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Article
Engineering, Biomedical
Shuang Zeng et al.
Summary: By targeting specific subcellular organelles and utilizing photosensitizers, we have successfully activated pyroptosis and immunogenic cell death, which effectively inhibits tumor growth and metastasis. In vivo experiments have demonstrated that this approach not only suppresses the growth of primary tumors but also has an abscopal effect on distant tumors and metastatic tumors.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Duo Wang et al.
Summary: By constructing an intratumorally synthesized Au bioreactor, heat diffusion in thermally sensitive hydrogel-filled tumors was dispersed, improving energy utilization efficiency and expanding the effective ablation zone. This approach reversed the immunosuppressive tumor microenvironment, enhanced microwavegenetics, and identified extracellular matrix viscosity as a general immune escape target. By remodeling ECM and blocking viscosity reprogramming, immune cell recruitment and activation were enhanced, leading to improved CAR-T immunotherapy against tumor recurrence after incomplete microwave ablation.
Review
Chemistry, Inorganic & Nuclear
Xueni Zhang et al.
Summary: Conventional chemotherapeutic drugs have severe side effects and low bioavailability, which hinders current clinical cancer treatments. Tumor microenvironment (TME)-responsive nanomedicine has emerged as a safe and effective approach for cancer diagnosis and therapy. In this review, the intratumoral biosynthesis of inorganic nanomaterials for cancer diagnosis and treatment, triggered by specific TME conditions, is systematically summarized. The review also discusses unresolved issues, potential solutions, perspectives, and future directions in this field.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Oncology
Duo Wang et al.
Summary: In this study, exosomes derived from M1 macrophages were engineered to deliver RSL3 and induce ferroptosis in tumor cells, activating immune responses and mitigating the immunosuppressive tumor microenvironment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Nanoscience & Nanotechnology
Lei Li et al.
Summary: By designing a carrier-free chemophotodynamic nanoplatform (A-C/NPs), pyroptosis can be induced to enhance the immune response and suppress the growth of breast cancer. A-C/NPs can trigger GSDME-mediated pyroptosis in a controllable manner through reactive oxygen species (ROS) accumulation, leading to immunogenic cell death (ICD). Additionally, A-C/NPs can synergistically stimulate the maturation of cytotoxic T lymphocytes with Ce6-mediated ICD, augmenting the anticancer effect.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Lulu Zheng et al.
Summary: Immunotherapy has significantly improved cancer treatment, but its efficacy is limited in tumors with low immune infiltration. This study introduces a novel photoimmunotherapy approach that remodels the inflammatory microenvironment and enhances the effectiveness of anti-PD-1 immunotherapy through cell pyroptosis and immune cell recruitment.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ke Li et al.
Summary: A Cu-TCPP(Fe) MOF-based nanosystem incorporating Au nanoparticles and RSL3 is reported in this study, which can universally suppress the antiferroptotic pathway in tumor cells and amplify ferroptotic damage. The nanosystem exhibits enzyme-like activities and can inhibit the antioxidant mechanisms involved in ferroptosis.
Review
Chemistry, Multidisciplinary
Jing Liu et al.
Summary: Cancer vaccines aim to stimulate tumor-specific immune responses while sparing normal tissues, with bioinspired materials and technologies playing a role in reshaping the field of cancer nanomedicine. By mimicking desirable properties in nature, bioinspired engineering of cancer vaccine delivery platforms can enhance therapeutic efficacy and safety profiles for clinical translation.
ADVANCED MATERIALS
(2022)
Review
Immunology
Connie Ross et al.
Summary: This article comprehensively reviews the mechanisms that govern the activity of inflammatory caspases, including activation and deactivation mechanisms, the physiological importance of caspase activity kinetics, mechanisms of caspase substrate selection, and how inflammasome and cell identities influence caspase activity and resultant inflammatory and pyroptotic cellular programs.
ANNUAL REVIEW OF IMMUNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Chenyang Jia et al.
Summary: Chemodynamic therapy (CDT) is a novel cancer treatment strategy that generates hydroxyl radicals in the tumor region using Fenton or Fenton-like reactions. It has advantages such as low side effects, independence from external stimulation, modulation of the tumor microenvironment, and low treatment cost. CDT can also be combined with other therapies to enhance anticancer effects.
Article
Chemistry, Multidisciplinary
Yun Chen et al.
