4.7 Article

Enhancement of Microglia Functions by Developed Nano-Immuno-Synergist to Ameliorate Immunodeficiency for Malignant Glioma Treatment

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma

Zengpanpan Ye et al.

Summary: Single-cell sequencing of glioblastoma tumor immune microenvironment (TIME) revealed that oxidative stress induces NR4A2-dependent transcriptional activity in microglia. Inhibition of NR4A2 or SQLE enhances the efficacy of immune-checkpoint blockade in GBM. Metabolic reprogramming of microglia informs synergistic vulnerabilities for immune-checkpoint blockade therapy in this immunologically cold brain tumor.

CANCER DISCOVERY (2023)

Review Medicine, Research & Experimental

Macrophages and microglia in glioblastoma: heterogeneity, plasticity, and therapy

Fatima Khan et al.

Summary: Glioblastoma (GBM) is the most aggressive tumor in the central nervous system and has a highly immunosuppressive tumor microenvironment (TME). Tumor-associated macrophages and microglia (TAMs) are dominant immune cells in the GBM TME and contribute to immunosuppression. Recent progress in single cell technologies allows for precise characterization of TAMs and identification of new TAM subpopulations with specific tumor-modulating functions in GBM. This review discusses TAM heterogeneity and plasticity in the TME and summarizes current potential therapeutic approaches targeting TAMs in GBM. The use of single cell technologies and functional studies is expected to accelerate the development of novel and effective TAM targeted therapeutics for GBM patients.

JOURNAL OF CLINICAL INVESTIGATION (2023)

Article Chemistry, Multidisciplinary

Nano-ultrasonic Contrast Agent for Chemoimmunotherapy of Breast Cancer by Immune Metabolism Reprogramming and Tumor Autophagy

Xupeng Yang et al.

Summary: This study determines that reprogramming the metabolism of immature dendritic cells (iDCs) and tumor-associated macrophages (TAMs) can enhance the ratio of mature dendritic cells (mDCs) and proinflammatory macrophages, thus improving the immune response against triple-negative breast cancer. The findings provide a candidate method for monitoring treatment and augmenting antitumor chemoimmunotherapy by suppressing tumor cell autophagy and reprogramming immunocyte metabolism.

ACS NANO (2022)

Article Engineering, Biomedical

A Micro-Environment Regulator for Filling the Clinical Treatment Gap after a Glioblastoma Operation

Yiwen Zhang et al.

Summary: An immediate and mild postoperative local treatment strategy is developed using an injectable hydrogel system to regulate the postoperative microenvironment and delay recurrence of glioblastoma. This hydrogel system can block the recruitment of microglia/macrohpages and activate cytotoxic T cells, effectively inhibiting glioblastoma recurrence and gaining valuable time for subsequent chemotherapy.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Engineering, Biomedical

Mature dendritic cell-derived dendrosomes swallow oxaliplatin-loaded nanoparticles to boost immunogenic chemotherapy and tumor antigen-specific immunotherapy

Xing Chen et al.

Summary: The cytomembrane-derived delivery platform is a promising biomimetic strategy for oncotherapy. By fusing mature dendrosomes with redox-responsive nanoparticles, durable and reliable tumor inhibition can be achieved, along with enhanced immunogenicity and immunocyte differentiation. Combination with aPD-L1 further enhances the antitumor effect.

BIOACTIVE MATERIALS (2022)

Article Medicine, Research & Experimental

Central nervous system immune interactome is a function of cancer lineage, tumor microenvironment, and STAT3 expression

Hinda Najem et al.

Summary: This study analyzed the distribution and functionality of immune cells in gliomas and lung metastases using tissue segmentation and multiplex imaging. The results showed that immunosuppressive macrophages are abundant in the highly infiltrated area of tumors, and the immune cell interactome differs between cancer lineages.

