期刊
ADVANCED HEALTHCARE MATERIALS
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202301926
关键词
chemodynamic therapy; doughnut-like structures; magnetite nanozymes; photothermal therapy; synergistic effects
In this study, a light-responsive carbon-encapsulated magnetite nanodoughnuts (CEMNDs) with dual-catalytic activities for photothermal-enhanced chemodynamic therapy (CDT) is reported. The CEMNDs can act as peroxidase to convert H2O2 to highly toxic hydroxyl radicals (& BULL;OH) and possess intrinsic glutathione oxidase-like activity for enhanced catalytic therapy. Furthermore, the CEMNDs can absorb 1064 nm light for photothermal therapy and enhanced CDT. The in vivo experiments demonstrate excellent synergistic anti-tumor function and no measurable systemic toxicity of CEMNDs in a mouse model of triple negative breast cancer.
Magnetite-based nanozymes have attracted great interest for catalytic cancer therapy enabled by catalyzing hydrogen peroxide (H2O2) to produce highly toxic hydroxyl radicals (& BULL;OH) to kill tumor cells. However, their therapeutic efficacies remain low due to insufficient & BULL;OH. Here, a light-responsive carbon-encapsulated magnetite nanodoughnuts (CEMNDs) with dual-catalytic activities for photothermal-enhanced chemodynamic therapy (CDT) is reported. The CEMNDs can accumulate in tumor and get into tumor cells and effectively act as peroxidase to convert H2O2 to & BULL;OH that causes tumor cell death. The CEMNDs also possess intrinsic glutathione oxidase-like activity that which catalyzes the oxidation of reduced glutathione and produce lipid peroxidase for enhanced catalytic therapy. Furthermore, the CEMNDs can absorb 1064 nm light to elevate local temperature and increase release of Fe ions for photothermal therapy and enhanced CDT respectively. The in vivo experiments in an aggressive and drug-resistant metastatic mouse model of triple negative breast cancer model demonstrate excellent synergistic anti-tumor function and no measurable systemic toxicity of CEMNDs.
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