Duality in response of intracranial vessels to nitroglycerin revealed in rats by imaging photoplethysmography

Article Clinical Neurology

Sphingosine-1 phosphate receptor 1 contributes to central sensitization in recurrent nitroglycerin-induced chronic migraine model

Qi Pan et al.

Summary: The study reveals that inhibiting S1PR1 signal can alleviate central sensitization and inhibit microglia activity in chronic migraine through the STAT3 signal pathway.

JOURNAL OF HEADACHE AND PAIN (2022)

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Article Clinical Neurology

IL-17 crosses the blood-brain barrier to trigger neuroinflammation: a novel mechanism in nitroglycerin-induced chronic migraine

Hao Chen et al.

Summary: This study optimized the NTG-induced migraine rat model and revealed the mechanism of NTG-induced migraine. The findings have important implications for the treatment of migraines.

JOURNAL OF HEADACHE AND PAIN (2022)

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Article Biochemical Research Methods

Study of cerebrovascular reactivity to hypercapnia by imaging photoplethysmography to develop a method for intraoperative assessment of the brain functional reserve

Maxim A. Volynsky et al.

Summary: Intraoperative assessment of cerebrovascular reactivity is crucial in neurosurgery. This study proposes the use of imaging photoplethysmography to measure changes in cortical perfusion caused by CO2 inhalation for evaluating the functional reserve of cerebral blood flow. The results reveal that the response to hypercapnia depends strongly on the cranial state. However, regardless of the direction of hemodynamic changes, the ratio of normalized changes in arterial blood pressure and cortical perfusion can serve as an indicator of cerebrovascular functional reserve.

BIOMEDICAL OPTICS EXPRESS (2022)

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Article Biochemistry & Molecular Biology

Neurogenic Inflammation: The Participant in Migraine and Recent Advancements in Translational Research

Eleonora Spekker et al.

Summary: Migraine is a debilitating primary headache disorder characterized by long-lasting and interfering pain. Neurogenic inflammation and neuropeptides play important roles in the pathophysiology of migraine, and recent advances in preclinical research and therapeutic approaches have provided new insights for its treatment.

BIOMEDICINES (2022)

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Article Anesthesiology

Global, regional, and national burden of migraine in 204 countries and territories, 1990 to 2019

Saeid Safiri et al.

Summary: The Global Burden of Disease Study 2019 revealed an increase in the burden of migraine from 1990 to 2019, with significant intercountry differences. Migraine prevalence was higher in females and decreased with age after the 40 to 44 age group. Enhanced migraine care is necessary to increase awareness of risk factors and treatment strategies, particularly among young adults and middle-aged women, as well as to gather more data on migraines.

PAIN (2022)

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Article Pharmacology & Pharmacy

Neuroprotective effect of sumatriptan in pentylenetetrazole-induced seizure is mediated through N-methyl-D-aspartate/nitric oxide and cAMP response element-binding protein signaling pathway

Faiza Mumtaz et al.

Summary: This study showed the interaction of sumatriptan with the NMDA/NO and CREB signaling pathways in PTZ-induced seizures, indicating its anticonvulsant effects.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2022)

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Review Clinical Neurology

The complexities of migraine: A debate among migraine researchers: A review

Amrit Sudershan et al.

Summary: Migraine is a neurovascular disorder influenced by genetic and environmental factors, associated with other diseases. There is debate over whether migraine is a disease of evolution or pathology.

CLINICAL NEUROLOGY AND NEUROSURGERY (2022)

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Review Clinical Neurology

The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates

Lars Jacob Stovner et al.

Summary: This article summarizes the epidemiological studies of headache disorders globally, finding that headache disorders remain highly prevalent worldwide, and identifies methodological factors explaining the large variation between study findings. While migraine prevalence estimates increased over time, estimates for all headache types varied between world regions.

JOURNAL OF HEADACHE AND PAIN (2022)

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Article Multidisciplinary Sciences

The role of the meningeal lymphatic system in local meningeal inflammation and trigeminal nociception

Nikita Mikhailov et al.

Summary: Malfunctioning of the lymphatic system in the meninges affects the balance of pro- and anti-migraine mediators, but does not directly trigger meningeal nociceptive state.

SCIENTIFIC REPORTS (2022)

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Review Physiology

Photoplethysmogram Analysis and Applications: An Integrative Review

Junyung Park et al.