JCI INSIGHT (2022)

Article Chemistry, Multidisciplinary

Engineered Macrophage-Membrane-Coated Nanoparticles with Enhanced PD-1 Expression Induce Immunomodulation for a Synergistic and Targeted Antiglioblastoma Activity

Tieying Yin et al.

Summary: This article reports an engineered macrophage-membrane-coated nanoplatform with enhanced programmed cell death-1 (PD-1) expression, which can efficiently traverse the blood-brain barrier and accumulate nanoparticles at the tumor site, thereby enhancing the effectiveness of immune checkpoint blockade therapy.

NANO LETTERS (2022)

Article Multidisciplinary Sciences

Interrogating glioma-M2 macrophage interactions identifies Gal-9/Tim-3 as a viable target against PTEN-null glioblastoma

Xiangrong Ni et al.

Summary: This study reveals that PTEN deficiency induces a symbiotic interaction between glioma cells and M2 macrophages, supporting the progression of glioma. The authors found that PTEN-deficient GBM cells secrete Gal-9, which drives macrophage M2 polarization and angiogenesis to support glioma growth. Blocking the Gal-9/Tim-3 signaling pathway inhibits macrophage M2 polarization and suppresses tumor growth. Additionally, the use of alpha-lactose attenuates glioma angiogenesis by down-regulating macrophage-derived VEGFA, providing a novel antivascularization strategy for glioma treatment.

SCIENCE ADVANCES (2022)

Review Oncology

Next Steps for Immunotherapy in Glioblastoma

Toni Q. Cao et al.

Summary: Despite current standard treatments, prognosis for glioblastoma patients remains poor. Immunotherapy, which harnesses the patient's immune system, has shown success in non-central nervous system cancers but lacks efficacy for glioblastoma. Factors impacting immunotherapy efficacy for glioblastoma have become a new focus of research.

CANCERS (2022)

Article Biochemical Research Methods

OMIP-079: Cell cycle of CD4+ and CD8+ naive/memory T cell subsets, and of Treg cells from mouse spleen

Ambra Natalini et al.

Summary: A multicolor flow cytometry panel was developed to define nine mouse T cell subsets and distinguish cell cycle phases based on Ki-67 expression and DNA content. This panel was optimized for analysis of mouse spleen samples.

CYTOMETRY PART A (2021)

Article Chemistry, Multidisciplinary

A dual-guide bioinspired drug delivery strategy of a macrophage-based carrier against postoperative triple-negative breast cancer recurrence

Yue Qiu et al.

Summary: In this study, a macrophage-based carrier was designed to enhance the efficiency of targeting recurrent tumors through a dual-guide strategy. Both in vitro and in vivo experiments demonstrated the significant effectiveness of the carrier in inhibiting tumor recurrence post-operation.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Chemistry, Multidisciplinary

A Virus-Mimicking Nucleic Acid Nanogel Reprograms Microglia and Macrophages for Glioblastoma Therapy

Xihui Gao et al.

Summary: Immunotherapy is a promising approach for treating cancers, but its effectiveness in glioblastoma treatment is limited due to the immunosuppressive tumor microenvironment. A virus-mimicking membrane-coated nucleic acid nanogel, Vir-Gel, has been developed to reprogram microglia and macrophages from a pro-invasive M2 phenotype to an anti-tumor M1 phenotype. This approach significantly enhances the targetability and cell uptake efficiency of therapeutic miRNA, demonstrating improved tumor inhibition efficacy.

ADVANCED MATERIALS (2021)

Article Nanoscience & Nanotechnology

Immunostimulant hydrogel for the inhibition of malignant glioma relapse post-resection

Jing Zhang et al.

Summary: The study introduces an injectable hydrogel system that stimulates tumoricidal immunity after GBM surgical resection, effectively reducing its recurrence. This system induces immunogenic cell death and sustained T-cell infiltration to attack residual tumor cells, significantly suppressing postoperative GBM recurrence.

