALTON TRANSACTIONS (2016)

Review Biotechnology & Applied Microbiology

The re-emergence of natural products for drug discovery in the genomics era

Alan L. Harvey et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

Article Biochemistry & Molecular Biology

Hiporfin-Mediated Photodynamic Therapy in Preclinical Treatment of Osteosarcoma

Mengxiong Sun et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2015)

Article Chemistry, Inorganic & Nuclear

Platinum(IV) Complexes Featuring One or Two Axial Ferrocene Bearing Ligands - Synthesis, Characterization, and Cytotoxicity

Jelena Banfic et al.

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Article Chemistry, Inorganic & Nuclear

Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle

Chun-Yi Sun et al.

DALTON TRANSACTIONS (2012)

Review Biotechnology & Applied Microbiology

Cellular processing of platinum anticancer drugs

D Wang et al.

NATURE REVIEWS DRUG DISCOVERY (2005)