Summary: This review examines the use of photoplethysmogram (PPG) in clinical and daily life settings, focusing on its generation mechanisms, measurement principles, clinical applications, noise definition, pre-processing techniques, feature detection techniques, and post-processing techniques. The study finds that the application field of PPG is expanding from clinical to mobile environments, and machine learning-based methods hold promise for future solutions.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Medicine, General & Internal

New Generation Gepants: Migraine Acute and Preventive Medications

David Moreno-Ajona et al.

Summary: Migraine is a debilitating disease and new treatment options are necessary due to the issues with existing medications. The latest generation of CGRP pathway-targeting drugs have shown efficacy, safety, and tolerability in clinical trials. This article reviews the clinical trials of existing and new drugs.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Hyperhomocysteinemia Increases Cortical Excitability and Aggravates Mechanical Hyperalgesia and Anxiety in a Nitroglycerine-Induced Migraine Model in Rats

Elena Gerasimova et al.

Summary: This study found that prenatal hyperhomocysteinemia increased the development of migraine-related symptoms and enhanced sensitivity to the migraine trigger nitroglycerin, suggesting that high levels of homocysteine may be a risk factor for migraine development.

BIOMOLECULES (2022)

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Article Health Care Sciences & Services

Unmet needs in the acute treatment of migraine attacks and the emerging role of calcitonin gene-related peptide receptor antagonists: An integrative review

Theresa Mallick-Searle et al.

Summary: The study found that 40% of migraine patients report at least one unmet treatment need, mainly due to the inability to use existing medications. Oral CGRP receptor antagonists, ubrogepant and rimegepant, demonstrated potential efficacy in treating migraines.

JOURNAL OF THE AMERICAN ASSOCIATION OF NURSE PRACTITIONERS (2021)

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Article Anesthesiology

Intradural artery dilation during experimentally induced migraine attacks

Casper E. Christensen et al.

Summary: The study found that during migraine attacks induced by calcitonin gene-related peptide and sildenafil, both the intradural middle meningeal artery and the middle cerebral artery dilated, indicating that intradural vasculature is affected by trigeminal nociceptor activation during migraine attacks.

PAIN (2021)

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Article Clinical Neurology

Lasmiditan for the acute treatment of migraine

Paul A. DeJulio et al.

Summary: Migraine, a major cause of pain and disability globally, is often treated with triptans despite contraindications in patients with certain conditions. Lasmiditan, the first 'ditan' drug, has shown to be a safe and effective alternative for acute migraine treatment in multiple studies, with common adverse effects being dizziness, tingling and sleepiness.

PAIN MANAGEMENT (2021)

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Review Clinical Neurology

Parenchymal neuroinflammatory signaling and dural neurogenic inflammation in migraine

Sefik Evren Erdener et al.

Summary: Inflammatory signaling pathways in both meningeal and parenchymal tissues may play crucial roles in the pathophysiology of migraine headaches, as suggested by rodent studies and emerging imaging findings from patients.

JOURNAL OF HEADACHE AND PAIN (2021)

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Review Biochemistry & Molecular Biology

Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance

Russell Pearson et al.

Summary: This review explores the history and mechanisms of glyceryl trinitrate (GTN) as a treatment for angina, focusing on the role of nitric oxide (NO) in its medicinal benefits. Recent research has highlighted the importance of the alcohol detoxification enzyme, aldehyde dehydrogenase (ALDH), in activating GTN and explaining its effects, particularly in individuals with a specific genetic mutation. Healthcare professionals should take note of these findings when administering GTN as an emergency treatment.

MOLECULES (2021)

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Article Anesthesiology

Spinal nociceptive sensitization and plasma palmitoylethanolamide levels during experimentally induced migraine attacks

Roberto De Icco et al.

Summary: This study found a role for PEA in the ictal phase of episodic migraine and no significant correlations between the endocannabinoid system (ES) and neurophysiological parameters. NTG-induced central sensitization and the observed increase in PEA levels and spinal sensitization were parallel and likely unrelated phenomena.

PAIN (2021)

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Review Medicine, General & Internal

Diagnosis and Management of Headache: A Review

Matthew S. Robbins

Summary: Headache is a common symptom that affects approximately 90% of people during their lifetime. Primary headache disorders include migraine, tension-type headache, trigeminal autonomic cephalalgias, and other primary headache disorders, while secondary headache disorders are caused by underlying medical conditions. Patients presenting with headaches should be evaluated to determine the root cause and appropriate treatment.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Clinical Neurology

Advantages of imaging photoplethysmography for migraine modeling: new optical markers of trigemino-vascular activation in rats

Alexey Y. Sokolov et al.

