期刊
ADVANCED HEALTHCARE MATERIALS
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202301474
关键词
biofilm infections; diabetic wound healing; nanozyme-based microneedles; reinfection prevention
Researchers have developed an integrated therapeutic and preventive nanozyme-based microneedle (Fe2C/GOx@MNs) for treating biofilm-infected diabetic wounds. The dissolvable tips of the microneedles can release Fe2C nanoparticles/glucose oxidase (GOx) in the active regions of the biofilm, improving tissue and biofilm permeability and achieving efficient biofilm elimination. The chitosan backing layer acts as a physical barrier and prevents bacterial reinvasion during wound healing. The study demonstrates the promising clinical application of Fe2C/GOx@MNs in biofilm-infected wound healing.
The healing of biofilm-infected diabetic wounds characterized by a deteriorative tissue microenvironment represents a substantial clinical challenge. Current treatments remain unsatisfactory due to the limited antibiofilm efficacy caused by weak tissue and biofilm permeability of drugs and the risk of reinfection during the healing process. To address these issues, an integrated therapeutic and preventive nanozyme-based microneedle (denoted as Fe2C/GOx@MNs) is engineered. The dissolvable tips with enough mechanical strength can deliver and rapidly release Fe2C nanoparticles (NPs)/glucose oxidase (GOx) in the biofilm active regions, enhancing tissue and biofilm permeability of Fe2C NPs/GOx, ultimately achieving highly efficient biofilm elimination. Meanwhile, the chitosan backing layer can not only act as an excellent physical barrier between the wound bed and the external environment, but also prevent the bacterial reinvasion during wound healing with its superior antibacterial property. Significantly, the biofilm elimination and reinfection prevention abilities of Fe2C/GOx@MNs on wound healing are proved on methicillin-resistant Staphylococcus aureus-biofilm-infected diabetic mouse model with full-thickness wound. Together, these results demonstrate the promising clinical application of Fe2C/GOx@MNs in biofilm-infected wound healing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据