Summary: By utilizing novel organic metal adjuvants (OMAs), the immunogenicity and immune response of tumor cells in photothermal immunotherapy (PTI) can be significantly enhanced. These OMAs exhibit strong phototherapeutic and adjuvant abilities through the modulation of optical properties and disruption of redox homeostasis, improving treatment outcomes.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Jae Ah Lee et al.
Summary: Therapeutic cancer vaccines have the potential to activate highly specific cytotoxic T cells, making them an attractive option for personalized cancer immunotherapy. However, their low immunogenicity has limited their use in clinical settings. To overcome this limitation, researchers have developed 'find-me' signaling polymeric microparticles (F-PMs) that efficiently recruit dendritic cells (DCs) and facilitate antigen presentation. When injected into tumor-bearing mice, F-PMs significantly increase mature DCs in the lymph nodes, resulting in effective tumor inhibition. Moreover, co-administration of F-PMs and an immune checkpoint inhibitor leads to a higher enrichment of CD8+ cytotoxic T cells in the tumor microenvironment. This study demonstrates the potential of F-PMs as a promising therapeutic option for cancer treatment.
Article
Chemistry, Multidisciplinary
Yaoben Wang et al.
Summary: A novel injectable hydrogel system capable of releasing nitric oxide (NO) and converting it into reactive nitrogen species (RNS) has been developed, which effectively boosts hydrogen peroxide (H2O2) concentration in cancer cells and suppresses tumor growth.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Pan Zheng et al.
Summary: Researchers have developed a pyroptosis inducer for cancer immunotherapy by inducing mitochondrial Ca2+ overload. The inducer triggers robust immune responses, effectively suppressing tumor proliferation and lung metastasis, providing new strategies and inspiration for pyroptosis-mediated cancer treatments.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Environmental
Miao Chen et al.
Summary: A theranostic agent combining Fe3O4-embedded magnetic mesoporous silica nanoparticles and chlorin e6 photosensitizers was developed to enhance ROS levels and induce pyroptosis. This approach successfully suppressed malignant breast cancer in vitro and in vivo by overcoming hypoxia-induced resistance to ROS.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Multidisciplinary Sciences
Judit Svensson-Arvelund et al.
Summary: Expanding dendritic cells to increase tumor antigen cross-presentation improves oncolytic virotherapy and induces neoepitope-specific T cell response.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Jian Wang et al.
Summary: Cancer stem cells (CSCs) are a subpopulation of tumor cells that drive tumor recurrence and metastasis. This study developed a photodynamic therapy (PDT) strategy targeting CSCs by utilizing the abundant ribosomes in CSCs. By co-assembling specific nanoparticles with a short peptide, the positively charged nanoparticles efficiently targeted CSCs and induced apoptosis upon light irradiation.
Article
Chemistry, Multidisciplinary
Min Gao et al.
Summary: A cell membrane-anchoring nano-photosensitizer (CMA-nPS) is developed to induce tumor-specific Ca2+ overload through disruption of endogenous Ca2+ homeostasis. The photosensitizer is anchored to the lung cancer cell membrane via functionalized cell membranes, resulting in membrane damage, mitochondrial dysfunction, and intracellular Ca2+ overload under light guidance. This approach shows synergistically enhanced antitumor efficacy in vitro and in vivo. It offers a new strategy for Ca2+-overload-based cancer therapy and anchoring photosensitizer on the cell membrane, with potential application in lung cancer treatment.
Review
Materials Science, Multidisciplinary
Yan Zhang et al.
Summary: This review highlights the importance of pyroptosis in tumors and inflammatory diseases and the potential of nanobiotechnology in treating pyroptosis-related diseases. It summarizes the pyroptosis pathways, inducers, and inhibitors, and explores the role of nanotechnology in regulating pyroptosis and treating cancer and inflammation-associated diseases.
Article
Endocrinology & Metabolism
Hongyun Zhao et al.
Summary: This study reveals that itaconate, produced by myeloid-derived suppressor cells (MDSCs), acts as an immune checkpoint metabolite to suppress CD8(+) T cells. Inhibition of IRG1 may enhance anti-tumour immunity and improve the efficacy of immune checkpoint blockade. These findings have implications for understanding immune surveillance and developing new strategies for cancer treatment.
Article
Chemistry, Multidisciplinary
Li Song et al.
