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Multifunctional Hydrogels for the Healing of Diabetic Wounds

ADVANCED HEALTHCARE MATERIALS (2023)

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Article Engineering, Biomedical

Wound microenvironment self-adaptive hydrogel with efficient angiogenesis for promoting diabetic wound healing

Zijian Shao et al.

Summary: A self-adaptive multifunctional hydrogel with self-healing property and injectability has been developed for treating diabetic wounds. The hydrogel can react with high glucose and hydrogen peroxide to alleviate oxidative stress and release drugs. In animal experiments, the hydrogel accelerates angiogenesis and wound closure. This self-adaptive multifunctional hydrogel shows potential for the treatment of diabetic wounds.

BIOACTIVE MATERIALS (2023)

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Article Chemistry, Multidisciplinary

A Whole-Course-Repair System Based on Neurogenesis-Angiogenesis Crosstalk and Macrophage Reprogramming Promotes Diabetic Wound Healing

Yuan Xiong et al.

Summary: Diabetic wound therapy is a significant challenge in medicine. A whole-course-repair system using a hydrogel has been introduced to achieve concurrent neurogenesis and angiogenesis for accelerated wound healing. The hydrogel can be injected into wounds to provide a physical barrier and release magnesium ions and engineered small extracellular vesicles for synergistic effects. This system recruits mesenchymal stem cells and stimulates neurogenic differentiation, while also promoting angiogenesis at the wound site. It offers a novel platform for combined diabetic wound therapy.

ADVANCED MATERIALS (2023)

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Review Toxicology

Artificial intelligence and machine learning disciplines with the potential to improve the nanotoxicology and nanomedicine fields: a comprehensive review

Ajay Vikram Singh et al.

Summary: The use of nanomaterials in medicine requires nanotoxicological evaluation to ensure safe application. Artificial intelligence and machine learning can analyze toxicological data and predict nanomaterial behavior and toxic effects. PBPK and Nano-QSAR models can analyze harmful events and toxicogenomics studies genetic basis of toxic responses. However, challenges and uncertainties still exist in this field. This review gives an overview of AI and ML techniques in nanomedicine and nanotoxicology to understand the potential toxic effects of nanomaterials at the nanoscale.

ARCHIVES OF TOXICOLOGY (2023)

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Article Chemistry, Multidisciplinary

Two-Pronged Microbe Delivery of Nitric Oxide and Oxygen for Diabetic Wound Healing

Huan-Huan Chen et al.

Summary: Chronic inflammation and hypoxia in diabetic foot ulcers can impede tissue regeneration. A novel hydrogel containing Weissella and Chlorella is introduced, which releases nitric oxide and oxygen alternatively to alleviate chronic inflammation and hypoxia. The hydrogel accelerates wound closure, re-epithelialization, and angiogenesis in diabetic mice, and improves the survival of skin grafts. This dual-gas therapy shows potential as a treatment option for diabetic wounds.

NANO LETTERS (2023)

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Review Chemistry, Multidisciplinary

Digital Transformation in Toxicology: Improving Communication and Efficiency in Risk Assessment

Ajay Vikram Singh et al.

Summary: Toxicology is being transformed by digital technologies, such as mobile apps, sensors, AI, and machine learning, which enable better data analysis, record-keeping, and risk assessment. This includes the use of blockchain technology for transparency in genomic data management and robotics and wearable devices for improved data collection and monitoring. The integration of digital technologies has revolutionized toxicology, offering potential for enhanced risk assessment and public health promotion.

ACS OMEGA (2023)

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Article Engineering, Biomedical

Enriching and Smart Releasing Curcumin via Phenylboronic Acid-Anchored Bioinspired Hydrogel for Diabetic Wound Healing

Bangjiao Zhao et al.

Summary: A PBA-anchored hydrogel (GOHA-PBA) is used to achieve active enrichment and smart release of curcumin (Cur), which can reverse the inflammatory microenvironment and promote wound healing.

ADVANCED NANOBIOMED RESEARCH (2023)

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Review Medicine, Research & Experimental

Integrative toxicogenomics: Advancing precision medicine and toxicology through artificial intelligence and OMICs technology

Ajay Vikram Singh et al.

Summary: More information about genetic makeup, drug response, multi-omics response, and genomic response is now available, leading to personalized treatment. Non-animal testing and computational toxicogenomics are becoming integral parts of risk assessment. Artificial intelligence (AI) has the potential to analyze patient data, predict treatment outcomes, and expedite data processing in personalized medicine and toxicogenomics. This article explores the current trends, future perspectives, challenges, and limitations in personalized medicine, toxicogenomics, and AI.

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Article Nanoscience & Nanotechnology

Novel Glucose-Responsive Antioxidant Hybrid Hydrogel for Enhanced Diabetic Wound Repair

Zejun Xu et al.

Summary: In this study, a novel glucose-responsive antioxidant hybrid hydrogel was designed and prepared for enhanced diabetic wound repair. The hydrogel achieved glucose-triggered antioxidant substance release and efficient reactive oxygen species scavenging, leading to improved inflammatory response, accelerated angiogenesis, and promoted diabetic wound healing.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing

Yongping Liang et al.

Summary: A dual-responsive hydrogel dressing was constructed for the treatment of type II diabetic foot ulcers and shown to promote wound healing in a rat model. The addition of metformin and graphene oxide further enhanced wound repair.

ACS NANO (2022)

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Article Cell Biology

Functional extracellular matrix hydrogel modified with MSC-derived small extracellular vesicles for chronic wound healing

Shiqing Ma et al.

Summary: This study successfully developed a functional hydrogel wound dressing with good mechanical properties, excellent biocompatibility, and superior stimulating angiogenesis capacity. It effectively enabled full-thickness skin wound healing in a diabetic rat model.

CELL PROLIFERATION (2022)

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Article Engineering, Environmental

Microwave-triggered ionic liquid-based hydrogel dressing with excellent hyperthermia and transdermal drug delivery performance

Yiru Gao et al.

Summary: A microwave-responsive hydrogel has been developed for eradicating bacterial infections and transdermal drug delivery with excellent therapeutic performance.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Engineering, Environmental

Exosomes laden self-healing injectable hydrogel enhances diabetic wound healing via regulating macrophage polarization to accelerate angiogenesis

Kai Wang et al.

Summary: This study developed a self-healing hydrogel capable of stably releasing exosomes to enhance diabetic wound healing. Through the synergistic effect of exosome release and M2 macrophage polarization, it accelerated angiogenesis and wound healing.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Engineering, Environmental

Remodeling microenvironment based on MOFs-Hydrogel hybrid system for improving diabetic wound healing

Linlin Yang et al.

Summary: This study presents a strategy to remodel the microenvironment of diabetic foot ulcers, using a hybrid composite Cur/MH/HKUST-1@Gel which reshapes the blood glucose and oxidative environment of the wounds, and significantly promotes wound healing in HaCat and HSF cells.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Engineering, Multidisciplinary

Engineered multifunctional nanocomposite hydrogel dressing to promote vascularization and anti-inflammation by sustained releasing of Mg2+ for diabetic wounds

Shuangli Zhu et al.

Summary: Diabetic ulcers are common and severe chronic wounds that are difficult to treat due to the risk of deep wound bacterial infection and lack of bioactivity for rapid wound repair. A bioactive hydrogel dressing with self-adaptation was developed in this study, showing promising results in accelerating wound healing, promoting vascularization, and reducing inflammation in diabetic wounds.

COMPOSITES PART B-ENGINEERING (2022)

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Article Biochemistry & Molecular Biology

Bio inspired growth factor loaded self assembling peptide nano hydrogel for chronic wound healing

E. Santhini et al.

Summary: This study investigates the use of RADA 16-I nanohydrogel to deliver growth factor PDGF-BB and destroy biofilm formed by wound-specific pathogens. The results demonstrate the ability of RADA 16-I to form a stable beta-sheet structure and sustainably release the growth factor, promoting angiogenesis and wound healing.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Facile formation of injectable quaternized chitosan/tannic acid hydrogels with antibacterial and ROS scavenging capabilities for diabetic wound healing

Wenhao Pan et al.

Summary: This study successfully constructed a hydrogel dressing with excellent ROS scavenging and antibacterial properties, which can promote wound healing and improve the therapeutic effects of skin defect models in diabetic rats.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Materials Science, Biomaterials

Bioactive and degradable hydrogel based on human platelet-rich plasma fibrin matrix combined with oxidized alginate in a diabetic mice wound healing model

Itxaso Garcia-Orue et al.

Summary: In this study, an injectable, bioactive, and degradable hydrogel composed of alginate and calcium-activated platelet rich plasma (PRP) was developed for wound healing applications. The hydrogel showed favorable mechanical and rheological properties, and in vitro studies demonstrated its ability to promote cell adhesion and proliferation without cytotoxic effects. However, the in vivo study conducted on diabetic mice did not show significant differences between PRP-HG-2.5% and the control group without PRP, possibly due to the xenogeneic origin of the PRP. Therefore, further evaluation of the effectiveness of PRP-HG-2.5% in a more reliable preclinical model is needed.

BIOMATERIALS ADVANCES (2022)

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Article Materials Science, Biomaterials

A multifunctional antibacterial and self-healing hydrogel laden with bone marrow mesenchymal stem cell-derived exosomes for accelerating diabetic wound healing

Xinrong Geng et al.

Summary: Chronic diabetic wound injury is a serious complication of diabetes, and effective treatment is crucial. In this study, a novel hydrogel loaded with bone marrow mesenchymal stem cell-derived exosomes was designed for chronic diabetic wound healing. The hydrogel promoted angiogenesis and adjusted the wound inflammation microenvironment to accelerate wound healing.

BIOMATERIALS ADVANCES (2022)

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Article Chemistry, Multidisciplinary

Symbiotic Algae-Bacteria Dressing for Producing Hydrogen to Accelerate Diabetic Wound Healing

Huanhuan Chen et al.

Summary: The hydrogen-producing hydrogel made of living Chlorella and bacteria within a cell-impermeable casing can continuously produce hydrogen for 60 hours, selectively reduce highly toxic ·OH and ONOO- species, and reduce inflammation. Studies have shown that the microbe-hydrogel dressing can promote cell proliferation and diabetic wound healing by almost 50% at day 3. This symbiotic algae-bacteria hydrogel demonstrates excellent biocompatibility and reactive oxygen species scavenging capabilities, suggesting great promise for clinical use.

NANO LETTERS (2022)

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Article Chemistry, Multidisciplinary

All-in-One: Multifunctional Hydrogel Accelerates Oxidative Diabetic Wound Healing through Timed-Release of Exosome and Fibroblast Growth Factor

Yuan Xiong et al.

Summary: The novel HA@MnO2/FGF-2/Exos hydrogel can improve diabetic wound healing by forming a protective barrier and providing long-term antibacterial protection, while utilizing MnO2/ε-PL nanosheets to catalyze H2O2 conversion to O-2, releasing M2 Exos and FGF-2 to promote the healing process.

SMALL (2022)

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Article Chemistry, Multidisciplinary

Multiple Stimuli-Responsive MXene-Based Hydrogel as Intelligent Drug Delivery Carriers for Deep Chronic Wound Healing

Xin Yang et al.

Summary: A novel MXene-based hydrogel drug delivery system for efficient treatment of deep chronic wounds is introduced in the study. This system demonstrates multiple response capability and controllable drug delivery ability, reducing toxic side effects of drugs and promoting wound healing process. The practical performance of the system in treating rat models indicates great prospect in clinical wound healing and related biomedical fields.

SMALL (2022)

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Article Engineering, Biomedical

Extracellular Matrix-Based Conductive Interpenetrating Network Hydrogels with Enhanced Neurovascular Regeneration Properties for Diabetic Wounds Repair

Lei Fan et al.

Summary: A conductive dressing synthesized from an interpenetrating polymer network hydrogel has been developed to promote diabetic wound healing by enhancing local neurovascular regeneration. This dressing combines water-swollen hydrogels with conductive polymers to provide tissue-matching electrical conductivity and mechanical properties for neurovascular regeneration. In vitro and in vivo studies show that the conductive hydrogel can promote neurovascular regeneration by increasing intracellular Ca2+ concentration, leading to phosphorylation of proteins in key signaling pathways, ultimately stimulating full-thickness diabetic wound repair.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Engineering, Biomedical

Bioinspired Multifunctional Black Phosphorus Hydrogel with Antibacterial and Antioxidant Properties: A Stepwise Countermeasure for Diabetic Skin Wound Healing

Qiuyue Ding et al.

Summary: This study developed a novel 4OI-BP nanosheet material that can rapidly gelate under laser irradiation and has antibacterial and antioxidant properties for promoting diabetic wound healing. The results showed that this material effectively eliminates bacterial infection, enhances antioxidant activity, promotes neovascularization, and accelerates wound closure.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Dermatology

Chronic wound healing by controlled release of chitosan hydrogels loaded with silver nanoparticles and calendula extract

Hugo Rodriguez-Acosta et al.

Summary: In this research, a chitosan-based hydrogel loaded with silver nanoparticles and calendula extract was developed. The release of nanoparticles and extract from the hydrogel showed antibacterial properties and promoted healing of chronic or exposed wounds. The study suggests that these hydrogels can be used as an alternative treatment for patients with poor healing capacity.

JOURNAL OF TISSUE VIABILITY (2022)

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Article Chemistry, Multidisciplinary

A Guanosine-Quadruplex Hydrogel as Cascade Reaction Container Consuming Endogenous Glucose for Infected Wound Treatment-A Study in Diabetic Mice

Yuanfeng Li et al.

Summary: A guanosine-quadruplex (G(4))-hydrogel loaded with glucose-oxidase and hemin is designed as a non-antibiotic based dressing for infected wounds in diabetic patients. The hydrogel undergoes cascade-reactions to generate reactive-oxygen-species (ROS) close to target bacteria, effectively killing biofilm bacteria. In diabetic mice, the G(4)-hydrogel promotes faster healing of infected wounds and reduces local glucose concentrations.

ADVANCED SCIENCE (2022)

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Article Engineering, Biomedical

Glucose and MMP-9 dual-responsive hydrogel with temperature sensitive self-adaptive shape and controlled drug release accelerates diabetic wound healing

Wanyi Zhou et al.

Bioactive Materials (2022)

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Article Engineering, Biomedical

Responsive and self-healing structural color supramolecular hydrogel patch for diabetic wound treatment

Canwen Chen et al.

Summary: The study presents a novel structural color supramolecular hydrogel patch for diabetic wound treatment. The hydrogel patch has superior mechanical properties, self-healing and antibacterial properties, as well as temperature responsiveness and color-sensing behavior. The results show that the hydrogel patch significantly enhances wound healing in diabetes rats.

BIOACTIVE MATERIALS (2022)

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Article Nanoscience & Nanotechnology

Development of a Microenvironment-Responsive Hydrogel Promoting Chronically Infected Diabetic Wound Healing through Sequential Hemostatic, Antibacterial, and Angiogenic Activities

Chuan Guo et al.

Summary: Microenvironment-responsive hydrogels have great potential in treating refractory wounds by releasing drugs on demand. In this study, a specially designed hydrogel was developed to target characteristics of chronically infected diabetic wounds. The hydrogel showed antibacterial and angiogenic properties, and significantly promoted healing of chronic infected diabetic wounds in vitro.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Biomimetic Microstructured Antifatigue Fracture Hydrogel Sensor for Human Motion Detection with Enhanced Sensing Sensitivity

Lianghao Jia et al.

Summary: Inspired by human muscle and skin tissues, an effective method is proposed to fabricate hydrogel sensors with antifatigue fracture performance and high sensing sensitivity for detecting human motions. The hydrogel sensors exhibit enhanced sensing sensitivity due to the microstructured surfaces and antifatigue fracture properties of cellulose nanofiber@carbon nanotube nanohybrids.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Thermosensitive Hydrogel Incorporating Prussian Blue Nanoparticles Promotes Diabetic Wound Healing via ROS Scavenging and Mitochondrial Function Restoration

Zhao Xu et al.

Summary: Diabetic foot ulcer is a serious complication in diabetes patients, and oxidative stress is thought to be a key driver of the pathogenesis of such ulcers. In this study, researchers synthesized Prussian blue nanoparticles with the ability to efficiently scavenge reactive oxygen species and incorporated them into a hydrogel for the treatment of diabetic foot ulcers.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Infant Skin Friendly Adhesive Hydrogel Patch Activated at Body Temperature for Bioelectronics Securing and Diabetic Wound Healing

Yanan Jiang et al.

Summary: A skin-friendly adhesive hydrogel patch based on protein-polyphenol complexation strategy is presented. The hydrogel exhibits a thermoresponsive network and can be activated upon contact with warm skin, while painless detachment can be achieved by placing an ice bag on the surface. The hydrogel also has immunomodulatory performance and can prevent irritation and allergic reactions during long-period contact with the skin.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Artificial Nonenzymatic Antioxidant MXene Nanosheet-Anchored Injectable Hydrogel as a Mild Photothermal-Controlled Oxygen Release Platform for Diabetic Wound Healing

Yang Li et al.

