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The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment

NUTRIENTS (2023)

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Summary: This study found that hyperhomocysteinemia exacerbates post-stroke depression in rats by affecting synaptic plasticity through decreased synapse numbers, decreased postsynaptic density area, and reduced expression of synaptic transmission-associated proteins. Additionally, N-methyl-D-aspartate receptors (NMDARs) play a critical role in this process.

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NUTRIENTS (2023)

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Maternal Hyperhomocysteinemia Produces Memory Deficits Associated with Impairment of Long-Term Synaptic Plasticity in Young Rats

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Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial

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Summary: Functional brain connectivity (FBC) is a sensitive biomarker for monitoring dementia progression. This study investigated the association between FBC and frailty in individuals at higher risk of dementia. The results showed that increasing frailty was associated with stronger connectivity between regions not typically linked, and this relationship differed by sex. These findings may provide insights into the progression of dementia.

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The combination of hyperventilation test and graph theory parameters to characterize EEG changes in mild cognitive impairment (MCI) condition

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Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)-induced chemobrain

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NUTRIENTS (2023)

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Unprocessed Red Meat and Processed Meat Consumption, Plasma Metabolome, and Risk of Ischemic Heart Disease: A Prospective Cohort Study of UK Biobank

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Summary: Protein dyshomeostasis plays a key role in age-related neurodegenerative disorders, such as Parkinson's disease, characterized by the deposition of Lewy bodies composed of alpha-synuclein protein aggregates. The proper functioning of proteostasis, including unfolded protein response, ubiquitin-proteasome system, and autophagy-lysosome pathway, is crucial for protein synthesis, folding, confirmation, and degradation. Mutational changes in the genes involved in these pathways, as well as epigenetic modifications and microRNA-mediated transcriptional changes, contribute to proteostasis dysregulation. Defective proteostasis leads to the deposition of proteins, which can serve as potential biomarkers for early diagnosis of Parkinson's disease. Targeting different aspects of proteostasis machinery holds promise for delaying the accumulation of pathological hallmarks.

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Hypertension and hyperhomocysteinemia as modifiable risk factors for Alzheimer's disease and dementia: New evidence, potential therapeutic strategies, and biomarkers

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Measurements of cerebral microvascular blood flow, oxygenation, and morphology in a mouse model of whole-brain irradiation-induced cognitive impairment by two-photon microscopy and optical coherence tomography: evidence for microvascular injury in the cerebral white matter

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Hippocampal vulnerability to hyperhomocysteinemia worsens pathological outcomes of mild traumatic brain injury in rats

Flaubert Tchantchou et al.

Summary: This study aimed to assess the deleterious impact of hyperhomocysteinemia (HHCY) on mild traumatic brain injury (mTBI)-associated hippocampal pathological changes. The results showed that moderate HHCY exacerbates mTBI-induced hippocampal pathological changes, including increased oxidative stress and working memory deficits. These findings suggest that HHCY is an epigenetic factor that modulates the pathological progression of mTBI in the hippocampus and represents a potential therapeutic target for mitigating disease severity.

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Hyperhomocysteinemia Increases Vascular Risk in Stroke Patients with Chronic Kidney Disease

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Atorvastatin rescues hyperhomocysteinemia-induced cognitive deficits and neuroinflammatory gene changes

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Cardiology in Review (2023)

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Alzheimer's Disease Genetic Influences Impact the Associations between Diet and Resting-State Functional Connectivity: A Study from the UK Biobank

Tianqi Li et al.

Summary: This study explores the association between red wine and dairy intake and brain network activity using functional magnetic resonance imaging (fMRI) data. The results show that red wine consumption is positively correlated with connectivity in the central executive function network and posterior default mode network, while milk intake is negatively correlated with connectivity in the left executive function network and posterior default mode network. These associations are influenced by genetic factors and family history.

NUTRIENTS (2023)

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Alzheimer's Disease-like Pathological Features in the Dorsal Hippocampus of Wild-Type Rats Subjected to Methionine-Diet-Evoked Mild Hyperhomocysteinaemia

Maria Kovalska et al.

Summary: This study investigates the effects of a high methionine diet on metabolic ratio and histomorphological alterations in the rat hippocampus. The results show that high methionine diet-induced hyperhomocysteinemia leads to significant changes in metabolism and tissue morphology in the hippocampus. These changes may contribute to the progression of neurodegeneration and the development of Alzheimer's disease-like pathological features.

CELLS (2023)

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Age- and gender-related dispersion of brain networks across the lifespan

Qing Wang et al.

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GEROSCIENCE (2023)

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Article Geriatrics & Gerontology

Resting-state fractal brain connectivity is associated with impaired cognitive performance in healthy aging

Akos Czoch et al.

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GEROSCIENCE (2023)

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Article Geriatrics & Gerontology

Prediction of cognitive performance differences in older age from multimodal neuroimaging data

Camilla Kraemer et al.

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Article Geriatrics & Gerontology

Combining exercise with cognitive training and vitamin D-3 to improve functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI). Results from the SYNERGIC trial

Nick W. Bray et al.

Summary: Changes in functional brain connectivity (FBC) can indicate the efficacy of lifestyle modifications in preventing dementia progression. In participants with mild cognitive impairment (MCI), FBC is altered and can be improved through physical exercise, cognitive training, and vitamin D-3 supplementation. However, the correlation between FBC change and changes in cognitive and physical function remains unclear.

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Article Geriatrics & Gerontology

Dorsal and ventral fronto-amygdala networks underlie risky decision-making in age-related cognitive decline

Ping Ren et al.

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GEROSCIENCE (2023)

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Article Geriatrics & Gerontology

Effects of Vitamin D on Physical Function: Results From the STURDY Trial

Jack M. Guralnik et al.

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DNA Damage in Circulating Hematopoietic Progenitor Stem Cells as Promising Biological Sensor of Frailty

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Summary: Frailty is an age-related syndrome that increases vulnerability and often leads to negative outcomes, including mortality. The mechanisms behind frailty are still unclear, but oxidative stress and DNA damage are believed to play a significant role. Early diagnosis and targeted treatments could potentially slow down the progression of frailty.

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Association Between Mediterranean Diet and Functional Status in Older Adults: A Longitudinal Study Based on the Washington Heights-Inwood Columbia Aging Project

Jing Guo et al.

Summary: The study found an association between Mediterranean diet intake and activities of daily living in older adults. Higher Mediterranean diet scores were associated with a decreased risk of ADL disability.

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Cerebral venous congestion exacerbates cerebral microhemorrhages in mice

Adam Nyul-Toth et al.

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GEROSCIENCE (2022)

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Article Geriatrics & Gerontology

Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling

Tamas Kiss et al.

Summary: Vascular aging plays a central role in the development of cardiovascular diseases, leading to increased mortality in older adults. Both cell-autonomous and cell-nonautonomous mechanisms contribute to the regulation of vascular aging processes. Recent studies have shown that circulating anti-geronic factors from young blood can promote vascular rejuvenation in aged mice. This study further investigated the role of circulating pro-geronic factors in the development of vascular aging phenotypes. The findings suggest that old blood can accelerate vascular aging processes, contributing to pathological vascular remodeling mediated by specific transcriptional regulators.

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Effects of task prioritization on a postural-motor task in early-stage Parkinson's disease: EEG connectivity and clinical implication

Cheng-Ya Huang et al.

Summary: Appropriate attentional resource allocation can minimize exaggerated dual-task interference in Parkinson's disease. This study used electroencephalography (EEG) functional connectivity to investigate the effects of task prioritization on dual-task performance and cortical reorganization in early-stage PD patients.

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Cingulo-opercular and frontoparietal control network connectivity and executive functioning in older adults

Hanna K. Hausman et al.

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GEROSCIENCE (2022)

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Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain

Tamas Kiss et al.

Summary: There is strong evidence that aging is associated with an increased presence of senescent cells in the brain. Using spatial transcriptomics analysis, researchers found that senescent cells accumulate in the white matter, hippocampi, and cortical grey matter of aged mice, potentially contributing to neuroinflammation.

GEROSCIENCE (2022)

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Pleiotropic predisposition to Alzheimer's disease and educational attainment: insights from the summary statistics analysis

Alexander M. Kulminski et al.

Summary: Epidemiological studies show beneficial associations between higher educational attainment and Alzheimer's disease, suggesting a potential protective effect of education against AD. Through pleiotropic analysis, multiple genes were found to have complex effects on both AD and EDU, with a significant impact from antagonistic genetic heterogeneity.

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Mediterranean Diet and Changes in Frequency, Severity, and Localization of Pain in Older Adults: The Seniors-ENRICA Cohorts

Rosario Ortola et al.

Summary: The study found that higher adherence to the Mediterranean diet was associated with improvements in pain characteristics in older adults, indicating that improving diet quality may help reduce the health impact of pain.

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Microvascular dysfunction and neurovascular uncoupling are exacerbated in peripheral artery disease, increasing the risk of cognitive decline in older adults

Cameron D. Owens et al.

Summary: Peripheral artery disease (PAD) is associated with cognitive decline, which may be due to microvascular endothelial dysfunction and neurovascular uncoupling.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2022)

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Red meat consumption and all-cause and cardiovascular mortality: results from the UK Biobank study

Mengying Wang et al.

Summary: High red meat consumption was found to be associated with increased risks of cardiovascular diseases, coronary heart disease, and stroke mortality, but not all-cause mortality. The associations between red meat consumption and mortality were not modified by dietary, lifestyle, and genetic risk factors. Replacing red meat with poultry or cereal was associated with lower risks of cardiovascular diseases and coronary heart disease mortality.

