Impact of the COVID-19 pandemic on liver transplant waitlist outcome in France

Article Surgery

A coordinated national UK liver transplant program response, prioritizing waitlist recipients with the highest need, provided excellent outcomes during the first wave of the COVID-19 pandemic

Steven Masson et al.

Summary: Healthcare provision, particularly organ transplantation, has been significantly impacted by COVID-19. This study examines the coordinated response and outcomes of liver transplant centers in the UK during the first wave. The results demonstrate successful prioritization of liver transplant recipients in highest need, with no significant reduction in patient or graft survival.

CLINICAL TRANSPLANTATION (2022)

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Article Gastroenterology & Hepatology

Comparison of mortality risk in patients with cirrhosis and COVID-19 compared with patients with cirrhosis alone and COVID-19 alone: multicentre matched cohort

Jasmohan S. Bajaj et al.

Summary: Patients with cirrhosis and COVID-19 had higher mortality compared with patients with COVID-19 alone, but similar mortality compared with patients with cirrhosis alone. Charlson Comorbidity Index (CCI) was the only independent predictor of mortality in the entire matched cohort.

GUT (2021)

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Editorial Material Gastroenterology & Hepatology

Elevated Liver Enzymes in Patients with COVID-19: Look, but Not Too Hard

Andrew M. Moon et al.

DIGESTIVE DISEASES AND SCIENCES (2021)

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Article Gastroenterology & Hepatology

Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study

Thomas Marjot et al.

Summary: This international registry study demonstrates that patients with cirrhosis are at increased risk of death from COVID-19. Mortality from COVID-19 was particularly high among patients with more advanced cirrhosis and those with alcohol-related liver disease.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Prognosis of French COVID-19 patients with chronic liver disease: A national retrospective cohort study for 2020

Vincent Mallet et al.

Summary: Chronic liver disease was found to increase the risk of COVID-19-related death in France in 2020. Therapeutic effort limitation may have contributed to the excess mortality in French residents with a liver-related complication or an alcohol use disorder.

JOURNAL OF HEPATOLOGY (2021)

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Article Immunology

Evidence of SARS-CoV-2 Infection in Cells, Tissues, and Organs and the Risk of Transmission Through Transplantation

Amaury Gaussen et al.

Summary: The emergence of SARS-CoV-2 raised concerns for transplantation programs due to the potential risk of transmission through donated organs. Initial consensus excluded COVID-19 positive patients from donation, leading to a global decrease in transplantation procedures. Studies on the transmission risk through transplantation have produced inconsistent findings, highlighting the need for standardized screening practices and systematic recipient follow-up.

TRANSPLANTATION (2021)

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Review Gastroenterology & Hepatology

Clinical outcomes in COVID-19 and cirrhosis: a systematic review and meta-analysis of observational studies

Paul Middleton et al.

Summary: COVID-19 continues to pose a significant healthcare challenge globally, with comorbidities like diabetes and hypertension associated with increased mortality risk. The clinical outcomes of patients with cirrhosis and COVID-19 have not been systematically assessed, but meta-analysis indicates that cirrhosis patients are at higher risk of mortality compared to non-cirrhotic patients.

BMJ OPEN GASTROENTEROLOGY (2021)

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Article Gastroenterology & Hepatology

COVID-19 in liver transplant candidates: pretransplant and post-transplant outcomes - an ELITA/ELTR multicentre cohort study

Luca Saverio Belli et al.

Summary: COVID-19 significantly impacts the mortality rate of liver transplant candidates, especially for those with high Lab-MELD scores and respiratory symptoms. Poor prognosis was observed in patients with decompensated cirrhosis, highlighting the need for strict preventive measures and urgent vaccination efficacy testing in this population. Prior symptomatic SARS-CoV-2 infection did not affect early post-transplant survival.

GUT (2021)

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Article Surgery

Liver transplantation in the United States during the COVID-19 pandemic: National and center-level responses

Alexandra T. Strauss et al.

Summary: COVID-19 profoundly affected the American healthcare system and had a negative impact on liver transplant waitlist, with decreases in new listings of LT and fewer DDLTs and LDLTs during the early stages of the pandemic. However, by August, waitlist outcomes were approaching expected rates, indicating the adaptability of the transplant community in addressing the challenges posed by the pandemic.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Surgery