NATURE NANOTECHNOLOGY (2021)

Review Oncology

Current status and recent advances in reirradiation of glioblastoma

Giuseppe Minniti et al.

Summary: Reirradiation has shown survival benefits for patients with recurrent GBM, but questions remain about the efficacy and toxicity of a second course of radiation. Current clinical discussions on reirradiation of GBM focus on appropriate patient selection, radiation technique, optimal dose fractionation, brain tolerance to reirradiation, and the risk of radiation necrosis.

RADIATION ONCOLOGY (2021)

Article Engineering, Biomedical

Asynchronous blockade of PD-L1 and CD155 by polymeric nanoparticles inhibits triple-negative breast cancer progression and metastasis

Chuanrong Chen et al.

Summary: PD-L1/PD-1 blockade therapy offers durable responses to triple-negative breast cancer (TNBC) with a low response rate. The coexpression of PD-L1 and CD155 on TNBC cells was verified and the use of P/PEALsiCD155 nanoparticles showed promising results in enhancing immune surveillance and preventing immune escape of TNBC tumors. This combination therapy also induced immunogenic cell death (ICD) and effectively inhibited TNBC progression and metastasis with superior safety in a preclinical model.

BIOMATERIALS (2021)

Review Oncology

IL-10 in glioma

Samuel S. Widodo et al.

Summary: The prognosis for patients with GBM is very poor despite current standard treatments. The immunosuppressive tumour microenvironment hinders the development of effective immunotherapies for GBM, and understanding the role of IL-10 in GBM is crucial for improving immunotherapy.

BRITISH JOURNAL OF CANCER (2021)

Article Pharmacology & Pharmacy

Macrophage-mediated multi-mode drug release system for photothermal combined with anti-inflammatory therapy against postoperative recurrence of triple negative breast cancer

Kebai Ren et al.

Summary: A macrophage-mediated photothermal therapy combined with anti-inflammatory strategy was proposed in the study, which effectively inhibited breast cancer postoperative relapse and achieved significant therapeutic effect.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Review Biochemistry & Molecular Biology

Phenotypic plasticity of myeloid cells in glioblastoma development, progression, and therapeutics

Zengpanpan Ye et al.

Summary: Research suggests that targeting infiltrating myeloid cells in the tumor microenvironment may offer a novel direction for immunotherapy in improving the prognosis of patients with Glioblastoma (GBM). These myeloid cells play a crucial role in regulating GBM progression and affecting therapeutic efficacy.

ONCOGENE (2021)

Article Multidisciplinary Sciences

Tumor-associated hematopoietic stem and progenitor cells positively linked to glioblastoma progression

I-Na Lu et al.

Summary: HSPCs in glioblastoma tumor tissues are associated with malignant and immunosuppressive phenotypes, predicting patient survival and potentially serving as a target for brain tumor immunotherapies. A deeper understanding of the immune cell profile within the brain cancer tumor microenvironment could lead to improved immunotherapy efficacy.

NATURE COMMUNICATIONS (2021)

Review Oncology

Debris-stimulated tumor growth: a Pandora's box?

Victoria M. Haak et al.

Summary: Current cancer therapies have a "double-edged sword" effect, where the cell debris produced during treatment may promote tumor growth and metastasis. While the specific molecular mechanisms are not fully understood, factors such as extracellular vesicles and miRNA are known to influence tumor growth.

CANCER AND METASTASIS REVIEWS (2021)

Article Chemistry, Multidisciplinary

Macrophage-Disguised Manganese Dioxide Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Modulating Inflammatory Microenvironment in Acute Ischemic Stroke

Chao Li et al.

Summary: This biomimetic nanomedicine utilizes macrophage-disguised manganese dioxide nanospheres loaded with fingolimod to target the damaged brain in ischemic stroke, reducing oxidative stress, promoting microglial transition, and ultimately enhancing neuronal survival. This new strategy offers a multitargeted combined treatment approach for ischemic stroke.