EUROPEAN JOURNAL OF NUTRITION (2022)

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Article Food Science & Technology

Epigenetic changes induced in mice liver by methionine-supplemented and methionine-deficient diets

Alexandre Ferro Aissa et al.

Summary: A diet deficient in donors of methyl group, such as methionine, affects DNA methylation, hepatic lipid metabolism, and other epigenetic mechanisms. This study investigated the effects of methionine-supplemented or methionine-deficient diets on chromatin-modifying genes, global DNA methylation, genes related to lipid metabolism, and microRNAs in mouse liver. Both diets altered gene expression, global DNA methylation, and microRNA expression, with the methionine-deficient diet having a more substantial effect.

FOOD AND CHEMICAL TOXICOLOGY (2022)

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Review Biochemistry & Molecular Biology

Blood-Brain Barrier Dysfunction and Astrocyte Senescence as Reciprocal Drivers of Neuropathology in Aging

Marcela K. Preininger et al.

Summary: As the most abundant cell type in the brain, astrocytes play essential roles in maintaining brain homeostasis, regulating immune response, and protecting the blood-brain barrier. However, dysfunction of astrocytes is closely associated with age-related neuropathology and neurodegenerative diseases. This review discusses two mechanisms by which astrocytes mediate neuropathology in the aging brain – age-associated blood-brain barrier dysfunction and senescence-induced neuroinflammation. Understanding the relationship between these mechanisms and astrocytes is crucial for exploring the aging process and neurodegenerative diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Vigorous Physical Activity and Cognitive Trajectory Later in Life: Prospective Association and Interaction by Apolipoprotein E e4 in the Nurses' Health Study

Philippine Fassier et al.

Summary: Vigorous physical activity is associated with better cognitive trajectories in older women, with stronger effects observed among APOE-e4 carriers.

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Article Geriatrics & Gerontology

Longitudinal Relation Between Structural Network Efficiency, Cognition, and Gait in Cerebral Small Vessel Disease

Mengfei Cai et al.

Summary: The disruption of the white matter structural network is associated with gait decline in older patients with cerebral small vessel disease (SVD), while cognitive decline does not have a significant effect.

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Association of Epigenetic Age Acceleration With Incident Mild Cognitive Impairment and Dementia Among Older Women

Aladdin H. Shadyab et al.

Summary: The study examined the association between epigenetic age acceleration and cognitive impairment, finding that intrinsic AgeAccel was not significantly associated with cognitive impairment overall, but was associated with impairment among women who developed coronary heart disease.

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Disease Burden Affects Aging Brain Function

Lori L. Beason-Held et al.

Summary: This study found that a higher number of chronic diseases is associated with changes in brain activity, indicating a link between health condition and aging brain function.

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Association of Markers of Inflammation, the Kynurenine Pathway and B Vitamins with Age and Mortality, and a Signature of Inflammaging

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Summary: Inflammation is a key feature of aging, and this study investigated the association of 34 blood markers with inflammatory processes, age, and mortality. The research developed a signature of inflammaging based on 10 markers, which was strongly associated with mortality, demonstrating its predictive power.

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Frailty Is Associated With Cognitive Decline Independent of Cerebral Small Vessel Disease and Brain Atrophy

Timothy P. Siejka et al.

Summary: This study examined the effect of frailty on cognitive decline and found that frailty is associated with early cognitive dysfunction. Measuring frailty may help identify the risk of cognitive decline.

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Review Geriatrics & Gerontology

Potential Regulators of the Senescence-Associated Secretory Phenotype During Senescence and Aging

Xiaojuan Han et al.

Summary: Senescent cells can express and secrete a variety of factors known as SASP, which have dual effects. SASP can reinforce cell cycle arrest and stimulate immune cells to clear abnormal cells, but it can also lead to inflammation and promote the growth of tumor cells.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2022)

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Article Geriatrics & Gerontology

Association Between Homocysteine, Frailty and Biomechanical Response of the CNS in NPH-Suspected Patients

Sophie Guillotin et al.

Summary: Frailty is a geriatric syndrome associated with alterations in the central nervous system's biomechanical response. This study found that homocysteine level is independently and positively associated with both the frailty index and the CNS elastance coefficient. Creatinine clearance and folate level were also independently associated with homocysteine level.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2022)

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Article Geriatrics & Gerontology

Higher-order resting state network association with the useful field of view task in older adults

Cheshire Hardcastle et al.

Summary: The connectivity of the cingulo-opercular network is associated with visual speed-of-processing and divided attention subcomponents of the Double Decision task, and stronger connectivity is related to better performance. This study confirms the unique role of the cingulo-opercular network in visual attention and sustained divided attention.

GEROSCIENCE (2022)

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Article Geriatrics & Gerontology

Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain

Gavin Yong-Quan Ng et al.

Summary: Intermittent fasting can modulate H3K9 trimethylation in the cerebellum and trigger transcriptomic changes associated with metabolic processes. Part of the epigenomic and transcriptomic modulations induced by IF can be preserved for at least 3 months post-IF, but termination of IF results in a loss of H3K9 trimethylation regulation of the transcriptome.

GEROSCIENCE (2022)

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Article Geriatrics & Gerontology

HIV, pathology and epigenetic age acceleration in different human tissues

Steve Horvath et al.

Summary: Epigenetic clocks based on DNA methylation patterns are important for understanding aging and disease, but there are basic questions to be resolved in their application. This study investigates the correlation of epigenetic age acceleration (EAA) between different tissues within an individual, the association of tissue pathology and clinical illness with EAA in the target organ, and the differences in EAA variability across tissues according to sex. The findings indicate that epigenetic age is moderately correlated across tissues, with blood showing the strongest correlation with spleen and bone marrow. However, blood does not correlate with liver epigenetic age. Clinically, hypertension and HIV infection are associated with EAA in different tissues, and male sex is associated with increased epigenetic acceleration in several tissues. Furthermore, greater multimorbidity is associated with higher EAA across all tissues.

GEROSCIENCE (2022)

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Article Geriatrics & Gerontology

Telomere length and epigenetic clocks as markers of cellular aging: a comparative study

Emily E. Pearce et al.

Summary: The relationship between telomere length and epigenetic clocks is limited to clocks reflecting phenotypic age. Telomere length shows significant associations with external epigenetic age acceleration, but not with intrinsic epigenetic age acceleration. Incorporating both telomere length and epigenetic clocks measurements may provide valuable insights into disease etiology and prognosis.

GEROSCIENCE (2022)

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Article Geriatrics & Gerontology

Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume

Lidija Milicic et al.

Summary: This study comprehensively investigated the relationship between five recognized measures of age acceleration based on DNA methylation patterns and cognition as well as AD-related neuroimaging phenotypes. Significant associations were observed between age acceleration and hippocampal volume, but not with other Alzheimer's disease-related phenotypes.

GEROSCIENCE (2022)

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Article Geriatrics & Gerontology

Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary

Jessica D. Hense et al.

Summary: Senescent cells accumulate in the ovaries of obese mice but can be reduced by treatment with senolytic drugs. However, neither obesity nor drug treatment affects the ovarian reserve.

GEROSCIENCE (2022)

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Article Geriatrics & Gerontology

Accelerated epigenetic aging and inflammatory/immunological profile (ipAGE) in patients with chronic kidney disease

Igor Yusipov et al.

Summary: This study found an accelerated aging phenotype in patients with chronic kidney disease (CKD), and the underlying inflammatory processes were better quantified by the inflammatory/immunological profile (ipAGE) than by epigenetic clocks.

GEROSCIENCE (2022)

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Article Geriatrics & Gerontology

Senolytic treatment rescues blunted muscle hypertrophy in old mice

Cory M. Dungan et al.

Summary: With aging, the ability of skeletal muscle to adapt to exercise decreases. Senescent cells, which are rarely present in resting muscle, emerge in response to resistance exercise. These cells may contribute to the blunted hypertrophic potential in old age.

GEROSCIENCE (2022)

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Article Geriatrics & Gerontology

Vitamin D supplementation is associated with slower epigenetic aging

Valentin Max Vetter et al.

Summary: Findings suggest that vitamin D supplementation may lead to lower DNAmAA in participants with pre-existing vitamin D deficiency.

GEROSCIENCE (2022)

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Editorial Material Geriatrics & Gerontology

From 1901 to 2022, how far are we from truly understanding the pathogenesis of age-related dementia?

Xing Fang et al.

Summary: From the first described AD case in 1901 to the current year 2022, research on the pathogenesis of Alzheimer's disease (AD) and dementia has come a long way. However, current medications and treatments have not been able to cure AD and AD-related dementias (AD/ADRD). Recent studies have identified neurovascular dysfunction and brain hypoperfusion as potential causal factors in the development of AD dementia. Different animal models and approaches used in studies may provide conflicting information, and it is important to critically analyze the available data. The use of aducanumab as a treatment for AD/ADRD and the development of new drugs targeting cerebral vascular pathways offer hope for improved outcomes.

GEROSCIENCE (2022)

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Review Geriatrics & Gerontology

Role of inflammatory markers in the diagnosis of vascular contributions to cognitive impairment and dementia: a systematic review and meta-analysis

Carlo Custodero et al.

Summary: This meta-analysis finds that there are differences in IL-6 levels between VaD and AD patients, suggesting IL-6 as a potential biomarker for differential diagnosis. Higher blood IL-6 levels may also be associated with an increased risk of future VaD.