Summary: This study develops an injectable hydrogel based on MXene nanosheets for diabetic wound healing. The hydrogel utilizes oxyhemoglobin to release oxygen controllably and MXene to scavenge reactive oxygen species and bacteria. The hydrogel also benefits from the regulation of macrophage polarization. Overall, it effectively promotes the healing of infected diabetic wounds.

ACS NANO (2022)

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Article Engineering, Biomedical

Hyaluronic acid-based glucose-responsive antioxidant hydrogel platform for enhanced diabetic wound repair

Zejun Xu et al.

Summary: In this study, a glucose-responsive HA-based hydrogel platform was developed for rapid repair of diabetic wounds. The HMPC hydrogel effectively promoted angiogenesis and reduced inflammatory response, leading to the rapid recovery of diabetic wounds.

ACTA BIOMATERIALIA (2022)

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Article Engineering, Biomedical

Glucose-responsive multifunctional metal-organic drug-loaded hydrogel for diabetic wound healing

Jiaxin Yang et al.

Summary: In this study, a glucose-responsive multifunctional metal-organic drug-loaded hydrogel (DG@Gel) was designed for diabetic wound healing. The hydrogel changed the hyperglycemic wound microenvironment, exhibited antibacterial and angiogenic activity, and showed good biocompatibility and biodegradability in vivo.

ACTA BIOMATERIALIA (2022)

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Article Engineering, Biomedical

VH298-loaded extracellular vesicles released from gelatin methacryloyl hydrogel facilitate diabetic wound healing by HIF-1a-me diate d enhancement of angiogenesis

Yaxi Wang et al.

Summary: The study demonstrates the potential therapeutic effect of EVs loaded with VH298 on diabetic wound healing and angiogenesis, as well as the sustained release of VH-EVs through GelMA hydrogel.

ACTA BIOMATERIALIA (2022)

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Article Engineering, Biomedical

An all-in-one CO gas therapy-based hydrogel dressing with sustained insulin release, anti-oxidative stress, antibacterial, and anti-inflammatory capabilities for infected diabetic wounds

Junpeng Chen et al.

Summary: A versatile hydrogel dressing has been developed for the treatment of diabetic wounds. This dressing can regulate blood glucose, anti-oxidative stress, antibacterial and anti-inflammatory. It has good tissue adhesion, injectability and self-healing properties, and can sustainably release insulin and generate CO in inflamed wound tissue. The dressing significantly promotes the healing of diabetic wounds and has excellent biocompatibility.

ACTA BIOMATERIALIA (2022)

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Article Engineering, Biomedical

Antibacterial adhesive self-healing hydrogels to promote diabetic wound healing

Jueying Chen et al.

Summary: The development of compressible, stretchable and self-healing hydrogel dressings with good adhesive, antibacterial and angiogenesis properties is needed to promote the regeneration of diabetic wounds in clinical applications.

ACTA BIOMATERIALIA (2022)

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Article Engineering, Environmental

Angiogenesis-based diabetic skin reconstruction through multifunctional hydrogel with sustained releasing of M2 Macrophage-derived exosome

Pei Liu et al.

Summary: Diabetic wound, a common complication of diabetes, is a challenging condition to treat. In this study, a multifunctional hydrogel was designed as a diabetic wound dressing, which effectively stopped bleeding, provided optimal healing conditions, and promoted angiogenesis for accelerated wound healing.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Chemistry, Multidisciplinary

Continuous Self-Oxygenated Double-Layered Hydrogel under Natural Light for Real-Time Infection Monitoring, Enhanced Photodynamic Therapy, and Hypoxia Relief in Refractory Diabetic Wounds Healing

Zhongqiang Zhu et al.

Summary: A double-layered hydrogel has been developed for the treatment of refractory keratitis and diabetic foot ulcers caused by bacterial infections. The hydrogel can visualize bacterial infections and supply oxygen to enhance antimicrobial photodynamic therapy and alleviate inflammation, promoting wound healing.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Immunoregulation in Diabetic Wound Repair with a Photoenhanced Glycyrrhizic Acid Hydrogel Scaffold

Yuna Qian et al.

Summary: A novel glycyrrhizic acid-based hybrid hydrogel dressing with intrinsic immunoregulatory properties is developed to promote rapid diabetic wound healing.

ADVANCED MATERIALS (2022)

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Article Engineering, Biomedical

Nano-oxygenated hydrogels for locally and permeably hypoxia relieving to heal chronic wounds

Zhengyang Yang et al.

Summary: This study reports a technique to deliver dissolved oxygen locally into wound surface by adding lyophilized oxygen encapsulated nanoparticles to traditional gel-based wound dressings. The results show that this technique has therapeutic effects on hypoxic cells in vitro and on open wounds and diabetic mice models. With its biocompatibility, effectiveness and practicality, this hydrogel has significant transformation value in caring for and accelerating the healing of various clinical wounds, especially chronic wounds.

BIOMATERIALS (2022)

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Article Engineering, Biomedical

Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties

Chenxi Tu et al.

Summary: In this study, a multifunctional hydrogel was designed and prepared for the treatment of diabetic wounds. The hydrogel showed abilities in scavenging ROS, killing bacteria, and protecting cells against oxidative stress. It also promoted wound healing and reduced inflammation.

BIOMATERIALS (2022)

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Article Engineering, Biomedical

3D direct writing egg white hydrogel promotes diabetic chronic wound healing via self-relied bioactive property

Lingling Guo et al.

Summary: This study presents a natural hydrogel platform derived from fresh egg white, which possesses inherent bioactive elements and promotes wound healing and angiogenesis without the need for exogenous growth factors. The hydrogel can be easily prepared and processed, making it a cost-effective and promising solution for chronic wound management and other biological applications.

BIOMATERIALS (2022)

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Article Chemistry, Applied

Carboxymethyl cellulose-based hydrogel film combined with berberine as an innovative tool for chronic wound management

S. Cometa et al.

Summary: In this study, a carboxymethyl cellulose-based hydrogel film loaded with berberine was developed for wound treatment. The biocomposite showed high thermal stability and significant fluid uptake performances. It was able to control oxidative stress and inflammation markers, promoting wound healing.

CARBOHYDRATE POLYMERS (2022)

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Article Chemistry, Applied

Carboxymethyl chitosan and carboxymethyl cellulose based self-healing hydrogel for accelerating diabetic wound healing

Guozhu Chang et al.

Summary: A new dual drug delivery system CMCSH was designed to promote diabetic wound healing effectively. This system improved drug availability, promoted cell proliferation, and reduced inflammation.

CARBOHYDRATE POLYMERS (2022)

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Article Engineering, Environmental

An M2 macrophage-polarized anti-inflammatory hydrogel combined with mild heat stimulation for regulating chronic inflammation and impaired angiogenesis of diabetic wounds

Yang Yuan et al.

Summary: An M2 macrophage-polarized anti-inflammatory hydrogel combined with mild heat stimulation is designed for the treatment of diabetic foot ulcers (DFUs). The hydrogel promotes angiogenesis and skin regeneration, resulting in shortened healing time of DFUs.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Engineering, Multidisciplinary

3D hybrid scaffold with aligned nanofiber yarns embedded in injectable hydrogels for monitoring and repairing chronic wounds

Weiwang Qiu et al.

Summary: This article introduces a 3D hybrid scaffold with conductive and antibacterial properties for monitoring and repairing chronic wounds. The scaffold displays favorable biocompatibility, self-healing, and antibacterial properties, showing promising medical applications in tissue engineering and wearable electronics.

COMPOSITES PART B-ENGINEERING (2022)

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Article Engineering, Multidisciplinary

Ionic liquid-based non-releasing antibacterial, anti-inflammatory, high-transparency hydrogel coupled with electrical stimulation for infected diabetic wound healing

Bin Liu et al.

Summary: In this study, a conductive antibacterial multifunctional hydrogel was constructed, combined with exogenous electrical stimulation, for Staphylococcus aureus-infected wound healing. The hydrogel exhibited properties such as antibacterial ability, anti-inflammatory capacity, transparency, protein absorption, and self-healing, and promoted cell proliferation, migration, angiogenesis, and collagen deposition.

COMPOSITES PART B-ENGINEERING (2022)

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Article Biochemistry & Molecular Biology

Histatin-1 loaded multifunctional, adhesive and conductive biomolecular hydrogel to treat diabetic wound

Shuoji Zhu et al.

Summary: In this study, a multifunctional hydrogel with promoted angiogenesis, cell proliferation, and anti-inflammation ability was developed for diabetic wound treatment. The hydrogel showed accelerated wound healing rate, down-regulated expression of pro-inflammatory factor TNF-alpha, and up-regulated expression of CD31 and alpha-SMA, indicating its potential application in diabetic wound healing.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Calcium ion cross-linked sodium alginate hydrogels containing deferoxamine and copper nanoparticles for diabetic wound healing

Shengbo Li et al.

Summary: Chronic non-healing diabetic wounds and ulcers are a major challenge in the medical field. In this study, a hydrogel with pro-angiogenesis and antibacterial properties was developed, showing potential clinical application in refractory wounds.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Bacterial responsive hydrogels based on quaternized chitosan and GQDs-?-PL for chemo-photothermal synergistic anti-infection in diabetic wounds

Cui Cheng et al.

Summary: This study presents a novel sprayable antibacterial hydrogel for the effective treatment of chronic diabetic ulcers. The hydrogel, composed of antibacterial macromolecules, photothermal antibacterial nanoparticles, and biocompatible macromolecules, demonstrated in situ formation, pH-dependent swelling, and degradability. It exhibited a synergistic effect of chemotherapy and xenon light irradiated photothermal therapy, accelerating wound healing by promoting migration and proliferation of fibroblast cells and enhancing the adhesion of platelet endothelial cells. The hydrogel also displayed self-healing, hemostatic, and biocompatible abilities, making it a potential dressing for the clinical treatment of diabetic ulcers.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Chemistry, Multidisciplinary

Injectable conductive and angiogenic hydrogels for chronic diabetic wound treatment

Can Wu et al.

Summary: A conductive and antibacterial hydrogel with pH responsiveness has been developed, which can smartly release pro-angiogenic drugs, promote endothelial cell proliferation and migration, enhance vascularization, and accelerate healing of infected diabetic wounds.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Pharmacology & Pharmacy

A chlorogenic acid-loaded hyaluronic acid-based hydrogel facilitates anti-inflammatory and pro-healing effects for diabetic wounds

Liu Song et al.

Summary: Chlorogenic acid shows potential in promoting diabetic wound healing by reducing inflammation, enhancing re-epithelialization and angiogenesis, and facilitating collagen remodeling.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

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Article Materials Science, Multidisciplinary

Gelatine methacrylamide-based multifunctional bilayer hydrogels for accelerating diabetic wound repair

Yang Hu et al.

Summary: The study developed a bilayer hydrogel for treating diabetic wounds, with the upper layer inhibiting bacterial growth and promoting wound closure, while the lower layer promotes cell adhesion, growth, and releases cytokines to stimulate tissue regeneration.

MATERIALS & DESIGN (2022)

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Article Chemistry, Physical

A novel hydrogel with glucose-responsive hyperglycemia regulation and antioxidant activity for enhanced diabetic wound repair

Zejun Xu et al.

Summary: A novel hydrogel with glucose-responsive hyperglycemia regulation and antioxidant activity has been developed for enhanced diabetic wound repair. The hydrogel platform shows remarkable biocompatibility and antioxidant properties, as well as the ability to regulate blood glucose levels, promote angiogenesis, and effectively treat inflammation.

NANO RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Persistent Luminescence-Based Theranostics for Real-Time Monitoring and Simultaneously Launching Photodynamic Therapy of Bacterial Infections

Zhanlin Zhang et al.

Summary: In this study, a therapeutic strategy was developed to integrate real-time optical imaging and simultaneous photodynamic therapy (PDT) of bacterial infections into persistent luminescence (PL) nanoparticles (NPs). The strategy enables precise imaging and non-antibiotic treatment of bacterial infections without causing side effects to normal tissues.

SMALL (2022)

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Article Engineering, Biomedical

Injectable Dual-Dynamic-Bond Cross-Linked Hydrogel for Highly Efficient Infected Diabetic Wound Healing

Shasha Yao et al.

Summary: A new type of healing hydrogel based on the essential amino acid histidine is developed, which has good injectable, adhesive, biocompatible, and antibacterial properties. It accelerates wound healing and allows complete repair within approximately 13 days.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Biotechnology & Applied Microbiology

A Composite Hydrogel Containing Mesoporous Silica Nanoparticles Loaded With Artemisia argyi Extract for Improving Chronic Wound Healing

Leyi Xue et al.

Summary: Chronic wounds are a global health problem that is on the rise, affecting the physical and mental health of individuals and placing a heavy burden on healthcare providers. In this study, a composite hydrogel scaffold based on methacrylate gelatin and methacrylate hyaluronic acid was developed, along with mesoporous silica nanoparticles as sustained-release drug carriers for the treatment of chronic wounds. The hydrogel exhibited excellent antibacterial activity and biocompatibility, and induced the differentiation of macrophages. Animal experiments further demonstrated that the hydrogel significantly promoted wound healing in chronic wounds. Overall, the GelMA/HAMA/MSN@AE hydrogel shows great potential for the treatment of chronic wounds.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Nanoscience & Nanotechnology

Glycosaminoglycan-Based Hydrogel Delivery System Regulates the Wound Microenvironment to Rescue Chronic Wound Healing

Xiang Zhang et al.

Summary: This study proposes a glycosaminoglycan-based hydrogel delivery system that combines the bioactivities of polysaccharides and drugs to regulate the wound microenvironment. The hydrogel effectively reduces immune cell influx and down-regulates inflammation, leading to accelerated wound healing.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Injectable Self-Healing Adhesive Chitosan Hydrogel with Antioxidative, Antibacterial, and Hemostatic Activities for Rapid Hemostasis and Skin Wound Healing

Shen Guo et al.

Summary: An injectable hydrogel material with excellent injectability, self-healing ability, and tissue-adhesiveness was designed and fabricated. It showed antioxidative, antibacterial, and hemostatic abilities, and could effectively stop bleeding and promote wound healing.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Artificial Intelligence-Assisted High-Throughput Screening of Printing Conditions of Hydrogel Architectures for Accelerated Diabetic Wound Healing

Baiqi Chen et al.

Summary: The article introduces an artificial intelligence-assisted high-throughput printing-condition-screening system for optimizing the 3D (bio)printing process to obtain uniformly structured scaffolds. The results show that the scaffolds printed using this system have good mechanical properties and biological effects, and demonstrate efficacy in accelerating the healing of diabetic wounds.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Chemistry, Applied

hUC-MSCs lyophilized powder loaded polysaccharide ulvan driven functional hydrogel for chronic diabetic wound healing

Yu Ren et al.

Summary: In this study, a hydrogel was prepared using ulvan from Ulva fenestrata for chronic diabetic wound healing. The hydrogel exhibited good mechanical properties, swelling capability, adhesiveness, antioxidant and antibacterial abilities, as well as promoting cell proliferation and migration. The results showed that the hUC-MSCs loaded UC-DPA-Ag hydrogel could effectively accelerate wound healing in diabetic model mice, providing a facile and effective way for diabetic chronic wound management. Additionally, this hydrogel offers a new route for utilizing Ulva as a valuable biomaterial for large-scale production of biomaterials.

CARBOHYDRATE POLYMERS (2022)

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Article Chemistry, Applied

Carboxymethyl chitosan-based hydrogels containing fibroblast growth factors for triggering diabetic wound healing

Yuanping Hao et al.

Summary: The BP/CS-bFGF hydrogel dressing prepared in this study shows great potential for diabetic chronic wound management. It has strong wet-tissue adhesion, self-mending, and antibacterial properties, and displays fast hemostasis capacity. The hydrogel dressing significantly accelerates full-thickness diabetic wound repair by increasing the production of Ki67, promoting the generation of epithelialization and collagen, inducing the formation of hair follicles, and enhancing neovascularization.

CARBOHYDRATE POLYMERS (2022)

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Article Chemistry, Applied

Injectable multifunctional hyaluronic acid/methylcellulose hydrogels for chronic wounds repairing

Linyu Long et al.

Summary: An injectable multifunctional hydrogel with rapid gelation, self-healing, high water absorbency, tissue adhesiveness and excellent antioxidant activity was fabricated. After loading Ag nanoparticles and recombinant humanized collagen type III, the hydrogel exhibited pH-/H2O2-responsive drug release, cell proliferation promotion, and antibacterial activity. In vivo experiments demonstrated that the hydrogel significantly accelerated wound repair.

CARBOHYDRATE POLYMERS (2022)

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Article Engineering, Environmental

All-in-one: Harnessing multifunctional injectable natural hydrogels for ordered therapy of bacteria-infected diabetic wounds

Xiaoliang Qi et al.