Summary: This study evaluated imaging photoplethysmography in assessing intracranial blood flow in rats, identifying markers associated with trigeminovascular system activation and migraine. Pharmacological validation showed significant inhibitory effect on one marker (APC) by anti-migraine drugs, while infusion did not affect another marker (OIS). Monitoring changes in APC caused by electrical stimulation can provide a new way to assess the efficacy of anti-migraine interventions.

JOURNAL OF HEADACHE AND PAIN (2021)

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Article Pharmacology & Pharmacy

Efficacy and Safety of Monoclonal Antibody Against Calcitonin Gene-Related Peptide or Its Receptor for Migraine: A Systematic Review and Network Meta-analysis

Xing Wang et al.

Summary: The study compared the efficacy of different monoclonal antibodies against CGRP or its receptor for adult patients with migraine, showing that most drugs performed similarly and were superior to placebo in terms of efficacy, but galcanezumab had slightly different safety profile.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Involvement of P2Y(12) receptors in a nitroglycerin-induced model of migraine in male mice

Flora Goloncser et al.

Summary: P2Y(12) receptors regulate pain and inflammation, and their inhibition alleviates migraine-like pain in mice by modulating c-fos expression. Platelet P2Y(12) receptors may also contribute to this effect, suggesting potential therapeutic implications against migraine.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

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Article Neurosciences

Hypothalamic functional MRI activity in the initiation phase of spontaneous and glyceryl trinitrate-induced migraine attacks

Willebrordus P. J. Oosterhout et al.

Summary: This study provides new and direct evidence of altered hypothalamic neuronal function in the immediate preclinical phase of both GTN-provoked and spontaneous migraine attacks. The study assessed hypothalamic neuronal activity in early premonitory phases of induced and spontaneous migraine attacks using a novel approach, with interesting findings regarding the BOLD response to glucose and the recovery patterns in migraineurs.

EUROPEAN JOURNAL OF NEUROSCIENCE (2021)

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Article Physiology

Vasodilatation by carbon dioxide and sodium nitroglycerin reduces compliance of the cerebral arteries in humans

M. Erin Moir et al.

Summary: The study reveals that cerebral vasodilatation significantly decreases cerebrovascular compliance, shedding light on the regulation of cerebral perfusion.

EXPERIMENTAL PHYSIOLOGY (2021)

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Article Neuroimaging

Cortical glutamate and gamma-aminobutyric acid over the course of a provoked migraine attack, a 7 Tesla magnetic resonance spectroscopy study

Gerrit L. J. Onderwater et al.

Summary: Enhanced activity of the glutamatergic system may be involved in the pathophysiology of migraines. This study used high- resolution 7T MR spectroscopy to show changes in the glutamatergic system during a migraine attack, with an increase in GABA concentration observed in migraine patients compared to healthy controls.

NEUROIMAGE-CLINICAL (2021)

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Article Anesthesiology

Therapeutic targeting of nitroglycerin-mediated trigeminovascular neuronal hypersensitivity predicts clinical outcomes of migraine abortives

Simon Akerman et al.

Summary: Nitroglycerin-induced cranial hypersensitivity can serve as a valid model to study migraine mechanisms and assess potential therapeutic targets, with gepants and ditans showing effectiveness in mitigating neuronal hypersensitivity. In contrast, the NK1 receptor antagonist GR205171 failed to show any efficacy in the treatment of migraine in this model.

PAIN (2021)

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Article Pharmacology & Pharmacy

The effects of acute sumatriptan treatment on renal ischemia/reperfusion injury in rat and the possible involvement of nitric oxide

Parnia Mobasheran et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2020)

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Article Neurosciences

The Influence of Metoclopramide on Trigeminovascular Nociception: Possible Anti-migraine Mechanism of Action

Antonina Dolgorukova et al.

NEUROSCIENCE (2020)

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Article Anesthesiology

Lasmiditan inhibits calcitonin gene-related peptide release in the rodent trigeminovascular system

Alejandro Labastida-Ramirez et al.

PAIN (2020)

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Article Clinical Neurology

Headache and non-headache symptoms provoked by nitroglycerin in migraineurs: A human pharmacological triggering study

Nazia Karsan et al.