GEROSCIENCE (2022)

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Article Geriatrics & Gerontology

Brain cellular senescence in mouse models of Alzheimer's disease

Angela O. Dorigatti et al.

Summary: This study aimed to identify mouse models of Alzheimer's disease (AD) and AD-related dementias that develop measurable markers of cellular senescence in the brain. The researchers found that P301S(PS19) and hTau mice may be useful models for studying brain cellular senescence in tauopathies, including AD.

GEROSCIENCE (2022)

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Article Geriatrics & Gerontology

Functional and transcriptional profiling of microglial activation during the chronic phase of TBI identifies an age-related driver of poor outcome in old mice

Rodney M. Ritzel et al.

Summary: Elderly patients with TBI have higher mortality and poorer outcomes. This study found that aged mice with TBI exhibited increased inflammation and microglial activation. Enhancing autophagy pathways improved functional recovery and reduced microglial activation in aged mice.

GEROSCIENCE (2022)

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Article Geriatrics & Gerontology

Association of cerebral microvascular dysfunction and white matter injury in Alzheimer's disease

Zsolt Bagi et al.

Summary: Patients with Alzheimer's disease often show dysfunction in vasodilation of white matter-penetrating arterioles, which is associated with white matter injury and disrupted white matter microstructural integrity. This dysfunction may be related to reduced nitric oxide levels and excess reactive oxygen species-mediated vascular endothelial dysfunction.

GEROSCIENCE (2022)

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Article Geriatrics & Gerontology

Analysis of complexity in the EEG activity of Parkinson's disease patients by means of approximate entropy

Chiara Pappalettera et al.

Summary: The objective of this study was to explore the differences in brain resting state between Parkinson's disease patients and healthy controls in terms of complexity of EEG signals. The results showed that Parkinson's disease patients had higher complexity in their EEG signals, indicating a remarkable modification of brain complexity and organization. Applying nonlinear approaches to EEG analysis could potentially be a useful tool in diagnosing and monitoring the progression of Parkinson's disease, as well as designing personalized rehabilitation programs.

GEROSCIENCE (2022)

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Article Geriatrics & Gerontology

Imaging subtle leaks in the blood-brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions

Axel Montagne et al.

Summary: Recent studies have found subtle blood-brain barrier leaks in the human brain during normal aging, age-related cognitive dysfunction, genetic risk for Alzheimer's disease, mild cognitive impairment, early Alzheimer's disease, cerebral small vessel disease, and other neurodegenerative disorders using dynamic contrast-enhanced magnetic resonance imaging. The quantified leaks are typically much lower than those in brain tumors, stroke, and multiple sclerosis relapses. The challenges lie in improving the detectability, reliability, and reproducibility of the technique, as well as standardizing and harmonizing data between different scanners.

GEROSCIENCE (2022)

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Article Biochemistry & Molecular Biology

Nitrosative stress induced by homocysteine thiolactone drives vascular cognitive impairments via GTP cyclohydrolase 1 S-nitrosylation in vivo

Ya -Ling Yin et al.

Summary: This study demonstrates that HHcy induces GCH1 protein S-nitrosylation, leading to cerebral vascular stiffness and cognitive impairments.

REDOX BIOLOGY (2022)

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Article Geriatrics & Gerontology

Genetic Association Between Epigenetic Aging-Acceleration and the Progression of Mild Cognitive Impairment to Alzheimer's Disease

Hongliang Liu et al.

Summary: This study investigated the association between genetic variations associated with aging acceleration and the progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD). The results showed genetic correlations between epigenetic age acceleration (IEAA/EEAA) and AD, and identified multiple SNPs associated with the progression from MCI to AD.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2022)

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Article Geriatrics & Gerontology

Inflammation and Epigenetic Aging Are Largely Independent Markers of Biological Aging and Mortality

Lachlan Cribb et al.

Summary: Limited evidence exists on the link between inflammation and epigenetic aging. This study found that most inflammation-related markers were associated with epigenetic aging cross-sectionally, but the association weakened after 11 years of follow-up. Epigenetic aging and inflammaging were both independently associated with mortality and can be used together to predict mortality.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2022)

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Article Geriatrics & Gerontology

Epigenome-wide Association Study Analysis of Calorie Restriction in Humans, CALERIE™ Trial Analysis

Megan E. Ramaker et al.

Summary: Calorie restriction has been shown to increase healthy lifespan and slow down aging-associated DNA methylation changes. A study conducted in humans found that calorie restriction can alter age-related DNA methylation patterns but no significant changes were observed at individual CpG sites.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2022)

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Article Geriatrics & Gerontology

Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study

Roger A. Fielding et al.

Summary: Cellular senescence is associated with age-related declines in physical performance, and senescence biomarkers are significantly correlated with physical function and muscle strength in older adults.

GEROSCIENCE (2022)

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Article Geriatrics & Gerontology

Aging results in DNA damage and telomere dysfunction that is greater in endothelial versus vascular smooth muscle cells and is exacerbated in atheroprone regions

Samuel Bloom et al.

Summary: Aging leads to DNA damage and telomere dysfunction in both endothelial cells and vascular smooth muscle cells; however, the effects are more pronounced in endothelial cells and atheroprone arterial regions.

GEROSCIENCE (2022)

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Article Geriatrics & Gerontology

Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment

Jordan Williamson et al.

Summary: Research shows that females are more impacted by mild cognitive impairment (MCI) and experience greater cognitive deterioration than males in the same disease stage. These sex differences are linked to neuroimaging markers of brain pathology, such as hippocampal volumes. This study found that males have stronger connectivity between the hippocampus and the precuneus cortex and brain stem compared to females.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Article Multidisciplinary Sciences

Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer's-like pathology in mouse and fly APP overexpression models

E. Sandra Chocron et al.

Summary: The proteasome plays a key role in neuronal proteostasis and its dysfunction is associated with Alzheimer's disease. Preventing proteasome dysfunction delays mortality, cell death, and cognitive deficits in AD models. Activating proteasome activity through peptidomimetics protects against cell death, cognitive decline, and mortality in AD models.

SCIENCE ADVANCES (2022)

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Article Geriatrics & Gerontology

Which components of the Mediterranean diet are associated with dementia? A UK Biobank cohort study

Ivelina Dobreva et al.

Summary: Cohort studies have shown that the Mediterranean diet is associated with better cognitive function, slower cognitive decline, and lower risk of dementia in older adults. This study aimed to investigate the individual contributions of different components of the Mediterranean diet to dementia risk. The results showed that moderate fish consumption (2.0-3.9 times per week) and fruit consumption (1.0-1.9 servings per day) were associated with a decreased risk of dementia. No other components of the Mediterranean diet were found to be associated with dementia risk. Further research is needed to understand the mechanisms behind these findings and to explore diet-based interventions for dementia prevention.

GEROSCIENCE (2022)

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Article Geriatrics & Gerontology

DNA methylation trajectories and accelerated epigenetic aging in incident type 2 diabetes

Eliza Fraszczyk et al.

Summary: This study found differences in DNAm levels between type 2 diabetes patients and non-patients, and the case group exhibited accelerated epigenetic aging. These findings are significant for predicting age-related diseases, including type 2 diabetes.

GEROSCIENCE (2022)

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Article Geriatrics & Gerontology

Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults

Luca Toth et al.

Summary: Impairment of neurovascular coupling (NVC) contributes to age-related cognitive decline, and this impairment is associated with decreases in circulating insulin-like growth factor-1 (IGF-1) levels. This study found that age-related declines in IGF-1 levels predicted the magnitude of age-related decline in NVC responses, indicating that circulating IGF-1 deficiency contributes to neurovascular aging.

GEROSCIENCE (2022)

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Article Neurosciences

Homocysteine Modulates Brain Functional Connectivity in a Memory Retrieval Task

Richard B. Silberstein et al.

Summary: This study found a significant correlation between plasma homocysteine levels and brain functional connectivity in the early stages of cognitive decline, specifically in individuals with homocysteine concentrations above 11 μmol/L.

JOURNAL OF ALZHEIMERS DISEASE (2022)

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Article Neurosciences

Serum Homocysteine, Vitamin B12, Folate, and Their Association with Mild Cognitive Impairment and Subtypes of Dementia

Yang Song et al.

Summary: This study investigates the changes of homocysteine, vitamin B12, and folate levels in different subtypes of dementia and their associations with cognitive function and MRI markers. The results show that elevated homocysteine levels and lower vitamin B12 levels are associated with various types of dementia. Homocysteine levels are correlated with temporal lobe atrophy in Alzheimer's disease, while vitamin B12 levels are associated with general cognition in vascular dementia. Hyperhomocysteinemia may increase the risk of Alzheimer's disease, vascular dementia, and frontotemporal dementia.

JOURNAL OF ALZHEIMERS DISEASE (2022)

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Article Neurosciences

Circulating Amyloid-β and Methionine-Related Metabolites to Predict the Risk of Mild Cognitive Impairment: A Nested Case-Control Study

Jingzhu Fu et al.

Summary: This study presents an individualized prediction nomogram based on easily accessible blood biomarkers for the identification and prediction of MCI risk in older adults.

JOURNAL OF ALZHEIMERS DISEASE (2022)

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Review Oncology

Science-Driven Nutritional Interventions for the Prevention and Treatment of Cancer

Lea Montegut et al.