Summary: An all-in-one hydrogel (QOP) has been developed to treat diabetic wounds. QOP can achieve rapid hemostasis, neutralize inflammatory cytokines, eliminate bacteria, regulate oxidation state, promote cell adhesion and migration, and facilitate angiogenesis. The QOP dressing can be fully absorbed by the organism after achieving the desired therapeutic effects.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Chemistry, Physical

Multifunctional hydrogel platform for biofilm scavenging and O2 generating with photothermal effect on diabetic chronic wound healing

Qian Wang et al.

Summary: A multifunctional hydrogel platform has been developed to address the challenges of diabetic wound treatment by eliminating bacterial biofilm and relieving wound hypoxia. The hydrogel, with the addition of polydopamine and manganese dioxide, demonstrated excellent biocompatibility and wound healing properties.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Materials Science, Multidisciplinary

Polyphenol-Metal Functionalized Hydrogel Dressing with Sustained Release, Antibacterial, and Antioxidant Properties for the Potential Treatment of Chronic Wounds

Zhiwen Zeng et al.

Summary: A silk fibroin/kappa-carrageenan hydrogel functionalized with epigallocatechin-3-gallate (EGCG) and Cu2+ is fabricated for chronic wound healing. The hydrogel exhibits good mechanical properties and sustained release of EGCG, enhancing antibacterial and antioxidant properties. This study provides a potential and effective strategy for chronic wound care management.

MACROMOLECULAR MATERIALS AND ENGINEERING (2022)

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Article Chemistry, Multidisciplinary

Tailored Hydrogel Delivering Niobium Carbide Boosts ROS-Scavenging and Antimicrobial Activities for Diabetic Wound Healing

Jing Chen et al.

Summary: In this study, an injectable thermosensitive niobium carbide (Nb2C)-based hydrogel (Nb2C@Gel) was developed to promote diabetic wound healing. The system showed antioxidative and antimicrobial activity, as it efficiently eliminated reactive oxygen species (ROS) and exhibited near-infrared (NIR) photothermal antimicrobial activity. In vivo experiments demonstrated that Nb2C@Gel reduced oxidative damage, eradicated bacterial infection, and accelerated angiogenesis, thus promoting wound healing.

SMALL (2022)

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Article Polymer Science

Mild Hyperthermia-Assisted ROS Scavenging Hydrogels Achieve Diabetic Wound Healing

Xiaoliang Qi et al.

Summary: This study reports the facile synthesis of a polyphenol/polysaccharide hydrogel for the treatment of diabetic wounds by scavenging ROS. The hydrogel showed antioxidant properties and could be strengthened by local photothermal heating, providing enhanced protection against oxidative damage.

ACS MACRO LETTERS (2022)

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Article Engineering, Biomedical

Planar-/Curvilinear-Bioprinted Tri-Cell-Laden Hydrogel for Healing Irregular Chronic Wounds

Shin-Da Wu et al.

Summary: A bioprintable hydrogel has been developed for the treatment of chronic and irregular wounds. The hydrogel can be printed in both planar and curvilinear shapes, and has been shown to promote complete repair and regeneration in both types of wounds.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Multidisciplinary Sciences

ECM-mimetic immunomodulatory hydrogel for methicillin-resistant Staphylococcus aureus-infected chronic skin wound healing

Wenshuai Liu et al.

Summary: A glycopeptide hybrid hydrogel with antibacterial and tissue environment-responsive properties was developed for chronic wound healing. The hydrogel can promote cell proliferation and macrophage polarization, and has potent antibacterial effects. It accelerated the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic and scalding skin by promoting M2-type macrophages, reducing inflammation, and promoting angiogenesis.

SCIENCE ADVANCES (2022)

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Article Engineering, Biomedical

A strain-programmed patch for the healing of diabetic wounds

Georgios Theocharidis et al.

Summary: A polymer patch that adheres to diabetic wounds and contracts in a pre-programmed manner has shown to promote wound closure and re-epithelialization in mouse and human skin, in mini-pigs and in humanized mice. The patch consists of a dried adhesive layer of crosslinked polymer networks and a pre-stretched hydrophilic elastomer backing, utilizing a hydration-based shape-memory mechanism. In preclinical trials, the patch enhanced the healing of diabetic wounds by promoting faster re-epithelialization and angiogenesis, and enriching the fibroblast populations with a pro-regenerative phenotype.

NATURE BIOMEDICAL ENGINEERING (2022)

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Article Engineering, Environmental

Temperature sensitive polyMOF hydrogel formed by in situ open-ring polymerization for infected chronic wound treatment

Wei Nie et al.

Summary: A multifunctional hydrogel dressing has been developed to effectively heal chronic wounds infected with drug-resistant bacteria through photothermal therapy. The innovative preparation strategy may have significant implications for clinical applications.

CHEMICAL ENGINEERING JOURNAL (2022)

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Review Chemistry, Multidisciplinary

Multifunctional Biomimetic Microstructured Surfaces for Healthcare Applications

Lianghao Jia et al.

Summary: This article reviews the typical applications of biomimetic microstructured surfaces in healthcare advances and the techniques used to fabricate these surfaces. The future challenges and opportunities in the field are also discussed.

ADVANCED MATERIALS INTERFACES (2022)

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Review Materials Science, Multidisciplinary

Intelligent hydrogels and their biomedical applications

Gayathri Chakrapani et al.

Summary: Intelligent biomaterials can modify their properties in response to physical, chemical, and biological stimuli, enabling early detection and treatment of diseases. Hydrogels have gained attention as smart materials due to their biocompatibility and ability to interact with body fluids. This review focuses on strategies for transforming conventional hydrogels into intelligent ones, their stimuli-responsiveness mechanisms, and biomedical applications.

MATERIALS ADVANCES (2022)

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Article Materials Science, Biomaterials

A smart hydrogel patch with high transparency, adhesiveness and hemostasis for all-round treatment and glucose monitoring of diabetic foot ulcers

Hou Liu et al.

Summary: The treatment and management of diabetic foot ulcers is a challenging issue, and this study developed a transparent monitoring system utilizing a conductive hydrogel patch to visually monitor wound-healing status and promote the healing of DFUs through various mechanisms, improving treatment efficacy.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Engineering, Biomedical

A hybrid hydrogel encapsulating human umbilical cord mesenchymal stem cells enhances diabetic wound healing

Hongjie Xu et al.

Summary: This study developed an optimized hydrogel combined with stem cells to improve the treatment of diabetic wounds. The encapsulation of stem cells in the hydrogel accelerated wound healing, inhibited inflammatory factor secretion, and promoted vascular regeneration and collagen deposition.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2022)

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Article Materials Science, Biomaterials

Au-Pt nanozyme-based multifunctional hydrogel dressing for diabetic wound healing

Bo Zhang et al.

Summary: A multifunctional self-healing hydrogel dressing has been developed to regulate the complex microenvironment of diabetic wounds and accelerate the healing process.

BIOMATERIALS ADVANCES (2022)

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Article Materials Science, Biomaterials

In-situ formable dextran/chitosan-based hydrogels functionalized with collagen and EGF for diabetic wounds healing

Ping Hu et al.

Summary: A bioactive, in-situ formable hydrogel wound dressing was designed by crosslinking oxidized dextran and carboxyethyl chitosan. Collagen and Epidermal Growth Factor were added to improve mechanical strength, biocompatibility, cell proliferation, and wound healing. The synergistic effect of collagen and EGF showed potential in accelerating wound healing in diabetic patients.

BIOMATERIALS ADVANCES (2022)

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Article Emergency Medicine

Curcumin-incorporated 3D bioprinting gelatin methacryloyl hydrogel reduces reactive oxygen species-induced adipose-derived stem cell apoptosis and improves implanting survival in diabetic wounds

Sizhan Xia et al.

Summary: In this study, Cur-incorporated 3D-printed GelMA hydrogel was developed and applied to diabetic wounds. The results showed that the incorporation of Cur improved the antioxidant activity of the GelMA hydrogel and mitigated ROS generation and apoptosis in ADSCs induced by the AGE/AGER/p65 axis. Furthermore, the Cur-GelMA scaffold promoted cell survival and expedited in vivo diabetic wound healing.

BURNS & TRAUMA (2022)

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Article Materials Science, Biomaterials

An injectable and self-healing hydrogel with antibacterial and angiogenic properties for diabetic wound healing

Xuexia Liu et al.

Summary: The treatment of diabetic wounds is a global challenge. Diabetic wound dressings require antibacterial, anti-inflammatory, and pro-angiogenic effects, as well as the ability to adapt to different wound morphologies, self-adhere, and self-heal. Herein, an injectable and self-healing hydrogel is constructed using chitosan and metal ions to improve infected and diabetic wound healing.

BIOMATERIALS SCIENCE (2022)

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Article Materials Science, Biomaterials

Tannic acid-reinforced zwitterionic hydrogels with multi-functionalities for diabetic wound treatment

Kun Fang et al.

Summary: In this study, a mechanically reinforced hydrogel with multiple biofunctionalities was developed by incorporating tannic acid (TA) in zwitterionic poly(sulfobetaine methacrylate) (polySBMA) hydrogel. The TA-reinforced hydrogel exhibited excellent mechanical properties and biological activities, and promoted the healing of diabetic wounds.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Nanoscience & Nanotechnology

Photopolymerized Zwitterionic Hydrogels with a Sustained Delivery of Cerium Oxide Nanoparticle-miR146a Conjugate Accelerate Diabetic Wound Healing

Michael A. Stager et al.

Summary: In the United States, a significant amount of money is spent on treating diabetic ulcers every year. This study demonstrates the potential use of photopolymerized zwitterionic hydrogels as a topical treatment for chronic diabetic wounds. The hydrogels not only reduce inflammation but also release therapeutic molecules to combat oxidative stress and inflammation. Additionally, the mechanical properties and release rate of the hydrogels can be adjusted according to the needs. In vivo experiments using diabetic mouse wound healing models showed that the hydrogels significantly improved the rate of diabetic wound healing.

ACS APPLIED BIO MATERIALS (2022)

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Article Materials Science, Biomaterials

Responsive hydrogel-based microneedle dressing for diabetic wound healing

Zhaoyang Guo et al.

Summary: In this study, a glucose-responsive insulin-releasing hydrogel microneedle dressing was developed for diabetic wound healing. The microneedle dressing exhibited mechanical stability, biocompatibility, glucose-responsive insulin release, and improved blood glucose control, making it effective for diabetic wound management and potentially useful for other chronic skin injuries.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Materials Science, Biomaterials

A multifunctional 3D dressing unit based on the core-shell hydrogel microfiber for diabetic foot wound healing

Qiwei Huang et al.

Summary: This study proposes a simple coaxial biological 3D printing technology for producing multifunctional medical dressings. These dressings have good biocompatibility and multiple functions, showing promising therapeutic effects on diabetic foot wounds.

BIOMATERIALS SCIENCE (2022)

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Article Materials Science, Biomaterials

An oxygen-sensitive probe and a hydrogel for optical imaging and photodynamic antimicrobial chemotherapy of chronic wounds

Shilu Ji et al.

Summary: A small molecular probe and a macromolecular optical probe were designed for hypoxia imaging and antibacterial chemotherapy. The small molecular probe is capable of emitting fluorescence in the red-wavelength region, while the macromolecular probe has a strong hydrophilicity for photodynamic therapy. The probes were also cross-linked with other substances to form a hydrogel that effectively inhibits bacterial growth and promotes wound healing.

BIOMATERIALS SCIENCE (2022)

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Article Materials Science, Biomaterials

A pH-responsive hyaluronic acid hydrogel for regulating the inflammation and remodeling of the ECM in diabetic wounds

Yile Jia et al.

Summary: A pH-responsive hyaluronic acid-collagen hydrogel was designed to reconstruct the ECM in diabetic wounds, promoting wound healing by enhancing fibroblast adhesion and infiltration and inhibiting macrophage growth.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Review Polymer Science

Functional Hydrogels for Treatment of Chronic Wounds

Ilayda Firlar et al.

Summary: Chronic wounds have a severe impact on 1-2% of the population in developed countries. The treatment of chronic wounds is crucial for the well-being and quality of life of patients. Hydrogel dressings, with their functional properties and advantages, have emerged as a promising choice for the treatment of chronic wounds.

GELS (2022)

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Article Materials Science, Multidisciplinary

Injectable melatonin-loaded carboxymethyl chitosan (CMCS)-based hydrogel accelerates wound healing by reducing inflammation and promoting angiogenesis and collagen deposition

Kai Chen et al.

Summary: The melatonin-loaded hydrogel promotes granulation tissue formation, accelerates wound healing, and reduces inflammation levels.

JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY (2021)

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Article Materials Science, Biomaterials

Injectable, self-healing, antibacterial, and hemostatic N,O-carboxymethyl chitosan/oxidized chondroitin sulfate composite hydrogel for wound dressing

Hongbin Li et al.

Summary: This work reports the development of an injectable, self-healing, antibacterial, hemostatic, and biocompatible hydrogel derived from the hybrid of N,O-carboxymethyl chitosan and oxidized chondroitin sulfate, which does not require any chemical crosslinking. The hydrogel exhibited excellent in vivo hemostatic performance and low cell toxicity, making it a promising wound dressing material.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Materials Science, Biomaterials

Novel silver and nanoparticle-encapsulated growth factor co-loaded chitosan composite hydrogel with sustained antimicrobility and promoted biological properties for diabetic wound healing

Yu-Hsiang Lee et al.

Summary: Diabetic foot ulcer is a common complication of diabetes that is difficult to treat and poses a serious threat to the health of patients. A study has developed a composite chitosan-based hydrogel named SNPECHG, which can help improve the healing speed of diabetic wounds.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Engineering, Biomedical

Bone marrow mesenchymal stem cells preconditioned with nitric-oxide-releasing chitosan/PVA hydrogel accelerate diabetic wound healing in rabbits

Rashid Ahmed et al.

Summary: The study introduced a NO-releasing hydrogel that enhanced the wound-healing potential of bone marrow mesenchymal stem cells in diabetic wounds by increasing cell viability and proliferation. The slow release of NO from the hydrogel promoted continuous cell-proliferating activity, resulting in faster tissue regeneration.

BIOMEDICAL MATERIALS (2021)

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Article Engineering, Environmental

Engineering poly(ionic liquid) semi-IPN hydrogels with fast antibacterial and anti-inflammatory properties for wound healing

Chao Zhou et al.

Summary: The synthesized semi-inter penetrate network hydrogels exhibited high antibacterial activities and anti-inflammatory properties, promoting wound healing by killing bacteria and accelerating tissue repair.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Biomedical

Modulation of macrophages by a paeoniflorin-loaded hyaluronic acid-based hydrogel promotes diabetic wound healing

Hao Yang et al.

Summary: The study confirmed the potential of paeoniflorin (PF) for transitioning macrophages and developed a high molecular weight hyaluronic acid (HA) hydrogel that significantly promoted cutaneous healing in experimental diabetic mice, showing promising clinical translation potential.

MATERIALS TODAY BIO (2021)

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Article Biochemistry & Molecular Biology

Promote anti-inflammatory and angiogenesis using a hyaluronic acid-based hydrogel with miRNA-laden nanoparticles for chronic diabetic wound treatment

Linglan Yang et al.

Summary: A novel hydrogel system was developed for the treatment of chronic diabetic wounds, which showed the ability to shorten the inflammatory stage and promote angiogenesis. Both in vitro and in vivo experiments demonstrated excellent biocompatibility and therapeutic potential of the prepared hydrogel.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Engineering, Environmental

Carbon dots-releasing hydrogels with antibacterial activity, high biocompatibility, and fluorescence performance as candidate materials for wound healing

Fangchao Cui et al.

Summary: An antibacterial hydrogel with excellent optical performance and high biocompatibility was developed using cationic carbon dots, pectin, and acrylic acid. The hydrogel showed long-term broad-spectrum antibacterial ability and high inhibitory capability without causing cytotoxicity or tissue toxicity. The release of high-cationic carbon dots from the hydrogel damaged bacterial membranes, making it effective against even drug-resistant bacteria.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Review Engineering, Biomedical

Functional hydrogels for diabetic wound management

Daqian Gao et al.

Summary: Diabetic wounds with slow healing and high infection risk can benefit from multifunctional hydrogels with antibacterial, pro-angiogenesis, and overall healing properties. These hydrogels, designed to accelerate diabetic wound healing, offer promising strategies for addressing the complex pathology of diabetic wounds.

APL BIOENGINEERING (2021)

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Article Polymer Science

Injectable and antibacterial ε-poly(L-lysine)-modified poly(vinyl alcohol)/chitosan/AgNPs hydrogels as wound healing dressings

Xu Yang et al.

Summary: The injectable and antibacterial hydrogels based on c-poly (L-lysine)-modified poly (vinyl alcohol)/chitosan/silver complexes displayed excellent bactericidal properties, biocompatibility, and accelerated wound healing effects.