ADVANCED SCIENCE (2021)

Article Materials Science, Biomaterials

Tunable phosphate-mediated stability of Ce3+ ions in cerium oxide nanoparticles for enhanced switching efficiency of their anti/pro-oxidant activities

Tamaki Naganuma

Summary: The study investigates the switching of oxidation states in cerium oxide nanoparticles in different environments and its impact on the nanozyme activities. The results demonstrate that the intervention of phosphate ions can regulate the stability of Ce3+ ions, enhancing the switching efficiency of their anti-oxidant and pro-oxidant activities.

BIOMATERIALS SCIENCE (2021)

Review Pharmacology & Pharmacy

The blood-brain barrier: Physiology and strategies for drug delivery

Rucha Pandit et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Article Multidisciplinary Sciences

VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours

Eric Song et al.

NATURE (2020)

Article Multidisciplinary Sciences

Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood-brain barrier

Oscar A. Marcos-Contreras et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Pharmacology & Pharmacy

Immunotherapy for Malignant Glioma: Current Status and Future Directions

Hongxiang Wang et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

Article Chemistry, Multidisciplinary

Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes

Bhagyashree S. Joshi et al.

ACS NANO (2020)

Article Multidisciplinary Sciences

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

Zhibin Zhang et al.

NATURE (2020)

Review Hematology

Cytokines and costimulation in acute graft-versus-host disease

Geoffrey R. Hill et al.

Review Oncology

Management of glioblastoma: State of the art and future directions

Aaron C. Tan et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Review Immunology

Tumour-intrinsic resistance to immune checkpoint blockade

Anusha Kalbasi et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

Chemotherapy-generated cell debris stimulates colon carcinoma tumor growth via osteopontin

Jaimie Chang et al.

FASEB JOURNAL (2019)

Article Biochemistry & Molecular Biology

Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma

Kurt A. Schalper et al.

NATURE MEDICINE (2019)

Article Neurosciences

Transcytosis at the blood-brain barrier

Swathi Ayloo et al.

CURRENT OPINION IN NEUROBIOLOGY (2019)

Review Clinical Neurology

The current state of immunotherapy for gliomas: an eye toward the future

Peter E. Fecci et al.

JOURNAL OF NEUROSURGERY (2019)

Review Engineering, Biomedical

Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

Jinbing Xie et al.

BIOMATERIALS (2019)

Review Chemistry, Multidisciplinary

Emerging Nano-/Microapproaches for Cancer Immunotherapy

Yu Mi et al.

ADVANCED SCIENCE (2019)

Review Immunology

Regulation and Function of the PD-L1 Checkpoint

Chong Sun et al.

IMMUNITY (2018)

Article Medicine, Research & Experimental

Carrier-Free, Pure Nanodrug Formed by the Self-Assembly of an Anticancer Drug for Cancer Immune Therapy

Lulu Fan et al.

MOLECULAR PHARMACEUTICS (2018)

Article Biochemistry & Molecular Biology

The roles of microglia macrophages in tumor progression of brain cancer and metastatic disease

Shih-Ying Wu

Frontiers in Bioscience-Landmark (2017)

Review Medicine, Research & Experimental

Microglia in steady state

Katrin Kierdorf et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Review Oncology

Blocking the PD-1/PD-L1 pathway in glioma: a potential new treatment strategy

Song Xue et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)

Review Clinical Neurology

Vaccine-based immunotherapeutic approaches to gliomas and beyond

Michael Weller et al.

NATURE REVIEWS NEUROLOGY (2017)

Review Immunology

CD69: from activation marker to metabolic gatekeeper

Danay Cibrian et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2017)

Review Pharmacology & Pharmacy

Investigation of endosome and lysosome biology by ultra pH-sensitive nanoprobes

Chensu Wang et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

Article Chemistry, Multidisciplinary

Nanoparticles Coated with Neutrophil Membranes Can Effectively Treat Cancer Metastasis

Ting Kang et al.