Summary: In population studies, dietary patterns have an impact on cancer development, progression, and therapeutic response. However, interventional dietary trials have had limited effect on cancer prevention and treatment. Standardization of nutritional interventions combined with high-level mode-of-action studies has the potential to identify specific entities and pathways with anti-cancer properties.

CANCER DISCOVERY (2022)

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Article Nutrition & Dietetics

Methionine Restriction Improves Cognitive Ability by Alleviating Hippocampal Neuronal Apoptosis through H19 in Middle-Aged Insulin-Resistant Mice

Chuanxing Feng et al.

Summary: The study showed that methionine restriction can protect hippocampal neurons in middle-aged mice from damage and apoptosis induced by a high-fat diet by inhibiting the overexpression of LncRNA H19, thereby improving cognitive ability.

NUTRIENTS (2022)

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Article Multidisciplinary Sciences

Diet moderates the effect of resting state functional connectivity on cognitive function

Alexandra M. Gaynor et al.

Summary: Past research has shown that lifestyle factors can affect brain health and cognitive performance. The current study investigated the impact of Mediterranean diet on the functional connectivity between brain networks and cognitive function. The results suggest that a healthy diet may support cognitive ability, despite differences in network connectivity.

SCIENTIFIC REPORTS (2022)

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Editorial Material Geriatrics & Gerontology

Editorial: New developments in understanding brain and cerebromicrovascular aging: Toward prevention of vascular cognitive impairment and Alzheimer's disease

Madison Sanford et al.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Article Geriatrics & Gerontology

Increased pulse wave velocity is related to impaired working memory and executive function in older adults with metabolic syndrome

Jigar Gosalia et al.

Summary: Age-related vascular alterations contribute to the development of vascular cognitive impairment (VCI). Metabolic syndrome (MetS) exacerbates cognitive impairment, and arterial stiffening moderates the association between cognitive dysfunction and MetS in older adults.

GEROSCIENCE (2022)

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Article Health Care Sciences & Services

Effects of omega-3 supplementation on quality of life, nutritional status, inflammatory parameters, lipid profile, exercise tolerance and inhaled medications in chronic obstructive pulmonary disease

Monika Fekete et al.

Summary: This study aimed to monitor omega-3 supplementation in COPD patients and evaluate its impact on quality of life, nutritional status, inflammatory parameters, lipid profile, comorbidities, exercise tolerance, and inhaled medications. The study found that omega-3 intake in COPD patients is insufficient, and omega-3 supplementation is associated with lower inflammatory markers, more favorable lipid profile, better quality of life, and fewer exacerbations.

ANNALS OF PALLIATIVE MEDICINE (2022)

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Review Biochemistry & Molecular Biology

Homocysteine, Cognitive Functions, and Degenerative Dementias: State of the Art

Simona Luzzi et al.

Summary: There is strong evidence that homocysteine is a risk factor for both cerebrovascular diseases and degenerative dementias. However, the impact of homocysteine on specific cognitive functions and its relationship with non-Alzheimer dementias have been poorly investigated.

BIOMEDICINES (2022)

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Review Cardiac & Cardiovascular Systems

Red meat consumption and risk for dyslipidaemia and inflammation: A systematic review and meta-analysis

Le Sun et al.

Summary: This study analyzed 574 studies and found that the consumption of red meat increased serum triglyceride levels, but had little effect on total cholesterol, LDL-C, HDL-C, and CRP or hs-CRP.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Nutrition & Dietetics

Stroke mortality attributable to high red meat intake in China and South Korea: An age-period-cohort and joinpoint analysis

Fangyao Chen et al.

Summary: The high intake of red meat is recognized as a major health concern worldwide. This study analyzed the long-term trends of stroke mortality attributable to high red meat intake in China and South Korea, with significant gender differences observed.

FRONTIERS IN NUTRITION (2022)

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Article Geriatrics & Gerontology

Trends of Physical Functioning, Morbidity, and Disability-Free Life Expectancy Among the Oldest Old: Six Repeated Cross-Sectional Surveys Between 2001 and 2018 in the Vitality 90+Study

Linda Enroth et al.

Summary: The study found that over time, there were improvements in functioning and increased life expectancy without ADL or mobility disabilities among the population aged 90 and older. However, morbidity increased for men, while life expectancy without cardiovascular and dementia morbidity decreased for men and increased for women.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Article Geriatrics & Gerontology

Older Adults' Drop in Cerebral Oxygenation on Standing Correlates With Postural Instability and May Improve With Sitting Prior to Standing

Laura K. Fitzgibbon-Collins et al.

Summary: Impaired blood pressure recovery with orthostatic hypotension is common in older adults and is associated with low cerebral blood flow. This study found that posture-related reductions in cerebral tissue oxygenation can impact stability upon standing, and a brief sit before standing may improve oxygenation and stability. Older adults with lower tissue oxygenation and greater instability might have an increased risk of future falls.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Article Geriatrics & Gerontology

A New Concept in Diet Restriction Is Cleaning Up!

Daniel E. L. Promislow

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Article Pharmacology & Pharmacy

High-methionine diet in skeletal muscle remodeling: epigenetic mechanism of homocysteine-mediated growth retardation

Mahavir Singh et al.

Summary: This study focuses on the impact of 1-carbon metabolism and HHcy on growth retardation and muscle abnormalities, while also considering the potential role of gut dysbiosis in this process. The results suggest that individuals with mild to moderate HHcy may be more susceptible to muscle injury and dysfunction.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2021)

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Article Geriatrics & Gerontology

Increasing Life-Space Mobility in Community-Dwelling Older Persons With Cognitive Impairment Following Rehabilitation: A Randomized Controlled Trial

Phoebe Ullrich et al.

Summary: This study evaluated the effects of a home-based physical training and activity promotion program on life-space mobility in community-dwelling older persons with cognitive impairment. The intervention significantly improved life-space mobility and independent life space in the vulnerable population, but the effects were not sustained over the follow-up period.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Article Geriatrics & Gerontology

Associations of Plasma Folate and Vitamin B6 With Blood DNA Methylation Age: An Analysis of One-Carbon Metabolites in the VA Normative Aging Study

Jamaji C. Nwanaji-Enwerem et al.

Summary: The study investigated the relationships between one-carbon metabolites and DNA methylation age in human population, revealing that log vitamin B(6) was associated with PhenoAge, log folate was linked to GrimAge and PhenoAge, and the cumulative mixture of metabolites had an impact on GrimAge. Further research is needed to validate and generalize these findings.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Article Geriatrics & Gerontology

Treatment with a DC-SIGN ligand reduces macrophage polarization and diastolic dysfunction in the aging female but not male mouse hearts

JoAnn Trial et al.

Summary: Cardiac diastolic dysfunction in aging, characterized by increased ventricular stiffness due to inflammation and interstitial fibrosis, can be prevented from worsening over time in females by the anti-inflammatory agent DCSL1. The severity of diastolic dysfunction in aging female mice, associated with unique changes in macrophage polarization, can be mitigated by treatment with DCSL1. The findings suggest that the characteristics of diastolic dysfunction in aging female mice resemble similar changes in aging women.

GEROSCIENCE (2021)

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Review Cardiac & Cardiovascular Systems

Obesity-induced cognitive impairment in older adults: a microvascular perspective

Priya Balasubramanian et al.

Summary: Over two-thirds of individuals aged 65 and older in the United States are obese or overweight, with an association between adiposity and cognitive dysfunction. This review discusses the pathophysiological roles of microvascular mechanisms in cognitive impairment in geriatric obesity.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

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Article Nutrition & Dietetics

Association of red and processed meat consumption with cardiovascular morbidity and mortality in participants with and without obesity: A prospective cohort study

Jufen Zhang et al.

Summary: There is a positive association between red and processed meat consumption and increased risk of cardiovascular death, regardless of obesity status. The risk of ischemic heart disease associated with red and processed meat consumption may be higher in individuals without obesity. Further studies are needed to fully understand the mechanism of this association.

CLINICAL NUTRITION (2021)

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Article Geriatrics & Gerontology

Cognitive Processing Speed Is Strongly Related to Driving Skills, Financial Abilities, and Other Instrumental Activities of Daily Living in Persons With Mild Cognitive Impairment and Mild Dementia

Virginia G. Wadley et al.

Summary: The study found that cognitive processing speed is closely associated with daily function and mobility in persons with MCI, and is related to genetic and neuroimaging biomarkers of AD risk, emphasizing the importance of processing speed in everyday task performance among individuals with MCI/mild dementia.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Article Geriatrics & Gerontology

Biological and Neuroimaging Markers as Predictors of 5-Year Incident Frailty in Older Adults: A Secondary Analysis of the MAPT Study

Wan-Hsuan Lu et al.

Summary: This study aimed to investigate the predictive value of biological and neuroimaging markers in determining incident frailty among older adults over a period of 5 years. Although some markers like 25-hydroxyvitamin D deficiency, homocysteine levels, and neuroimaging data were significantly associated with incident frailty in unadjusted models, these associations disappeared after adjustment for age, sex, and other confounders. Omega-3 index was the only marker that showed a trend of association with incident frailty.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Article Geriatrics & Gerontology

Dietary Pattern Trajectories in Middle Age and Physical Function in Older Age

Sameera A. Talegawkar et al.

Summary: This study found that improving diet quality in middle age may contribute to better physical function in older age. The results showed an association between dietary trajectories improvement and subsequent improvement in physical function.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Article Geriatrics & Gerontology

Plasma dilution improves cognition and attenuates neuroinflammation in old mice

Melod Mehdipour et al.