POLYMER (2021)

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Article Nanoscience & Nanotechnology

Ultrashort Peptides and Hyaluronic Acid-Based Injectable Composite Hydrogels for Sustained Drug Release and Chronic Diabetic Wound Healing

Ling Wang et al.

Summary: The study successfully developed composite hydrogels with excellent mechanical properties and self-healing capabilities by incorporating hyaluronic acid with diphenylalanine conjugated with different aromatic moieties. The sustained release of curcumin in the composite hydrogel contributed to promoting chronic diabetic wound healing.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Intrinsic Antibacterial and Conductive Hydrogels Based on the Distinct Bactericidal Effect of Polyaniline for Infected Chronic Wound Healing

Can Wu et al.

Summary: The study demonstrates the distinct bactericidal effect of polyaniline against Gram-positive bacteria, potentially through specific interaction with lipoteichoic acid to disrupt the bacterial cell wall. Additionally, a hydrogel constructed with polyaniline and sulfonated hyaluronic acid shows superior electrical stimulation for promoting infected chronic wound healing compared to conventional electrodes.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Multifunctional Thermoplastic Polyurea Based on the Synergy of Dynamic Disulfide Bonds and Hydrogen Bond Cross-Links

Zhen Xiang et al.

Summary: The study prepared multifunctional thermoplastic polyureas with solid-state plasticity and self-healing properties, which can quickly undergo shape transition and damage repair after heating. These materials have multipathway remodeling capabilities, broadening the channels for reprocessing smart materials.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Chemistry, Multidisciplinary

Stimuli-Responsive Nanocomposite Hydrogels for Biomedical Applications

Pedro Lavrador et al.

Summary: Recent advances in the design of stimuli-responsive nanocomposite hydrogels have expanded their potential for operating as advanced systems in various biomedical applications, benefitting from tailored single or multi-responsiveness. The combination of hydrogels and nanoparticles showcases an intrinsic ability to react to external or internal/physiological stimuli, developing intelligent systems with application-oriented features.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Engineering, Biomedical

A novel hot spring-mimetic hydrogel with excellent angiogenic properties for chronic wound healing

Lili Sheng et al.

Summary: The study introduces a novel bioactive photothermal hydrogel with hot spring effect, which stimulates angiogenesis and facilitates chronic wound healing. By releasing bioactive ions and providing heating function, the hydrogel exhibits significant enhancement in vivo.

BIOMATERIALS (2021)

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Article Engineering, Environmental

Low-drug resistance carbon quantum dots decorated injectable self-healing hydrogel with potent antibiofilm property and cutaneous wound healing

Peili Li et al.

Summary: This study successfully synthesized low-drug-resistance antibacterial carbon quantum dots and applied them to hydrogels, demonstrating multiple functions and potential benefits for treating bacterial infections.

CHEMICAL ENGINEERING JOURNAL (2021)

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Review Chemistry, Medicinal

Overview of in situ gelling injectable hydrogels for diabetic wounds

Lavanya Mude et al.

Summary: Diabetic wound is a devastating complication of diabetes, with limited treatment options and poor outcomes.

DRUG DEVELOPMENT RESEARCH (2021)

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Article Chemistry, Physical

Polymersome Wound Dressing Spray Capable of Bacterial Inhibition and H2S Generation for Complete Diabetic Wound Healing

Danqing Liu et al.

Summary: Diabetic wounds are difficult to heal due to bacterial infection and decreased cell proliferation and migration. A polymersome-based wound dressing spray was shown to inhibit bacteria, generate H2S, and promote cell growth and angiogenesis in diabetic wounds, offering a new insight into effective treatment.

CHEMISTRY OF MATERIALS (2021)

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Article Biochemistry & Molecular Biology

A biodegradable antibacterial alginate/carboxymethyl chitosan/Kangfuxin sponges for promoting blood coagulation and full-thickness wound healing

Yun He et al.

Summary: The development of multifunctional composite sponges incorporating traditional Chinese medicine Kangfuxin into alginate/carboxymethyl chitosan shows great potential for promoting wound healing, with properties such as suitable water vapor transmittance, antibacterial behavior, cytocompatibility, and rapid hemostasis. In a rat full-thickness wounds model, the composite sponge significantly facilitates wound closure compared to conventional wound dressings.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Engineering, Multidisciplinary

Peptidoglycan-inspired peptide-modified injectable hydrogels with enhanced elimination capability of bacterial biofilm for chronic wound healing

Weiwang Qiu et al.

Summary: A peptide-modified polysaccharide-based injectable hydrogel has been synthesized for effective anti-biofilm and infected wound healing. The synergistic effect of quaternary ammonium salt groups and the peptide significantly enhances the anti-biofilm property of the hydrogels. The hydrogel also exhibits excellent self-healing property and biocompatibility, making it a promising multifunctional dressing in biomedical applications.

COMPOSITES PART B-ENGINEERING (2021)

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Article Engineering, Biomedical

Human decellularized adipose matrix derived hydrogel assists mesenchymal stem cells delivery and accelerates chronic wound healing

Zhaoyang Chen et al.

Summary: Biological scaffolds based stem cell delivery using a hydrogel made from human decellularized adipose matrix show promising results in accelerating chronic wound healing. The hydrogel supports survival and proliferation of stem cells, and enhances paracrine activity. In diabetic mouse model experiments, the composite treatment led to faster wound closure and increased neovascularization.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

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Article Multidisciplinary Sciences

Octenidine-based hydrogel shows anti-inflammatory and protease-inhibitory capacities in wounded human skin

Saskia Seiser et al.

Summary: Octenidine dihydrochloride (OCT) is a widely used antiseptic molecule that promotes skin wound healing and improves scar quality after surgical procedures. This study showed that OCT-treated skin wounds had lower levels of key players in tissue remodeling and reepithelization, as well as reduced enzymatic activity of matrix-metalloproteinases (MMPs). The data provide insights on how OCT positively influences wound healing through its anti-inflammatory and protease-inhibitory activities.

SCIENTIFIC REPORTS (2021)

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Article Nanoscience & Nanotechnology

Plasma Exosomes Loaded pH-Responsive Carboxymethylcellulose Hydrogel Promotes Wound Repair by Activating the Vascular Endothelial Growth Factor Signaling Pathway in Type 1 Diabetic Mice

Lijuan Huang et al.

Summary: The P-Exos-loaded CMC hydrogel is an effective therapeutic agent for accelerating diabetic wound repair by promoting angiogenesis and re-epithelialization. It enhances wound healing process in diabetic type 1 mice through activating angiogenesis-related pathways mediated by VEGF.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2021)

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Article Materials Science, Biomaterials

Zwitterionized Nanofibrous Poly(vinylidene fluoride) Membranes for Improving the Healing of Diabetic Wounds

Irish Valerie Maggay et al.

Summary: By utilizing a combination of zwitterionic membranes with improved hydration properties, this study demonstrates their potential as wound-dressing materials for promoting healing of acute and chronic wounds. The membranes exhibit low biofouling, enhanced blood compatibility, and high cell viability, leading to accelerated wound healing kinetics and improved quality of new tissue.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Materials Science, Biomaterials

Injectable Self-Healing Hydrogels Containing CuS Nanoparticles with Abilities of Hemostasis, Antibacterial activity, and Promoting Wound Healing

Yue Kong et al.

Summary: Injectable self-healing CuS NP hydrogels with multiple functions such as hemostasis, antibacterial activity, and promotion of infected wound healing were developed and demonstrated to have promising effects in accelerating wound healing in a mouse model. These hydrogels show great potential as in situ wound dressings.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Dermatology

The Anti-inflammatory and Proangiogenic Properties of High-Density Lipoproteins: An Emerging Role in Diabetic Wound Healing

Zahra Lotfollahi et al.

Summary: This review highlights the importance of high-density lipoproteins (HDL) in promoting wound healing, particularly in diabetic patients. New wound healing treatments targeting the two principal factors are needed. Diabetic foot ulcers leading to amputation pose a significant social and economic burden, with a therapeutic void still existing in the field.

ADVANCES IN WOUND CARE (2021)

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Article Nanoscience & Nanotechnology

Antifouling Antioxidant Zwitterionic Dextran Hydrogels as Wound Dressing Materials with Excellent Healing Activities

Xia Qiu et al.

Summary: Dextran-based hydrogels with zwitterionic structures showed faster wound healing rates compared to natural dextran hydrogel and commercial dressings, attributed to their protein resistance and ability to scavenge free radicals. These hydrogels also demonstrated excellent cytocompatibility and antibacterial properties, along with self-healing capabilities for irregular wounds, providing a new pathway for multifunctional polysaccharide hydrogels in wound treatment and pain relief during dressing changes.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

An All-in-One Tannic Acid-Containing Hydrogel Adhesive with High Toughness, Notch Insensitivity, Self-Healability, Tailorable Topography, and Strong, Instant, and On-Demand Underwater Adhesion

Kaiwen Chen et al.

Summary: This study innovatively developed a strategy to prepare hydrogel adhesives with strong underwater adhesion and high toughness, demonstrating potential biomedical applications in accelerating wound healing. The incorporation of tannic acid into a covalent network significantly enhanced the adhesion properties of the hydrogels and provided reversible cross-linking for improved mechanical performance, showing promising prospects for enhancing the efficacy of hydrogel adhesives for wound healing.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

Sprayable hydrogel dressing accelerates wound healing with combined reactive oxygen species-scavenging and antibacterial abilities

Hao Cheng et al.

Summary: The study introduces a novel sprayable hydrogel wound dressing loaded with cerium oxide nanoparticles and an antimicrobial peptide, providing ROS-scavenging and antibacterial properties. By adopting a mussel-inspired strategy, the hydrogel exhibited improved binding affinity to wet skin surfaces and demonstrated excellent biocompatibility.

ACTA BIOMATERIALIA (2021)

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Article Engineering, Biomedical

Glucose-triggered in situ forming keratin hydrogel for the treatment of diabetic wounds

Yansong Chen et al.

Summary: The study developed a glucose-triggered in situ forming keratin hydrogel via higher oxidation force of hydrogen peroxide, which shortened gelation time and improved mechanical strength. This method required no additional crosslinking agents or chemical modifications on keratins and showed potential in treating diabetic wounds.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

Green Tea Derivative Driven Smart Hydrogels with Desired Functions for Chronic Diabetic Wound Treatment

Xiaodan Zhao et al.

Summary: This study developed a smart hydrogel dressing through copolymerization of catechol groups and epigallocatechin-3-gallate (EGCG) with acrylamide, providing adequate mechanical properties, self-healing capability, and tissue adhesiveness. The substantial release of EGCG from the hydrogel enables multiple therapeutic effects, facilitates easy dressing change, and offers a convenient and effective method for the management of chronic diabetic wounds.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Bioinspired Conductive Silk Microfiber Integrated Bioelectronic for Diagnosis and Wound Healing in Diabetes

Zhanrong Jia et al.

Summary: Conductive silk microfibers were fabricated using a bioinspired method in this study, which were then used to make a conductive flexible silk fibroin patch for monitoring physiological signals and promoting chronic diabetic wound healing with excellent performance.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Injectable Self-Healing Hydrogel Wound Dressing with Cysteine-Specific On-Demand Dissolution Property Based on Tandem Dynamic Covalent Bonds

Xiaoya Ding et al.

Summary: An injectable self-healing hydrogel with rapid gelation and cysteine-specific on-demand dissolution was designed for wound dressings, showing excellent injectability, self-healing ability, and rapid cysteine-triggered dissolution. The hydrogel displayed favorable biocompatibility, achieved rapid wound closure in seconds, and fast on-demand dissolution for dressing changes, highlighting its potential for wound healing applications.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Engineering, Biomedical

Cryogel/hydrogel biomaterials and acupuncture combined to promote diabetic skin wound healing through immunomodulation

Tsai-Yu Chen et al.

Summary: The study developed functional and antimicrobial hydrogel and cryogel biomaterials for treating diabetic skin wounds, achieving good wound healing outcomes.

BIOMATERIALS (2021)

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Article Engineering, Environmental

Super-ductile, injectable, fast self-healing collagen-based hydrogels with multi-responsive and accelerated wound-repair properties

Min Zhang et al.

Summary: A multifunctional, extremely soft collagen-based hydrogel (COL-GG-PNIPAMs) was prepared by introducing collagen, guar gum, poly(N-isopropylacrylamide), graphene oxide, and borax, showing desirable properties like processability, injectability, and remoldability. The hydrogels exhibited super-ductile deformation, self-healing, thermal sensitivity, and NIR-responsive properties. They also showed potential for strain sensing and enhanced skin wound repair effect, expanding the applications of collagen-based hydrogels.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Environmental

Dual cross-linked organic-inorganic hybrid hydrogels accelerate diabetic skin wound healing

Yuna Qian et al.

Summary: Limited treatment options are available for chronic non-self-healing diabetic wounds characterized by bacterial infection and hypoxic microenvironment. A multifunctional organic-inorganic hybrid hydrogel, SF/Hb/Ga, was developed to address these challenges. This hybrid hydrogel demonstrated antibacterial properties, promoted cell proliferation, and accelerated tissue repair phases, leading to complete healing of infected diabetic wounds in vivo within 15 days.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Materials Science, Biomaterials

Injectable and self-healing chitosan-based hydrogel with MOF-loaded α-lipoic acid promotes diabetic wound healing

Qianyun Li et al.

Summary: An injectable self-healing hydrogel based on chitosan and hyaluronic acid was developed for wound healing in diabetic animals, showing significant promotion in the wound healing process. The hydrogel displayed properties of promoting cell proliferation and migration, as well as antioxidant and antibacterial effects.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Materials Science, Biomaterials

An excellent antibacterial and high self-adhesive hydrogel can promote wound fully healing driven by its shrinkage under NIR

Haofei Huang et al.

Summary: A novel hydrogel composed of PDA, Ag and GO was fabricated for wound dressing via the chemical crosslinking of NIPAM and BIS, showing effective antibacterial properties and high adhesion ability. Under NIR irradiation, the hydrogel can produce strong contractility to accelerate wound healing, achieving a 100% wound healing rate within 15 days.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Review Polymer Science

The fabrication of antibacterial hydrogels for wound healing

Xiumei Zhang et al.

Summary: Antimicrobial hydrogels are interesting materials for wound healing, with two main preparation methods: physical combination and chemical combination. Light-assisted antimicrobial hydrogels are also commonly used. With advancements in technology, novel antimicrobial hydrogels are constantly being developed.

EUROPEAN POLYMER JOURNAL (2021)

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Article Biochemistry & Molecular Biology

In-vivo evaluation of Alginate-Pectin hydrogel film loaded with Simvastatin for diabetic wound healing in Streptozotocin-induced diabetic rats

Masoud Rezvanian et al.

Summary: The study demonstrated that the novel hydrogel film wound dressing showed significant efficacy in accelerating diabetic wound healing, with pro-angiogenic effects, faster re-epithelialization, and increased collagen deposition.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Bioactive Carboxymethyl Starch-Based Hydrogels Decorated with CuO Nanoparticles: Antioxidant and Antimicrobial Properties and Accelerated Wound Healing In Vivo

Zahra Abdollahi et al.

Summary: The study synthesized nanocomposite hydrogels containing CuO nanoparticles for wound healing applications. The hydrogels exhibited antibacterial and antioxidant activities, low cytotoxicity, and good biocompatibility, showing potential for accelerating wound healing. Incorporation of CuO nanoparticles improved the hydrogel's antibacterial properties, antioxidant activity, and swelling capacity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Physical

Nanofibers reinforced injectable hydrogel with self-healing, antibacterial, and hemostatic properties for chronic wound healing

Weiwang Qiu et al.

Summary: The peptide modified nanofibers reinforced hydrogel designed by Schiff base dynamic crosslinking not only maintains a healthy wound microenvironment, but also greatly enhances the stability and mechanical strength of the hydrogel.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Article Materials Science, Biomaterials

Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment

Danica Z. Zmejkoski et al.

Summary: Nanocomposites of nanochitosan dots encapsulated in bacterial cellulose show potential antibacterial properties and could be effective in wound healing treatment, as demonstrated in this study through detailed analyses and experiments.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Nanoscience & Nanotechnology

Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing

Jiahui He et al.

Summary: A series of injectable pH-responsive self-healing adhesive hydrogels have been developed for treating gastric bleeding and wound healing after endoscopic treatment. These hydrogels show great potential as endoscopic sprayable bioadhesive materials, with good hemostatic properties and enhanced wound healing effects in animal models.

NANO-MICRO LETTERS (2021)

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Review Polymer Science

3D Printable Electrically Conductive Hydrogel Scaffolds for Biomedical Applications: A Review

Sandya Shiranthi Athukorala et al.

