期刊
NANO LETTERS
卷 16, 期 4, 页码 2781-2785出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.6b00530
关键词
nanotechnology; DNA origami; controlled release; uncaging; photolabile cross-linker; bioactive cargo
类别
资金
- NIH Director's new innovator award [1DP2NS082126]
- Pew Foundation
- Alfred P. Sloan Foundation
- Boston University Biomedical Engineering Department
- NIH [MH079407]
- NIH T32 Training Grant
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1337811] Funding Source: National Science Foundation
Recent innovations in DNA nanofabrication allow the creation of intricately shaped nanostructures ideally suited for many biological applications. To advance the use of DNA nanotechnology for the controlled release of bioactive molecules, we report a general strategy that uses light to liberate encapsulated cargoes from DNA nanostructures with high spatiotemporal precision. Through the incorporation of a custom, photolabile cross-linker, we encapsulated cargoes ranging in size from small molecules to full-sized proteins within DNA nanocages and then released such cargoes upon brief exposure to light. This novel molecular uncaging technique offers a general approach for precisely releasing a large variety of bioactive molecules, allowing investigation into their mechanism of action, or finely tuned delivery with high temporal precision for broad biomedical and materials applications.
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