CEPHALALGIA (2020)

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Article Anesthesiology

Premonitory symptoms in glyceryl trinitrate triggered migraine attacks: a case-control study

Gerrit L. J. Onderwater et al.

PAIN (2020)

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Article Biochemistry & Molecular Biology

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Nathalie Percie du Sert et al.

PLOS BIOLOGY (2020)

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Review Nutrition & Dietetics

A Paradoxical Vasodilatory Nutraceutical Intervention for Prevention and Attenuation of Migraine-A Hypothetical Review

Devahuti Rai Chaliha et al.

NUTRIENTS (2020)

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Article Multidisciplinary Sciences

Animal model of assessing cerebrovascular functional reserve by imaging photoplethysmography

Oleg V. Mamontov et al.

SCIENTIFIC REPORTS (2020)

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Review Endocrinology & Metabolism

Cerebral hemodynamics in the different phases of migraine and cluster headache

Jakob M. Hansen et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2019)

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Article Endocrinology & Metabolism

Targeting the central projection of the dural trigeminovascular system for migraine prophylaxis

Simon Akerman et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2019)

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Review Endocrinology & Metabolism

Neurovascular mechanisms of migraine and cluster headache

Jan Hoffmann et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2019)

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Review Clinical Neurology

Current understanding of meningeal and cerebral vascular function underlying migraine headache

Dan Levy et al.

CEPHALALGIA (2019)

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Review Neurosciences

Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back

Chiara Demartini et al.

PROGRESS IN NEUROBIOLOGY (2019)

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Article Surgery

Sumatriptan Increases Skin Flap Survival through Activation of 5-Hydroxytryptamine 1b/1d Receptors in Rats: The Mediating Role of the Nitric Oxide Pathway

Amir Dehdashtian et al.

PLASTIC AND RECONSTRUCTIVE SURGERY (2019)

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Article Immunology

Sumatriptan protects against myocardial ischaemia-reperfusion injury by inhibition of inflammation in rat model

Mohammad Sheibani et al.

INFLAMMOPHARMACOLOGY (2019)

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Review Clinical Neurology

Migraine and the trigeminovascular system-40 years and counting

Messoud Ashina et al.

LANCET NEUROLOGY (2019)

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Article Medicine, Research & Experimental

Inhibition of ovalbumin-induced allergic rhinitis by sumatriptan through the nitric oxide pathway in mice

Sara Hemmati et al.

LIFE SCIENCES (2019)

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Article Neurosciences

Contactless Assessment of Cerebral Autoregulation by Photoplethysmographic Imaging at Green Illumination

Olga A. Lyubashina et al.

FRONTIERS IN NEUROSCIENCE (2019)

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Article Clinical Neurology

Meningeal contribution to migraine pain: a magnetic resonance angiography study

Sabrina Khan et al.

BRAIN (2019)

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Review Biochemistry & Molecular Biology

Side effects associated with current and prospective antimigraine pharmacotherapies

Abimael Gonzalez-Hernandez et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2018)

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Article Pharmacology & Pharmacy

Pharmacological evidence of involvement of nitric oxide pathway in anti-pruritic effects of sumatriptan in chloroquine-induced scratching in mice

Nazgol-Sadat Haddadi et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2018)

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Article Clinical Neurology

Dural and pial pain-sensitive structures in humans: new inputs from awake craniotomies

Denys Fontaine et al.

BRAIN (2018)

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Article Clinical Neurology

Chronic and intermittent administration of systemic nitroglycerin in the rat induces an increase in the gene expression of CGRP in central areas: potential contribution to pain processing

Rosaria Greco et al.

JOURNAL OF HEADACHE AND PAIN (2018)

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Review Neurosciences

Vascular Contributions to Migraine: Time to Revisit?

Bianca N. Mason et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

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Article Multidisciplinary Sciences

Alterations of blood pulsations parameters in carotid basin due to body position change

Alexei A. Kamshilin et al.

SCIENTIFIC REPORTS (2018)

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Review Clinical Neurology

Triptans and CGRP blockade - impact on the cranial vasculature

Silvia Benemei et al.

JOURNAL OF HEADACHE AND PAIN (2017)

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Article Engineering, Biomedical

Ballistocardiographic Artifacts in PPG Imaging

Andreia Vieira Moco et al.

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING (2016)

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Article Biochemical Research Methods

Influence of polarization filtration on the information readout from pulsating blood vessels

Igor S. Sidorov et al.