Summary: Electrically conductive hydrogels (ECHs) are a promising class of biomaterials for a wide range of biomedical applications, with 3D printing being an advanced technique for rapid fabrication of future biomedical implants and devices with versatile designs and adjustable functionalities. This review provides an overview of state-of-the-art 3D printed ECHs, discussing mechanisms of electrical conductivity, design considerations, and recent advances in formulation of 3D printable bioinks. Challenges and limitations of 3D printing of ECHs are identified, along with highlighting new 3D printing-based hybrid methods for selective deposition and controlled nanostructure fabrication.

POLYMERS (2021)

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Article Materials Science, Biomaterials

Injectable Desferrioxamine-Laden Silk Nanofiber Hydrogels for Accelerating Diabetic Wound Healing

Zhaozhao Ding et al.

Summary: The use of DFO-laden silk nanofiber hydrogels in treating diabetic wounds can alleviate dysangiogenesis and chronic inflammation, promoting faster wound healing and increased collagen deposition. Both in vitro and in vivo studies suggest the potential clinical applications of these DFO-laden hydrogels in diabetic ulcer treatment.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Materials Science, Biomaterials

Antioxidant biocompatible composite collagen dressing for diabetic wound healing in rat model

Bei Qian et al.

Summary: This study demonstrated that a COL-based implantable scaffold containing a mixture of GO capable of sustained delivery of NAC showed beneficial effects on wound healing in diabetic rats by potentially inducing antioxidant defense system. The findings suggest that this antioxidant biocompatible composite collagen dressing may enrich approaches for surgeons in treating diabetic wounds in the future.

REGENERATIVE BIOMATERIALS (2021)

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Article Materials Science, Multidisciplinary

Pterocarpus marsupium Roxburgh heartwood extract/chitosan nanoparticles loaded hydrogel as an innovative wound healing agent in the diabetic rat model

Anupama Ammulu Manne et al.

Summary: The study synthesized PM-CNPs loaded hydrogel, evaluated its wound healing effects in diabetic rat models, and identified an optimized formulation, PM-CNPsH-1, which significantly accelerated wound healing and promoted re-epithelization and granular tissue growth.

MATERIALS TODAY COMMUNICATIONS (2021)

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Article Nanoscience & Nanotechnology

Ultrafast Fabrication of Self-Healing and Injectable Carboxymethyl Chitosan Hydrogel Dressing for Wound Healing

Jinfeng Cao et al.

Summary: A new type of injectable CMCh hydrogel wound dressing with self-healing properties is constructed using coordination bonds and alkali/urea aqueous solutions. The hydrogel exhibits self-healing, self-adaption, and thermoresponsive ability, significantly accelerating skin tissue regeneration and wound closure. It has great potential in tissue engineering applications.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Multifunctional Injectable Hydrogel Dressings for Effectively Accelerating Wound Healing: Enhancing Biomineralization Strategy

Hui Zhang et al.

Summary: In this study, Gel-DA was used as a biotemplate to synthesize Gel-DA@Ag NPs with antioxidant activity and NIR laser irradiation synergistic antibacterial behavior for the first time. These NPs were then incorporated into guar gum based hydrogels to achieve remolding, injectable, and self-healing properties. The multifunctional hydrogels demonstrated the ability to completely cover irregular wound shapes and accelerate wound healing under NIR, with the appearance of skin appendages like hair follicles and blood vessels.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Biotechnology & Applied Microbiology

A thermoreversible antibacterial zeolite-based nanoparticles loaded hydrogel promotes diabetic wound healing via detrimental factor neutralization and ROS scavenging

Yao Qi et al.

Summary: The study involved the development of nanoparticles loaded hydrogel to neutralize detrimental factors and promote diabetic wound healing. The cerium-doped zeolite nanoparticles eliminated mitochondrial ROS and neutralized inflammatory factors, remodeling the wound's anti-inflammatory microenvironment and enhancing angiogenesis. The thermoreversible hydrogel showed strong haemostatic and bactericidal properties, offering a promising multi-targeted therapy for diabetic wound healing.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Engineering, Environmental

Injectable self-healing CuS nanoparticle complex hydrogels with antibacterial, anti-cancer, and wound healing properties

Liangqin Zhou et al.

Summary: This study developed a CuS nanoparticle complex hydrogel system with multiple functions, including excellent self-healing ability, photothermal/photodynamic performance, and biocompatibility, for accelerating wound healing.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Environmental

Dual-crosslinked mussel-inspired smart hydrogels with enhanced antibacterial and angiogenic properties for chronic infected diabetic wound treatment via pH-responsive quick cargo release

Cheng Hu et al.

Summary: The study successfully overcame the challenges in healing chronic diabetic wounds, such as bacterial infections and difficulty in angiogenesis, by using a pH-responsive double-crosslinking hydrogel.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Materials Science, Multidisciplinary

pH-responsive hydrogel loaded with insulin as a bioactive dressing for enhancing diabetic wound healing

Zuhao Li et al.

Summary: A self-healing, injectable, and pH responsive hydrogel was successfully synthesized and incorporated with insulin glargine, showing promising potential in accelerating the healing of diabetic foot ulcers by shortening the inflammatory phase, promoting tissue formation, and improving treatment outcomes.

MATERIALS & DESIGN (2021)

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Article Engineering, Biomedical

An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing

Bin Hu et al.

Summary: A hyaluronic acid and chitosan based hydrogel with antioxidant, anti-inflammatory, and migration-promoting effects was designed in this study. The hydrogel exhibited excellent drug release capabilities in vitro and dramatically improved diabetic wound healing by flexibly releasing curcumin and epidermal growth factor according to the phases of wound healing.

BIOACTIVE MATERIALS (2021)

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Article Engineering, Biomedical

Bioactive skin-mimicking hydrogel band-aids for diabetic wound healing and infectious skin incision treatment

Yuxuan Yang et al.

Summary: In this study, a bioactive skin-mimicking hydrogel band-aid was developed to promote the recovery of skin incision and defects on diabetic mice. The hydrogel showed promising anti-inflammation, antibacterial, and antioxidant properties, as well as moisture-resistant adhesiveness.

BIOACTIVE MATERIALS (2021)

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Article Engineering, Biomedical

Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity

Sophia Hauck et al.

Summary: This study successfully modulated the inflammatory macrophage activities in disturbed wound healing process through the use of hydrogels containing high-sulfated hyaluronan (sHA), leading to significant effects in a mouse model.

BIOACTIVE MATERIALS (2021)

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Article Multidisciplinary Sciences

Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring

Shamik Mascharak et al.

Summary: This study identified a dermal ENF subpopulation that activates Engrailed-1 expression through mechanical tension, promoting skin tissue regeneration. Blocking mechanotransduction signaling can stimulate ENF-mediated wound regeneration, leading to recovery of skin appendages and mechanical strength.

SCIENCE (2021)

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Article Cell Biology

Advanced bandages for diabetic wound healing

Simon Matoori et al.

Summary: The study reviews current treatment options for foot ulcers related to diabetes and discusses the development of wound dressings tailored to the diabetic wound environment.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Multifunctional Injectable Hydrogel Loaded with Cerium-Containing Bioactive Glass Nanoparticles for Diabetic Wound Healing

Yue-Hua Chen et al.

Summary: The development of a multifunctional injectable composite hydrogel containing cerium-containing bioactive glass (Ce-BG) and Gelatin methacryloyl (GelMA) has shown great potential in promoting diabetic foot wound healing by improving angiogenesis and antibacterial properties. In vitro studies demonstrated good cytocompatibility and promotion of endothelial cells migration and tube formation. Additionally, in vivo studies showed accelerated wound healing in diabetic rats through improved granulation tissue formation, collagen deposition, and angiogenesis.

BIOMOLECULES (2021)

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Article Materials Science, Biomaterials

Superabsorbent poly(acrylic acid) and antioxidant poly(ester amide) hybrid hydrogel for enhanced wound healing

Jianhua Zhang et al.

Summary: The PAA/PEA hybrid hydrogel dressing exhibits good antioxidant properties which can promote wound healing, support cell proliferation, and angiogenesis. Experimental results on mouse skin wounds demonstrate that the hybrid hydrogel scaffolds significantly accelerate the wound healing process, showing superior healing effects.

REGENERATIVE BIOMATERIALS (2021)

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Article Nanoscience & Nanotechnology

Novel Diabetic Foot Wound Dressing Based on Multifunctional Hydrogels with Extensive Temperature-Tolerant, Durable, Adhesive, and Intrinsic Antibacterial Properties

Hou Liu et al.

Summary: This study developed a temperature-tolerant antibacterial hydrogel dressing with excellent properties, effectively promoting the healing of diabetic foot ulcers (DFUs).

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

In Situ Photo-Cross-Linking Hydrogel Accelerates Diabetic Wound Healing through Restored Hypoxia-Inducible Factor 1-Alpha Pathway and Regulated Inflammation

Libin Pang et al.

Summary: The SF-MA-BS hydrogel can significantly accelerate diabetic wound healing by restoring the HIF-1a pathway through interaction between HIF-1a and Cu2+, promoting angiogenesis and regulating inflammation effectively to avoid long-term detrimental inflammation.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Biomimetic Microstructured Hydrogels with Thermal-Triggered Switchable Underwater Adhesion and Stable Antiswelling Property

Bo Zhang et al.

Summary: This study presents a biomimetic hydrogel with shape-memory effect and switchable adhesion, suitable for adhesion on various material surfaces in wet environments and exhibiting stable anti-swelling properties. The hydrogel can autonomously adhere and detach through thermal-triggered shape transformation, and it shows significantly improved underwater adhesion strength due to its patterned structure inspired by tree-frog footpads.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Inflammation-Responsive Drug-Loaded Hydrogels with Sequential Hemostasis, Antibacterial, and Anti-Inflammatory Behavior for Chronically Infected Diabetic Wound Treatment

Yu Wang et al.

Summary: The study synthesized a dual-responsive hydrogel (pH and ROS) for drug release under inflammatory stimulation. This novel design retained dynamic functions of hydrogels and achieved sequential and on-demand drug delivery at diabetic-infected wound sites.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

Injectable self-assembling peptide nanofiber hydrogel as a bioactive 3D platform to promote chronic wound tissue regeneration

Peng Lou et al.

Summary: The study introduces a self-assembling peptide (KGH) hydrogel that enhances chronic wound healing in diabetic mice by promoting extracellular matrix remodeling and angiogenesis. The hydrogel not only accelerates wound closure and enhances cell proliferation, granulation tissue formation, and ECM deposition in vivo, but also creates a favorable 3D growth environment for skin cells in vitro.

ACTA BIOMATERIALIA (2021)

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Article Engineering, Biomedical

Nanoparticle-driven self-assembling injectable hydrogels provide a multi-factorial approach for chronic wound treatment

Silvia Perez-Rafael et al.

Summary: This study developed a novel multifunctional hydrogel for the treatment of chronic wounds, showing significant efficacy in inhibiting harmful enzymes, reducing bacterial load, and promoting tissue remodeling and skin integrity restoration. It possesses antibacterial and antioxidant properties and is non-toxic to human keratinocytes after direct contact, making it a promising candidate for chronic wound management.

ACTA BIOMATERIALIA (2021)

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Article Engineering, Biomedical

Injectable adaptive self-healing hyaluronic acid/poly (γ-glutamic acid) hydrogel for cutaneous wound healing

Rong Yang et al.

Summary: The bionic extracellular matrix hydrogels developed in this study possess dynamic covalent network and self-healing capability, showing typical viscoelastic characteristics, degradation property, and free radical scavenging capability. The properties of the hydrogels can be tuned by adjusting polymer content, and they significantly enhance wound healing process by promoting angiogenesis and collagen deposition, demonstrating great application potential in biomedical areas.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

Engineering Bacteria-Activated Multifunctionalized Hydrogel for Promoting Diabetic Wound Healing

Yifei Lu et al.

Summary: This study presents a novel approach of using a delivery system comprising living Lactococcus to bioengineer the wound microenvironment and enhance angiogenesis in a highly dynamic-temporal manner, aiming to drive rapid healing in chronic wounds.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Flexible Bicolorimetric Polyacrylamide/Chitosan Hydrogels for Smart Real-Time Monitoring and Promotion of Wound Healing

Kaikai Zheng et al.

Summary: The study presents multifunctional hydrogels for real-time monitoring of wound healing, which can detect pH level, reduce bacterial infection, and promote wound healing simultaneously. The hybridization of CQDs and pH indicator with the hydrogels allows for high responsiveness and accurate indication of pH variability, enabling real-time evaluation of wound conditions. These hydrogels have potential as a smart and flexible wound dressing platform for theranostic skin regeneration.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Multifunctional DNA Hydrogels with Hydrocolloid-Cotton Structure for Regeneration of Diabetic Infectious Wounds

Liping Zhou et al.

Summary: The multifunctional DNA hydrogel dressing offers a wide range of functions such as absorbability, self-healing ability, antibacterial properties, and tissue regeneration promotion. Its advanced collaborative strategy provides an effective method for cascade management of clinical guided tissue regeneration, accelerating nerve and hair regeneration.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Bioinspired Intrinsic Versatile Hydrogel Fabricated by Amyloidal Toxin Simulant-Based Nanofibrous Assemblies for Accelerated Diabetic Wound Healing

Qize Xuan et al.

Summary: This study investigated a versatile hydrogel based on amyloid-derived toxin simulant, which promotes angiogenesis, has broad-spectrum antibacterial activity, and accelerates wound healing for diabetic patients, showing great potential for clinical application.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing

Mahshid Kharaziha et al.

Summary: The immune reaction plays a critical role in chronic wound healing, with modulation of macrophages' polarization being an appealing approach in regenerative medicine. The use of hydrogels-based constructs has been recently developed to adjust immune cell functions in various stages of wound healing. The properties of hydrogels have significant effects on immunogenic features and the wound healing process.

ADVANCED MATERIALS (2021)

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Article Biochemistry & Molecular Biology

Injectable and pH-Sensitive Hyaluronic Acid-Based Hydrogels with On-Demand Release of Antimicrobial Peptides for Infected Wound Healing

Huinan Suo et al.

Summary: The study developed an antibiotic-free hydrogel-based biomaterial for the management of chronic bacteria-infected wounds, utilizing an antimicrobial peptide as a cross-linking agent to achieve acidity-triggered release of AMP, along with high biostability and enhanced mechanical strength.

BIOMACROMOLECULES (2021)

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Article Medicine, Research & Experimental

Development of nitric oxide releasing visible light crosslinked gelatin methacrylate hydrogel for rapid closure of diabetic wounds

Alap Ali Zahid et al.

Summary: The study explores the use of GelMA hydrogel patches loaded with SNAP to enhance diabetic wound healing by improving cell proliferation and migration, showing promising results in promoting wound healing in diabetic rats.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Engineering, Environmental

Enzyme hybrid virus-like hollow mesoporous CuO adhesive hydrogel spray through glucose-activated cascade reaction to efficiently promote diabetic wound healing

Peiyuan Wang et al.

Summary: A hydrogel spray containing CuO nanospheres was developed for efficient promotion of diabetic wound healing, with antibacterial and hypoxia alleviation effects. This approach may provide a reliable tool for synergistic reconstruction of chronic non-healing wounds.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Environmental

Ionic liquid functionalized non-releasing antibacterial hydrogel dressing coupled with electrical stimulation for the promotion of diabetic wound healing

Pan Liu et al.

Summary: A multifunctional and conductive hydrogel dressing developed in this study based on polymerized ionic liquid and konjac glucomannan showed excellent mechanical properties, biocompatibility, and an efficient sterilization effect. When combined with electrical stimulation, it significantly improved fibroblast cell migration and proliferation, as well as the treatment effect on diabetic skin wounds, providing a novel strategy for efficiently treating chronic wounds.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Materials Science, Biomaterials

Improved drug delivery and accelerated diabetic wound healing by chondroitin sulfate grafted alginate-based thermoreversible hydrogels

Syed Ahmed Shah et al.

Summary: This study presents an injectable hydrogel based on chondroitin sulphate and sodium alginate loaded with curcumin for diabetic wound repair. The hydrogel demonstrated good biocompatibility and tissue regeneration ability, with controlled release of curcumin showing promising results in promoting wound healing.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Polymer Science

Mechano-Responsive Hydrogels Driven by the Dissociation of a Host-Guest Complex

Akihide Sugawara et al.

Summary: A mechano-responsive hydrogel was developed using the dissociation of a host-guest complex to induce phase transition of a thermoresponsive polymer, demonstrating a decrease in transmittance when mechanical stress was applied. This strategy provides a new approach for applications requiring controlled functions through applied stress.

ACS MACRO LETTERS (2021)

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Article Engineering, Biomedical

In Situ Synthesized Selenium Nanoparticles-Decorated Bacterial Cellulose/Gelatin Hydrogel with Enhanced Antibacterial, Antioxidant, and Anti-Inflammatory Capabilities for Facilitating Skin Wound Healing

Lin Mao et al.