Summary: The study shows that neutral blood exchange can enhance brain health and function in old mice, reducing neuroinflammation and improving cognitive abilities.

GEROSCIENCE (2021)

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Article Geriatrics & Gerontology

Senescent cell accumulation mechanisms inferred from parabiosis

Omer Karin et al.

Summary: Senescent cells are growth-arrested cells that contribute to inflammation and aging. Accumulation of senescent cells can be delayed by preventing their production and enhancing their removal, as shown in parabiosis experiments involving young and old mice. The quantitative understanding from these experiments can guide the design of optimal treatments for removing senescent cells.

GEROSCIENCE (2021)

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Article Cardiac & Cardiovascular Systems

Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by longitudinal intravital two-photon microscopy and optical coherence tomography

Adam Nyul-Toth et al.

Summary: Age-related blood-brain barrier disruption and cerebromicrovascular rarefaction play important roles in the pathogenesis of vascular cognitive impairment and dementia (VCID) and Alzheimer's disease (AD). Recent advances in geroscience research have provided new interventions for preventing these diseases. Sensitive and easy-to-adapt imaging methods are urgently needed for longitudinal assessment of changes in BBB permeability and brain capillarization in aged mice.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

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Editorial Material Public, Environmental & Occupational Health

The future of healthy aging: translation of geroscience discoveries to public health practice

Zoltan Ungvari et al.

EUROPEAN JOURNAL OF PUBLIC HEALTH (2021)

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Review Neurosciences

Hyperhomocysteinemia is an emerging comorbidity in ischemic stroke

Ranjana Poddar

Summary: Hyperhomocysteinemia, a common metabolic disorder, is considered a risk factor for ischemic stroke, but it is unclear whether predisposition to this disorder affects the severity of stroke outcome. Current research focuses on the advantages and limitations of rodent models, the impact of mild hyperhomocysteinemia on ischemic brain damage, and the mechanisms of homocysteine-induced neurotoxicity. These findings provide insight into hyperhomocysteinemia as a comorbidity for ischemic stroke and its implications for potential therapeutic agents.

EXPERIMENTAL NEUROLOGY (2021)

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Article Food Science & Technology

Public health risk-benefit assessment of red meat in France: Current consumption and alternative scenarios

Juliana De Oliveira Mota et al.

Summary: Consumption of red meat is associated with risks of colorectal cancer, cardiovascular disease, and foodborne diseases, but can also benefit reduction of iron deficiency anemia. Assessing health risks and benefits for different sub-populations is important for providing tailored recommendations.

FOOD AND CHEMICAL TOXICOLOGY (2021)

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Review Biochemistry & Molecular Biology

Homocysteine in Neurology: A Possible Contributing Factor to Small Vessel Disease

Rita Moretti et al.

Summary: Homocysteine plays a crucial role in various diseases, particularly in cardiovascular diseases. However, there is limited research on its association with small vessel disease, despite evidence suggesting its potential key role in pathogenesis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Geriatrics & Gerontology

National Institute on Aging Workshop: Repurposing Drugs or Dietary Supplements for Their Senolytic or Senomorphic Effects: Considerations for Clinical Trials

Sergei Romashkan et al.

Summary: Cell senescence is linked to various age-related conditions, and there is interest in repurposing drugs to treat these diseases. Future research should focus on finding better and more specific senolytics and senomorphics, as well as implementing standardized measures for data comparison and sharing.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Article Geriatrics & Gerontology

Prevalence of Memory-Related Diagnoses Among US Older Adults With Early Symptoms of Cognitive Impairment

Yuting Qian et al.

Summary: The study found a low prevalence of early diagnosis, or a high rate of underdiagnosis, among older adults showing symptoms of cognitive impairment, especially among non-Whites and socioeconomically disadvantaged subgroups. These results call for targeted interventions to improve the rate of early diagnosis, especially among vulnerable populations.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Article Geriatrics & Gerontology

Epigenetic Age Acceleration and Cognitive Decline:A Twin Study

Viola Vaccarino et al.

Summary: While no association was found between DNAm age acceleration and cognitive function scores at baseline, a longitudinal analysis showed that for each additional year of age acceleration using Horvath's method, there was a 3% decline in composite executive function scores and a 2.5% decline in memory function scores within twin pairs. These results suggest that middle-aged men with older DNAm age compared to their twin brothers experienced a faster rate of cognitive decline over the subsequent 11.5 years, highlighting the role of epigenetic modifications in cognitive aging.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Review Geriatrics & Gerontology

Disrupted ubiquitin proteasome system underlying tau accumulation in Alzheimer's disease

Fang-Lin Weng et al.

Summary: This article discusses the importance of phosphorylated tau in Alzheimer's disease, as well as the critical role of the ubiquitin proteasome system in regulating this process, revealing the close relationship between the two.

NEUROBIOLOGY OF AGING (2021)

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Review Geriatrics & Gerontology

Intermittent fasting: from calories to time restriction

Eleonora Duregon et al.

Summary: Calorie restriction (CR) is a dietary manipulation that can increase health and longevity, and recently, the length and periodicity of daily fasting have emerged as potential drivers behind beneficial health effects. Numerous strategies and eating patterns have been successfully developed to recapitulate the benefits of CR.

GEROSCIENCE (2021)

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Review Geriatrics & Gerontology

Cell-to-cell variation in gene expression and the aging process

Alexander R. Mendenhall et al.

Summary: There is significant variation in biological traits, much of which cannot be explained by changes in DNA sequence. Differences in gene expression are emerging as a key source of variation, impacting traits such as the rate of aging. Changes in cell-to-cell variation in gene expression during aging may be linked to disease vulnerability.

GEROSCIENCE (2021)

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Editorial Material Geriatrics & Gerontology

Heterochronic blood exchange attenuates age-related neuroinflammation and confers cognitive benefits: do microvascular protective effects play a role?

Derek M. Huffman et al.

GEROSCIENCE (2021)

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Article Geriatrics & Gerontology

IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging

Stefano Tarantini et al.

Summary: This study found that disrupted IGF1R signaling pathway affects astrocyte responses to external stimuli, decreases the release of vasodilators, accelerates the metabolism and inactivation of EETs, leading to impaired neurovascular coupling.

GEROSCIENCE (2021)

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Review Geriatrics & Gerontology

The Interplay of the Unfolded Protein Response in Neurodegenerative Diseases: A Therapeutic Role of Curcumin

Sitabja Mukherjee et al.

Summary: The abnormal accumulation of misfolded proteins in the endoplasmic reticulum and their aggregation lead to inflammation, endoplasmic reticulum stress, and the development of neurodegenerative diseases. Curcumin, a mixture of low molecular weight polyphenolic compounds from turmeric, has shown promising effects in preventing various diseases, including SARS-CoV-2 infection and neurodegenerative disorders by regulating the unfolded protein response.

FRONTIERS IN AGING NEUROSCIENCE (2021)

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Article Clinical Neurology

Hypertension With High Homocysteine Is Associated With Default Network Gray Matter Loss

Yanliang Kong et al.

Summary: The study found that high homocysteine levels and hypertension may lead to gray matter loss in the brain's default network, which is associated with cognitive decline.

FRONTIERS IN NEUROLOGY (2021)

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Article Biochemistry & Molecular Biology

Methionine Diet Evoked Hyperhomocysteinemia Causes Hippocampal Alterations, Metabolomics Plasma Changes and Behavioral Pattern in Wild Type Rats

Maria Kovalska et al.

Summary: This study induced mild hyperhomocysteinemia in adult male Wistar rats using a diet enriched with L-methionine, leading to alterations in plasma metabolome, behavioral patterns, and histomorphological changes in the vulnerable hippocampal CA 1 area. The results suggest that mild hyperhomocysteinemia can have negative effects on nervous tissue, likely due to the changes induced by high methionine intake.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Geriatrics & Gerontology

Associations Between Physical Activity, Blood-Based Biomarkers of Neurodegeneration, and Cognition in Healthy Older Adults: The MAPT Study

Jeremy Raffin et al.

Summary: This study found that physical activity is associated with blood NFL concentrations, but not with A beta(42/40). Furthermore, it suggests that physical activity may attenuate the negative association between amyloid load and cognition, while having high NFL levels mitigates the favorable relationship between physical activity and cognition. Additional research on nondemented older adults is needed for further validation of these findings.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Article Geriatrics & Gerontology

Frailty, With or Without Cognitive Impairment, Is a Strong Predictor of Recurrent Falls in a US Population-Representative Sample of Older Adults

Mei-Ling Ge et al.

Summary: This study found that physical frailty and cognitive impairment were separately associated with falls in older adults, and there was a lack of synergistic effect between frailty and cognitive impairment.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Article Geriatrics & Gerontology

Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial: Results of a Post-Hoc Subgroup Analysis

Ruth Stephen et al.

Summary: The study investigated the association between change in CAIDE score and change in neuroimaging biomarkers, finding that reduction in CAIDE score during the intervention was associated with less decline in hippocampus volume. This exploratory finding needs further testing and validation in larger studies.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Review Geriatrics & Gerontology

A ride through the epigenetic landscape: aging reversal by reprogramming

Lucas Paulo de Lima Camillo et al.

Summary: This review explores the interplay between epigenetics and aging, with a focus on the potential of epigenetic reprogramming for age reversal. While in vivo partial reprogramming holds promise as a therapy, there are several limitations that need to be addressed. Reprogramming for rejuvenation is a young but rapidly expanding subfield in the biology of aging.