BIOMEDICAL OPTICS EXPRESS (2016)

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Article Multidisciplinary Sciences

A new look at the essence of the imaging photoplethysmography

Alexei A. Kamshilin et al.

SCIENTIFIC REPORTS (2015)

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Article Multidisciplinary Sciences

Opposite Reactivity of Meningeal versus Cortical Microvessels to the Nitric Oxide Donor Glyceryl Trinitrate Evaluated In Vivo with Two-Photon Imaging

Evgeny Pryazhnikov et al.

PLOS ONE (2014)

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Review Biochemistry & Molecular Biology

Sumatriptan: a review of its pharmacokinetics, pharmacodynamics and efficacy in the acute treatment of migraine

Peer Tfelt-Hansen et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2013)

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Article Neurosciences

Pituitary adenylate cyclase-activating polypeptide plays a key role in nitroglycerol-induced trigeminovascular activation in mice

Adrienn Markovics et al.

NEUROBIOLOGY OF DISEASE (2012)

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Article Clinical Neurology

Temporal profile of vascular changes induced by systemic nitroglycerin in the meningeal and cortical districts

Rosaria Greco et al.

CEPHALALGIA (2011)

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Article Radiology, Nuclear Medicine & Medical Imaging

Pharmacological Modulation of the BOLD Response: A Study of Acetazolamide and Glyceryl Trinitrate in Humans

Mohammad S. Asghar et al.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2011)

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Review Anesthesiology

Utility of the photoplethysmogram in circulatory monitoring

Andrew Reisner et al.

ANESTHESIOLOGY (2008)

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Article Clinical Neurology

Intravenous valproate aborts glyceryl trinitrate-induced migraine attacks: a clinical and quantitative EEG study

T. Thomaides et al.

CEPHALALGIA (2008)

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Article Clinical Neurology

Role of KATP channels in cephalic vasodilatation induced by calcitonin gene-related peptide, nitric oxide, and transcranial electrical stimulation in the rat

Aydin Gozalov et al.

HEADACHE (2008)

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Article Clinical Neurology

Role of BKCa channels in cephalic vasodilation induced by CGRP, NO and transcranial electrical stimulation in the rat

A. Gozalov et al.

CEPHALALGIA (2007)

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Article Pharmacology & Pharmacy

Effects of current and prospective antimigraine drugs on the porcine isolated meningeal artery

Suneet Mehrotra et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2006)

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Article Medicine, Research & Experimental

Triptan-induced contractile (5-HT1B receptor) responses in human cerebral and coronary arteries:: relationship to clinical effect

L Edvinsson et al.

CLINICAL SCIENCE (2005)

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Article Clinical Neurology

Sumatriptan causes parallel decrease in plasma calcitonin gene-related peptide (CGRP) concentration and migraine headache during nitroglycerin induced migraine attack

G Juhasz et al.

CEPHALALGIA (2005)

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Article Clinical Neurology

The prophylactic effect of valproate on glyceryltrinitrate induced migraine

JF Tvedskov et al.

CEPHALALGIA (2004)

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Review Clinical Neurology

Coronary vasoconstrictor potential of triptans: A review of in vitro pharmacologic data

A MaassenVanDenBrink et al.

HEADACHE (2004)

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Article Physiology

Endothelium-dependent relaxant responses to selective 5-HT1B/1D receptor agonists in the isolated middle cerebral artery of the rat

J Hansen-Schwartz et al.

JOURNAL OF VASCULAR RESEARCH (2003)

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Article Clinical Neurology

Transcranial Doppler in migraine attacks before and after treatment with oral zolmitriptan or sumatriptan

T Thomaides et al.

HEADACHE (2003)

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Article Clinical Neurology

Brain blood flow in the nitroglycerin (GTN) model of migraine: measurement using positron emission tomography and transcranial Doppler

EM Bednarczyk et al.

CEPHALALGIA (2002)

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Article Neurosciences

Effect of serotonin depletion on nitric oxide induced cerebrovascular nociceptive response

A Srikiatkhachorn et al.

NEUROREPORT (2001)

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Article Pharmacology & Pharmacy

Sumatriptan elicits both constriction and dilation in human and bovine brain intracortical arterioles

A Elhusseiny et al.

BRITISH JOURNAL OF PHARMACOLOGY (2001)

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Duality in response of intracranial vessels to nitroglycerin revealed in rats by imaging photoplethysmography

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