Summary: The multifunctional nanocomposite hydrogels based on bacterial cellulose, gelatin, and selenium nanoparticles showed excellent antibacterial, antioxidant, and anti-inflammatory capabilities, as well as promising wound healing performance in a rat full-thickness defect model. The hydrogels demonstrated superior mechanical properties, good swelling ability, flexibility, biodegradability, and biocompatibility, making them a great potential wound dressing for preventing infection and accelerating skin regeneration in clinic.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Biotechnology & Applied Microbiology

Biomimetic Hydrogels to Promote Wound Healing

Fei Fan et al.

Summary: Hydrogels play a crucial role in wound healing by supporting a hydrated environment and promoting better healing outcomes through the incorporation of biomolecules and supporting cells. Various types of hydrogels have been developed and modified to match different stages of wound healing, with challenges related to adoption and future perspectives discussed.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Eradication of Mature Bacterial Biofilms with Concurrent Improvement in Chronic Wound Healing Using Silver Nanoparticle Hydrogel Treatment

Hanif Haidari et al.

Summary: The development of highly potent ultrasmall AgNPs combined with a biocompatible hydrogel has shown promising results in eliminating mature biofilm infections in vivo and promoting wound healing. The treatment exhibited superior antibacterial efficacy and improved wound closure, re-epithelization, and collagen deposition compared to conventional silver-based treatments.

BIOMEDICINES (2021)

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Article Materials Science, Biomaterials

Conductive dual hydrogen bonding hydrogels for the electrical stimulation of infected chronic wounds

Ye Wu et al.

Summary: A study successfully prepared a tough conductive hydrogel with similar conductivity to human skin and superior mechanical properties. The hydrogel exhibited intense antimicrobial activity, and electrical stimulation via the conductive hydrogel was more effective in healing infected wounds than traditional methods.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Materials Science, Biomaterials

Glucose oxidase and Fe3O4/TiO2/Ag3PO4 co-embedded biomimetic mineralization hydrogels as controllable ROS generators for accelerating diabetic wound healing

Tingting Huang et al.

Summary: By embedding glucose oxidase and nanoparticles in a hydrogel, a multifunctional antibacterial platform is created to promote diabetic wound healing and control drug release rate, potentially preventing toxicity and oxidative stress in the body.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Materials Science, Biomaterials

An injectable photothermally active antibacterial composite hydroxypropyl chitin hydrogel for promoting the wound healing process through photobiomodulation

Mengsi Ma et al.

Summary: The injectable photothermally active antibacterial composite hydrogel based on HPCH/TA/Fe demonstrated effective prevention of bacterial infection, accelerated wound closure, and good biocompatibility. Combining low-level laser therapy with the hydrogel resulted in accelerated wound closure and promotion of skin tissue repair.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Materials Science, Biomaterials

Injectable keratin hydrogels as hemostatic and wound dressing materials

Ao Tang et al.

Summary: Injectable hydrogels based on keratin and Au(iii) salt were developed through dynamic exchange between disulfide bonds (S-S) and gold(i)-thiolates (Au-S). This hydrogel showed a good hemostatic effect and was efficient as a drug loading carrier, demonstrating desirable wound healing effects in various models.

BIOMATERIALS SCIENCE (2021)

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Article Materials Science, Biomaterials

Polyvinyl alcohol/chitosan composite hydrogels with sustained release of traditional Tibetan medicine for promoting chronic diabetic wound healing

Zuxin Wang et al.

Summary: The study demonstrates that TEP-loaded hydrogels have significant anti-inflammatory and wound healing effects, are non-toxic to cells, and are suitable for treating diabetic wounds.

BIOMATERIALS SCIENCE (2021)

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Review Materials Science, Biomaterials

Advances of hydrogel dressings in diabetic wounds

Heni Wang et al.

Summary: Hydrogel dressings with moisture retention, biocompatibility, and therapeutic properties have played a crucial role in diabetic wound treatment. Recent studies have shown promising results with functionalized hydrogel dressings, leading to improvements in diabetic wounds.

BIOMATERIALS SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Tannic acid-thioctic acid hydrogel: a novel injectable supramolecular adhesive gel for wound healing

Chen Chen et al.

Summary: The TATA supramolecular hydrogel, synthesized through ring-opening polymerization, possesses self-healing and injectable properties, and has been successfully used for skin wound healing and burn wound infection treatment. XPS confirmed successful intermolecular crosslinking, showcasing its potential as a surgical antibacterial bioadhesive.

GREEN CHEMISTRY (2021)

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Article Nanoscience & Nanotechnology

Pristine Gellan Gum Collagen Interpenetrating Network Hydrogels as Mechanically Enhanced Anti-inflammatory Biologic Wound Dressings for Burn Wound Therapy

Jian Yao Ng et al.

Summary: The combination of gellan gum and collagen to create a full interpenetrating network hydrogel has shown to enhance wound healing properties and promote regeneration by utilizing adipose-derived mesenchymal stem cells. The introduced hydrogel fabrication process demonstrated temperature-dependent simultaneous interpenetrating network, leading to improved mechanical properties and the ability to retain sufficient mass for cell-based therapy. Additionally, the incorporation of stem cells within the hydrogel structure showed increased stiffness and enhanced cell adhesion, ultimately resulting in successful application for burn wound therapy.

ACS APPLIED BIO MATERIALS (2021)

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Article Polymer Science

Salt-responsive polyampholyte-based hydrogel actuators with gradient porous structures

Zijian Shao et al.

Summary: This paper presents a polyampholyte-based hydrogel with gradient pore construction that can rapidly change shape and recover. By adjusting chemical and non-chemical factors, the shape deformation degree and response/recovery time of the hydrogel can be controlled, making it a potential material for multiple applications.

POLYMER CHEMISTRY (2021)

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Article Chemistry, Physical

Salt-mediated triple shape-memory ionic conductive polyampholyte hydrogel for wearable flexible electronics

Shanshan Wu et al.

Summary: The supramolecular polyampholyte hydrogel designed in this study exhibits salt-mediated triple shape-memory effect, high ionic conductivity, high stretchability, and self-healing property, making it suitable for applications as shape-memory sensor and strain sensor, capable of detecting concentration changes in saline solutions and human activities.

JOURNAL OF MATERIALS CHEMISTRY A (2021)

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Article Materials Science, Biomaterials

One-pot, self-catalyzed synthesis of self-adherent hydrogels for photo-thermal, antimicrobial wound treatment

Pengfei Li et al.

Summary: The study introduces a simple one-pot synthesis procedure for self-adhesive hydrogels composed of PAM, CS, and TA@Fe3+, which effectively eliminates bacterial activity through photothermal responsiveness, prevents infection, and accelerates tissue regeneration. These hydrogels show promise as functional materials for wound healing applications.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Review Chemistry, Multidisciplinary

Biomimetic anti-freezing polymeric hydrogels: keeping soft-wet materials active in cold environments

Yukun Jian et al.

Summary: Hydrogels, as outstanding materials, have been extensively studied for various fields of application, but their properties are compromised at sub-zero temperatures. Lowering the liquid-solid phase transition temperature is crucial for expanding their applications. Research on anti-freezing hydrogels mainly focuses on additives, polymer network modification, and future developments hold promising research directions.

MATERIALS HORIZONS (2021)

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Article Chemistry, Multidisciplinary

Copper Tannic Acid Coordination Nanosheet: A Potent Nanozyme for Scavenging ROS from Cigarette Smoke

Shichao Lin et al.

SMALL (2020)

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Article Chemistry, Multidisciplinary

A Multifunctional Pro-Healing Zwitterionic Hydrogel for Simultaneous Optical Monitoring of pH and Glucose in Diabetic Wound Treatment

Yingnan Zhu et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

A Novel Double-Crosslinking-Double-Network Design for Injectable Hydrogels with Enhanced Tissue Adhesion and Antibacterial Capability for Wound Treatment

Lei Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Chemistry, Multidisciplinary

Stimuli-Responsive Biomolecule-Based Hydrogels and Their Applications

Margarita Vazquez-Gonzalez et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Biochemistry & Molecular Biology

MMP-9 responsive dipeptide-tempted natural protein hydrogel-based wound dressings for accelerated healing action of infected diabetic wound

Jegatheeswaran Sonamuthu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Chemistry, Multidisciplinary

Bioactive Anti-inflammatory, Antibacterial, Antioxidative Silicon-Based Nanofibrous Dressing Enables Cutaneous Tumor Photothermo-Chemo Therapy and Infection-Induced Wound Healing

Yuewei Xi et al.

ACS NANO (2020)

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Article Engineering, Biomedical

In situ forming and reactive oxygen species-scavenging gelatin hydrogels for enhancing wound healing efficacy

Phuong Le Thi et al.

ACTA BIOMATERIALIA (2020)

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Article Chemistry, Multidisciplinary

Physical Double-Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self-Healing, Antioxidant and NIR/pH Stimulus-Responsiveness for Multidrug-Resistant Bacterial Infection and Removable Wound Dressing

Xin Zhao et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Applied

A new waterborne chitosan-based polyurethane hydrogel as a vehicle to transplant bone marrow mesenchymal cells improved wound healing of ulcers in a diabetic rat model

Christian Viezzer et al.

CARBOHYDRATE POLYMERS (2020)

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Article Engineering, Environmental

Arginine derivatives assist dopamine-hyaluronic acid hybrid hydrogels to have enhanced antioxidant activity for wound healing

Shaohan Zhang et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Review Engineering, Environmental

Naturally biomimicked smart shape memory hydrogels for biomedical functions

Jay M. Korde et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Chemistry, Multidisciplinary

Injectable baicalin/F127 hydrogel with antioxidant activity for enhanced wound healing

Guiting Liu et al.

CHINESE CHEMICAL LETTERS (2020)

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Article Nanoscience & Nanotechnology

Incorporation of ROS-Responsive Substance P-Loaded Zeolite Imidazolate Framework-8 Nanoparticles into a Ca2+-Cross-Linked Alginate/Pectin Hydrogel for Wound Dressing Applications

Yiming Zhu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Engineering, Biomedical

Development of a chitosan hydrogel containing flavonoids extracted from Passiflora edulis leaves and the evaluation of its antioxidant and wound healing properties for the treatment of skin lesions in diabetic mice

Rita D. F. Soares et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2020)

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Article Materials Science, Multidisciplinary

Preparation of reactive oxygen species-responsive antibacterial hydrogels for efficient anti-infection therapy

Jingxuan Hu et al.

MATERIALS LETTERS (2020)

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Article Chemistry, Multidisciplinary

Injectable Polypeptide-Protein Hydrogels for Promoting Infected Wound Healing

Liang Cheng et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

A Macroporous Hydrogel Dressing with Enhanced Antibacterial and Anti-Inflammatory Capabilities for Accelerated Wound Healing

Wen-Can Huang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Engineering, Biomedical

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Zejun Xu et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Article Biochemistry & Molecular Biology

Injectable Antimicrobial Conductive Hydrogels for Wound Disinfection and Infectious Wound Healing

Yongping Liang et al.

BIOMACROMOLECULES (2020)

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Article Chemistry, Multidisciplinary

Characterization and Application of Lignin-Carbohydrate Complexes from Lignocellulosic Materials as Antioxidants for Scavenging In Vitro and In Vivo Reactive Oxygen Species

Huiling Dong et al.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2020)

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Article Chemistry, Medicinal

IGF-1C domain-modified chitosan hydrogel accelerates cutaneous wound healing by promoting angiogenesis

Qiong Li et al.

FUTURE MEDICINAL CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Smart Flexible Electronics-Integrated Wound Dressing for Real-Time Monitoring and On-Demand Treatment of Infected Wounds

Qian Pang et al.

ADVANCED SCIENCE (2020)

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Article Engineering, Biomedical

Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing

Sha Liu et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Article Biochemistry & Molecular Biology

Injectable Enzyme-Based Hydrogel Matrix with Precisely Oxidative Stress Defense for Promoting Dermal Repair of Burn Wound

Dongmei Zhang et al.

MACROMOLECULAR BIOSCIENCE (2020)

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Article Materials Science, Biomaterials

Encapsulation of green tea polyphenol nanospheres in PVA/alginate hydrogel for promoting wound healing of diabetic rats by regulating PI3K/AKT pathway

Guanyu Chen et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Review Chemistry, Multidisciplinary

Designer Self-Assembling Peptide Hydrogels to Engineer 3D Cell Microenvironments for Cell Constructs Formation and Precise Oncology Remodeling in Ovarian Cancer

Zehong Yang et al.

ADVANCED SCIENCE (2020)

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Article Chemistry, Multidisciplinary

Microporous Organic Nanoparticles Anchoring CeO2 Materials: Reduced Toxicity and Efficient Reactive Oxygen Species-Scavenging for Regenerative Wound Healing

Dong Wook Kim et al.

CHEMNANOMAT (2020)

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Article Biotechnology & Applied Microbiology

Copper Sulfide Nanoparticles-Incorporated Hyaluronic Acid Injectable Hydrogel With Enhanced Angiogenesis to Promote Wound Healing

Wencheng Zhou et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Nanoscience & Nanotechnology

Mussel-Inspired Dual-Cross-linking Hyaluronic Acid/ε-Polylysine Hydrogel with Self-Healing and Antibacterial Properties for Wound Healing

Shuai Liu et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Biomedical

κ-carrageenan-C-phycocyanin based smart injectable hydrogels for accelerated wound recovery and real-time monitoring

Atul Dev et al.

ACTA BIOMATERIALIA (2020)

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Article Engineering, Environmental

Conductive adhesive self-healing nanocomposite hydrogel wound dressing for photothermal therapy of infected full-thickness skin wounds

Jiahui He et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Biochemistry & Molecular Biology

Dual Cross-linked HHA Hydrogel Supplies and Regulates MΦ2 for Synergistic Improvement of Immunocompromise and Impaired Angiogenesis to Enhance Diabetic Chronic Wound Healing

Sha Liu et al.

BIOMACROMOLECULES (2020)

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Article Engineering, Biomedical

Injectable redox and light responsive MnO2 hybrid hydrogel for simultaneous melanoma therapy and multidrug-resistant bacteria-infected wound healing

Shenqiang Wang et al.

BIOMATERIALS (2020)

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Article Materials Science, Biomaterials

Novel Self-Healing Hydrogel with Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties Based on Collagen and Chitosan

Cuicui Ding et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Materials Science, Biomaterials

Reactive Oxygen Species Scavenging and Biodegradable Peptide Hydrogel as 3D Culture Scaffold for Cardiomyocytes

Zhiwei Shen et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Pharmacology & Pharmacy

Study of injectable Blueberry anthocyanins-loaded hydrogel for promoting full-thickness wound healing

Wenchang Zhang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Pharmacology & Pharmacy

A Novel Composite Hydrogel Composed of Formic Acid-Decellularized Pepsin-Soluble Extracellular Matrix Hydrogel and Sacchachitin Hydrogel as Wound Dressing to Synergistically Accelerate Diabetic Wound Healing

Chien-Ming Hsieh et al.

PHARMACEUTICS (2020)

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Article Chemistry, Multidisciplinary

Photo -responsive supramolecular hyaluronic acid hydrogels for accelerated wound healing

Weiyi Zhao et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Chemistry, Multidisciplinary

Dual-responsive injectable hydrogels encapsulating drug-loaded micelles for on-demand antimicrobial activity and accelerated wound healing

Cheng Hu et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Nanoscience & Nanotechnology

Highly Stretchable and Conductive Self-Healing Hydrogels for Temperature and Strain Sensing and Chronic Wound Treatment

Jieyu Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Biomedical

Sulfated chitosan rescues dysfunctional macrophages and accelerates wound healing in diabetic mice

Tong Shen et al.

ACTA BIOMATERIALIA (2020)

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Article Chemistry, Multidisciplinary

Metal-Phenolic Networks Nanoplatform to Mimic Antioxidant Defense System for Broad-Spectrum Radical Eliminating and Endotoxemia Treatment

Zhiwei Wei et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Bioinspired Nanofibrous Glycopeptide Hydrogel Dressing for Accelerating Wound Healing: A Cytokine-Free, M2-Type Macrophage Polarization Approach

Zujian Feng et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Bioactive Self-Pumping Composite Wound Dressings with Micropore Array Modified Janus Membrane for Enhanced Diabetic Wound Healing

Feng Bao et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Medicine, Research & Experimental

Chitosan hydrogels functionalized with either unfractionated heparin or bemiparin improve diabetic wound healing

Alberto Cifuentes et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Chemistry, Multidisciplinary

Nanoenzyme-Reinforced Injectable Hydrogel for Healing Diabetic Wounds Infected with Multidrug Resistant Bacteria

Shenqiang Wang et al.

NANO LETTERS (2020)

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Article Polymer Science

Functionalization of cellulose-based nanocomposite hydrogel films with zinc oxide complex and grapefruit seed extract for potential applications in treating chronic wounds

K. Dharmalingam et al.

POLYMER (2020)

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Article Multidisciplinary Sciences

Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases

Tengfei Liu et al.