GEROSCIENCE (2021)

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Article Geriatrics & Gerontology

Rapamycin restores brain vasculature, metabolism, and blood-brain barrier in an inflammaging model

Rheal A. Towner et al.

Summary: Rapamycin has been shown to have neuroprotective properties in rat neuroinflammatory pathologies and has high translational capability in inhibiting neuroinflammation.

GEROSCIENCE (2021)

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Article Pharmacology & Pharmacy

Mild hyperhomocysteinemia induces blood-brain barrier dysfunction but not neuroinflammation in the cerebral cortex and hippocampus of wild-type mice

Min Chu et al.

Summary: This study revealed that mild hyperhomocysteinemia can lead to BBB damage, disrupting brain structure. Even a slight increase in homocysteine levels can destabilize the BBB, but microglia activation and the STAT3 signaling pathway may not play a significant role in this process.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2021)

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Article Nutrition & Dietetics

Hypohomocysteinemia may increases the risk of dementia and Alzheimer's disease: A nationwide population-based prospective cohort study

Jong Bin Bae et al.

Summary: The study showed that both high and low homocysteine levels significantly increased the risk of dementia and AD in older adults. Misuse of vitamin supplements could lead to an increased risk of dementia.

CLINICAL NUTRITION (2021)

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Review Biochemistry & Molecular Biology

Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation

Amany Tawfik et al.

Summary: Hyperhomocysteinemia (HHcy) is common among the aging population, and is linked to neurodegenerative diseases and eye diseases. The disruption of the blood barrier function in the brain and retina due to HHcy leads to inflammatory events that worsen disease pathology, particularly in Alzheimer's disease (AD).

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Geriatrics & Gerontology

Milk, Yogurt, and Cheese Intake Is Positively Associated With Cognitive Executive Functions in Older Adults of the Canadian Longitudinal Study on Aging

Anne-Julie Tessier et al.

Summary: In this study involving older adults, dairy product intake was positively associated with executive function, verbal fluency, and memory domains independently of important covariates. These findings suggest a specific role for dairy components in cognitive performance, particularly in phonemic verbal fluency and memory. Dairy product intake may be a modifiable factor targeted in interventions promoting cognitive health.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Review Urology & Nephrology

Hypertension-induced cognitive impairment: from pathophysiology to public health

Zoltan Ungvari et al.

Summary: Hypertension has significant impacts on cerebral microcirculation which can lead to cognitive impairment, especially in the elderly. Interventions targeting blood pressure reduction, lifestyle changes, and promoting microvascular health have the potential to prevent or delay vascular cognitive impairment and Alzheimer's disease in hypertensive patients.

NATURE REVIEWS NEPHROLOGY (2021)

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Article Geriatrics & Gerontology

Effect of genetic depletion of MMP-9 on neurological manifestations of hypertension-induced intracerebral hemorrhages in aged mice

Stefano Tarantini et al.

Summary: Clinical and experimental studies have shown that hypertension leads to intracerebral hemorrhages, with aging exacerbating the activation of matrix metalloproteinases (MMPs) mediated by oxidative stress, but the activation of MMP-9 does not play a role in the age-related exacerbation of hypertension-induced ICH.

GEROSCIENCE (2021)

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Article Geriatrics & Gerontology

Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity

Kyle M. Schachtschneider et al.

Summary: DNA-methylation profiles have been used to develop accurate biomarkers of age called epigenetic clocks for pigs, showing compatibility with different tissue types and species. The study identified CpG differences between minipigs and domestic pigs, with overlapping genes related to body mass index in humans. Epigenetic and genetic studies highlight potential mechanisms underlying weight gain and susceptibility to cardiovascular disease in different pig breeds.

GEROSCIENCE (2021)

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Review Geriatrics & Gerontology

Imaging retinal microvascular manifestations of carotid artery disease in older adults: from diagnosis of ocular complications to understanding microvascular contributions to cognitive impairment

Lilla Istvan et al.

Summary: CAS is a consequence of systemic atherosclerotic disease affecting the aging populations of the Western world, often associated with cognitive impairment. Understanding the microvascular contributions to cognitive decline associated with CAS is crucial, and the retinal microvasculature provides a unique opportunity to study this. Ocular examination can be used as a noninvasive screening tool to investigate pathological changes in the CNS associated with CAS.

GEROSCIENCE (2021)

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Article Geriatrics & Gerontology

Epigenetic clock and methylation studies in the rhesus macaque

Steve Horvath et al.

Summary: Epigenetic clocks based on methylation levels at specific CpG positions in the genome have been developed for accurate estimation of age, with conservation of principles across mammalian species. Successful development of epigenetic clocks for rhesus macaques highlights their potential for predicting age-related conditions in this widely used nonhuman primate.

GEROSCIENCE (2021)

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Article Geriatrics & Gerontology

Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype

Stefano Tarantini et al.

Summary: The impairment of neurovascular coupling plays a role in the pathogenesis of vascular cognitive impairment, with endothelium-mediated microvascular dilation being central to NVC responses. Disruption of endothelial IGF1R signaling leads to decreased nitric oxide-dependent component of NVC responses, highlighting the importance of IGF-1 in maintaining normal cerebromicrovascular endothelial health.

GEROSCIENCE (2021)

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Article Geriatrics & Gerontology

Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice

Stefano Tarantini et al.

Summary: The present study found that NVC responses were significantly impaired in aged mice, and treatment with ABT263/Navitoclax improved NVC response and hippocampal-encoded functions of learning and memory. The findings suggest that senescent cells in the aged brain may contribute to age-related neurovascular uncoupling, exacerbating cognitive decline. The neurovascular protective effects of ABT263/Navitoclax treatment highlight the potential of senolytic treatments as effective interventions in patients at risk for vascular cognitive impairment.

GEROSCIENCE (2021)

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Review Geriatrics & Gerontology

Role of heat shock proteins in aging and chronic inflammatory diseases

Christian R. Gomez

Summary: Aging is associated with a decrease in response to stress, leading to chronic inflammation and diseases. Heat shock proteins (HSP) play a crucial role in age-related pathology linked to chronic inflammation, offering a potential target for delaying age-related chronic disorders.

GEROSCIENCE (2021)

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Article Geriatrics & Gerontology

Cognitive decrement in older adults with symptomatic peripheral artery disease

Andrew W. Gardner et al.

Summary: Participants with symptomatic peripheral artery disease (PAD) showed significantly lower cognitive function compared to those without PAD, particularly in areas of attention, working memory, and verbal memory. These cognitive difficulties may hinder patient adherence to treatments and require more intensive monitoring and follow-up to address potential cognitive decline affecting care.

GEROSCIENCE (2021)

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Article Geriatrics & Gerontology

DNA methylation age analysis of rapamycin in common marmosets

Steve Horvath et al.

Summary: Researchers have developed epigenetic clocks for common marmosets based on novel DNA methylation data, which showed moderate age correlations with other non-human primate species. The study tested the effects of rapamycin on marmoset epigenetic age but found no significant impact. Additionally, it was noted that unlike other mammals, accurate estimators of sex based on DNA methylation data could not be built for common marmosets.

GEROSCIENCE (2021)

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Article Geriatrics & Gerontology

Necroptosis increases with age in the brain and contributes to age-related neuroinflammation

Nidheesh Thadathil et al.

Summary: Chronic inflammation of the central nervous system (CNS) known as neuroinflammation is a key characteristic of aging and cognitive decline, with necroptosis and the MLKL pathway playing a role in age-related neuroinflammation in specific regions of the brain. Blocking necroptosis can reduce neuroinflammation markers in the brains of old mice.

GEROSCIENCE (2021)

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Article Geriatrics & Gerontology

Einstein-Nathan Shock Center: translating the hallmarks of aging to extend human health span

Ana Maria Cuervo et al.

Summary: The Einstein-Nathan Shock Center aims to make scientific discoveries in geroscience, translate them towards drug discovery, and confirm their relevance to humans. Through cutting-edge research programs and unique support cores, the center integrates key hallmarks of aging and facilitates translational biological research programs. The collaborative nature of the supporting research cores forms the foundation of research success at the E-NSC, allowing for expansion in translational research and new drug design services targeting the hallmarks of aging.

GEROSCIENCE (2021)

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Article Medicine, General & Internal

Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China

Yide Yang et al.

Summary: The study found that the prevalence of hyperhomocysteinemia was 35.4%, with higher rates in men compared to women. Older age, smoking, higher BMI, and lower fruit and vegetable consumption were all associated with increased risk of hyperhomocysteinemia. Sex, education level, and alcohol consumption also interacted to influence the risk of hyperhomocysteinemia.

BMJ OPEN (2021)

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Article Geriatrics & Gerontology

Adherence to the Mediterranean Diet and Physical Resilience in Older Adults: The Seniors-ENRICA Cohort

Mercedes Sotos-Prieto et al.

Summary: Higher adherence to the Mediterranean diet in older adults is associated with greater likelihood of physical resilience, even in the presence of chronic and acute stressors.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Editorial Material Geriatrics & Gerontology

Astrocyte senescence contributes to cognitive decline

Tamas Csipo et al.

GEROSCIENCE (2020)

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Article Geriatrics & Gerontology

Methionine restriction delays aging-related urogenital diseases in male Fischer 344 rats

Despina Komninou et al.

GEROSCIENCE (2020)

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Article Clinical Neurology

Hypertension with Hyperhomocysteinemia Increases the Risk of Early Cognitive Impairment after First-Ever Ischemic Stroke

Zhen-Hui Lu et al.

