期刊
NANO LETTERS
卷 16, 期 7, 页码 4019-4024出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.6b00466
关键词
Phospholipid; small-angle X-ray scattering (SAXS); carbon nanotube; porins
类别
资金
- U.S. Department of Energy by Lawrence Livermore National Laboratory [DE-AC52-07NA27344]
- U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering [SCW0972]
- U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-76SF00515]
- DOE Office of Biological and Environmental Research
- National Institutes of Health, National Institute of General Medical Sciences [P41GM103393]
Carbon nanotube porins (CNTPs), small segments of carbon nanotubes capable of forming defined pores in lipid membranes, are important future components for bionanoelectronic devices as they could provide a robust analog of biological membrane channels. In order to control the incorporation of these CNT channels into lipid bilayers, it is important to understand the structure of the CNTPs before and after insertion into the lipid bilayer as well as the impact of such insertion on the bilayer structure. Here we employed a noninvasive in situ probe, small-angle X-ray scattering, to study the integration of CNT porins into dioleoylphosphatidylcholine bilayers. Our results show that CNTPs in solution are stabilized by a monolayer of lipid molecules wrapped around their outer surface. We also demonstrate that insertion of CNTPs into the lipid bilayer results in decreased bilayer thickness with the magnitude of this effect increasing with the concentration of CNTPs.
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