NATURE COMMUNICATIONS (2020)

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Review Engineering, Biomedical

Artificial Intelligence and Machine Learning in Computational Nanotoxicology: Unlocking and Empowering Nanomedicine

Ajay Vikram Singh et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Review Polymer Science

Transparent Conductive Supramolecular Hydrogels with Stimuli-Responsive Properties for On-Demand Dissolvable Diabetic Foot Wound Dressings

Yue Zhao et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Polydeoxyribonucleotide-delivering therapeutic hydrogel for diabetic wound healing

Da Yong Shin et al.

SCIENTIFIC REPORTS (2020)

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Article Materials Science, Multidisciplinary

Self-contracting oxidized starch/gelatin hydrogel for noninvasive wound closure and wound healing

Qin Mao et al.

MATERIALS & DESIGN (2020)

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Article Materials Science, Multidisciplinary

Nitric oxide released injectable hydrogel combined with synergistic photothermal therapy for antibacterial and accelerated wound healing

Huiling Liu et al.

APPLIED MATERIALS TODAY (2020)

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Article Nanoscience & Nanotechnology

Self-Assembled Herbal Medicine Encapsulated by an Oxidation-Sensitive Supramolecular Hydrogel for Chronic Wound Treatment

Weiyi Zhao et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Injectable Hypoxia-Induced Conductive Hydrogel to Promote Diabetic Wound Healing

Xin Jin et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Improving Chronic Diabetic Wound Healing through an Injectable and Self-Healing Hydrogel with Platelet-Rich Plasma Release

Zhiyong Qian et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Injectable Adhesive Self-Healing Multicross-Linked Double-Network Hydrogel Facilitates Full-Thickness Skin Wound Healing

Bo Yang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Applied

Catechol modified quaternized chitosan enhanced wet adhesive and antibacterial properties of injectable thermo-sensitive hydrogel for wound healing

Zhiqiang Zheng et al.

CARBOHYDRATE POLYMERS (2020)

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Article Engineering, Environmental

Hierarchical micro/nanofibrous scaffolds incorporated with curcumin and zinc ion eutectic metal organic frameworks for enhanced diabetic wound healing via anti-oxidant and anti-inflammatory activities

Yitong Wang et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Review Chemistry, Multidisciplinary

Biomimetic micro/nano structures for biomedical applications

Tao Xiang et al.

NANO TODAY (2020)

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Article Nanoscience & Nanotechnology

A Tough Polysaccharide-Based Hydrogel with an On-Demand Dissolution Feature for Chronic Wound Care through Light-Induced Ultrafast Degradation

Ning Cui et al.

ACS APPLIED BIO MATERIALS (2020)

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Article Materials Science, Biomaterials

Conductive and antimicrobial macroporous nanocomposite hydrogels generated from air-in-water Pickering emulsions for neural stem cell differentiation and skin wound healing

Mingjian Xu et al.

BIOMATERIALS SCIENCE (2020)

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Article Polymer Science

Polydopamine Antioxidant Hydrogels for Wound Healing Applications

Naphtali A. O'Connor et al.

GELS (2020)

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Review Biochemistry & Molecular Biology

Design Strategies of Conductive Hydrogel for Biomedical Applications

Junpeng Xu et al.

MOLECULES (2020)

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Article Nanoscience & Nanotechnology

Mechano-Responsive, Tough, and Antibacterial Zwitterionic Hydrogels with Controllable Drug Release for Wound Healing Applications

Kun Fang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Injectable In Situ Self-Cross-Linking Hydrogels Based on Hemoglobin, Carbon Quantum Dots, and Sodium Alginate for Real-Time Detection of Wound Bacterial Infection and Efficient Postoperative Prevention of Tumor Recurrence

Qicheng Zhang et al.

LANGMUIR (2020)

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Article Chemistry, Multidisciplinary

A Reactive Oxygen Species Scavenging and O2 Generating Injectable Hydrogel for Myocardial Infarction Treatment In vivo

Jie Ding et al.

SMALL (2020)

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Article Materials Science, Biomaterials

Carbon nanodot decorated acellular dermal matrix hydrogel augments chronic wound closure

Kamakshi Bankoti et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Review Materials Science, Biomaterials

In situformation of injectable hydrogels for chronic wound healing

Yunfen Gao et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Pharmacology & Pharmacy

HDL Nanoparticles Have Wound Healing and Anti-Inflammatory Properties and Can Topically Deliver miRNAs

Junyi Wang et al.

ADVANCED THERAPEUTICS (2020)

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Article Materials Science, Biomaterials

A near-infrared light-triggered shape-memory polymer for long-time fluorescence imaging in deep tissues

Chengzhen Chu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Engineering, Biomedical

ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds

He Zhao et al.

BIOMATERIALS (2020)

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Article Chemistry, Applied

Fucoidan-loaded hydrogels facilitates wound healing using photodynamic therapy by in vitro and in vivo evaluation

Karuppusamy Shanmugapriya et al.

CARBOHYDRATE POLYMERS (2020)

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Article Chemistry, Multidisciplinary

Development of an antimicrobial and antioxidant hydrogel/nano-electrospun wound dressing

Alejandra Romero-Montero et al.

RSC ADVANCES (2020)

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Review Endocrinology & Metabolism

Prevalence and interrelationships of foot ulcer, risk-factors and antibiotic resistance in foot ulcers in diabetic populations: A systematic review and meta-analysis

Mohammad Zubair

WORLD JOURNAL OF DIABETES (2020)

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Article Medicine, Research & Experimental

Bioactive antibacterial silica-based nanocomposites hydrogel scaffolds with high angiogenesis for promoting diabetic wound healing and skin repair

Yannan Li et al.

THERANOSTICS (2020)

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Article Materials Science, Biomaterials

Tannic acid-based nanogel as an efficient anti-inflammatory agent

Jiwon Yeo et al.

BIOMATERIALS SCIENCE (2020)

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Review Pharmacology & Pharmacy

Acellular and cellular approaches to improve diabetic wound healing

Hongkwan Cho et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Review Pharmacology & Pharmacy

Therapeutic strategies for enhancing angiogenesis in wound healing

Austin P. Veith et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Article Chemistry, Multidisciplinary

Ionic-Strength Responsive Zwitterionic Copolymer Hydrogels with Tunable Swelling and Adsorption Behaviors

Tao Xiang et al.

LANGMUIR (2019)

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Article Chemistry, Applied

Influence of chitosan oligosaccharide on the gelling and wound healing properties of injectable hydrogels based on carboxymethyl chitosan/alginate polyelectrolyte complexes

Xiaojie Lv et al.

CARBOHYDRATE POLYMERS (2019)

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Review Biochemistry & Molecular Biology

Recent advancements in biopolymer and metal nanoparticle-based materials in diabetic wound healing management

Veena Vijayakumar et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Chemistry, Multidisciplinary

Promoting Angiogenesis in Oxidative Diabetic Wound Microenvironment Using a Nanozyme-Reinforced Self-Protecting Hydrogel

Haibin Wu et al.

ACS CENTRAL SCIENCE (2019)

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Article Engineering, Biomedical

Porous Se@SiO2 nanosphere-coated catheter accelerates prostatic urethra wound healing by modulating macrophage polarization through reactive oxygen species-NF-κB pathway inhibition

Bo-Yu Yang et al.

ACTA BIOMATERIALIA (2019)

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Review Engineering, Biomedical

Advances in injectable self-healing biomedical hydrogels

Yujie Tu et al.

ACTA BIOMATERIALIA (2019)

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Article Engineering, Environmental

Degradable conductive injectable hydrogels as novel antibacterial, anti-oxidant wound dressings for wound healing

Jin Qu et al.

CHEMICAL ENGINEERING JOURNAL (2019)

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Review Polymer Science

Molecular design, synthesis and biomedical applications of stimuli-responsive shape memory hydrogels

Ruixue Liang et al.

EUROPEAN POLYMER JOURNAL (2019)

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Article Chemistry, Multidisciplinary

Skin-Inspired Antibacterial Conductive Hydrogels for Epidermal Sensors and Diabetic Foot Wound Dressings

Yue Zhao et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Engineering, Biomedical

Application of Ti3C2 MXene Quantum Dots for Immunomodulation and Regenerative Medicine

Alireza Rafieerad et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Chemistry, Multidisciplinary

pH-Switchable Antimicrobial Nanofiber Networks of Hydrogel Eradicate Biofilm and Rescue Stalled Healing in Chronic Wounds

Jianhao Wang et al.

ACS NANO (2019)

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Article Biochemistry & Molecular Biology

Enhanced cutaneous wound healing by functional injectable thermo-sensitive chitosan-based hydrogel encapsulated human umbilical cord-mesenchymal stem cells

Hongjie Xu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Chemistry, Multidisciplinary

Orange-Emissive Carbon Quantum Dots: Toward Application in Wound pH Monitoring Based on Colorimetric and Fluorescent Changing

Pei Yang et al.

SMALL (2019)

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Article Chemistry, Physical

Mussel-inspired, antibacterial, conductive, antioxidant, injectable composite hydrogel wound dressing to promote the regeneration of infected skin

Yongping Liang et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Article Materials Science, Biomaterials

Injectable hydrogel composed of hydrophobically modified chitosan/oxidized-dextran for wound healing

Xinchen Du et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Biochemistry & Molecular Biology

Injectable, Self-Healing, and Multi-Responsive Hydrogels via Dynamic Covalent Bond Formation between Benzoxaborole and Hydroxyl Groups

Yangjun Chen et al.

BIOMACROMOLECULES (2019)

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Article Engineering, Biomedical

In situ formed anti-inflammatory hydrogel loading plasmid DNA encoding VEGF for burn wound healing

Peng Wang et al.

ACTA BIOMATERIALIA (2019)

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Article Nanoscience & Nanotechnology

Reduced Graphene Oxide Incorporated GelMA Hydrogel Promotes Angiogenesis For Wound Healing Applications

Syed Raza Ur Rehman et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Polymer Science

Cotton-hydrogel composite for improved wound healing: Antimicrobial activity and anti-inflammatory evaluation-Part 2

Eva Pinho et al.

POLYMERS FOR ADVANCED TECHNOLOGIES (2019)

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Review Biotechnology & Applied Microbiology

Biofilms in Chronic Wounds: Pathogenesis and Diagnosis

Yuan-Kun Wu et al.

TRENDS IN BIOTECHNOLOGY (2019)

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Article Materials Science, Multidisciplinary

An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair

Hao Chen et al.

NPG ASIA MATERIALS (2019)

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Article Engineering, Biomedical

A Photoresponsive Hyaluronan Hydrogel Nanocomposite for Dynamic Macrophage Immunomodulation

Haoyu Wang et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Materials Science, Biomaterials

In Vivo Cell Tracking, Reactive Oxygen Species Scavenging, and Antioxidative Gene Down Regulation by Long-Term Exposure of Biomass-Derived Carbon Dots

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ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)

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Article Instruments & Instrumentation

pH-responsive calcium alginate hydrogel laden with protamine nanoparticles and hyaluronan oligosaccharide promotes diabetic wound healing by enhancing angiogenesis and antibacterial activity

Tao Wang et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2019)

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Article Chemistry, Analytical

Electrochemical aptasensor based on conductive supramolecular polymer hydrogels for thrombin detection with high selectivity

Xinyan Wang et al.

TALANTA (2019)

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Article Engineering, Biomedical

In-situ doping of a conductive hydrogel with low protein absorption and bacterial adhesion for electrical stimulation of chronic wounds

Yuhui Lu et al.

ACTA BIOMATERIALIA (2019)

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Review Polymer Science

Trends in polymeric shape memory hydrogels and hydrogel actuators

Jiaojiao Shang et al.

POLYMER CHEMISTRY (2019)

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Article Nanoscience & Nanotechnology

Antistaphylococcal and Neutrophil Chemotactic Injectable κ-Carrageenan Hydrogel for Infectious Wound Healing

Shiva Muthuswamy et al.

ACS APPLIED BIO MATERIALS (2019)

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Article Polymer Science

A pH-induced self-healable shape memory hydrogel with metal-coordination cross-links

Liuxuan Lu et al.

POLYMER CHEMISTRY (2019)

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Combining antioxidant hydrogels with self-assembled microparticles for multifunctional wound dressings

Mariagrazia di Luca et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

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Article Medicine, Research & Experimental

Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration

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THERANOSTICS (2019)

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Article Cell & Tissue Engineering

Oral Immunization of FMDV Vaccine Using pH-Sensitive and Mucoadhesive Thiolated Cellulose Acetate Phthalate Microparticles

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TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2018)

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Article Cell & Tissue Engineering

Oral Immunization of FMDV Vaccine Using pH-Sensitive and Mucoadhesive Thiolated Cellulose Acetate Phthalate Microparticles

Ho-Bin Lee et al.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2018)

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Article Nanoscience & Nanotechnology

Encapsulation of Curcumin Nanoparticles with MMP9-Responsive and Thermos-Sensitive Hydrogel Improves Diabetic Wound Healing

Juan Liu et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Engineering, Biomedical

An aligned porous electrospun fibrous membrane with controlled drug delivery - An efficient strategy to accelerate diabetic wound healing with improved angiogenesis

Xiaozhi Ren et al.

ACTA BIOMATERIALIA (2018)

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Article Engineering, Biomedical

A hybrid injectable hydrogel from hyperbranched PEG macromer as a stem cell delivery and retention platform for diabetic wound healing

Qian Xu et al.

ACTA BIOMATERIALIA (2018)

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Article Chemistry, Multidisciplinary

Bioinspired Multifunctional Hybrid Hydrogel Promotes Wound Healing

Guopu Chen et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Article Biochemistry & Molecular Biology

Bioinspired pH- and Temperature-Responsive Injectable Adhesive Hydrogels with Polyplexes Promotes Skin Wound Healing

Thai Minh Duy Le et al.

BIOMACROMOLECULES (2018)

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Article Engineering, Biomedical

Reactive oxygen species scavenging with a biodegradable, thermally responsive hydrogel compatible with soft tissue injection

Yang Zhu et al.

BIOMATERIALS (2018)

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Nanofibrous peptide hydrogel elicits angiogenesis and neurogenesis without drugs, proteins, or cells

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BIOMATERIALS (2018)

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Injectable methylcellulose hydrogel containing silver oxide nanoparticles for burn wound healing

Min Hee Kim et al.

CARBOHYDRATE POLYMERS (2018)

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Article Chemistry, Physical

Mussel-Inspired Cellulose Nanocomposite Tough Hydrogels with Synergistic Self-Healing, Adhesive, and Strain-Sensitive Properties

Changyou Shao et al.

CHEMISTRY OF MATERIALS (2018)

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Article Chemistry, Physical

Stretchable, Conductive, and Self-Healing Hydrogel with Super Metal Adhesion

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CHEMISTRY OF MATERIALS (2018)

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IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

N. H. Cho et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

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Review Biochemistry & Molecular Biology

The importance of boron in biological systems

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JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2018)

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Article Multidisciplinary Sciences

Potent laminin-inspired antioxidant regenerative dressing accelerates wound healing in diabetes

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Injectable hyperbranched poly(beta-amino ester) hydrogels with on-demand degradation profiles to match wound healing processes

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CHEMICAL SCIENCE (2018)

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ROS scavenging Mn3O4 nanozymes for in vivo anti-inflammation

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CHEMICAL SCIENCE (2018)

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Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing

Xin Zhao et al.

NATURE COMMUNICATIONS (2018)

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Injectable Hybrid Poly(epsilon-caprolactone)-b-poly(ethylene glycol)-b-poly(epsilon-caprolactone) Porous Microspheres/Alginate Hydrogel Cross-linked by Calcium Gluconate Crystals Deposited in the Pores of Microspheres Improved Skin Wound Healing

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ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Review Chemistry, Multidisciplinary

Antibacterial Hydrogels

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ADVANCED SCIENCE (2018)

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Article Materials Science, Biomaterials

Injectable Hybrid Poly(epsilon-caprolactone)-b-poly(ethylene glycol)-b-poly(epsilon-caprolactone) Porous Microspheres/Alginate Hydrogel Cross-linked by Calcium Gluconate Crystals Deposited in the Pores of Microspheres Improved Skin Wound Healing

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ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Article Nanoscience & Nanotechnology

Bioactive Injectable Hydrogels Containing Desferrioxamine and Bioglass for Diabetic Wound Healing

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ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Nanoscience & Nanotechnology

Three-Dimensionally Printed Silk-Sericin-Based Hydrogel Scaffold: A Promising Visualized Dressing Material for Real-Time Monitoring of Wounds

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ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Engineering, Biomedical

Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing

Jin Qu et al.