EUROPEAN NEUROLOGY (2020)

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Review Cardiac & Cardiovascular Systems

Mechanisms of Vascular Aging, A Geroscience Perspective JACC Focus Seminar

Zoltan Ungvari et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Article Geriatrics & Gerontology

Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation-induced impairment of neurovascular coupling responses protecting cognitive function in mice

Andriy Yabluchanskiy et al.

GEROSCIENCE (2020)

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Article Geriatrics & Gerontology

One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project

Noemie Gensous et al.

GEROSCIENCE (2020)

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Article Geriatrics & Gerontology

Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects

Tamas Kiss et al.

GEROSCIENCE (2020)

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Article Biochemistry & Molecular Biology

Homocysteine Induces Inflammation in Retina and Brain

Nehal M. Elsherbiny et al.

BIOMOLECULES (2020)

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Letter Medicine, General & Internal

Red and Processed Meat Consumption and Risk for All-Cause Mortality and Cardiometabolic Outcomes RESPONSE

Dena Zeraatkar et al.

ANNALS OF INTERNAL MEDICINE (2020)

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Article Geriatrics & Gerontology

Human brain networks: a graph theoretical analysis of cortical connectivity normative database from EEG data in healthy elderly subjects

Fabrizio Vecchio et al.

GEROSCIENCE (2020)

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Article Geriatrics & Gerontology

Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood

Tamas Kiss et al.

GEROSCIENCE (2020)

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Article Geriatrics & Gerontology

Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain

Tamas Kiss et al.

GEROSCIENCE (2020)

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Article Geriatrics & Gerontology

Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues

Matthew J. Yousefzadeh et al.

GEROSCIENCE (2020)

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Review Cell Biology

Neurovascular Inflammaging in Health and Disease

Adam Meszaros et al.

CELLS (2020)

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Review Geriatrics & Gerontology

Sleep, brain vascular health and ageing

Arehally M. Mahalakshmi et al.

GEROSCIENCE (2020)

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Review Biochemistry & Molecular Biology

Implication of Hyperhomocysteinemia in Blood Retinal Barrier (BRB) Dysfunction

Amany Tawfik et al.

BIOMOLECULES (2020)

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Review Clinical Neurology

Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop

Berislav Zlokovic et al.

ALZHEIMERS & DEMENTIA (2020)

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Article Cell Biology

Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

Ying-Wooi Wan et al.

CELL REPORTS (2020)

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Review Biochemistry & Molecular Biology

Homocysteine and Mitochondria in Cardiovascular and Cerebrovascular Systems

Peter Kaplan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Immunology

Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer's disease

David J. Braun et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Review Biochemical Research Methods

Proteomic exploration of cystathionine β-synthase deficiency: implications for the clinic

Hieronim Jakubowski

Summary: Homocystinuria due to CBS deficiency is a genetic disorder with severe physiological abnormalities affecting multiple organ systems, for which current treatments are inadequate. Recent research suggests that dysregulated proteostasis plays a key role in the pathogenesis, providing insights for potential drug development and therapeutic interventions.

EXPERT REVIEW OF PROTEOMICS (2020)

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Article Geriatrics & Gerontology

A subtype of cerebrovascular pericytes is associated with blood-brain barrier disruption that develops during normal aging and simian immunodeficiency virus infection

Diana G. Bohannon et al.

NEUROBIOLOGY OF AGING (2020)

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Article Medicine, General & Internal

A Concurrent Ischemic Stroke, Myocardial Infarction, and Aortic Thrombi in a Young Patient with Hyperhomocysteinemia: A Case Report

Sukaina Rawashdeh et al.

INTERNATIONAL MEDICAL CASE REPORTS JOURNAL (2020)

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Review Cell Biology

Mastering organismal aging through the endoplasmic reticulum proteostasis network

Rebecca C. Taylor et al.

AGING CELL (2020)

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Article Veterinary Sciences

The effect of different dietary ratios of lysine and arginine in diets with high or low methionine levels on oxidative and epigenetic DNA damage, the gene expression of tight junction proteins and selected metabolic parameters in Clostridium perfringens-challenged turkeys

Katarzyna Ognik et al.

VETERINARY RESEARCH (2020)

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Article Geriatrics & Gerontology

IGF-1 Deficiency Promotes Pathological Remodeling of Cerebral Arteries: A Potential Mechanism Contributing to the Pathogenesis of Intracerebral Hemorrhages in Aging

Gabor A. Fulop et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2019)

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Article Cardiac & Cardiovascular Systems

Neurovascular and Cognitive Dysfunction in Hypertension Epidemiology, Pathobiology, and Treatment

Costantino Iadecola et al.

CIRCULATION RESEARCH (2019)

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Review Food Science & Technology

The Role of Nutrition for the Aging Population: Implications for Cognition and Alzheimer's Disease

Rebecca Power et al.

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 10 (2019)

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Review Biochemistry & Molecular Biology

NRF2 and NF-κB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches

Farzane Sivandzade et al.

REDOX BIOLOGY (2019)

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Article Geriatrics & Gerontology

High rates of undiagnosed vascular cognitive impairment among American Indian veterans

Angelia C. Kirkpatrick et al.

GEROSCIENCE (2019)

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Review Neurosciences

Aerobic exercise training and vascular function with ageing in healthy men and women

Douglas R. Seals et al.

JOURNAL OF PHYSIOLOGY-LONDON (2019)

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Article Neurosciences

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model

Peisu Zhang et al.

NATURE NEUROSCIENCE (2019)

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Article Geriatrics & Gerontology

Age-related decline in peripheral vascular health predicts cognitive impairment

Tamas Csipo et al.

GEROSCIENCE (2019)

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Article Geriatrics & Gerontology

Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice

Gabriela E. Farias Quipildor et al.

GEROSCIENCE (2019)

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Article Geriatrics & Gerontology

Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment

Tamas Kiss et al.

GEROSCIENCE (2019)

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Article Cardiac & Cardiovascular Systems

Vascular Cognitive Impairment and Dementia

Costantino Iadecola et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice

Stefano Tarantini et al.

REDOX BIOLOGY (2019)

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Article Geriatrics & Gerontology

Age-related impairment of neurovascular coupling responses: a dynamic vessel analysis (DVA)-based approach to measure decreased flicker light stimulus-induced retinal arteriolar dilation in healthy older adults

Agnes Lipecz et al.

GEROSCIENCE (2019)

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Review Medicine, General & Internal

Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes A Systematic Review of Randomized Trials

Dena Zeraatkar et al.

ANNALS OF INTERNAL MEDICINE (2019)

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Article Medicine, General & Internal

Unprocessed Red Meat and Processed Meat Consumption: Dietary Guideline Recommendations From the Nutritional Recommendations (NutriRECS) Consortium

Bradley C. Johnston et al.

ANNALS OF INTERNAL MEDICINE (2019)

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Article Food Science & Technology

Dietary Supplementation of Methyl Donor l-Methionine Alters Epigenetic Modification in Type 2 Diabetes

Umashanker Navik et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2019)

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Review Clinical Neurology

Ageing as a risk factor for neurodegenerative disease

Yujun Hou et al.

NATURE REVIEWS NEUROLOGY (2019)

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Article Geriatrics & Gerontology

Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects

Tamas Kiss et al.

GEROSCIENCE (2019)

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Review Biochemistry & Molecular Biology

Implication of homocysteine in protein quality control processes

V. Sudhakar Reddy et al.

BIOCHIMIE (2019)

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Review Biochemistry & Molecular Biology

The Blood-Brain Barrier and Its Intercellular Junctions in Age-Related Brain Disorders

Laura Costea et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Multidisciplinary Sciences

NLRP3 inflammasome activation drives tau pathology

Christina Ising et al.

NATURE (2019)

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Article Multidisciplinary Sciences

Sex differences in risk factors for stroke in patients with hypertension and hyperhomocysteinemia

Hui Pang et al.

SCIENTIFIC REPORTS (2019)

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Article Cell Biology

Homocysteine and age-associated disorders

E. A. Ostrakhovitch et al.

AGEING RESEARCH REVIEWS (2019)

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Review Geriatrics & Gerontology

Assessment of age-related decline of neurovascular coupling responses by functional near-infrared spectroscopy (fNIRS) in humans

Tamas Csipo et al.

GEROSCIENCE (2019)

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Article Geriatrics & Gerontology

Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD plus depletion hypothesis of neurovascular aging

Stefano Tarantini et al.

GEROSCIENCE (2019)

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Article Geriatrics & Gerontology

Overexpression of catalase targeted to mitochondria improves neurovascular coupling responses in aged mice

Anna Csiszar et al.

GEROSCIENCE (2019)

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Article Geriatrics & Gerontology

Cerebral venous congestion promotes blood-brain barrier disruption and neuroinflammation, impairing cognitive function in mice

Gabor A. Fulop et al.