ACS NANO (2017)

Review Immunology

Immunogenic cell death in cancer and infectious disease

Lorenzo Galluzzi et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Article Medicine, Research & Experimental

A therapeutic cancer vaccine against GL261 murine glioma

Mark S. Kindy et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2016)

Article Chemistry, Multidisciplinary

Blocking of the PD-1/PD-L1 Interaction by a D-Peptide Antagonist for Cancer Immunotherapy

Hao-Nan Chang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Article Chemistry, Multidisciplinary

Tumor Acidity-Sensitive Polymeric Vector for Active Targeted siRNA Delivery

Chun-Yang Sun et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Article Multidisciplinary Sciences

Structural and functional features of central nervous system lymphatic vessels

Antoine Louveau et al.

NATURE (2015)

Review Immunology

Perforin and granzymes: function, dysfunction and human pathology

Ilia Voskoboinik et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Review Pharmacology & Pharmacy

Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

Nicolas Bertrand et al.

ADVANCED DRUG DELIVERY REVIEWS (2014)

Review Oncology

Immunotherapy for Brain Cancer: Recent Progress and Future Promise

Christopher M. Jackson et al.

CLINICAL CANCER RESEARCH (2014)

Article Medicine, General & Internal

A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma

Mark R. Gilbert et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Pharmacology & Pharmacy

IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets

Malte Bachmann et al.

BIOCHEMICAL PHARMACOLOGY (2013)

Review Pharmacology & Pharmacy

Interleukins in glioblastoma pathophysiology: implications for therapy

Y. T. Yeung et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

Review Oncology

Nanooncology: The Future of Cancer Diagnosis and Therapy

Avnesh S. Thakor et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2013)

Review Medicine, General & Internal

Glioblastoma and Other Malignant Gliomas A Clinical Review

Antonio Omuro et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

Review Clinical Neurology

The role of Stat3 in glioblastoma multiforme

Rodney B. Luwor et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2013)

Article Biochemistry & Molecular Biology

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Stephanie M. Pyonteck et al.

NATURE MEDICINE (2013)

Review Pharmacology & Pharmacy

Current status of local therapy in malignant gliomas - A clinical review of three selected approaches

Tareq A. Juratli et al.

PHARMACOLOGY & THERAPEUTICS (2013)

Review Immunology

Impact of Temozolomide on Immune Response during Malignant Glioma Chemotherapy

Sadhak Sengupta et al.

CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2012)

Review Immunology

Differential macrophage programming in the tumor microenvironment

Brian Ruffell et al.

TRENDS IN IMMUNOLOGY (2012)

Article Pharmacology & Pharmacy

Uptake and permeability studies of BBB-targeting immunoliposomes using the hCMEC/D3 cell line

Eleni Markoutsa et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2011)

Article Multidisciplinary Sciences

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

Che-Ming J. Hu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Immunology

Microglial cell origin and phenotypes in health and disease

Kaoru Saijo et al.

NATURE REVIEWS IMMUNOLOGY (2011)

Review Oncology

Experience with irinotecan for the treatment of malignant glioma

James J. Vredenburgh et al.

NEURO-ONCOLOGY (2009)

Article Clinical Neurology

The effects of natalizumab on the innate and adaptive immune system in the central nervous system

Olaf Stueve

JOURNAL OF THE NEUROLOGICAL SCIENCES (2008)

Article Multidisciplinary Sciences

Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6-STAT3 signaling pathway

Siyuan Liang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

CXCR4 antagonism increases T cell trafficking in the central nervous system and improves survival from West Nile virus encephalitis

Erin E. McCandless et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

M Kortylewski et al.

NATURE MEDICINE (2005)

Article Biochemistry & Molecular Biology

IL-6 is required for glioma development in a mouse model

J Weissenberger et al.

ONCOGENE (2004)