BIOMATERIALS (2018)

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Article Chemistry, Applied

An injectable self-healing hydrogel with adhesive and antibacterial properties effectively promotes wound healing

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CARBOHYDRATE POLYMERS (2018)

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Anti-Oxidant Bactericidal Conductive Injectable Hydrogel as Self-Healing Wound Dressing for Subcutaneous Wound Healing in Nursing Care

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SCIENCE OF ADVANCED MATERIALS (2018)

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Article Engineering, Biomedical

In Situ Forming Injectable Silk Fibroin Hydrogel Promotes Skin Regeneration in Full Thickness Burn Wounds

Dimple Chouhan et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Article Chemistry, Multidisciplinary

Targeted Reinforcement of Macrophage Reprogramming Toward M2 Polarization by IL-4-Loaded Hyaluronic Acid Particles

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ACS OMEGA (2018)

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Review Polymer Science

Incorporation of Conductive Materials into Hydrogels for Tissue Engineering Applications

Ji Hong Min et al.

POLYMERS (2018)

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Article Cell & Tissue Engineering

Pulsed electrical stimulation modulates fibroblasts' behaviour through the Smad signalling pathway

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JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2017)

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Article Pharmacology & Pharmacy

The Novelty in Fabrication of Poly Vinyl Alcohol/κ-Carrageenan Hydrogel with Lactobacillus bulgaricus Extract as Anti-inflammatory Wound Dressing Agent

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AAPS PHARMSCITECH (2017)

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Article Chemistry, Multidisciplinary

A Cooperative Copper Metal-Organic Framework-Hydrogel System Improves Wound Healing in Diabetes

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ADVANCED FUNCTIONAL MATERIALS (2017)

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Review Chemistry, Multidisciplinary

Reactive-Oxygen-Species-Responsive Drug Delivery Systems: Promises and Challenges

Gurusamy Saravanakumar et al.

ADVANCED SCIENCE (2017)

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Article Polymer Science

Preparation and characterization of a novel gelatin-poly(vinyl alcohol) hydrogel film loaded with Zataria multiflora essential oil for antibacterial-antioxidant wound-dressing applications

Gholamreza Kavoosi et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2017)

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Article Chemistry, Multidisciplinary

Comprehensive Insights into the Multi-Antioxidative Mechanisms of Melanin Nanoparticles and Their Application To Protect Brain from Injury in Ischemic Stroke

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Article Medicine, Research & Experimental

Biocompatible Injectable Hydrogel with Potent Wound Healing and Antibacterial Properties

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MOLECULAR PHARMACEUTICS (2017)

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Article Multidisciplinary Sciences

Accelerated Healing of Diabetic Wounds Treated with L-Glutamic acid Loaded Hydrogels Through Enhanced Collagen Deposition and Angiogenesis: An In Vivo Study

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SCIENTIFIC REPORTS (2017)

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Article Engineering, Biomedical

A Reloadable Self-Healing Hydrogel Enabling Diffusive Transport of C-Dots Across Gel-Gel Interface for Scavenging Reactive Oxygen Species

Jing Chen et al.

ADVANCED HEALTHCARE MATERIALS (2017)

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Article Engineering, Biomedical

An Advanced Multifunctional Hydrogel-Based Dressing for Wound Monitoring and Drug Delivery

Bahram Mirani et al.

ADVANCED HEALTHCARE MATERIALS (2017)

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Article Materials Science, Biomaterials

Diabetic wound regeneration using heparin-mimetic peptide amphiphile gel in db/db mice

Berna Senturk et al.

BIOMATERIALS SCIENCE (2017)

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Article Chemistry, Multidisciplinary

Nanotechnology-Driven Therapeutic Interventions in Wound Healing: Potential Uses and Applications

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ACS CENTRAL SCIENCE (2017)

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Article Materials Science, Multidisciplinary

Deoxy-sugar releasing biodegradable hydrogels promote angiogenesis and stimulate wound healing

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MATERIALS TODAY COMMUNICATIONS (2017)

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Anti-freezing, Conductive Self-healing Organohydrogels with Stable Strain-Sensitivity at Subzero Temperatures

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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Review Biochemistry & Molecular Biology

Redox Signaling in Diabetic Wound Healing Regulates Extracellular Matrix Deposition

Britta Kunkemoeller et al.

ANTIOXIDANTS & REDOX SIGNALING (2017)

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Article Nanoscience & Nanotechnology

pH and Glucose Dual-Responsive Injectable Hydrogels with Insulin and Fibroblasts as Bioactive Dressings for Diabetic Wound Healing

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ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Biophysics

Sensitive immunosensing of squamous cell carcinoma antigen based on a nanocomposite of poly{3-amine-N-[3-(N-pyrrole)propyl]imidazole bromide} ionic liquid and gold nanoroots

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BIOSENSORS & BIOELECTRONICS (2017)

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Article Chemistry, Physical

Hydrogels incorporated with silver nanocolloids prepared from antioxidant rich Aerva javanica as disruptive agents against burn wound infections

Muhammad Uzair Hashmi et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2017)

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Skin-Inspired Multifunctional Autonomic-Intrinsic Conductive Self-Healing Hydrogels with Pressure Sensitivity, Stretchability, and 3D Printability

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ADVANCED MATERIALS (2017)

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Article Chemistry, Multidisciplinary

Injectable and Tunable Gelatin Hydrogels Enhance Stem Cell Retention and Improve Cutaneous Wound Healing

Yixiao Dong et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

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Article Engineering, Biomedical

A macrophage-activating, injectable hydrogel to sequester endogenous growth factors for in situ angiogenesis

Yanxian Feng et al.

BIOMATERIALS (2017)

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Article Chemistry, Multidisciplinary

Tough Supramolecular Polymer Networks with Extreme Stretchability and Fast Room-Temperature Self-Healing

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ADVANCED MATERIALS (2017)

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Article Engineering, Biomedical

Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing

Xin Zhao et al.

BIOMATERIALS (2017)

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Article Nanoscience & Nanotechnology

Fe3+-, pH-, Thermoresponsive Supramolecular Hydrogel with Multishape Memory Effect

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ACS APPLIED MATERIALS & INTERFACES (2017)

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Review Chemistry, Multidisciplinary

Supramolecular shape memory hydrogels: a new bridge between stimuli-responsive polymers and supramolecular chemistry

Wei Lu et al.

CHEMICAL SOCIETY REVIEWS (2017)

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Article Biophysics

Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art

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COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

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Article Chemistry, Multidisciplinary

Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties

Volkan Yesilyurt et al.

ADVANCED MATERIALS (2016)

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Article Chemistry, Multidisciplinary

Dietary Iron Oxide Nanoparticles Delay Aging and Ameliorate Neurodegeneration in Drosophila

Yi Zhang et al.

ADVANCED MATERIALS (2016)

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Article Biochemistry & Molecular Biology

Injectable and Thermosensitive Soluble Extracellular Matrix and Methylcellulose Hydrogels for Stem Cell Delivery in Skin Wounds

Eun Ji Kim et al.

BIOMACROMOLECULES (2016)

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Article Nanoscience & Nanotechnology

Anti-staphylococcal Activity of Injectable Nano Tigecycline/Chitosan-PRP Composite Hydrogel Using Drosophila melanogaster Model for Infectious Wounds

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ACS APPLIED MATERIALS & INTERFACES (2016)

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Article Nanoscience & Nanotechnology

Strontium-Substituted Submicrometer Bioactive Glasses Modulate Macrophage Responses for Improved Bone Regeneration

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ACS APPLIED MATERIALS & INTERFACES (2016)

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Article Nanoscience & Nanotechnology

Antibacterial and Anti-Inflammatory pH-Responsive Tannic Acid-Carboxylated Agarose Composite Hydrogels for Wound Healing

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ACS APPLIED MATERIALS & INTERFACES (2016)

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Article Chemistry, Multidisciplinary

Facet Energy versus Enzyme-like Activities: The Unexpected Protection of Palladium Nanocrystals against Oxidative Damage

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ACS NANO (2016)

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Article Chemistry, Multidisciplinary

New Developments in Smart Bandage Technologies for Wound Diagnostics

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ADVANCED MATERIALS (2016)

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Review Chemistry, Multidisciplinary

Self-Healing Hydrogels

Danielle Lynne Taylor et al.

ADVANCED MATERIALS (2016)

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Review Biochemistry & Molecular Biology

Transition from inflammation to proliferation: a critical step during wound healing

Ning Xu Landen et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

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Article Chemistry, Multidisciplinary

Light-, pH- and thermal-responsive hydrogels with the triple-shape memory effect

Yao-Yu Xiao et al.

CHEMICAL COMMUNICATIONS (2016)

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Article Biophysics

Inherently antioxidant and antimicrobial tannic acid release from poly(tannic acid) nanoparticles with controllable degradability

Nurettin Sahiner et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2016)

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Review Immunology

Macrophages in Tissue Repair, Regeneration, and Fibrosis

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IMMUNITY (2016)

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Article Chemistry, Multidisciplinary

Sustained release of stromal cell derived factor-1 from an antioxidant thermoresponsive hydrogel enhances dermal wound healing in diabetes

Yunxiao Zhu et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Article Chemistry, Multidisciplinary

Prussian Blue Nanoparticles as Multienzyme Mimetics and Reactive Oxygen Species Scavengers

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

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Review Surgery

A systematic review and meta-analysis of debridement methods for chronic diabetic foot ulcers

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JOURNAL OF VASCULAR SURGERY (2016)

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Review Biochemical Research Methods

A practical guide to hydrogels for cell culture

Steven R. Caliari et al.

NATURE METHODS (2016)

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Article Multidisciplinary Sciences

Diabetic wound regeneration using peptide-modified hydrogels to target re-epithelialization

Yun Xiao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Stretchable supramolecular hydrogels with triple shape memory effect

Xiaoxia Le et al.

CHEMICAL SCIENCE (2016)

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Article Engineering, Biomedical

Upregulating Hif-1 by Hydrogel Nanofibrous Scaffolds for Rapidly Recruiting Angiogenesis Relative Cells in Diabetic Wound

Hao Chen et al.

ADVANCED HEALTHCARE MATERIALS (2016)

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Article Materials Science, Biomaterials

Quickly promoting angiogenesis by using a DFO-loaded photo-crosslinked gelatin hydrogel for diabetic skin regeneration

Hao Chen et al.

JOURNAL OF MATERIALS CHEMISTRY B (2016)

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Article Engineering, Biomedical

Ductile electroactive biodegradable hyperbranched polylactide copolymers enhancing myoblast differentiation

Meihua Xie et al.

BIOMATERIALS (2015)

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Article Biophysics

Polyurethane foam containing rhEGF as a dressing material for healing diabetic wounds: Synthesis, characterization, in vitro and in vivo studies

Do Gi Pyun et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2015)

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Article Polymer Science

pH- and Sugar-Induced Shape Memory Hydrogel Based on Reversible Phenylboronic Acid-Diol Ester Bonds

Hao Meng et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2015)

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Article Biochemistry & Molecular Biology

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

Siu Ling Wong et al.

NATURE MEDICINE (2015)

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Article Chemistry, Analytical

An electrochemical sensor for fast detection of wound infection based on myeloperoxidase activity

Martin Hajnsek et al.

SENSORS AND ACTUATORS B-CHEMICAL (2015)

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Article Chemistry, Multidisciplinary

Designing bio-mimetic moxifloxacin loaded hydrogel wound dressing to improve antioxidant and pharmacology properties

Baljit Singh et al.

RSC ADVANCES (2015)

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Article Chemistry, Multidisciplinary

Injectable polysaccharide hybrid hydrogels as scaffolds for burn wound healing

Ziyi Li et al.

RSC ADVANCES (2015)

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Article Multidisciplinary Sciences

Mesenchymal stem cell-laden anti-inflammatory hydrogel enhances diabetic wound healing

Shixuan Chen et al.

SCIENTIFIC REPORTS (2015)

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Article Engineering, Biomedical

Porous Hyaluronic Acid Hydrogels for Localized Nonviral DNA Delivery in a Diabetic Wound Healing Model

Talar Tokatlian et al.

ADVANCED HEALTHCARE MATERIALS (2015)

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Article Materials Science, Biomaterials

A laminin mimetic peptide SIKVAV-conjugated chitosan hydrogel promoting wound healing by enhancing angiogenesis, re-epithelialization and collagen deposition

Shixuan Chen et al.

JOURNAL OF MATERIALS CHEMISTRY B (2015)

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Article Materials Science, Biomaterials

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

Jamie E. Rayahin et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2015)

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Article Materials Science, Biomaterials

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

Jamie E. Rayahin et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2015)

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Review Dermatology

Challenges in the Treatment of Chronic Wounds

Robert G. Frykberg et al.

ADVANCES IN WOUND CARE (2015)

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Article Engineering, Biomedical

Gelatin hydrogel impregnated with platelet-rich plasma releasate promotes angiogenesis and wound healing in murine model

Priscilla Valentin Notodihardjo et al.

JOURNAL OF ARTIFICIAL ORGANS (2015)

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Article Multidisciplinary Sciences

Transdermal deferoxamine prevents pressure-induced diabetic ulcers

Dominik Duscher et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Engineering, Biomedical

Poly (3-hydroxyalkanoates)-co-(6-hydroxyhexanoate) hydrogel promotes angiogenesis and collagen deposition during cutaneous wound healing in rats

Ahmad Mohammed Gumel et al.

BIOMEDICAL MATERIALS (2015)

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Review Engineering, Biomedical

Conductive polymers: Towards a smart biomaterial for tissue engineering

Richard Balint et al.

ACTA BIOMATERIALIA (2014)

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Article Chemistry, Multidisciplinary

Adaptable Hetero Diels-Alder Networks for Fast Self-Healing under Mild Conditions

Kim K. Oehlenschlaeger et al.

ADVANCED MATERIALS (2014)

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Article Chemistry, Multidisciplinary

Inverse Opal Spheres Based on Polyionic Liquids as Functional Microspheres with Tunable Optical Properties and Molecular Recognition Capabilities

Jiecheng Cui et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

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Article Chemistry, Medicinal

Accelerated wound healing and anti-inflammatory effects of physically cross linked polyvinyl alcohol-chitosan hydrogel containing honey bee venom in diabetic rats

Mohamed A. Amin et al.

ARCHIVES OF PHARMACAL RESEARCH (2014)

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Article Biochemistry & Molecular Biology

A Thermoresponsive Biodegradable Polymer with Intrinsic Antioxidant Properties

Jian Yang et al.

BIOMACROMOLECULES (2014)

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Article Oncology

Galvanic microparticles increase migration of human dermal fibroblasts in a wound-healing model via reactive oxygen species pathway

Nina Tandon et al.

EXPERIMENTAL CELL RESEARCH (2014)

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Article Immunology

Tissue integrity signals communicated by high-molecular weight hyaluronan and the resolution of inflammation

S. M. Ruppert et al.

IMMUNOLOGIC RESEARCH (2014)

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Article Polymer Science

Reactive macromolecular micelle crosslinked highly elastic hydrogel with water-triggered shape-memory behaviour

Tingting Zhao et al.

POLYMER CHEMISTRY (2014)

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Article Multidisciplinary Sciences

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

Mikael M. Martino et al.

SCIENCE (2014)

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Review Chemistry, Physical

Multi-scale multi-mechanism design of tough hydrogels: building dissipation into stretchy networks

Xuanhe Zhao

SOFT MATTER (2014)

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Review Cell Biology

The effects of pH on wound healing, biofilms, and antimicrobial efficacy

Steven L. Percival et al.

WOUND REPAIR AND REGENERATION (2014)

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Article Multidisciplinary Sciences

An antioxidant nanozyme that uncovers the cytoprotective potential of vanadia nanowires

Amit A. Vernekar et al.

NATURE COMMUNICATIONS (2014)

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Article Dermatology

Biofilms and chronic wound inflammation

R.D. Wolcott et al.

Journal of Wound Care (2014)

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Article Endocrinology & Metabolism

Blocking Interleukin-1β Induces a Healing-Associated Wound Macrophage Phenotype and Improves Healing in Type 2 Diabetes

Rita E. Mirza et al.

DIABETES (2013)

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Meeting Abstract Chemistry, Multidisciplinary

Collagen-PVP hybrid based anti-inflammatory hydrogel for wound repairing

Jinghua Chen et al.

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Immune responses to implants - A review of the implications for the design of immunomodulatory biomaterials

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pH-sensitive polymer hydrogels derived from morpholine to prevent the crystallization of ibuprofen

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Engineering the Growth Factor Microenvironment with Fibronectin Domains to Promote Wound and Bone Tissue Healing

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Randomized clinical comparisons of diclofenac concentration in the soft tissues and blood plasma between topical and oral applications

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A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding

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Materials engineering for immunomodulation

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The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues

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Anti-inflammatory properties of a liposomal hydrogel with povidone-iodine (Repithel®) for wound healing in vitro

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Nanoceria as antioxidant: Synthesis and biomedical applications

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Oxidative stress in normal and impaired wound repair

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Influence of pH on wound-healing: a new perspective for wound-therapy?

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Biological properties of curcumin-cellular and molecular mechanisms of action

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