GEROSCIENCE (2019)

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Time course of neuropathological events in hyperhomocysteinemic amyloid depositing mice reveals early neuroinflammatory changes that precede amyloid changes and cerebrovascular events

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Dietary methionine restriction regulated energy and protein homeostasis by improving thyroid function in high fat diet mice

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High methionine, low folate and low vitamin B6/B12 (HM-LF-LV) diet causes neurodegeneration and subsequent short-term memory loss

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Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation

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Homocysteine concentrations in the cognitive progression of Alzheimer's disease

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Association between hyperhomocysteinemia and stroke with atherosclerosis and small artery occlusion depends on homocysteine metabolism-related vitamin levels in Chinese patients with normal renal function

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Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging

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Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

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Association of Hyperhomocysteinemia with Stroke Recurrence after Initial Stroke

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Red Meat Consumption and the Risk of Stroke: A Dose-Response Meta-analysis of Prospective Cohort Studies

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Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

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Hyperhomocysteinemia impairs regional blood flow: involvements of endothelial and neuronal nitric oxide

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Senescent intimal foam cells are deleterious at all stages of atherosclerosis

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Association of Hyperhomocysteinemia with Stroke Recurrence after Initial Stroke

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Red Meat Consumption and the Risk of Stroke: A Dose-Response Meta-analysis of Prospective Cohort Studies

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High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE-/- mice

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Dietary Methionine Restriction in Mice Elicits an Adaptive Cardiovascular Response to Hyperhomocysteinemia

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Long-term methionine-diet induced mild hyperhomocysteinemia associated cardiac metabolic dysfunction in multiparous rats

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Alterations of Retinal. Vasculature in Cystathionine-β-Synthase Heterozygous Mice A Model of Mild to Moderate Hyperhomocysteinemia

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Hyperhomocysteinemia and Bleomycin Hydrolase Modulate the Expression of Mouse Brain Proteins Involved in Neurodegeneration

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Obesity in Aging Exacerbates Blood-Brain Barrier Disruption, Neuroinflammation, and Oxidative Stress in the Mouse Hippocampus: Effects on Expression of Genes Involved in Beta-Amyloid Generation and Alzheimer's Disease

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Aging Exacerbates Obesity-induced Cerebromicrovascular Rarefaction, Neurovascular Uncoupling, and Cognitive Decline in Mice

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Methionine Restriction Activates the Retrograde Response and Confers Both Stress Tolerance and Lifespan Extension to Yeast, Mouse and Human Cells

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Aging-Induced Dysregulation of Dicer1-Dependent MicroRNA Expression Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells

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Circulating Factors Induced by Caloric Restriction in the Nonhuman Primate Macaca Mulatta Activate Angiogenic Processes in Endothelial Cells

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Methionine-enriched diet decreases hippocampal antioxidant defences and impairs spontaneous behaviour and long-term potentiation in rats

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Methionine-Restricted C57BL/6J Mice Are Resistant to Diet-Induced Obesity and Insulin Resistance but Have Low Bone Density

Gene P. Ables et al.

PLOS ONE (2012)

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Red Meat Consumption and Risk of Stroke A Meta-Analysis of Prospective Studies

Joanna Kaluza et al.

STROKE (2012)

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Red meat consumption and risk of stroke in Swedish men

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AMERICAN JOURNAL OF CLINICAL NUTRITION (2011)

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Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response

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AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2011)

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Aging Causes Collateral Rarefaction and Increased Severity of Ischemic Injury in Multiple Tissues

James E. Faber et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)

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Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine

Alexander McCampbell et al.

JOURNAL OF NEUROCHEMISTRY (2011)

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Age-Associated Vascular Oxidative Stress, Nrf2 Dysfunction, and NF-κB Activation in the Nonhuman Primate Macaca mulatta

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Deborah E. Barnes et al.

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MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2011)

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

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NATURE (2011)

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Methionine diet-induced hyperhomocysteinemia accelerates cerebral aneurysm formation in rats

Yong Xu et al.

NEUROSCIENCE LETTERS (2011)

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Trends in meat consumption in the USA

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PUBLIC HEALTH NUTRITION (2011)

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Red Meat Consumption and Risk of Stroke in Swedish Women

Susanna C. Larsson et al.

STROKE (2011)

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Genotype-independent in vivo oxidative stress following a methionine loading test: Maximal platelet activation in subjects with early-onset thrombosis

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THROMBOSIS RESEARCH (2011)

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Review Cardiac & Cardiovascular Systems

Red and Processed Meat Consumption and Risk of Incident Coronary Heart Disease, Stroke, and Diabetes Mellitus A Systematic Review and Meta-Analysis

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Review Geriatrics & Gerontology

Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction

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JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2010)

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Review Cell Biology

Folate, DNA damage and the aging brain

Michael Fenech

MECHANISMS OF AGEING AND DEVELOPMENT (2010)

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Early-onset ischaemic stroke: Analysis of 58 polymorphisms in 17 genes involved in methionine metabolism

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THROMBOSIS AND HAEMOSTASIS (2010)

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The Krebs Cycle and Mitochondrial Mass Are Early Victims of Endothelial Dysfunction Proteomic Approach

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AMERICAN JOURNAL OF PATHOLOGY (2009)

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Resveratrol Improves Endothelial Function Role of TNFα and Vascular Oxidative Stress

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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)

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Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair

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Homocysteine and inflammation as main determinants of oxidative stress in the elderly

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FREE RADICAL BIOLOGY AND MEDICINE (2009)

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High dietary methionine plus cholesterol stimulates early atherosclerosis and late fibrous cap development which is associated with a decrease in GRP78 positive plaque cells

Anthony Zulli et al.

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2009)

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Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart

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JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2009)

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Aging and sedentarism decrease vascularization and VEGF levels in the rat substantia nigra. Implications for Parkinson's disease

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JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2009)

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Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age

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JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2009)

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Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1

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MECHANISMS OF AGEING AND DEVELOPMENT (2009)

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Review Geriatrics & Gerontology

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NEUROBIOLOGY OF AGING (2009)

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Forty Percent Methionine Restriction Decreases Mitochondrial Oxygen Radical Production and Leak at Complex I During Forward Electron Flow and Lowers Oxidative Damage to Proteins and Mitochondrial DNA in Rat Kidney and Brain Mitochondria

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REJUVENATION RESEARCH (2009)

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STROKE (2009)

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Folate, vitamin B6, vitamin B12, and methionine intakes and risk of stroke subtypes in male smokers

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AMERICAN JOURNAL OF EPIDEMIOLOGY (2008)

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B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Effect of cerebrovascular risk factors on regional cerebral blood flow

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RADIOLOGY (2008)

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Editorial Material Geriatrics & Gerontology

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REJUVENATION RESEARCH (2008)

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Methionine deficiency and hepatic injury in a dietary steatohepatitis model

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Increased mitochondrial H2O2 production promotes endothelial NF-κB activation in aged rat arteries

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Influence of combined methionine synthase (NITR 2756A > G) and methylenetetrahydrofolate reductase (MTHFR 677C>T) polymorphisms to plasma homocysteine levels in Korean patients with ischemic stroke

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Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging

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JOURNAL OF NUTRITION (2006)

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The many facets of hyperhomocysteinemia: Studies from the Framingham cohorts

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JOURNAL OF NUTRITION (2006)

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Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins

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Oxidative stress promotes endothelial cell apoptosis and loss of microvessels in the spontaneously hypertensive rats

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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)

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JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2005)

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Reduced nitric oxide bioavailability contributes to skeletal muscle microvessel rarefaction in the metabolic syndrome

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MICROCIRCULATION (2005)

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Melatonin improves learning and memory performances impaired by hyperhomocysteinemia in rats

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BRAIN RESEARCH (2005)

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Article Nutrition & Dietetics

Mild hyperhomocysteinemia induced by feeding rats diets rich in methionine or deficient in folate promotes early atherosclerotic inflammatory processes

RF Zhang et al.

JOURNAL OF NUTRITION (2004)

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Article Cardiac & Cardiovascular Systems

High dietary methionine plus cholesterol exacerbates atherosclerosis formation in the left main coronary artery of rabbits

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ATHEROSCLEROSIS (2004)

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Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice

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STROKE (2004)

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Remodeling of the skeletal muscle microcirculation increases resistance to perfusion in obese Zucker rats

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AGEING RESEARCH REVIEWS (2003)

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Increased superoxide production in coronary arteries in hyperhomocysteinemia -: Role of tumor necrosis factor-α, NAD(P)H oxidase, and inducible nitric oxide synthase

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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2003)

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Effects of acute hyperhomocysteinemia on the neurovascular coupling mechanism in healthy young adults

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STROKE (2003)

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Article Nutrition & Dietetics

Hyperhomocysteinemia due to short-term folate deprivation is related to electron microscopic changes in the rat brain

JM Kim et al.

JOURNAL OF NUTRITION (2002)

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Impaired nitric oxide-mediated flow-induced coronary dilation in hyperhomocysteinemia - Morphological and functional evidence for increased peroxynitrite formation

Z Ungvari et al.

AMERICAN JOURNAL OF PATHOLOGY (2002)

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Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function

A Csiszar et al.

CIRCULATION RESEARCH (2002)

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Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia - Possible role of peroxynitrite

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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2002)

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Overexpression of cellular glutathione peroxidase rescues homocyst(e)ine-induced endothelial dysfunction

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli -: Important role of nitric oxide

J Hoffmann et al.

CIRCULATION RESEARCH (2001)

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Dietary supplementation with methionine and homocysteine promotes early atherosclerosis but not plaque rupture in apoE-deficient mice

J Zhou et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2001)

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Flow-induced constriction in arterioles of hyperhomocysteinemic rats is due to impaired nitric oxide and enhanced thromboxane A2 mediation

Z Bagi et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2001)

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Simultaneously increased TxA2 activity in isolated arterioles and platelets of rats with hyperhomocysteinemia

Z Ungvari et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2000)

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Effects of methionine-induced hyperhomocysteinemia on endothelium-dependent vasodilation and oxidative status in healthy adults

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CIRCULATION (2000)

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