Summary: Sonodynamic therapy (SDT) is a more preferable therapeutic modality than photodynamic therapy (PDT) due to its deeper tissue penetration. However, SDT still suffers from low ROS production efficiency and insufficient systematic immune activation. Efforts have been made to overcome these challenges, including the development of inorganic sonosensitizers and the modulation of the tumor microenvironment (TME) to enhance SDT. More research is needed to further improve the understanding and application of TME modulation in SDT.
ACCOUNTS OF MATERIALS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Yue Yan et al.
Summary: The study highlights the importance of regulating the tumor microenvironment to enhance the therapeutic efficacy of active-targeted nanophotosensitizers, with normalization of tumor vasculature and photoablation of stromal cells improving tumor accumulation and cancer cell accessibility of the nanoparticles. This sequential regulation strategy significantly enhances the antitumor efficacy of active-targeted nanoparticles, providing a basis for accelerating their clinical translation.
Review
Biochemistry & Molecular Biology
Junwei Hou et al.
Summary: ICP and CCP are processes of cell pyroptosis activated by different molecular mechanisms, affecting antitumor immunity and therapeutic outcomes.
Article
Cell Biology
Haein An et al.
Summary: Tetraarsenic hexoxide induces pyroptotic cell death in TNBC cells by activating mitochondrial ROS-mediated caspase-3/GSDME pathway, effectively suppressing tumor growth and metastasis.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Heng Lin et al.
Summary: Immunotherapy can induce durable clinical responses in some cancer patients, but resistance poses a major challenge. The expression of tumor STC1 is correlated with immunotherapy efficacy and negatively associated with patient survival across different cancer types. This study suggests that tumor STC1 may inhibit APC phagocytosis and contribute to tumor immune evasion and immunotherapy resistance.
Article
Chemistry, Multidisciplinary
Yao Xiao et al.
Summary: The absence of tumor antigens poses a challenge in ICB therapy, but inducing tumor-specific pyroptosis while reducing injury in normal tissues is urgently needed. A ROS/GSH dual-responsive nano-prodrug called MCPP with high PTX and P18 loading is designed to selectively induce pyroptosis in tumor cells. Chemo-photodynamic therapy and controlled-release PTX synergistically induce pyroptosis, releasing DAMPs and enhancing ICB efficiency, suggesting a smart strategy to trigger pyroptosis and augment ICB efficiency.
Article
Oncology
Jeong A. Park et al.
Summary: Modulating tumor infiltrating myeloid cells (TIMs) can potentially improve the efficacy of bispecific antibodies (BsAbs) by enhancing T cell infiltration and persistence in tumors, thus improving the anti-tumor response.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kai Li et al.
Summary: MDSCs are a group of immunosuppressive cells that play a crucial role in tumor progression, affecting tumor development through various pathways and interfering with the efficacy of current anti-tumor therapies. Targeting MDSCs is a promising strategy for future cancer treatment.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Cell Biology
Jitka Fucikova et al.
Summary: CALR is a protein located in the endoplasmic reticulum that plays important roles in cellular processes and protein folding. It acts as a chaperone in healthy cells, assisting protein folding and supporting Ca2+-dependent processes, while also being exposed on the cell surface in cancer cells to promote immunogenic cell death. Loss-of-functionCALRmutations can promote oncogenesis by impairing cellular homeostasis and compromising natural and therapy-driven immunosurveillance.
Review
Biochemistry & Molecular Biology
Ling Wei et al.
Article
Chemistry, Multidisciplinary
Yao Lu et al.
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Fei Gong et al.
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Yuqiong Xia et al.
ADVANCED MATERIALS
(2020)
Article
Multidisciplinary Sciences
Lang Rao et al.
NATURE COMMUNICATIONS
(2020)
Editorial Material
Chemistry, Multidisciplinary
Xiaoyuan Shawn Chen et al.
ACCOUNTS OF CHEMICAL RESEARCH
(2020)
Article
Chemistry, Multidisciplinary
Yu Chen et al.
Article
Multidisciplinary Sciences
K. Hayashi et al.
NATURE COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Fangyuan Zhou et al.
ADVANCED MATERIALS
(2019)
Article
Chemistry, Multidisciplinary
Yang Liu et al.
Article
Multidisciplinary Sciences
Yupeng Wang et al.
Review
Oncology
T. Shekarian et al.
ANNALS OF ONCOLOGY
(2017)
Article
Multidisciplinary Sciences
Xing Liu et al.
Article
Cell Biology
Yushan Zhu et al.
